Rac2 is required for alternative macrophage activation and bleomycin induced pulmonary fibrosis; a macrophage autonomous phenotype

Joshi, Shweta; Singh, Alok R.; Wong, Simon S.; Zulcic, Muamera; Jiang, Min; Pardo, Annie; Selman, Moises; Hagood, James S.; Durden, Donald L.; Schnapp, ed., Lynn M.

doi:10.1371/journal.pone.0182851

Title: Rac2 is required for alternative macrophage activation and bleomycin induced pulmonary fibrosis; a macrophage autonomous phenotype

Journal Article · 17 August 2017 · PLoS ONE

DOI: https://doi.org/10.1371/journal.pone.0182851 · OSTI ID:1375506

Joshi, Shweta; Singh, Alok R.; Wong, Simon S.; Zulcic, Muamera; Jiang, Min; Pardo, Annie; Selman, Moises; Hagood, James S.;

; Schnapp, ed., Lynn M.

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Sponsoring Organization:: USDOE

Grant/Contract Number:: CA192646

OSTI ID:: 1375506

Journal Information:: PLoS ONE, Journal Name: PLoS ONE Vol. 12 Journal Issue: 8; ISSN 1932-6203

Publisher:: Public Library of Science (PLoS)Copyright Statement

Country of Publication:: United States

Language:: English

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References (44)

