Organoids: A historical perspective of thinking in three dimensions
Abstract
In the last ten years, there has been a dramatic surge in the number of publications where single or groups of cells are grown in substrata that have elements of basement membrane leading to the formation of tissue-like structures referred to as organoids. However, this field of research began many decades ago, when the pioneers of cell culture began to ask questions we still ask today: How does organogenesis occur? How do signals integrate to make such vastly different tissues and organs given that the sequence of the genome in our trillions of cells is identical? Here, we summarize how work over the past century generated the conceptual framework that has allowed us to make progress in the understanding of tissue-specific morphogenetic programs. The development of cell culture systems that provide accurate and physiologically relevant models are proving to be key in establishing appropriate platforms for the development of new therapeutic strategies.
- Publication Date:
- Research Org.:
- Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC)
- OSTI Identifier:
- 1340023
- Alternate Identifier(s):
- OSTI ID: 1379625
- Grant/Contract Number:
- AC02-05CH11231
- Resource Type:
- Published Article
- Journal Name:
- Journal of Cell Biology
- Additional Journal Information:
- Journal Name: Journal of Cell Biology Journal Volume: 216 Journal Issue: 1; Journal ID: ISSN 0021-9525
- Publisher:
- Rockefeller University Press
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Simian, Marina, and Bissell, Mina J. Organoids: A historical perspective of thinking in three dimensions. United States: N. p., 2016.
Web. doi:10.1083/jcb.201610056.
Simian, Marina, & Bissell, Mina J. Organoids: A historical perspective of thinking in three dimensions. United States. https://doi.org/10.1083/jcb.201610056
Simian, Marina, and Bissell, Mina J. Wed .
"Organoids: A historical perspective of thinking in three dimensions". United States. https://doi.org/10.1083/jcb.201610056.
@article{osti_1340023,
title = {Organoids: A historical perspective of thinking in three dimensions},
author = {Simian, Marina and Bissell, Mina J.},
abstractNote = {In the last ten years, there has been a dramatic surge in the number of publications where single or groups of cells are grown in substrata that have elements of basement membrane leading to the formation of tissue-like structures referred to as organoids. However, this field of research began many decades ago, when the pioneers of cell culture began to ask questions we still ask today: How does organogenesis occur? How do signals integrate to make such vastly different tissues and organs given that the sequence of the genome in our trillions of cells is identical? Here, we summarize how work over the past century generated the conceptual framework that has allowed us to make progress in the understanding of tissue-specific morphogenetic programs. The development of cell culture systems that provide accurate and physiologically relevant models are proving to be key in establishing appropriate platforms for the development of new therapeutic strategies.},
doi = {10.1083/jcb.201610056},
journal = {Journal of Cell Biology},
number = 1,
volume = 216,
place = {United States},
year = {Wed Dec 28 00:00:00 EST 2016},
month = {Wed Dec 28 00:00:00 EST 2016}
}
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