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Title: Rac2 is required for alternative macrophage activation and bleomycin induced pulmonary fibrosis; a macrophage autonomous phenotype

Authors:
; ; ; ; ; ; ; ; ORCiD logo;
Publication Date:
Sponsoring Org.:
USDOE
OSTI Identifier:
1375506
Grant/Contract Number:  
CA192646
Resource Type:
Published Article
Journal Name:
PLoS ONE
Additional Journal Information:
Journal Name: PLoS ONE Journal Volume: 12 Journal Issue: 8; Journal ID: ISSN 1932-6203
Publisher:
Public Library of Science (PLoS)
Country of Publication:
United States
Language:
English

Citation Formats

Joshi, Shweta, Singh, Alok R., Wong, Simon S., Zulcic, Muamera, Jiang, Min, Pardo, Annie, Selman, Moises, Hagood, James S., Durden, Donald L., and Schnapp, ed., Lynn M. Rac2 is required for alternative macrophage activation and bleomycin induced pulmonary fibrosis; a macrophage autonomous phenotype. United States: N. p., 2017. Web. doi:10.1371/journal.pone.0182851.
Joshi, Shweta, Singh, Alok R., Wong, Simon S., Zulcic, Muamera, Jiang, Min, Pardo, Annie, Selman, Moises, Hagood, James S., Durden, Donald L., & Schnapp, ed., Lynn M. Rac2 is required for alternative macrophage activation and bleomycin induced pulmonary fibrosis; a macrophage autonomous phenotype. United States. doi:10.1371/journal.pone.0182851.
Joshi, Shweta, Singh, Alok R., Wong, Simon S., Zulcic, Muamera, Jiang, Min, Pardo, Annie, Selman, Moises, Hagood, James S., Durden, Donald L., and Schnapp, ed., Lynn M. Thu . "Rac2 is required for alternative macrophage activation and bleomycin induced pulmonary fibrosis; a macrophage autonomous phenotype". United States. doi:10.1371/journal.pone.0182851.
@article{osti_1375506,
title = {Rac2 is required for alternative macrophage activation and bleomycin induced pulmonary fibrosis; a macrophage autonomous phenotype},
author = {Joshi, Shweta and Singh, Alok R. and Wong, Simon S. and Zulcic, Muamera and Jiang, Min and Pardo, Annie and Selman, Moises and Hagood, James S. and Durden, Donald L. and Schnapp, ed., Lynn M.},
abstractNote = {},
doi = {10.1371/journal.pone.0182851},
journal = {PLoS ONE},
number = 8,
volume = 12,
place = {United States},
year = {2017},
month = {8}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record
DOI: 10.1371/journal.pone.0182851

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Cited by: 2 works
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Works referenced in this record:

The Acute Respiratory Distress Syndrome
journal, May 2000


Pulmonary fibrosis: patterns and perpetrators
journal, August 2012

  • Noble, Paul W.; Barkauskas, Christina E.; Jiang, Dianhua
  • Journal of Clinical Investigation, Vol. 122, Issue 8
  • DOI: 10.1172/JCI60323

Exploring the full spectrum of macrophage activation
journal, December 2008

  • Mosser, David M.; Edwards, Justin P.
  • Nature Reviews Immunology, Vol. 8, Issue 12
  • DOI: 10.1038/nri2448

Mammary epithelial cell: Influence of extracellular matrix composition and organization during development and tumorigenesis
journal, January 2007

  • Kass, Laura; Erler, Janine T.; Dembo, Micah
  • The International Journal of Biochemistry & Cell Biology, Vol. 39, Issue 11
  • DOI: 10.1016/j.biocel.2007.06.025

Receptor Tyrosine Kinases and TLR/IL1Rs Unexpectedly Activate Myeloid Cell PI3Kγ, A Single Convergent Point Promoting Tumor Inflammation and Progression
journal, June 2011

  • Schmid, Michael C.; Avraamides, Christie J.; Dippold, Holly C.
  • Cancer Cell, Vol. 19, Issue 6
  • DOI: 10.1016/j.ccr.2011.04.016

Blocking the  4 integrin paxillin interaction selectively impairs mononuclear leukocyte recruitment to an inflammatory site
journal, March 2006

  • Feral, C. C.
  • Journal of Clinical Investigation, Vol. 116, Issue 3
  • DOI: 10.1172/JCI26091