Rac2 Is an Essential Regulator of Neutrophil Nicotinamide Adenine Dinucleotide Phosphate Oxidase Activation in Response to Specific Signaling Pathways Kim, Chaekyun; Dinauer, Mary C. The Journal of Immunology, Vol. 166, Issue 2 https://doi.org/10.4049/jimmunol.166.2.1223	journal	January 2001
The Acute Respiratory Distress Syndrome Ware, Lorraine B.; Matthay, Michael A. New England Journal of Medicine, Vol. 342, Issue 18 https://doi.org/10.1056/NEJM200005043421806	journal	May 2000
Pulmonary fibrosis: patterns and perpetrators Noble, Paul W.; Barkauskas, Christina E.; Jiang, Dianhua Journal of Clinical Investigation, Vol. 122, Issue 8 https://doi.org/10.1172/JCI60323	journal	August 2012
Exploring the full spectrum of macrophage activation Mosser, David M.; Edwards, Justin P. Nature Reviews Immunology, Vol. 8, Issue 12 https://doi.org/10.1038/nri2448	journal	December 2008
Mammary epithelial cell: Influence of extracellular matrix composition and organization during development and tumorigenesis Kass, Laura; Erler, Janine T.; Dembo, Micah The International Journal of Biochemistry & Cell Biology, Vol. 39, Issue 11 https://doi.org/10.1016/j.biocel.2007.06.025	journal	January 2007
Receptor Tyrosine Kinases and TLR/IL1Rs Unexpectedly Activate Myeloid Cell PI3Kγ, A Single Convergent Point Promoting Tumor Inflammation and Progression Schmid, Michael C.; Avraamides, Christie J.; Dippold, Holly C. Cancer Cell, Vol. 19, Issue 6 https://doi.org/10.1016/j.ccr.2011.04.016	journal	June 2011
Blocking the 4 integrin paxillin interaction selectively impairs mononuclear leukocyte recruitment to an inflammatory site Feral, C. C. Journal of Clinical Investigation, Vol. 116, Issue 3 https://doi.org/10.1172/JCI26091	journal	March 2006
Ly6C ^hi Monocytes Direct Alternatively Activated Profibrotic Macrophage Regulation of Lung Fibrosis Gibbons, Michael A.; MacKinnon, Alison C.; Ramachandran, Prakash American Journal of Respiratory and Critical Care Medicine, Vol. 184, Issue 5 https://doi.org/10.1164/rccm.201010-1719OC	journal	September 2011
A tense situation: forcing tumour progression Butcher, Darci T.; Alliston, Tamara; Weaver, Valerie M. Nature Reviews Cancer, Vol. 9, Issue 2 https://doi.org/10.1038/nrc2544	journal	February 2009
Important Roles for Macrophage Colony-stimulating Factor, CC Chemokine Ligand 2, and Mononuclear Phagocytes in the Pathogenesis of Pulmonary Fibrosis Baran, Christopher P.; Opalek, Judy M.; McMaken, Sara American Journal of Respiratory and Critical Care Medicine, Vol. 176, Issue 1 https://doi.org/10.1164/rccm.200609-1279OC	journal	July 2007
The chemokine system in diverse forms of macrophage activation and polarization Mantovani, A.; Sica, A.; Sozzani, S. Trends in Immunology, Vol. 25, Issue 12 https://doi.org/10.1016/j.it.2004.09.015	journal	December 2004
The pathophysiologic role of alpha 4 integrins in vivo. Lobb, R. R.; Hemler, M. E. Journal of Clinical Investigation, Vol. 94, Issue 5 https://doi.org/10.1172/JCI117519	journal	November 1994
Acute Exacerbations of Idiopathic Pulmonary Fibrosis Collard, Harold R.; Moore, Bethany B.; Flaherty, Kevin R. American Journal of Respiratory and Critical Care Medicine, Vol. 176, Issue 7 https://doi.org/10.1164/rccm.200703-463PP	journal	October 2007
Autophagy in Idiopathic Pulmonary Fibrosis Patel, Avignat S.; Lin, Ling; Geyer, Alexander PLoS ONE, Vol. 7, Issue 7 https://doi.org/10.1371/journal.pone.0041394	journal	July 2012
Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer Cox, T. R.; Erler, J. T. Disease Models & Mechanisms, Vol. 4, Issue 2 https://doi.org/10.1242/dmm.004077	journal	February 2011
Rac2 Specificity in Macrophage Integrin Signaling: POTENTIAL ROLE FOR Syk KINASE Pradip, De; Peng, Xiaodong; Durden, Donald L. Journal of Biological Chemistry, Vol. 278, Issue 43 https://doi.org/10.1074/jbc.M306491200	journal	August 2003
Rac2 Controls Tumor Growth, Metastasis and M1-M2 Macrophage Differentiation In Vivo Joshi, Shweta; Singh, Alok R.; Zulcic, Muamera PLoS ONE, Vol. 9, Issue 4 https://doi.org/10.1371/journal.pone.0095893	journal	April 2014
A Novel Mechanism for CCR4 in the Regulation of Macrophage Activation in Bleomycin-Induced Pulmonary Fibrosis Trujillo, Glenda; O'Connor, Erica C.; Kunkel, Steven L. The American Journal of Pathology, Vol. 172, Issue 5 https://doi.org/10.2353/ajpath.2008.070832	journal	May 2008
Expression of RAC2 in endothelial cells is required for the postnatal neovascular response De, Pradip; Peng, Qiong; Traktuevc, Dmitry O. Experimental Cell Research, Vol. 315, Issue 2 https://doi.org/10.1016/j.yexcr.2008.10.003	journal	January 2009
Idiopathic pulmonary fibrosis Meltzer, Eric B.; Noble, Paul W. Orphanet Journal of Rare Diseases, Vol. 3, Issue 1 https://doi.org/10.1186/1750-1172-3-8	journal	March 2008
Integrin modulation and signaling in leukocyte adhesion and migration Rose, David M.; Alon, Ronen; Ginsberg, Mark H. Immunological Reviews, Vol. 218, Issue 1 https://doi.org/10.1111/j.1600-065X.2007.00536.x	journal	August 2007
Activation of Alveolar Macrophages via the Alternative Pathway in Herpesvirus-Induced Lung Fibrosis Mora, Ana L.; Torres-González, Edilson; Rojas, Mauricio American Journal of Respiratory Cell and Molecular Biology, Vol. 35, Issue 4 https://doi.org/10.1165/rcmb.2006-0121OC	journal	October 2006
