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Title: Modified release from lipid bilayer coated mesoporous silica nanoparticles using PEO–PPO–PEO triblock copolymers [Modified release from lipid bilayer coated mesoporous silica nanoparticles using PEO PPO PEO triblock copolymers]

Triblock copolymers comprised of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO, or trade name Pluronic) interact with lipid bilayers to increase their permeability. Here we demonstrate a novel application of Pluronic L61 and L64 as modification agents in tailoring the release rate of a molecular indicator species from 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) bilayer-coated superparamagnetic Fe 3O 4/mesoporous silica coreshell nanoparticles. Lastly, we show there is a direct relationship between Pluronic concentration and the indicator molecule release, suggesting Pluronic may be useful for the controlled release of drugs from lipid bilayer-coated carriers.
Authors:
ORCiD logo [1] ;  [1] ;  [1] ;  [1] ;  [1] ;  [2] ; ORCiD logo [1]
  1. Univ. of California, Davis, CA (United States). Dept. of Chemical Engineering and Materials Science
  2. Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
Publication Date:
Report Number(s):
LLNL-JRNL-651806
Journal ID: ISSN 0927-7765
Grant/Contract Number:
AC52-07NA27344
Type:
Accepted Manuscript
Journal Name:
Colloids and Surfaces. B, Biointerfaces
Additional Journal Information:
Journal Volume: 122; Journal Issue: C; Journal ID: ISSN 0927-7765
Publisher:
Elsevier
Research Org:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY; 36 MATERIALS SCIENCE; 77 NANOSCIENCE AND NANOTECHNOLOGY
OSTI Identifier:
1376015

Rahman, Masoud, Yu, Erick, Forman, Evan, Roberson-Mailloux, Cameron, Tung, Jonathan, Tringe, Joseph, and Stroeve, Pieter. Modified release from lipid bilayer coated mesoporous silica nanoparticles using PEO–PPO–PEO triblock copolymers [Modified release from lipid bilayer coated mesoporous silica nanoparticles using PEO PPO PEO triblock copolymers]. United States: N. p., Web. doi:10.1016/j.colsurfb.2014.08.013.
Rahman, Masoud, Yu, Erick, Forman, Evan, Roberson-Mailloux, Cameron, Tung, Jonathan, Tringe, Joseph, & Stroeve, Pieter. Modified release from lipid bilayer coated mesoporous silica nanoparticles using PEO–PPO–PEO triblock copolymers [Modified release from lipid bilayer coated mesoporous silica nanoparticles using PEO PPO PEO triblock copolymers]. United States. doi:10.1016/j.colsurfb.2014.08.013.
Rahman, Masoud, Yu, Erick, Forman, Evan, Roberson-Mailloux, Cameron, Tung, Jonathan, Tringe, Joseph, and Stroeve, Pieter. 2014. "Modified release from lipid bilayer coated mesoporous silica nanoparticles using PEO–PPO–PEO triblock copolymers [Modified release from lipid bilayer coated mesoporous silica nanoparticles using PEO PPO PEO triblock copolymers]". United States. doi:10.1016/j.colsurfb.2014.08.013. https://www.osti.gov/servlets/purl/1376015.
@article{osti_1376015,
title = {Modified release from lipid bilayer coated mesoporous silica nanoparticles using PEO–PPO–PEO triblock copolymers [Modified release from lipid bilayer coated mesoporous silica nanoparticles using PEO PPO PEO triblock copolymers]},
author = {Rahman, Masoud and Yu, Erick and Forman, Evan and Roberson-Mailloux, Cameron and Tung, Jonathan and Tringe, Joseph and Stroeve, Pieter},
abstractNote = {Triblock copolymers comprised of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO, or trade name Pluronic) interact with lipid bilayers to increase their permeability. Here we demonstrate a novel application of Pluronic L61 and L64 as modification agents in tailoring the release rate of a molecular indicator species from 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) bilayer-coated superparamagnetic Fe3O4/mesoporous silica coreshell nanoparticles. Lastly, we show there is a direct relationship between Pluronic concentration and the indicator molecule release, suggesting Pluronic may be useful for the controlled release of drugs from lipid bilayer-coated carriers.},
doi = {10.1016/j.colsurfb.2014.08.013},
journal = {Colloids and Surfaces. B, Biointerfaces},
number = C,
volume = 122,
place = {United States},
year = {2014},
month = {8}
}