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Title: PET Imaging of Tau Deposition in the Aging Human Brain

Tau pathology is a hallmark of Alzheimer’s disease (AD) but also occurs in normal cognitive aging. In this study, using the tau PET agent 18F-AV-1451, we examined retention patterns in cognitively normal older people in relation to young controls and AD patients. Age and β-amyloid (measured using PiB PET) were differentially associated with tau tracer retention in healthy aging. Older age was related to increased tracer retention in regions of the medial temporal lobe, which predicted worse episodic memory performance. PET detection of tau in other isocortical regions required the presence of cortical β-amyloid and was associated with decline in global cognition. Furthermore, patterns of tracer retention corresponded well with Braak staging of neurofibrillary tau pathology. In conclusion, the present study defined patterns of tau tracer retention in normal aging in relation to age, cognition, and β-amyloid deposition.
Authors:
 [1] ;  [2] ;  [3] ;  [4] ;  [4] ;  [5] ;  [4] ;  [2] ;  [4] ;  [2] ;  [6] ;  [7]
  1. Univ. of California, Berkeley, CA (United States). Helen Wills Neuroscience Institute; University of Gothenburg (Sweden). MedTech West and the Department of Clinical Neuroscience and Rehabilitation
  2. Univ. of California, Berkeley, CA (United States). Helen Wills Neuroscience Institute
  3. University of California, San Francisco, CA (United States). Department of Neurology, Memory and Aging Center
  4. Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
  5. Univ. of California, Berkeley, CA (United States). Helen Wills Neuroscience Institut; University of California, San Francisco, CA (United States). Department of Neurology, Memory and Aging Center; VU University Medical Center, Amsterdam (The Netherlands). Department of Neurology & Alzheimer Center, Neuroscience Campus Amsterdam
  6. Univ. of California, Berkeley, CA (United States). Helen Wills Neuroscience Institute; University of California, San Francisco, CA (United States). Department of Neurology, Memory and Aging Center ; Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
  7. Univ. of California, Berkeley, CA (United States). Helen Wills Neuroscience Institute; Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Publication Date:
Grant/Contract Number:
AC02-05CH11231
Type:
Accepted Manuscript
Journal Name:
Neuron
Additional Journal Information:
Journal Volume: 89; Journal Issue: 5; Journal ID: ISSN 0896-6273
Publisher:
Cell Press / Elsevier
Research Org:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org:
USDOE; National Institutes of Health (NIH)
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; tau; amyloid; PET; aging; memory
OSTI Identifier:
1379129