Rac2 is required for alternative macrophage activation and bleomycin induced pulmonary fibrosis; a macrophage autonomous phenotype

Joshi, Shweta; Singh, Alok R.; Wong, Simon S.; Zulcic, Muamera; Jiang, Min; Pardo, Annie; Selman, Moises; Hagood, James S.; Durden, Donald L.; Schnapp, ed., Lynn M.

doi:10.1371/journal.pone.0182851

Title: Rac2 is required for alternative macrophage activation and bleomycin induced pulmonary fibrosis; a macrophage autonomous phenotype

Authors:

Joshi, Shweta; Singh, Alok R.; Wong, Simon S.; Zulcic, Muamera; Jiang, Min; Pardo, Annie; Selman, Moises; Hagood, James S.;

; Schnapp, ed., Lynn M.

Publication Date:: 2017-08-17

Sponsoring Org.:: USDOE

OSTI Identifier:: 1375506

Grant/Contract Number:: CA192646

Resource Type:: Published Article

Journal Name:: PLoS ONE

Additional Journal Information:: Journal Name: PLoS ONE Journal Volume: 12 Journal Issue: 8; Journal ID: ISSN 1932-6203

Publisher:: Public Library of Science (PLoS)

Country of Publication:: United States

Language:: English

Citation Formats


                    Joshi, Shweta, Singh, Alok R., Wong, Simon S., Zulcic, Muamera, Jiang, Min, Pardo, Annie, Selman, Moises, Hagood, James S., Durden, Donald L., and Schnapp, ed., Lynn M. Rac2 is required for alternative macrophage activation and bleomycin induced pulmonary fibrosis; a macrophage autonomous phenotype.  United States: N. p., 2017. 
Web.  doi:10.1371/journal.pone.0182851.

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                    Joshi, Shweta, Singh, Alok R., Wong, Simon S., Zulcic, Muamera, Jiang, Min, Pardo, Annie, Selman, Moises, Hagood, James S., Durden, Donald L., & Schnapp, ed., Lynn M. Rac2 is required for alternative macrophage activation and bleomycin induced pulmonary fibrosis; a macrophage autonomous phenotype.  United States.  https://doi.org/10.1371/journal.pone.0182851

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                    Joshi, Shweta, Singh, Alok R., Wong, Simon S., Zulcic, Muamera, Jiang, Min, Pardo, Annie, Selman, Moises, Hagood, James S., Durden, Donald L., and Schnapp, ed., Lynn M. Thu .  
"Rac2 is required for alternative macrophage activation and bleomycin induced pulmonary fibrosis; a macrophage autonomous phenotype".  United States.  https://doi.org/10.1371/journal.pone.0182851.

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@article{osti_1375506,

  title        = {Rac2 is required for alternative macrophage activation and bleomycin induced pulmonary fibrosis; a macrophage autonomous phenotype},

  author       = {Joshi, Shweta and Singh, Alok R. and Wong, Simon S. and Zulcic, Muamera and Jiang, Min and Pardo, Annie and Selman, Moises and Hagood, James S. and Durden, Donald L. and Schnapp, ed., Lynn M.},

  abstractNote = {},

  doi          = {10.1371/journal.pone.0182851},

  journal      = {PLoS ONE},

  number       = 8,

  volume       = 12,

  place        = {United States},

  year         = {2017},

  month        = {8}

}

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Works referenced in this record:

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Title: Rac2 is required for alternative macrophage activation and bleomycin induced pulmonary fibrosis; a macrophage autonomous phenotype

Citation Formats

Rac2 Is an Essential Regulator of Neutrophil Nicotinamide Adenine Dinucleotide Phosphate Oxidase Activation in Response to Specific Signaling Pathways journal, January 2001

The Acute Respiratory Distress Syndrome journal, May 2000

Pulmonary fibrosis: patterns and perpetrators journal, August 2012

Exploring the full spectrum of macrophage activation journal, December 2008

Mammary epithelial cell: Influence of extracellular matrix composition and organization during development and tumorigenesis journal, January 2007

Receptor Tyrosine Kinases and TLR/IL1Rs Unexpectedly Activate Myeloid Cell PI3Kγ, A Single Convergent Point Promoting Tumor Inflammation and Progression journal, June 2011

Blocking the 4 integrin paxillin interaction selectively impairs mononuclear leukocyte recruitment to an inflammatory site journal, March 2006

Ly6C hi Monocytes Direct Alternatively Activated Profibrotic Macrophage Regulation of Lung Fibrosis journal, September 2011

