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Title: CO 2 -Reactive Ionic Liquid Surfactants for the Control of Colloidal Morphology

Here, this article reports on a new class of stimuli-responsive surfactant generated from commercially available amphiphiles such as dodecyltrimethylammmonium bromide (DTAB) by substitution of the halide counterion with counterions such as 2-cyanopyrrolide, 1,2,3-triazolide, and L-proline that complex reversibly with CO 2. Through a combination of small-angle neutron scattering (SANS), electrical conductivity measurements, thermal gravimetric analysis, and molecular dynamics simulations, we show how small changes in charge reorganization and counterion shape and size induced by complexation with CO 2 allow for fine-tunability of surfactant properties. Additionally, we then use these findings to demonstrate a range of potential practical uses, from manipulating microemulsion droplet morphology to controlling micellar and vesicular aggregation. In particular, we focus on the binding of these surfactants to DNA and the reversible compaction of surfactant–DNA complexes upon alternate bubbling of the solution with CO 2 and N 2.
Authors:
ORCiD logo [1] ;  [1] ;  [1] ;  [1] ;  [2] ;  [1] ;  [1] ; ORCiD logo [3] ; ORCiD logo [1] ; ORCiD logo [1] ; ORCiD logo [1]
  1. Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States). Department of Chemical Engineering
  2. Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States). Synthetic Biology Group, MIT Synthetic Biology Center, Research Laboratory of Electronics, Department of Biological Engineering, Department of Electrical Engineering and Computer Science; Eli and Edythe L. Broad Institute of MIT and Harvard, Cambridge, MA (United States); Harvard Univ., Cambridge, MA (United States). Harvard Biophysics Program
  3. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Biology and Soft Matter Division
Publication Date:
Grant/Contract Number:
AC05-00OR22725
Type:
Accepted Manuscript
Journal Name:
Langmuir
Additional Journal Information:
Journal Volume: 33; Journal Issue: 31; Journal ID: ISSN 0743-7463
Publisher:
American Chemical Society
Research Org:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Sponsoring Org:
USDOE Office of Science (SC)
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; Surfactants; CO2-responsive; DNA compaction; MD simulations; Ionic Liquids
OSTI Identifier:
1399973

Brown, Paul, Sresht, Vishnu, Eral, Burak H., Fiore, Andrew, de la Fuente-Núñez, César, O’Mahony, Marcus, Mendes, Gabriel P., Heller, William T., Doyle, Patrick S., Blankschtein, Daniel, and Hatton, T. Alan. CO2 -Reactive Ionic Liquid Surfactants for the Control of Colloidal Morphology. United States: N. p., Web. doi:10.1021/acs.langmuir.7b00679.
Brown, Paul, Sresht, Vishnu, Eral, Burak H., Fiore, Andrew, de la Fuente-Núñez, César, O’Mahony, Marcus, Mendes, Gabriel P., Heller, William T., Doyle, Patrick S., Blankschtein, Daniel, & Hatton, T. Alan. CO2 -Reactive Ionic Liquid Surfactants for the Control of Colloidal Morphology. United States. doi:10.1021/acs.langmuir.7b00679.
Brown, Paul, Sresht, Vishnu, Eral, Burak H., Fiore, Andrew, de la Fuente-Núñez, César, O’Mahony, Marcus, Mendes, Gabriel P., Heller, William T., Doyle, Patrick S., Blankschtein, Daniel, and Hatton, T. Alan. 2017. "CO2 -Reactive Ionic Liquid Surfactants for the Control of Colloidal Morphology". United States. doi:10.1021/acs.langmuir.7b00679. https://www.osti.gov/servlets/purl/1399973.
@article{osti_1399973,
title = {CO2 -Reactive Ionic Liquid Surfactants for the Control of Colloidal Morphology},
author = {Brown, Paul and Sresht, Vishnu and Eral, Burak H. and Fiore, Andrew and de la Fuente-Núñez, César and O’Mahony, Marcus and Mendes, Gabriel P. and Heller, William T. and Doyle, Patrick S. and Blankschtein, Daniel and Hatton, T. Alan},
abstractNote = {Here, this article reports on a new class of stimuli-responsive surfactant generated from commercially available amphiphiles such as dodecyltrimethylammmonium bromide (DTAB) by substitution of the halide counterion with counterions such as 2-cyanopyrrolide, 1,2,3-triazolide, and L-proline that complex reversibly with CO2. Through a combination of small-angle neutron scattering (SANS), electrical conductivity measurements, thermal gravimetric analysis, and molecular dynamics simulations, we show how small changes in charge reorganization and counterion shape and size induced by complexation with CO2 allow for fine-tunability of surfactant properties. Additionally, we then use these findings to demonstrate a range of potential practical uses, from manipulating microemulsion droplet morphology to controlling micellar and vesicular aggregation. In particular, we focus on the binding of these surfactants to DNA and the reversible compaction of surfactant–DNA complexes upon alternate bubbling of the solution with CO2 and N2.},
doi = {10.1021/acs.langmuir.7b00679},
journal = {Langmuir},
number = 31,
volume = 33,
place = {United States},
year = {2017},
month = {7}
}