Analysis of urinary excretion data from three plutonium-contaminated wounds at Los Alamos National Laboratory
Abstract
The NCRP-156 Report proposes seven different biokinetic models for the wound cases depending on the physicochemistry of the contaminant. Because the models were heavily based on experimental animal data, the authors of the report encouraged application and validation of the models using bioassay data from actual human exposures. Each of the wound models was applied to three plutonium-contaminated wounds, and the models resulted in a good agreement to only one of the cases. We then applied a simpler biokinetic model structure to the bioassay data and showed that fitting the transfer rates from this model structure yielded better agreement with the data than does the best-fitting NCRP-156 model. Because the biokinetics of radioactive material in each wound is different, it is impractical to propose a discrete set of model parameters to describe the biokinetics of radionuclides in all wounds, and thus each wound should be treated empirically.
- Authors:
-
- Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
- Publication Date:
- Research Org.:
- Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1375884
- Report Number(s):
- LA-UR-17-24233
Journal ID: ISSN 0144-8420
- Grant/Contract Number:
- AC52-06NA25396
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Radiation Protection Dosimetry
- Additional Journal Information:
- Journal Volume: 178; Journal Issue: 2; Journal ID: ISSN 0144-8420
- Publisher:
- Oxford University Press
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 61 RADIATION PROTECTION AND DOSIMETRY; Radiation Protection
Citation Formats
Poudel, Deepesh, Klumpp, John A., Waters, Tom L., and Bertelli, Luiz. Analysis of urinary excretion data from three plutonium-contaminated wounds at Los Alamos National Laboratory. United States: N. p., 2017.
Web. doi:10.1093/rpd/ncx090.
Poudel, Deepesh, Klumpp, John A., Waters, Tom L., & Bertelli, Luiz. Analysis of urinary excretion data from three plutonium-contaminated wounds at Los Alamos National Laboratory. United States. https://doi.org/10.1093/rpd/ncx090
Poudel, Deepesh, Klumpp, John A., Waters, Tom L., and Bertelli, Luiz. Fri .
"Analysis of urinary excretion data from three plutonium-contaminated wounds at Los Alamos National Laboratory". United States. https://doi.org/10.1093/rpd/ncx090. https://www.osti.gov/servlets/purl/1375884.
@article{osti_1375884,
title = {Analysis of urinary excretion data from three plutonium-contaminated wounds at Los Alamos National Laboratory},
author = {Poudel, Deepesh and Klumpp, John A. and Waters, Tom L. and Bertelli, Luiz},
abstractNote = {The NCRP-156 Report proposes seven different biokinetic models for the wound cases depending on the physicochemistry of the contaminant. Because the models were heavily based on experimental animal data, the authors of the report encouraged application and validation of the models using bioassay data from actual human exposures. Each of the wound models was applied to three plutonium-contaminated wounds, and the models resulted in a good agreement to only one of the cases. We then applied a simpler biokinetic model structure to the bioassay data and showed that fitting the transfer rates from this model structure yielded better agreement with the data than does the best-fitting NCRP-156 model. Because the biokinetics of radioactive material in each wound is different, it is impractical to propose a discrete set of model parameters to describe the biokinetics of radionuclides in all wounds, and thus each wound should be treated empirically.},
doi = {10.1093/rpd/ncx090},
journal = {Radiation Protection Dosimetry},
number = 2,
volume = 178,
place = {United States},
year = {Fri Jul 14 00:00:00 EDT 2017},
month = {Fri Jul 14 00:00:00 EDT 2017}
}
Free Publicly Available Full Text
Publisher's Version of Record
Other availability
Search WorldCat to find libraries that may hold this journal
Cited by: 1 work
Citation information provided by
Web of Science
Web of Science
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.
Works referenced in this record:
Model and Practical Information Concerning the Radiotoxicological Assessment of a Wound Contaminated by Plutonium
journal, January 1989
- Piechowski, J.; Cavadore, D.; Tourte, J.
- Radiation Protection Dosimetry, Vol. 26, Issue 1-4
IMBA Professional Plus: a flexible approach to internal dosimetry
journal, December 2006
- Birchall, A.; Puncher, M.; Marsh, J. W.
- Radiation Protection Dosimetry, Vol. 125, Issue 1-4
Scientific basis for the development of biokinetic models for radionuclides-contaminated wounds
journal, July 2003
- A. Guilmette, R.; W. Durbin, P.
- Radiation Protection Dosimetry, Vol. 105, Issue 1-4
AIDE: internal dosimetry software
journal, February 2008
- Bertelli, L.; Melo, D. R.; Lipsztein, J.
- Radiation Protection Dosimetry, Vol. 130, Issue 3
The NCRP wound model: development and application
journal, June 2007
- Guilmette, R. A.; Durbin, P. W.; Toohey, R. E.
- Radiation Protection Dosimetry, Vol. 127, Issue 1-4
Bayesian Prior Probability Distributions for Internal Dosimetry
journal, April 2001
- Miller, G.; Inkret, W. C.; Little, T. T.
