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Title: Impact of lifestyle dimensions on brain pathology and cognition

Single lifestyle factors affect brain biomarkers and cognition. Here in this work, we addressed the covariance of various lifestyle elements and investigated their impact on positron emission tomography-based β-amyloid (Aβ), hippocampal volume, and cognitive function in aged controls. Lower Aβ burden was associated with a lifestyle comprising high cognitive engagement and low vascular risk, particularly in apolipoprotein E ε4 carriers. Although cognitive function was related to high lifetime cognitive engagement and low vascular risk, Aβ load had no relation to current cognitive function. The covariance between high adult socioeconomic status, high education, and low smoking prevalence predicted better cognitive function and this was mediated by larger hippocampal volume. Our data show that lifestyle is a complex construct composed of associated variables, some of which reflect factors operating over the life span and others which may be developmental. These factors affect brain health via different pathways, which may reinforce one another. Finally, our findings moreover support the importance of an intellectually enriched lifestyle accompanied by vascular health on both cognition and presumed cerebral mediators of cognitive function.
Authors:
 [1] ;  [2] ; ORCiD logo [2] ;  [2] ;  [3] ;  [4]
  1. Univ. of California, Berkeley, CA (United States). Helen Wills Neuroscience Institute; Otto-von-Guericke University, Magdeburg (Germany); German Center for Neurodegenerative Diseases (DZNE), Magdeburg (Germany)
  2. Univ. of California, Berkeley, CA (United States). Helen Wills Neuroscience Institute
  3. Technische Universitat Braunschweig, Braunschweig (Germany). Department of Control Engineering
  4. Univ. of California, Berkeley, CA (United States). Helen Wills Neuroscience Institute; Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Life Sciences Division
Publication Date:
Grant/Contract Number:
AC02-05CH11231
Type:
Accepted Manuscript
Journal Name:
Neurobiology of Aging
Additional Journal Information:
Journal Volume: 40; Journal Issue: C; Journal ID: ISSN 0197-4580
Research Org:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org:
USDOE: National Institutes of Health (NIH)
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; 59 BASIC BIOLOGICAL SCIENCES; Aging; Amyloid; APOE; Hippocampus; PIB
OSTI Identifier:
1379260