A tense situation: forcing tumour progression journal, February 2009

Important Roles for Macrophage Colony-stimulating Factor, CC Chemokine Ligand 2, and Mononuclear Phagocytes in the Pathogenesis of Pulmonary Fibrosis journal, July 2007

The chemokine system in diverse forms of macrophage activation and polarization journal, December 2004

The pathophysiologic role of alpha 4 integrins in vivo. journal, November 1994

Acute Exacerbations of Idiopathic Pulmonary Fibrosis journal, October 2007

Autophagy in Idiopathic Pulmonary Fibrosis journal, July 2012

Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer journal, February 2011

Rac2 Specificity in Macrophage Integrin Signaling: POTENTIAL ROLE FOR Syk KINASE journal, August 2003

Rac2 Controls Tumor Growth, Metastasis and M1-M2 Macrophage Differentiation In Vivo journal, April 2014

A Novel Mechanism for CCR4 in the Regulation of Macrophage Activation in Bleomycin-Induced Pulmonary Fibrosis journal, May 2008

Expression of RAC2 in endothelial cells is required for the postnatal neovascular response journal, January 2009

Idiopathic pulmonary fibrosis journal, March 2008

Integrin modulation and signaling in leukocyte adhesion and migration journal, August 2007

Activation of Alveolar Macrophages via the Alternative Pathway in Herpesvirus-Induced Lung Fibrosis journal, October 2006

Therapeutic effect of lecithinized superoxide dismutase on bleomycin-induced pulmonary fibrosis journal, March 2010

Integrin α 4 β 1 Promotes Monocyte Trafficking and Angiogenesis in Tumors journal, February 2006

TGF-beta driven lung fibrosis is macrophage dependent and blocked by Serum amyloid P journal, January 2011

Lung Collagens Perpetuate Pulmonary Fibrosis via CD204 and M2 Macrophage Activation journal, November 2013

Inhibition of Rac activity alleviates lipopolysaccharide-induced acute pulmonary injury in mice journal, July 2011

Increased Expression of CC16 in Patients with Idiopathic Pulmonary Fibrosis journal, December 2016

Murine models of pulmonary fibrosis journal, February 2008

Integrins in angiogenesis and lymphangiogenesis journal, May 2008

Myeloid-Specific Disruption of Tyrosine Phosphatase Shp2 Promotes Alternative Activation of Macrophages and Predisposes Mice to Pulmonary Fibrosis journal, August 2014

Effect of antibody against integrin α4 on bleomycin-induced pulmonary fibrosis in mice journal, December 2000

The distribution of immunomodulatory cells in the lungs of patients with idiopathic pulmonary fibrosis journal, October 2011

Alternative activation of macrophages journal, January 2003

Deficiency of the Hematopoietic Cell-Specific Rho Family GTPase Rac2 Is Characterized by Abnormalities in Neutrophil Function and Host Defense journal, February 1999

IRAK-M Promotes Alternative Macrophage Activation and Fibroproliferation in Bleomycin-Induced Lung Injury journal, January 2015

Regulation of inflammation by Rac2 in immune complex-mediated acute lung injury journal, December 2009

Rac GTPase interacts with GAPs and target proteins through multiple effector sites. journal, November 1995

Multiplex protein profiling of bronchoalveolar lavage in idiopathic pulmonary fibrosis and hypersensitivity pneumonitis journal, January 2013

Unravelling mononuclear phagocyte heterogeneity journal, May 2010

MMP28 promotes macrophage polarization toward M2 cells and augments pulmonary fibrosis journal, August 2013

Rac2 is involved in bleomycin-induced lung inflammation leading to pulmonary fibrosis journal, January 2014

New concepts of IL-10-induced lung fibrosis: fibrocyte recruitment and M 2 activation in a CCL2/CCR2 axis journal, March 2011

Mechanisms of Pulmonary Fibrosis journal, February 2004

Rac2 Is an Essential Regulator of Neutrophil Nicotinamide Adenine Dinucleotide Phosphate Oxidase Activation in Response to Specific Signaling Pathways
journal, January 2001

The Acute Respiratory Distress Syndrome
journal, May 2000

Pulmonary fibrosis: patterns and perpetrators
journal, August 2012

Exploring the full spectrum of macrophage activation
journal, December 2008

Mammary epithelial cell: Influence of extracellular matrix composition and organization during development and tumorigenesis
journal, January 2007

