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Title: CO 2 -Reactive Ionic Liquid Surfactants for the Control of Colloidal Morphology

Here, this article reports on a new class of stimuli-responsive surfactant generated from commercially available amphiphiles such as dodecyltrimethylammmonium bromide (DTAB) by substitution of the halide counterion with counterions such as 2-cyanopyrrolide, 1,2,3-triazolide, and L-proline that complex reversibly with CO 2. Through a combination of small-angle neutron scattering (SANS), electrical conductivity measurements, thermal gravimetric analysis, and molecular dynamics simulations, we show how small changes in charge reorganization and counterion shape and size induced by complexation with CO 2 allow for fine-tunability of surfactant properties. Additionally, we then use these findings to demonstrate a range of potential practical uses, from manipulating microemulsion droplet morphology to controlling micellar and vesicular aggregation. In particular, we focus on the binding of these surfactants to DNA and the reversible compaction of surfactant–DNA complexes upon alternate bubbling of the solution with CO 2 and N 2.
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  1. Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States). Department of Chemical Engineering
  2. Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States). Synthetic Biology Group, MIT Synthetic Biology Center, Research Laboratory of Electronics, Department of Biological Engineering, Department of Electrical Engineering and Computer Science; Eli and Edythe L. Broad Institute of MIT and Harvard, Cambridge, MA (United States); Harvard Univ., Cambridge, MA (United States). Harvard Biophysics Program
  3. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Biology and Soft Matter Division
Publication Date:
Grant/Contract Number:
Accepted Manuscript
Journal Name:
Additional Journal Information:
Journal Volume: 33; Journal Issue: 31; Journal ID: ISSN 0743-7463
American Chemical Society
Research Org:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Sponsoring Org:
USDOE Office of Science (SC)
Country of Publication:
United States
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; Surfactants; CO2-responsive; DNA compaction; MD simulations; Ionic Liquids
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