Amyloid in dementia associated with familial FTLD: not an innocent bystander
Abstract
We present that patients with frontotemporal lobar degeneration (FTLD) can show superimposed amyloid pathology, though the impact of amyloid on the clinical presentation of FTLD is not well characterized. This cross-sectional case–control study compared clinical features, fluorodeoxyglucose-positron emission tomography metabolism and gray matter volume loss in 30 patients with familial FTLD in whom amyloid status was confirmed with autopsy or Pittsburgh compound B-PET. Compared to the amyloid-negative patients, the amyloid-positive patients performed significantly worse on several cognitive tests and showed hypometabolism and volume loss in more temporoparietal regions. Finally, our results suggest that in FTLD amyloid positivity is associated with a more Alzheimer’s disease-like pattern of neurodegeneration.
- Authors:
-
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- University of California, San Francisco, CA (United States). Memory and Aging Center, Dept. of Neurology
- University of California, Los Angeles, CA (United States). Department of Psychiatry, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine
- University of California, San Francisco, CA (United States). Department of Radiology
- Univ. of California, Berkeley, CA (United States). School of Public Health; Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
- Publication Date:
- Research Org.:
- Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
- Sponsoring Org.:
- USDOE; National Institutes of Health (NIH)
- OSTI Identifier:
- 1379022
- Grant/Contract Number:
- AC02-05CH11231
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Neurocase
- Additional Journal Information:
- Journal Volume: 22; Journal Issue: 1; Journal ID: ISSN 1355-4794
- Publisher:
- Taylor & Francis
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 60 APPLIED LIFE SCIENCES; frontotemporal dementia; Alzheimer’s disease; amyloid; MRI; FDG-PET
Citation Formats
Naasan, Georges, Rabinovici, Gil D., Ghosh, Pia, Elofson, Jonathan D., Miller, Bruce L., Coppola, Giovanni, Karydas, Anna, Fong, Jamie, Perry, David, Lee, Suzee E., Yokoyama, Jennifer S., Seeley, William W., Kramer, Joel H., Weiner, Michael W., Schuff, Norbert, Jagust, William J., Grinberg, Lea T., Pribadi, Mochtar, Yang, Zhongan, Sears, Renee, Klein, Eric, Wojta, Kevin, and Rosen, Howard J. Amyloid in dementia associated with familial FTLD: not an innocent bystander. United States: N. p., 2015.
Web. doi:10.1080/13554794.2015.1046458.
Naasan, Georges, Rabinovici, Gil D., Ghosh, Pia, Elofson, Jonathan D., Miller, Bruce L., Coppola, Giovanni, Karydas, Anna, Fong, Jamie, Perry, David, Lee, Suzee E., Yokoyama, Jennifer S., Seeley, William W., Kramer, Joel H., Weiner, Michael W., Schuff, Norbert, Jagust, William J., Grinberg, Lea T., Pribadi, Mochtar, Yang, Zhongan, Sears, Renee, Klein, Eric, Wojta, Kevin, & Rosen, Howard J. Amyloid in dementia associated with familial FTLD: not an innocent bystander. United States. https://doi.org/10.1080/13554794.2015.1046458
Naasan, Georges, Rabinovici, Gil D., Ghosh, Pia, Elofson, Jonathan D., Miller, Bruce L., Coppola, Giovanni, Karydas, Anna, Fong, Jamie, Perry, David, Lee, Suzee E., Yokoyama, Jennifer S., Seeley, William W., Kramer, Joel H., Weiner, Michael W., Schuff, Norbert, Jagust, William J., Grinberg, Lea T., Pribadi, Mochtar, Yang, Zhongan, Sears, Renee, Klein, Eric, Wojta, Kevin, and Rosen, Howard J. Thu .
"Amyloid in dementia associated with familial FTLD: not an innocent bystander". United States. https://doi.org/10.1080/13554794.2015.1046458. https://www.osti.gov/servlets/purl/1379022.
@article{osti_1379022,
title = {Amyloid in dementia associated with familial FTLD: not an innocent bystander},
author = {Naasan, Georges and Rabinovici, Gil D. and Ghosh, Pia and Elofson, Jonathan D. and Miller, Bruce L. and Coppola, Giovanni and Karydas, Anna and Fong, Jamie and Perry, David and Lee, Suzee E. and Yokoyama, Jennifer S. and Seeley, William W. and Kramer, Joel H. and Weiner, Michael W. and Schuff, Norbert and Jagust, William J. and Grinberg, Lea T. and Pribadi, Mochtar and Yang, Zhongan and Sears, Renee and Klein, Eric and Wojta, Kevin and Rosen, Howard J.},
abstractNote = {We present that patients with frontotemporal lobar degeneration (FTLD) can show superimposed amyloid pathology, though the impact of amyloid on the clinical presentation of FTLD is not well characterized. This cross-sectional case–control study compared clinical features, fluorodeoxyglucose-positron emission tomography metabolism and gray matter volume loss in 30 patients with familial FTLD in whom amyloid status was confirmed with autopsy or Pittsburgh compound B-PET. Compared to the amyloid-negative patients, the amyloid-positive patients performed significantly worse on several cognitive tests and showed hypometabolism and volume loss in more temporoparietal regions. Finally, our results suggest that in FTLD amyloid positivity is associated with a more Alzheimer’s disease-like pattern of neurodegeneration.},
doi = {10.1080/13554794.2015.1046458},
journal = {Neurocase},
number = 1,
volume = 22,
place = {United States},
year = {Thu Jun 04 00:00:00 EDT 2015},
month = {Thu Jun 04 00:00:00 EDT 2015}
}
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