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Title: Is amyloid-β harmful to the brain? Insights from human imaging studies

Although the amyloid-β protein associated with the Alzheimer’s disease plaque has been detectable in living people for over a decade, its importance in the pathogenesis of Alzheimer’s disease is still debated. The frequent presence of amyloid-β in the brains of cognitively healthy older people has been interpreted as evidence against a causative role. If amyloid-β is crucial to the development of Alzheimer’s disease, it should be associated with other Alzheimer’s disease-like neurological changes. Here, this review examines whether amyloid-β is associated with other biomarkers indicative of early Alzheimer’s disease in normal older people. The preponderance of evidence links amyloid-β to functional change, progressive brain atrophy, and cognitive decline. Individuals at greatest risk of decline seem to be those with evidence of both amyloid-β and findings suggestive of neurodegeneration. Lastly, the crucial question is thus how amyloid-β is related to brain degeneration and how these two processes interact to cause cognitive decline and dementia.
Authors:
 [1]
  1. Univ. of California, Berkeley, CA (United States). Helen Wills Neuroscience Inst.
Publication Date:
Grant/Contract Number:
AC02-05CH11231; AG034570
Type:
Accepted Manuscript
Journal Name:
Brain (Journal of Neurology)
Additional Journal Information:
Journal Name: Brain (Journal of Neurology); Journal Volume: 139; Journal Issue: 1; Journal ID: ISSN 0006-8950
Research Org:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org:
USDOE; National Institutes of Health (NIH)
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES; ageing; Alzheimer’s disease; amyloid; neurodegeneration; biomarkers
OSTI Identifier:
1378658

Jagust, William. Is amyloid-β harmful to the brain? Insights from human imaging studies. United States: N. p., Web. doi:10.1093/brain/awv326.
Jagust, William. Is amyloid-β harmful to the brain? Insights from human imaging studies. United States. doi:10.1093/brain/awv326.
Jagust, William. 2015. "Is amyloid-β harmful to the brain? Insights from human imaging studies". United States. doi:10.1093/brain/awv326. https://www.osti.gov/servlets/purl/1378658.
@article{osti_1378658,
title = {Is amyloid-β harmful to the brain? Insights from human imaging studies},
author = {Jagust, William},
abstractNote = {Although the amyloid-β protein associated with the Alzheimer’s disease plaque has been detectable in living people for over a decade, its importance in the pathogenesis of Alzheimer’s disease is still debated. The frequent presence of amyloid-β in the brains of cognitively healthy older people has been interpreted as evidence against a causative role. If amyloid-β is crucial to the development of Alzheimer’s disease, it should be associated with other Alzheimer’s disease-like neurological changes. Here, this review examines whether amyloid-β is associated with other biomarkers indicative of early Alzheimer’s disease in normal older people. The preponderance of evidence links amyloid-β to functional change, progressive brain atrophy, and cognitive decline. Individuals at greatest risk of decline seem to be those with evidence of both amyloid-β and findings suggestive of neurodegeneration. Lastly, the crucial question is thus how amyloid-β is related to brain degeneration and how these two processes interact to cause cognitive decline and dementia.},
doi = {10.1093/brain/awv326},
journal = {Brain (Journal of Neurology)},
number = 1,
volume = 139,
place = {United States},
year = {2015},
month = {11}
}