TSLP signaling blocking alleviates E-cadherin dysfunction of airway epithelium in a HDM-induced asthma model

Hu, Yahui; Dong, Hangming; Zou, Mengchen; Huang, Chaowen; Luo, Lishan; Yu, Changhui; Chen, JiaLong; Xie, Zhefan; Zhao, Haijin; Le, Yanqing; Zou, Fei; Liu, Laiyu; Cai, Shaoxi

doi:10.1016/j.cellimm.2017.02.003

Title: TSLP signaling blocking alleviates E-cadherin dysfunction of airway epithelium in a HDM-induced asthma model

Full Record
Other Related Research

Authors:: Hu, Yahui; Dong, Hangming; Zou, Mengchen; Huang, Chaowen; Luo, Lishan; Yu, Changhui; Chen, JiaLong; Xie, Zhefan; Zhao, Haijin; Le, Yanqing; Zou, Fei; Liu, Laiyu; Cai, Shaoxi

Publication Date:: 2017-05-01

Sponsoring Org.:: USDOE Office of Electricity (OE), Advanced Grid Research & Development. Power Systems Engineering Research

OSTI Identifier:: 1396891

Grant/Contract Number:: 81470228; 81270087; 81500023; 81300029; 81270089; 81670026; 2012CB518203; S2013040013505; 2014A030310325; 2015A030313236; 2016A020215117; 201512223175676

Resource Type:: Publisher's Accepted Manuscript

Journal Name:: Cellular Immunology

Additional Journal Information:: Journal Name: Cellular Immunology Journal Volume: 315 Journal Issue: C; Journal ID: ISSN 0008-8749

Publisher:: Elsevier

Country of Publication:: United States

Language:: English

Citation Formats


                    Hu, Yahui, Dong, Hangming, Zou, Mengchen, Huang, Chaowen, Luo, Lishan, Yu, Changhui, Chen, JiaLong, Xie, Zhefan, Zhao, Haijin, Le, Yanqing, Zou, Fei, Liu, Laiyu, and Cai, Shaoxi. TSLP signaling blocking alleviates E-cadherin dysfunction of airway epithelium in a HDM-induced asthma model.  United States: N. p., 2017. 
Web.  doi:10.1016/j.cellimm.2017.02.003.

Copy to clipboard


                    Hu, Yahui, Dong, Hangming, Zou, Mengchen, Huang, Chaowen, Luo, Lishan, Yu, Changhui, Chen, JiaLong, Xie, Zhefan, Zhao, Haijin, Le, Yanqing, Zou, Fei, Liu, Laiyu, & Cai, Shaoxi. TSLP signaling blocking alleviates E-cadherin dysfunction of airway epithelium in a HDM-induced asthma model.  United States.  https://doi.org/10.1016/j.cellimm.2017.02.003

Copy to clipboard


                    Hu, Yahui, Dong, Hangming, Zou, Mengchen, Huang, Chaowen, Luo, Lishan, Yu, Changhui, Chen, JiaLong, Xie, Zhefan, Zhao, Haijin, Le, Yanqing, Zou, Fei, Liu, Laiyu, and Cai, Shaoxi. Mon .  
"TSLP signaling blocking alleviates E-cadherin dysfunction of airway epithelium in a HDM-induced asthma model".  United States.  https://doi.org/10.1016/j.cellimm.2017.02.003.

Copy to clipboard


                    
@article{osti_1396891,

  title        = {TSLP signaling blocking alleviates E-cadherin dysfunction of airway epithelium in a HDM-induced asthma model},

  author       = {Hu, Yahui and Dong, Hangming and Zou, Mengchen and Huang, Chaowen and Luo, Lishan and Yu, Changhui and Chen, JiaLong and Xie, Zhefan and Zhao, Haijin and Le, Yanqing and Zou, Fei and Liu, Laiyu and Cai, Shaoxi},

  abstractNote = {},

  doi          = {10.1016/j.cellimm.2017.02.003},

  journal      = {Cellular Immunology},

  number       = C,

  volume       = 315,

  place        = {United States},

  year         = {2017},

  month        = {5}

}

Copy to clipboard

Journal Article:

Free Publicly Available Full Text

Accepted Manuscript (Publisher)

Publisher's Version of Record
https://doi.org/10.1016/j.cellimm.2017.02.003

Other availability

Search WorldCat to find libraries that may hold this journal

Citation Metrics:

Cited by: 4 works

Citation information provided by
Web of Science

Save / Share:

Export Metadata

Save to My Library

Similar Records in DOE PAGES and OSTI.GOV collections:

Resveratrol alleviates diabetes-induced testicular dysfunction by inhibiting oxidative stress and c-Jun N-terminal kinase signaling in rats

Journal Article Faid, Iman ; Al-Hussaini, Heba ; Kilarkaje, Narayana - Toxicology and Applied Pharmacology

