The chicken or the egg: mitochondrial dysfunction as a cause or consequence of toxicity in Huntington’s disease
Abstract
Mitochondrial dysfunction and ensuing oxidative damage is typically thought to be a primary cause of Huntington's disease, Alzheimer's disease, and Parkinson disease. There is little doubt that mitochondria (MT) become defective as neurons die, yet whether MT defects are the primary cause or a detrimental consequence of toxicity remains unanswered. Oxygen consumption rate (OCR) and glycolysis provide sensitive and informative measures of the functional status MT and the cells metabolic regulation, yet these measures differ depending on the sample source; species, tissue type, age at measurement, and whether MT are measured in purified form or in a cell. The effects of these various parameters are difficult to quantify and not fully understood, but clearly have an impact on interpreting the bioenergetics of MT or their failure in disease states. A major goal of the review is to discuss issues and coalesce detailed information into a reference table to help in assessing mitochondrial dysfunction as a cause or consequence of Huntington's disease.
- Authors:
-
[1];
- Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Molecular Biophysics and Integrated Bioimaging Division
- Publication Date:
- Research Org.:
- Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
- Sponsoring Org.:
- National Institutes of Health (NIH)
- OSTI Identifier:
- 1393099
- Grant/Contract Number:
- AC02-05CH11231; NS060115; CA092584
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Mechanisms of Ageing and Development
- Additional Journal Information:
- Journal Volume: 161; Journal Issue: Part A; Journal ID: ISSN 0047-6374
- Publisher:
- Elsevier
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 60 APPLIED LIFE SCIENCES; 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Polyzos, Aris A., and McMurray, Cynthia T. The chicken or the egg: mitochondrial dysfunction as a cause or consequence of toxicity in Huntington’s disease. United States: N. p., 2016.
Web. doi:10.1016/j.mad.2016.09.003.
Polyzos, Aris A., & McMurray, Cynthia T. The chicken or the egg: mitochondrial dysfunction as a cause or consequence of toxicity in Huntington’s disease. United States. https://doi.org/10.1016/j.mad.2016.09.003
Polyzos, Aris A., and McMurray, Cynthia T. Mon .
"The chicken or the egg: mitochondrial dysfunction as a cause or consequence of toxicity in Huntington’s disease". United States. https://doi.org/10.1016/j.mad.2016.09.003. https://www.osti.gov/servlets/purl/1393099.
@article{osti_1393099,
title = {The chicken or the egg: mitochondrial dysfunction as a cause or consequence of toxicity in Huntington’s disease},
author = {Polyzos, Aris A. and McMurray, Cynthia T.},
abstractNote = {Mitochondrial dysfunction and ensuing oxidative damage is typically thought to be a primary cause of Huntington's disease, Alzheimer's disease, and Parkinson disease. There is little doubt that mitochondria (MT) become defective as neurons die, yet whether MT defects are the primary cause or a detrimental consequence of toxicity remains unanswered. Oxygen consumption rate (OCR) and glycolysis provide sensitive and informative measures of the functional status MT and the cells metabolic regulation, yet these measures differ depending on the sample source; species, tissue type, age at measurement, and whether MT are measured in purified form or in a cell. The effects of these various parameters are difficult to quantify and not fully understood, but clearly have an impact on interpreting the bioenergetics of MT or their failure in disease states. A major goal of the review is to discuss issues and coalesce detailed information into a reference table to help in assessing mitochondrial dysfunction as a cause or consequence of Huntington's disease.},
doi = {10.1016/j.mad.2016.09.003},
journal = {Mechanisms of Ageing and Development},
number = Part A,
volume = 161,
place = {United States},
year = {Mon Sep 12 00:00:00 EDT 2016},
month = {Mon Sep 12 00:00:00 EDT 2016}
}
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Guidelines on experimental methods to assess mitochondrial dysfunction in cellular models of neurodegenerative diseases
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Guidelines on experimental methods to assess mitochondrial dysfunction in cellular models of neurodegenerative diseases
journal, December 2017
- Connolly, Niamh M. C.; Theurey, Pierre; Adam-Vizi, Vera
- Cell Death & Differentiation, Vol. 25, Issue 3