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Title: Analysis of urinary excretion data from three plutonium-contaminated wounds at Los Alamos National Laboratory

The NCRP-156 Report proposes seven different biokinetic models for the wound cases depending on the physicochemistry of the contaminant. Because the models were heavily based on experimental animal data, the authors of the report encouraged application and validation of the models using bioassay data from actual human exposures. Each of the wound models was applied to three plutonium-contaminated wounds, and the models resulted in a good agreement to only one of the cases. We then applied a simpler biokinetic model structure to the bioassay data and showed that fitting the transfer rates from this model structure yielded better agreement with the data than does the best-fitting NCRP-156 model. Because the biokinetics of radioactive material in each wound is different, it is impractical to propose a discrete set of model parameters to describe the biokinetics of radionuclides in all wounds, and thus each wound should be treated empirically.
Authors:
 [1] ;  [1] ;  [1] ;  [1]
  1. Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Publication Date:
Report Number(s):
LA-UR-17-24233
Journal ID: ISSN 0144-8420
Grant/Contract Number:
AC52-06NA25396
Type:
Accepted Manuscript
Journal Name:
Radiation Protection Dosimetry
Additional Journal Information:
Journal Volume: 178; Journal Issue: 2; Journal ID: ISSN 0144-8420
Publisher:
Oxford University Press
Research Org:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
61 RADIATION PROTECTION AND DOSIMETRY; Radiation Protection
OSTI Identifier:
1375884