Engineering Gram Selectivity of Mixed‐Charge Gold Nanoparticles by Tuning the Balance of Surface Charges
Abstract
Abstract Nanoparticles covered with ligand shells comprising both positively and negatively charged ligands exhibit Gram‐selective antibacterial action controlled by a single experimental parameter, namely the proportion of [+] and [−] ligands tethered onto these particles. Gram selectivity is attributed to the interplay between polyvalent electrostatic and non‐covalent interactions that work in unison to disrupt the bacterial cell wall. The [+/−] nanoparticles are effective in low doses, are non‐toxic to mammalian cells, and are tolerated well in mice. These results constitute the first example of rational engineering of Gram selectivity at the (macro)molecular level.
- Authors:
-
- Department of Chemistry and Department of Chemical and Biological Engineering Northwestern University 2145 Sheridan Road Evanston IL 60208 USA, Department of Chemistry Indian Institute of Science Education and Research (IISER) Pune Dr. Homi Bhabha Road Pune 411008 India
- Department of Chemistry and Department of Chemical and Biological Engineering Northwestern University 2145 Sheridan Road Evanston IL 60208 USA
- IBS Center for Soft and Living Matter and Department of Chemistry Ulsan National Institute of Science and Technology (UNIST) Ulsan South Korea
- Publication Date:
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1400458
- Grant/Contract Number:
- SC0000989
- Resource Type:
- Publisher's Accepted Manuscript
- Journal Name:
- Angewandte Chemie
- Additional Journal Information:
- Journal Name: Angewandte Chemie Journal Volume: 128 Journal Issue: 30; Journal ID: ISSN 0044-8249
- Publisher:
- Wiley Blackwell (John Wiley & Sons)
- Country of Publication:
- Germany
- Language:
- English
Citation Formats
Pillai, Pramod P., Kowalczyk, Bartlomiej, Kandere‐Grzybowska, Kristiana, Borkowska, Magdalena, and Grzybowski, Bartosz A. Engineering Gram Selectivity of Mixed‐Charge Gold Nanoparticles by Tuning the Balance of Surface Charges. Germany: N. p., 2016.
Web. doi:10.1002/ange.201602965.
Pillai, Pramod P., Kowalczyk, Bartlomiej, Kandere‐Grzybowska, Kristiana, Borkowska, Magdalena, & Grzybowski, Bartosz A. Engineering Gram Selectivity of Mixed‐Charge Gold Nanoparticles by Tuning the Balance of Surface Charges. Germany. https://doi.org/10.1002/ange.201602965
Pillai, Pramod P., Kowalczyk, Bartlomiej, Kandere‐Grzybowska, Kristiana, Borkowska, Magdalena, and Grzybowski, Bartosz A. Thu .
"Engineering Gram Selectivity of Mixed‐Charge Gold Nanoparticles by Tuning the Balance of Surface Charges". Germany. https://doi.org/10.1002/ange.201602965.
@article{osti_1400458,
title = {Engineering Gram Selectivity of Mixed‐Charge Gold Nanoparticles by Tuning the Balance of Surface Charges},
author = {Pillai, Pramod P. and Kowalczyk, Bartlomiej and Kandere‐Grzybowska, Kristiana and Borkowska, Magdalena and Grzybowski, Bartosz A.},
abstractNote = {Abstract Nanoparticles covered with ligand shells comprising both positively and negatively charged ligands exhibit Gram‐selective antibacterial action controlled by a single experimental parameter, namely the proportion of [+] and [−] ligands tethered onto these particles. Gram selectivity is attributed to the interplay between polyvalent electrostatic and non‐covalent interactions that work in unison to disrupt the bacterial cell wall. The [+/−] nanoparticles are effective in low doses, are non‐toxic to mammalian cells, and are tolerated well in mice. These results constitute the first example of rational engineering of Gram selectivity at the (macro)molecular level.},
doi = {10.1002/ange.201602965},
journal = {Angewandte Chemie},
number = 30,
volume = 128,
place = {Germany},
year = {Thu Jun 02 00:00:00 EDT 2016},
month = {Thu Jun 02 00:00:00 EDT 2016}
}
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