Ly6C hi Monocytes Direct Alternatively Activated Profibrotic Macrophage Regulation of Lung Fibrosis
journal, September 2011

  • Gibbons, Michael A.; MacKinnon, Alison C.; Ramachandran, Prakash
  • American Journal of Respiratory and Critical Care Medicine, Vol. 184, Issue 5
  • DOI: 10.1164/rccm.201010-1719OC

A tense situation: forcing tumour progression
journal, February 2009

  • Butcher, Darci T.; Alliston, Tamara; Weaver, Valerie M.
  • Nature Reviews Cancer, Vol. 9, Issue 2
  • DOI: 10.1038/nrc2544

Important Roles for Macrophage Colony-stimulating Factor, CC Chemokine Ligand 2, and Mononuclear Phagocytes in the Pathogenesis of Pulmonary Fibrosis
journal, July 2007

  • Baran, Christopher P.; Opalek, Judy M.; McMaken, Sara
  • American Journal of Respiratory and Critical Care Medicine, Vol. 176, Issue 1
  • DOI: 10.1164/rccm.200609-1279OC

The chemokine system in diverse forms of macrophage activation and polarization
journal, December 2004


The pathophysiologic role of alpha 4 integrins in vivo.
journal, November 1994

  • Lobb, R. R.; Hemler, M. E.
  • Journal of Clinical Investigation, Vol. 94, Issue 5
  • DOI: 10.1172/JCI117519

Acute Exacerbations of Idiopathic Pulmonary Fibrosis
journal, October 2007

  • Collard, Harold R.; Moore, Bethany B.; Flaherty, Kevin R.
  • American Journal of Respiratory and Critical Care Medicine, Vol. 176, Issue 7
  • DOI: 10.1164/rccm.200703-463PP

Autophagy in Idiopathic Pulmonary Fibrosis
journal, July 2012


Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer
journal, February 2011

  • Cox, T. R.; Erler, J. T.
  • Disease Models & Mechanisms, Vol. 4, Issue 2
  • DOI: 10.1242/dmm.004077

Rac2 Specificity in Macrophage Integrin Signaling: POTENTIAL ROLE FOR Syk KINASE
journal, August 2003

  • Pradip, De; Peng, Xiaodong; Durden, Donald L.
  • Journal of Biological Chemistry, Vol. 278, Issue 43
  • DOI: 10.1074/jbc.M306491200

Rac2 Controls Tumor Growth, Metastasis and M1-M2 Macrophage Differentiation In Vivo
journal, April 2014


A Novel Mechanism for CCR4 in the Regulation of Macrophage Activation in Bleomycin-Induced Pulmonary Fibrosis
journal, May 2008

  • Trujillo, Glenda; O'Connor, Erica C.; Kunkel, Steven L.
  • The American Journal of Pathology, Vol. 172, Issue 5
  • DOI: 10.2353/ajpath.2008.070832

Expression of RAC2 in endothelial cells is required for the postnatal neovascular response
journal, January 2009


Idiopathic pulmonary fibrosis
journal, March 2008

  • Meltzer, Eric B.; Noble, Paul W.
  • Orphanet Journal of Rare Diseases, Vol. 3, Issue 1
  • DOI: 10.1186/1750-1172-3-8

Integrin modulation and signaling in leukocyte adhesion and migration
journal, August 2007


Activation of Alveolar Macrophages via the Alternative Pathway in Herpesvirus-Induced Lung Fibrosis
journal, October 2006

  • Mora, Ana L.; Torres-González, Edilson; Rojas, Mauricio
  • American Journal of Respiratory Cell and Molecular Biology, Vol. 35, Issue 4
  • DOI: 10.1165/rcmb.2006-0121OC

Therapeutic effect of lecithinized superoxide dismutase on bleomycin-induced pulmonary fibrosis
journal, March 2010

  • Tanaka, Ken-Ichiro; Ishihara, Tomoaki; Azuma, Arata
  • American Journal of Physiology-Lung Cellular and Molecular Physiology, Vol. 298, Issue 3
  • DOI: 10.1152/ajplung.00289.2009

Integrin α 4 β 1 Promotes Monocyte Trafficking and Angiogenesis in Tumors
journal, February 2006


TGF-beta driven lung fibrosis is macrophage dependent and blocked by Serum amyloid P
journal, January 2011