- Radiation Protection Dosimetry, Vol. 94, Issue 4
Three Plutonium Chelation Cases at los Alamos National Laboratory
journal, January 2010
- Bertelli, Luiz; Waters, Tom L.; Miller, Guthrie
- Health Physics, Vol. 99, Issue 4
Software for Empirical Building of Biokinetic Models for Normal and Decorporation-affected Data
journal, January 2012
- Miller, Guthrie; Bertelli, Luiz; Klare, Kenneth
- Health Physics, Vol. 103, Issue 4
Development of the Plutonium-DTPA Biokinetic Model
journal, January 2015
- Konzen, Kevin; Brey, Richard
- Health Physics, Vol. 108, Issue 6
Statistical modelling of Poisson/log normal data
journal, June 2007
- Miller, G.
- Radiation Protection Dosimetry, Vol. 124, Issue 2
Interpretation of Urinary Excretion Data From Plutonium Wound Cases Treated With DTPA: Application of Different Models and Approaches
journal, January 2017
- Poudel, Deepesh; Bertelli, Luiz; Klumpp, John A.
- Health Physics, Vol. 113, Issue 1
An analysis of a puncture wound case with medical intervention
journal, July 2003
- R. Bailey, B.; F. Eckerman, K.; W. Townsend, L.
- Radiation Protection Dosimetry, Vol. 105, Issue 1-4
Plutonium Contaminated Wound Experience and Assay Techniques at the Los Alamos Scientific Laboratory
journal, January 1974
- Johnson, Lamar J.; Lawrence, James N. P.
- Health Physics, Vol. 27, Issue 1
Medical and Health Physics Management of a Plutonium Wound
journal, January 1989
- Carbaugh, E. H.; Decker, W. A.; Swint, M. J.
- Radiation Protection Dosimetry, Vol. 26, Issue 1-4
A 32-year Medical Follow-up of Manhattan Project Plutonium Workers
journal, January 1979
- Voelz, George L.; Hempelmann, Louis H.; Lawrence, J. N. P.
- Health Physics, Vol. 37, Issue 4
A CASE OF WOUND INTAKE OF PLUTONIUM ISOTOPES AND 241Am IN A HUMAN: APPLICATION AND IMPROVEMENT OF THE NCRP WOUND MODEL
journal, January 2010
- Schadilov, Anatoly E.; Belosokhov, Maxim V.; Levina, Elena S.
- Health Physics, Vol. 99, Issue 4
Application of Multi-Compartment Wound Models to Plutonium-Contaminated Wounds Incurred by Former Workers at Rocky Flats
journal, January 2006
- Falk, Roger B.; Daugherty, Nancy M.; Aldrich, Joe M.
- Health Physics, Vol. 91, Issue 2
Twenty-Four Years of Follow-Up for a Hanford Plutonium Wound case
journal, January 2010
- Carbaugh, Eugene H.; Lynch, Timothy P.; Antonio, Cheryl L.
- Health Physics, Vol. 99, Issue 4
The Management of an Extensive Plutonium Wound and the Evaluation of the Residual Internal Deposition of Plutonium
journal, January 1968
- Larson, H. V.; Newton, C. E.; Baumgartner, W. V.
- Physics in Medicine and Biology, Vol. 13, Issue 1
Evaluation of scattering factor values for internal dose assessment following the IDEAS guidelines: preliminary results
journal, June 2007
- Marsh, J. W.; Blanchardon, E.; Castellani, C. M.
- Radiation Protection Dosimetry, Vol. 127, Issue 1-4
Observed Effects of Plutonium in Wounds Over a Long Period of Time
journal, January 1964
- Hammond, S. E.; Putzier, E. A.
- Health Physics, Vol. 10, Issue 6
Treatment and Evaluation of a Plutonium-238 Nitrate Contaminated Puncture Wound: A Two-year Case History
journal, January 1972
- Jolly, Lewis; McClearen, H. A.; Poda, G. A.
- Health Physics, Vol. 23, Issue 3
A Microcomputer Algorithm for Solving First-order Compartmental Models Involving Recycling
journal, January 1989
- Birchall, A.; James, A. C.
- Health Physics, Vol. 56, Issue 6
Assessment and Management of a Plutonium Contaminated Wound Case
journal, January 1974
- Schofield, G. B.; Howells, H.; Ward, F.
- Health Physics, Vol. 26, Issue 6
Application of NCRP 156 Wound Models for the Analysis of Bioassay Data from Plutonium Wound Cases
journal, January 2017
- Poudel, Deepesh; Guilmette, Raymond A.; Klumpp, John A.
- Health Physics, Vol. 113, Issue 3
Mayak Worker Study: An Improved Biokinetic Model for Reconstructing Doses from Internally Deposited Plutonium
journal, August 2005
- Leggett, R. W.; Eckerman, K. F.; Khokhryakov, V. F.
- Radiation Research, Vol. 164, Issue 2
Determination of u in Human Tissues by Delayed Neutron Activation Analysis
journal, January 1988
- Gonzales, Edward R.; Gladney, Ernest S.; Boyd, Howard A.
- Health Physics, Vol. 55, Issue 6