Plasma Retention and Systemic Kinetics of 90Sr Intramuscularly Injected in Female Nonhuman Primates
- Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
- Lovelace Respiratory Research Inst., Albuquerque, NM (United States); Ray Guilmette and Associates LLC, Perry, ME (United States)
- Idaho State Univ., Pocatello, ID (United States). Dept. of Nuclear Engineering and Health Physics
Thirteen female Rhesus macaques were intramuscularly injected with 90Sr(NO3)2 diluted in sodium citrate solution. The biokinetic data from these animals were compared against the predictions of the NCRP 156 wound models combined with the ICRP systemic models. We observed observed that the activities measured in plasma of these nonhuman primates (NHPs) were consistently lower than those predicted by the default human biokinetic models. The urinary excretion from the NHPs at times immediately after injection was much greater than that in humans. The fecal excretion rates were found to be in relatively better agreement with humans. Similarly, the activities retained in the skeleton of the NHPs were lower than that in humans. These differences were attributed to the higher calcium diet of the NHPs (0.03 to 0.12 g/d/kg body weight) compared to that of humans. These observations were consistent with the early animal and human studies that showed the effect of calcium on strontium metabolism, specifically urinary excretion. Strontium is preferentially filtered at a much higher rate in kidneys than calcium because it is less completely bound to protein than is calcium. Furthermore, these differences, along with large inter-animal variability, should be considered when estimating the behavior of Sr in humans from the metabolic data in animals or vice-versa.
- Research Organization:
- Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
- Sponsoring Organization:
- USDOE
- Grant/Contract Number:
- AC52-06NA25396
- OSTI ID:
- 1375873
- Report Number(s):
- LA-UR-17-20466
- Journal Information:
- Health Physics, Vol. 113, Issue 2; ISSN 0017-9078
- Publisher:
- Health Physics SocietyCopyright Statement
- Country of Publication:
- United States
- Language:
- English
Similar Records
Comparative sequence analysis of cytokine genes from human and nonhuman primates
Clinicopathologic and Transcriptomic Analysis of Radiation-Induced Lung Injury in Nonhuman Primates