  • Murray, Lynne A.; Chen, Qingsheng; Kramer, Michael S.
  • The International Journal of Biochemistry & Cell Biology, Vol. 43, Issue 1
  • DOI: 10.1016/j.biocel.2010.10.013

Lung Collagens Perpetuate Pulmonary Fibrosis via CD204 and M2 Macrophage Activation
journal, November 2013


Inhibition of Rac activity alleviates lipopolysaccharide-induced acute pulmonary injury in mice
journal, July 2011

  • Yao, Hong-yi; Chen, Lihua; Xu, Chengyun
  • Biochimica et Biophysica Acta (BBA) - General Subjects, Vol. 1810, Issue 7
  • DOI: 10.1016/j.bbagen.2011.03.020

Increased Expression of CC16 in Patients with Idiopathic Pulmonary Fibrosis
journal, December 2016


Murine models of pulmonary fibrosis
journal, February 2008

  • Moore, Bethany B.; Hogaboam, Cory M.
  • American Journal of Physiology-Lung Cellular and Molecular Physiology, Vol. 294, Issue 2
  • DOI: 10.1152/ajplung.00313.2007

Integrins in angiogenesis and lymphangiogenesis
journal, May 2008

  • Avraamides, Christie J.; Garmy-Susini, Barbara; Varner, Judith A.
  • Nature Reviews Cancer, Vol. 8, Issue 8
  • DOI: 10.1038/nrc2353

Effect of antibody against integrin α4 on bleomycin-induced pulmonary fibrosis in mice
journal, December 2000


The distribution of immunomodulatory cells in the lungs of patients with idiopathic pulmonary fibrosis
journal, October 2011


Alternative activation of macrophages
journal, January 2003

  • Gordon, Siamon
  • Nature Reviews Immunology, Vol. 3, Issue 1
  • DOI: 10.1038/nri978

IRAK-M Promotes Alternative Macrophage Activation and Fibroproliferation in Bleomycin-Induced Lung Injury
journal, January 2015

  • Ballinger, Megan N.; Newstead, Michael W.; Zeng, Xianying
  • The Journal of Immunology, Vol. 194, Issue 4
  • DOI: 10.4049/jimmunol.1402377

Regulation of inflammation by Rac2 in immune complex-mediated acute lung injury
journal, December 2009

  • Dooley, James L.; Abdel-Latif, Dalia; St. Laurent, Chris D.
  • American Journal of Physiology-Lung Cellular and Molecular Physiology, Vol. 297, Issue 6
  • DOI: 10.1152/ajplung.90471.2008

Rac GTPase interacts with GAPs and target proteins through multiple effector sites.
journal, November 1995


Multiplex protein profiling of bronchoalveolar lavage in idiopathic pulmonary fibrosis and hypersensitivity pneumonitis
journal, January 2013

  • Wim, AWuyts; Bart, MVanaudenaerde; Christophe, Dooms
  • Annals of Thoracic Medicine, Vol. 8, Issue 1
  • DOI: 10.4103/1817-1737.105718

Unravelling mononuclear phagocyte heterogeneity
journal, May 2010

  • Geissmann, Frédéric; Gordon, Siamon; Hume, David A.
  • Nature Reviews Immunology, Vol. 10, Issue 6
  • DOI: 10.1038/nri2784

MMP28 promotes macrophage polarization toward M2 cells and augments pulmonary fibrosis
journal, August 2013

  • Gharib, S. A.; Johnston, L. K.; Huizar, I.
  • Journal of Leukocyte Biology, Vol. 95, Issue 1
  • DOI: 10.1189/jlb.1112587

Rac2 is involved in bleomycin-induced lung inflammation leading to pulmonary fibrosis
journal, January 2014

  • Arizmendi, Narcy; Puttagunta, Lakshmi; Chung, Kerri L.
  • Respiratory Research, Vol. 15, Issue 1
  • DOI: 10.1186/1465-9921-15-71

New concepts of IL-10-induced lung fibrosis: fibrocyte recruitment and M 2 activation in a CCL2/CCR2 axis
journal, March 2011

  • Sun, Lei; Louie, Marisa C.; Vannella, Kevin M.
  • American Journal of Physiology-Lung Cellular and Molecular Physiology, Vol. 300, Issue 3
  • DOI: 10.1152/ajplung.00122.2010

Mechanisms of Pulmonary Fibrosis
journal, February 2004