Estimating the reproductive number, total outbreak size, and reporting rates for Zika epidemics in South and Central America
Abstract
As South and Central American countries prepare for increased birth defects from Zika virus outbreaks and plan for mitigation strategies to minimize ongoing and future outbreaks, understanding important characteristics of Zika outbreaks and how they vary across regions is a challenging and important problem. We developed a mathematical model for the 2015/2016 Zika virus outbreak dynamics in Colombia, El Salvador, and Suriname. We fit the model to publicly available data provided by the Pan American Health Organization, using Approximate Bayesian Computation to estimate parameter distributions and provide uncertainty quantification. The model indicated that a country-level analysis was not appropriate for Colombia. We then estimated the basic reproduction number to range between 4 and 6 for El Salvador and Suriname with a median of 4.3 and 5.3, respectively. We estimated the reporting rate to be around 16% in El Salvador and 18% in Suriname with estimated total outbreak sizes of 73,395 and 21,647 people, respectively. The uncertainty in parameter estimates highlights a need for research and data collection that will better constrain parameter ranges.
- Authors:
-
- Virginia Military Inst., Lexington, VA (United States)
- Los Alamos National Lab. (LANL), Los Alamos, NM (United States); The New Mexico Consortium, Los Alamos, NM (United States)
- Colorado School of Mines, Golden, CO (United States)
- Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
- Publication Date:
- Research Org.:
- Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
- Sponsoring Org.:
- National Science Foundation (NSF); USDOE
- OSTI Identifier:
- 1396120
- Report Number(s):
- LA-UR-17-20963
Journal ID: ISSN 1755-4365
- Grant/Contract Number:
- AC52-06NA25396
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Epidemics
- Additional Journal Information:
- Journal Volume: 21; Journal ID: ISSN 1755-4365
- Publisher:
- Elsevier
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 60 APPLIED LIFE SCIENCES; Mathematics
Citation Formats
Shutt, Deborah P., Manore, Carrie A., Pankavich, Stephen, Porter, Aaron T., and Del Valle, Sara Y. Estimating the reproductive number, total outbreak size, and reporting rates for Zika epidemics in South and Central America. United States: N. p., 2017.
Web. doi:10.1016/j.epidem.2017.06.005.
Shutt, Deborah P., Manore, Carrie A., Pankavich, Stephen, Porter, Aaron T., & Del Valle, Sara Y. Estimating the reproductive number, total outbreak size, and reporting rates for Zika epidemics in South and Central America. United States. https://doi.org/10.1016/j.epidem.2017.06.005
Shutt, Deborah P., Manore, Carrie A., Pankavich, Stephen, Porter, Aaron T., and Del Valle, Sara Y. Thu .
"Estimating the reproductive number, total outbreak size, and reporting rates for Zika epidemics in South and Central America". United States. https://doi.org/10.1016/j.epidem.2017.06.005. https://www.osti.gov/servlets/purl/1396120.
@article{osti_1396120,
title = {Estimating the reproductive number, total outbreak size, and reporting rates for Zika epidemics in South and Central America},
author = {Shutt, Deborah P. and Manore, Carrie A. and Pankavich, Stephen and Porter, Aaron T. and Del Valle, Sara Y.},
abstractNote = {As South and Central American countries prepare for increased birth defects from Zika virus outbreaks and plan for mitigation strategies to minimize ongoing and future outbreaks, understanding important characteristics of Zika outbreaks and how they vary across regions is a challenging and important problem. We developed a mathematical model for the 2015/2016 Zika virus outbreak dynamics in Colombia, El Salvador, and Suriname. We fit the model to publicly available data provided by the Pan American Health Organization, using Approximate Bayesian Computation to estimate parameter distributions and provide uncertainty quantification. The model indicated that a country-level analysis was not appropriate for Colombia. We then estimated the basic reproduction number to range between 4 and 6 for El Salvador and Suriname with a median of 4.3 and 5.3, respectively. We estimated the reporting rate to be around 16% in El Salvador and 18% in Suriname with estimated total outbreak sizes of 73,395 and 21,647 people, respectively. The uncertainty in parameter estimates highlights a need for research and data collection that will better constrain parameter ranges.},
doi = {10.1016/j.epidem.2017.06.005},
journal = {Epidemics},
number = ,
volume = 21,
place = {United States},
year = {Thu Jul 13 00:00:00 EDT 2017},
month = {Thu Jul 13 00:00:00 EDT 2017}
}
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