Title: Reactive species responsible for the inactivation of feline calicivirus by a two‐dimensional array of integrated coaxial microhollow dielectric barrier discharges in air

Abstract

The use of low‐temperature plasmas for bio‐decontamination and sterilization has been gaining increased attention. In this study, a two‐dimensional array of integrated coaxial microhollow micro‐discharges generated in dry air at atmospheric pressure is used to treat metal surfaces (gas‐phase) and solution (liquid‐phase) contaminated with a known concentration of feline calicivirus (FCV). FCV acts as a surrogate for human norovirus, which is responsible for causing outbreaks of acute gastroenteritis in humans. The decontamination efficacy as well as the primary chemical pathways leading to virus inactivation in both the treatments are studied and compared. It is found that the humidity of the bio‐sample for gas‐phase treatment in dry air is required to achieve >5 log ₁₀ reduction in FCV titer within 3 min. The gas‐phase FCV inactivation is found to be due to a combination of ozone (O ₃ ) and reactive nitrogen species (RNS), most likely NO _x . The liquid‐phase FCV inactivation mechanism is pH‐dependent and is primarily due to RNS, most likely acidified nitrites. O ₃ has a negligible effect on FCV suspended in solution. Previous studies performed in a batch reactor have shown that the inactivation pathways through O ₃ and RNS are mutually exclusive due to ozone poisoningmore » at high N _x O _y concentrations. The present study employs a flow‐through system which avoids accumulation of reactive species and allows for the coexistence of NO _x and O ₃ for the gas residence times used in this study, giving rise to these specific inactivation pathways.« less

Authors:

Nayak, Gaurav  ^[1];

• Search DOE PAGES for author "Nayak, Gaurav"
• Search DOE PAGES for ORCID "0000-0001-5716-0062"

Aboubakr, Hamada A. ^[2]; Goyal, Sagar M. ^[2]; Bruggeman, Peter J.  ^[1]

• Search DOE PAGES for author "Bruggeman, Peter J."
• Search DOE PAGES for ORCID "0000-0003-3346-7275"

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+ Show Author Affiliations

1. Department of Mechanical Engineering University of Minnesota 111 Church Street SE Minneapolis 55414 Minnesota
2. Veterinary Diagnostic Laboratory, College of Veterinary Medicine University of Minnesota 1333 Gortner Avenue St. Paul 55108 Minnesota

Publication Date:

Fri Sep 29 00:00:00 EDT 2017

Sponsoring Org.:

USDOE

OSTI Identifier:

1395599

Grant/Contract Number:  

DE‐SC0001939

Resource Type:

Publisher's Accepted Manuscript

Journal Name:

Plasma Processes and Polymers

Additional Journal Information:

Journal Name: Plasma Processes and Polymers Journal Volume: 15 Journal Issue: 1; Journal ID: ISSN 1612-8850

Publisher:

Wiley Blackwell (John Wiley & Sons)

Country of Publication:

Germany

Language:

English