Receptor Tyrosine Kinases and TLR/IL1Rs Unexpectedly Activate Myeloid Cell PI3Kγ, A Single Convergent Point Promoting Tumor Inflammation and Progression
journal, June 2011

Blocking the 4 integrin paxillin interaction selectively impairs mononuclear leukocyte recruitment to an inflammatory site
journal, March 2006

Ly6C ^hi Monocytes Direct Alternatively Activated Profibrotic Macrophage Regulation of Lung Fibrosis
journal, September 2011

A tense situation: forcing tumour progression
journal, February 2009

Important Roles for Macrophage Colony-stimulating Factor, CC Chemokine Ligand 2, and Mononuclear Phagocytes in the Pathogenesis of Pulmonary Fibrosis
journal, July 2007

The chemokine system in diverse forms of macrophage activation and polarization
journal, December 2004

The pathophysiologic role of alpha 4 integrins in vivo.
journal, November 1994

Acute Exacerbations of Idiopathic Pulmonary Fibrosis
journal, October 2007

Autophagy in Idiopathic Pulmonary Fibrosis
journal, July 2012

Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer
journal, February 2011

Rac2 Specificity in Macrophage Integrin Signaling: POTENTIAL ROLE FOR Syk KINASE
journal, August 2003

Rac2 Controls Tumor Growth, Metastasis and M1-M2 Macrophage Differentiation In Vivo
journal, April 2014

A Novel Mechanism for CCR4 in the Regulation of Macrophage Activation in Bleomycin-Induced Pulmonary Fibrosis
journal, May 2008

Expression of RAC2 in endothelial cells is required for the postnatal neovascular response
journal, January 2009

Idiopathic pulmonary fibrosis
journal, March 2008

Integrin modulation and signaling in leukocyte adhesion and migration
journal, August 2007

Activation of Alveolar Macrophages via the Alternative Pathway in Herpesvirus-Induced Lung Fibrosis
journal, October 2006

Therapeutic effect of lecithinized superoxide dismutase on bleomycin-induced pulmonary fibrosis
journal, March 2010

Integrin α ₄ β ₁ Promotes Monocyte Trafficking and Angiogenesis in Tumors
journal, February 2006

TGF-beta driven lung fibrosis is macrophage dependent and blocked by Serum amyloid P
journal, January 2011

Lung Collagens Perpetuate Pulmonary Fibrosis via CD204 and M2 Macrophage Activation
journal, November 2013

Inhibition of Rac activity alleviates lipopolysaccharide-induced acute pulmonary injury in mice
journal, July 2011

Increased Expression of CC16 in Patients with Idiopathic Pulmonary Fibrosis
journal, December 2016

Murine models of pulmonary fibrosis
journal, February 2008

Integrins in angiogenesis and lymphangiogenesis
journal, May 2008

Myeloid-Specific Disruption of Tyrosine Phosphatase Shp2 Promotes Alternative Activation of Macrophages and Predisposes Mice to Pulmonary Fibrosis
journal, August 2014

Effect of antibody against integrin α4 on bleomycin-induced pulmonary fibrosis in mice
journal, December 2000

The distribution of immunomodulatory cells in the lungs of patients with idiopathic pulmonary fibrosis
journal, October 2011

Alternative activation of macrophages
journal, January 2003

Deficiency of the Hematopoietic Cell-Specific Rho Family GTPase Rac2 Is Characterized by Abnormalities in Neutrophil Function and Host Defense
journal, February 1999

IRAK-M Promotes Alternative Macrophage Activation and Fibroproliferation in Bleomycin-Induced Lung Injury
journal, January 2015

Regulation of inflammation by Rac2 in immune complex-mediated acute lung injury
journal, December 2009

Rac GTPase interacts with GAPs and target proteins through multiple effector sites.
journal, November 1995

Multiplex protein profiling of bronchoalveolar lavage in idiopathic pulmonary fibrosis and hypersensitivity pneumonitis
journal, January 2013

Unravelling mononuclear phagocyte heterogeneity
journal, May 2010

MMP28 promotes macrophage polarization toward M2 cells and augments pulmonary fibrosis
journal, August 2013

Rac2 is involved in bleomycin-induced lung inflammation leading to pulmonary fibrosis
journal, January 2014

New concepts of IL-10-induced lung fibrosis: fibrocyte recruitment and M ₂ activation in a CCL2/CCR2 axis
journal, March 2011

Mechanisms of Pulmonary Fibrosis
journal, February 2004