Diabetes adversely affects reproductive functions in humans and animals. The present study investigated the effects of Resveratrol on diabetes-induced alterations in oxidative stress, c-Jun N-terminal kinase (JNK) signaling and apoptosis in the testis. Adult male Wistar rats (13–15 weeks; n = 6/group) were segregated into 1) normal control, 2) Resveratrol-treated (5 mg/kg; ip; given during last 3 weeks), 3) Streptozotocin-induced diabetic and, 4) Resveratrol-treated diabetic groups, and euthanized on day 42 after the confirmation of diabetes. Resveratrol did not normalize blood glucose levels in diabetic rats. Resveratrol supplementation recovered diabetes-induced decreases in reproductive organ weights, sperm count and motility, intra-testicularmore »« less
https://doi.org/10.1016/J.TAAP.2015.10.012
Vasoactive intestinal peptide inhibits airway smooth muscle cell proliferation in a mouse model of asthma via the ERK1/2 signaling pathway

Journal Article Wang, Juan ; Shang, Yun-Xiao ; Cai, Xu-Xu ; ... - Experimental Cell Research

Highlights: • VIP inhibited the occurrence of OVA-induced airway remodeling in mice. • VIP inhibited the proliferation of ASMCs by inhibiting the down-regulation of Cav-1. • VIP inhibited the proliferation of ASMCs via the ERK1/2 signaling pathway and decreased the proportion of cells in S phase. • VIP inhibited airway remodeling and therefore provided a new approach for the treatment of asthma. Asthma is a heterogeneous clinical syndrome characterized by airway inflammation, hyper-responsiveness and remodeling. Airway remodeling is irreversible by current antiasthmatic drugs, and it is the main cause of severe asthma. Airway smooth muscle cells (ASMCs) act as themore »« less
https://doi.org/10.1016/J.YEXCR.2018.01.042
A semisynthetic diterpenoid lactone inhibits NF-κB signalling to ameliorate inflammation and airway hyperresponsiveness in a mouse asthma model

Journal Article Lim, J. C.-W. ; Goh, F. -Y. ; Sagineedu, S. -R. ; ... - Toxicology and Applied Pharmacology

Andrographolide (AGP) and 14-deoxy-11,12-didehydroandrographolide (DDAG), two main diterpenoid constituents of Andrographis paniculata were previously shown to ameliorate asthmatic symptoms in a mouse model. However, due to inadequacies of both compounds in terms of drug-likeness, DDAG analogues were semisynthesised for assessment of their anti-asthma activity. A selected analogue, 3,19-diacetyl-14-deoxy-11,12-didehydroandrographolide (SRS27), was tested for inhibitory activity of NF-κB activation in TNF-α-induced A549 cells and was subsequently evaluated in a mouse model of ovalbumin (OVA)-induced asthma. Female BALB/c mice, 6–8 weeks old were sensitized on days 0 and 14, and challenged on days 22, 23 and 24 with OVA. Compound or vehicle (3%more »« less
https://doi.org/10.1016/J.TAAP.2016.04.004
Clonorchis sinensis-derived total protein attenuates airway inflammation in murine asthma model by inducing regulatory T cells and modulating dendritic cell functions

Journal Article Jeong, Young-Il ; Kim, Seung Hyun ; Ju, Jung Won ; ... - Biochemical and Biophysical Research Communications

Highlights: {yields} Treatment with Clonorchis sinensis-derived total protein attenuates OVA-induced airway inflammation and AHR to methacholine. {yields} Induction of CD4{sup +}CD25{sup +}Foxp3{sup +} T cells and IL-10 along with suppression of splenocyte proliferation by C. sinensis-derived total protein. {yields} C. sinensis-derived total protein interferes with the expression of co-stimulatory molecules in DCs. -- Abstract: Asthma is characterized by Th2-mediated inflammation, resulting in airway hyperresponsiveness (AHR) through airway remodeling. Recent epidemiological and experimental reports have suggested an inverse relationship between the development of allergy and helminth infections. Infection by Clonorchis sinensis, a liver fluke that resides in the bile duct ofmore »« less
https://doi.org/10.1016/J.BBRC.2011.03.102
Anti-inflammatory effects of Tat-Annexin protein on ovalbumin-induced airway inflammation in a mouse model of asthma

Journal Article Lee, Sun Hwa ; Kim, Dae Won ; Kim, Hye Ri ; ... - Biochemical and Biophysical Research Communications

Highlights: Black-Right-Pointing-Pointer We construct a cell permeable Tat-ANX1 fusion protein. Black-Right-Pointing-Pointer We examined the protective effects of Tat-ANX1 protein on OVA-induced asthma in animal models. Black-Right-Pointing-Pointer Transduced Tat-ANX1 protein protects from the OVA-induced production of cytokines and eosinophils in BAL fluid. Black-Right-Pointing-Pointer Tat-ANX1 protein markedly reduced OVA-induced MAPK in lung tissues. Black-Right-Pointing-Pointer Tat-ANX1 protein could be useful as a therapeutic agent for lung disorders including asthma. -- Abstract: Chronic airway inflammation is a key feature of bronchial asthma. Annexin-1 (ANX1) is an anti-inflammatory protein that is an important modulator and plays a key role in inflammation. Although the precise actionmore »« less
https://doi.org/10.1016/J.BBRC.2011.12.084

Similar Records