Therapeutic effect of lecithinized superoxide dismutase on bleomycin-induced pulmonary fibrosis Tanaka, Ken-Ichiro; Ishihara, Tomoaki; Azuma, Arata American Journal of Physiology-Lung Cellular and Molecular Physiology, Vol. 298, Issue 3 https://doi.org/10.1152/ajplung.00289.2009	journal	March 2010
Integrin α ₄ β ₁ Promotes Monocyte Trafficking and Angiogenesis in Tumors Jin, Hui; Su, Jingmei; Garmy-Susini, Barbara Cancer Research, Vol. 66, Issue 4 https://doi.org/10.1158/0008-5472.CAN-05-2704	journal	February 2006
TGF-beta driven lung fibrosis is macrophage dependent and blocked by Serum amyloid P Murray, Lynne A.; Chen, Qingsheng; Kramer, Michael S. The International Journal of Biochemistry & Cell Biology, Vol. 43, Issue 1 https://doi.org/10.1016/j.biocel.2010.10.013	journal	January 2011
Lung Collagens Perpetuate Pulmonary Fibrosis via CD204 and M2 Macrophage Activation Stahl, Mirjam; Schupp, Jonas; Jäger, Benedikt PLoS ONE, Vol. 8, Issue 11 https://doi.org/10.1371/journal.pone.0081382	journal	November 2013
Inhibition of Rac activity alleviates lipopolysaccharide-induced acute pulmonary injury in mice Yao, Hong-yi; Chen, Lihua; Xu, Chengyun Biochimica et Biophysica Acta (BBA) - General Subjects, Vol. 1810, Issue 7 https://doi.org/10.1016/j.bbagen.2011.03.020	journal	July 2011
Increased Expression of CC16 in Patients with Idiopathic Pulmonary Fibrosis Buendía-Roldán, Ivette; Ruiz, Víctor; Sierra, Patricia PLOS ONE, Vol. 11, Issue 12 https://doi.org/10.1371/journal.pone.0168552	journal	December 2016
Murine models of pulmonary fibrosis Moore, Bethany B.; Hogaboam, Cory M. American Journal of Physiology-Lung Cellular and Molecular Physiology, Vol. 294, Issue 2 https://doi.org/10.1152/ajplung.00313.2007	journal	February 2008
Integrins in angiogenesis and lymphangiogenesis Avraamides, Christie J.; Garmy-Susini, Barbara; Varner, Judith A. Nature Reviews Cancer, Vol. 8, Issue 8 https://doi.org/10.1038/nrc2353	journal	May 2008
Myeloid-Specific Disruption of Tyrosine Phosphatase Shp2 Promotes Alternative Activation of Macrophages and Predisposes Mice to Pulmonary Fibrosis Tao, Bo; Jin, Wei; Xu, Jiaqi The Journal of Immunology, Vol. 193, Issue 6 https://doi.org/10.4049/jimmunol.1303463	journal	August 2014
Effect of antibody against integrin α4 on bleomycin-induced pulmonary fibrosis in mice Wang, Qingjian; Wang, Yingjin; Hyde, Dallas M. Biochemical Pharmacology, Vol. 60, Issue 12 https://doi.org/10.1016/S0006-2952(00)00491-3	journal	December 2000
The distribution of immunomodulatory cells in the lungs of patients with idiopathic pulmonary fibrosis Nuovo, Gerard J.; Hagood, James S.; Magro, Cynthia M. Modern Pathology, Vol. 25, Issue 3 https://doi.org/10.1038/modpathol.2011.166	journal	October 2011
Alternative activation of macrophages Gordon, Siamon Nature Reviews Immunology, Vol. 3, Issue 1 https://doi.org/10.1038/nri978	journal	January 2003
Deficiency of the Hematopoietic Cell-Specific Rho Family GTPase Rac2 Is Characterized by Abnormalities in Neutrophil Function and Host Defense Roberts, Andrew W.; Kim, Chaekyun; Zhen, Ling Immunity, Vol. 10, Issue 2 https://doi.org/10.1016/S1074-7613(00)80019-9	journal	February 1999
IRAK-M Promotes Alternative Macrophage Activation and Fibroproliferation in Bleomycin-Induced Lung Injury Ballinger, Megan N.; Newstead, Michael W.; Zeng, Xianying The Journal of Immunology, Vol. 194, Issue 4 https://doi.org/10.4049/jimmunol.1402377	journal	January 2015
Regulation of inflammation by Rac2 in immune complex-mediated acute lung injury Dooley, James L.; Abdel-Latif, Dalia; St. Laurent, Chris D. American Journal of Physiology-Lung Cellular and Molecular Physiology, Vol. 297, Issue 6 https://doi.org/10.1152/ajplung.90471.2008	journal	December 2009
Rac GTPase interacts with GAPs and target proteins through multiple effector sites. Diekmann, D.; Nobes, C. D.; Burbelo, P. D. The EMBO Journal, Vol. 14, Issue 21 https://doi.org/10.1002/j.1460-2075.1995.tb00214.x	journal	November 1995
Multiplex protein profiling of bronchoalveolar lavage in idiopathic pulmonary fibrosis and hypersensitivity pneumonitis Wim, AWuyts; Bart, MVanaudenaerde; Christophe, Dooms Annals of Thoracic Medicine, Vol. 8, Issue 1 https://doi.org/10.4103/1817-1737.105718	journal	January 2013
Unravelling mononuclear phagocyte heterogeneity Geissmann, Frédéric; Gordon, Siamon; Hume, David A. Nature Reviews Immunology, Vol. 10, Issue 6 https://doi.org/10.1038/nri2784	journal	May 2010
MMP28 promotes macrophage polarization toward M2 cells and augments pulmonary fibrosis Gharib, S. A.; Johnston, L. K.; Huizar, I. Journal of Leukocyte Biology, Vol. 95, Issue 1 https://doi.org/10.1189/jlb.1112587	journal	August 2013
Rac2 is involved in bleomycin-induced lung inflammation leading to pulmonary fibrosis Arizmendi, Narcy; Puttagunta, Lakshmi; Chung, Kerri L. Respiratory Research, Vol. 15, Issue 1 https://doi.org/10.1186/1465-9921-15-71	journal	January 2014
New concepts of IL-10-induced lung fibrosis: fibrocyte recruitment and M ₂ activation in a CCL2/CCR2 axis Sun, Lei; Louie, Marisa C.; Vannella, Kevin M. American Journal of Physiology-Lung Cellular and Molecular Physiology, Vol. 300, Issue 3 https://doi.org/10.1152/ajplung.00122.2010	journal	March 2011
Mechanisms of Pulmonary Fibrosis Thannickal, Victor J.; Toews, Galen B.; White, Eric S. Annual Review of Medicine, Vol. 55, Issue 1 https://doi.org/10.1146/annurev.med.55.091902.103810	journal	February 2004

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