Sickle cells produce functional immune modulators and cytotoxics

Sun, Chiao-Wang; Wu, Li-Chen; Knopick, Peter L.; Bradley, David S.; Townes, Tim; Terman, David S.

doi:10.1002/ajh.24836

Title: Sickle cells produce functional immune modulators and cytotoxics

Authors:

Sun, Chiao-Wang ^[1]; Wu, Li-Chen ^[1]; Knopick, Peter L. ^[2]; Bradley, David S. ^[2]; Townes, Tim ^[1];

^[1]

Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, School of Medicine, Birmingham Alabama
Department of Biomedical Sciences, University of North Dakota School of Medicine and Health Sciences, Grand Forks North Dakota

Publication Date:: Sat Jun 24 00:00:00 EDT 2017

Sponsoring Org.:: USDOE Office of Science (SC), Nuclear Physics (NP)

OSTI Identifier:: 1375483

Resource Type:: Publisher's Accepted Manuscript

Journal Name:: American Journal of Hematology

Additional Journal Information:: Journal Name: American Journal of Hematology Journal Volume: 92 Journal Issue: 10; Journal ID: ISSN 0361-8609

Country of Publication:: United States

Language:: English

Citation Formats


                    Sun, Chiao-Wang, Wu, Li-Chen, Knopick, Peter L., Bradley, David S., Townes, Tim, and Terman, David S. Sickle cells produce functional immune modulators and cytotoxics.  United States: N. p., 2017. 
Web.  doi:10.1002/ajh.24836.

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                    Sun, Chiao-Wang, Wu, Li-Chen, Knopick, Peter L., Bradley, David S., Townes, Tim, & Terman, David S. Sickle cells produce functional immune modulators and cytotoxics.  United States.  https://doi.org/10.1002/ajh.24836

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                    Sun, Chiao-Wang, Wu, Li-Chen, Knopick, Peter L., Bradley, David S., Townes, Tim, and Terman, David S. Sat .  
"Sickle cells produce functional immune modulators and cytotoxics".  United States.  https://doi.org/10.1002/ajh.24836.

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@article{osti_1375483,

  title        = {Sickle cells produce functional immune modulators and cytotoxics},

  author       = {Sun, Chiao-Wang and Wu, Li-Chen and Knopick, Peter L. and Bradley, David S. and Townes, Tim and Terman, David S.},

  abstractNote = {},

  doi          = {10.1002/ajh.24836},

  journal      = {American Journal of Hematology},

  number       = 10,

  volume       = 92,

  place        = {United States},

  year         = {Sat Jun 24 00:00:00 EDT 2017},

  month        = {Sat Jun 24 00:00:00 EDT 2017}

}

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Title: Sickle cells produce functional immune modulators and cytotoxics

Citation Formats

Enhanced permeability and retention of macromolecular drugs in solid tumors: A royal gate for targeted anticancer nanomedicines journal, January 2007

Perforin and granzymes: function, dysfunction and human pathology journal, May 2015

Hypoxia, DNA repair and genetic instability journal, March 2008

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Perforin: structure, function, and role in human immunopathology: Perforin structure and function journal, April 2010

A single erythroid-specific DNase I super-hypersensitive site activates high levels of human beta-globin gene expression in transgenic mice. journal, March 1989

egc , A Highly Prevalent Operon of Enterotoxin Gene, Forms a Putative Nursery of Superantigens in Staphylococcus aureus journal, January 2001

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Position-independent, high-level expression of the human β-globin gene in transgenic mice journal, December 1987

Potentially therapeutic levels of anti-sickling globin gene expression following lentivirus-mediated gene transfer in sickle cell disease bone marrow CD34 + cells journal, May 2015

Targeted Cancer Therapeutics journal, February 2009

Profound deletion of mature T cells in vivo by chronic exposure to exogenous superantigen. journal, May 1993

Drug delivery by red blood cells journal, July 2011

Correction of Sickle Cell Disease in Transgenic Mouse Models by Gene Therapy journal, December 2001

Extracellular granzyme A, complexed to proteoglycans, is protected against inactivation by protease inhibitors journal, February 2000

Targeting hypoxia in cancer therapy journal, May 2011

Locus control region elements HS1 and HS4 enhance the therapeutic efficacy of globin gene transfer in β-thalassemic mice journal, December 2007

Molecular analysis of the human beta-globin locus activation region. journal, July 1989

Pathogenesis of the toxic shock syndrome: T cell mediated lethal shock caused by the superantigen TSST-1 journal, July 1993

Exploiting tumour hypoxia in cancer treatment journal, June 2004

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Sickle Erythrocytes Target Cytotoxics to Hypoxic Tumor Microvessels and Potentiate a Tumoricidal Response journal, January 2013

Drug-loaded sickle cells programmed ex vivo for delayed hemolysis target hypoxic tumor microvessels and augment tumor drug delivery journal, October 2013

Stem cell–derived erythroid cells mediate long-term systemic protein delivery journal, July 2006

Synthesis of functional human hemoglobin in transgenic mice journal, September 1989

Staphylococcal entertotoxins of the enterotoxin Gene cluster (egcSEs) induce nitrous oxide- and cytokine dependent tumor cell apoptosis in a broad panel of human tumor cells journal, January 2013

Correction of a mouse model of sickle cell disease: lentiviral/antisickling β-globin gene transduction of unmobilized, purified hematopoietic stem cells journal, December 2003

Generation of T-cell receptor retrogenic mice journal, June 2006

Programmed sickle cells for targeted delivery to hypoxic tumors journal, October 2013

Ex Vivo Expanded Hematopoietic Stem Cells Overcome the MHC Barrier in Allogeneic Transplantation journal, August 2011

Sickle Cells Abolish Melanoma Tumorigenesis in Hemoglobin SS Knockin Mice and Augment the Tumoricidal Effect of Oncolytic Virus In Vivo journal, July 2016

International seminar on the red blood cells as vehicles for drugs journal, October 2011

Two 3' sequences direct adult erythroid-specific expression of human beta-globin genes in transgenic mice. journal, October 1987

Therapeutic haemoglobin synthesis in β-thalassaemic mice expressing lentivirus-encoded human β-globin journal, July 2000

The toxicity of staphylococcal enterotoxin B in mice is mediated by T cells journal, February 1990

Staphylococcal Superantigens of the Enterotoxin Gene Cluster (egc) for Treatment of Stage IIIb Non–Small Cell Lung Cancer with Pleural Effusion journal, June 2006

Enhanced permeability and retention of macromolecular drugs in solid tumors: A royal gate for targeted anticancer nanomedicines
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Perforin and granzymes: function, dysfunction and human pathology
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Hypoxia, DNA repair and genetic instability
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Perforin: structure, function, and role in human immunopathology: Perforin structure and function
journal, April 2010

A single erythroid-specific DNase I super-hypersensitive site activates high levels of human beta-globin gene expression in transgenic mice.
journal, March 1989

egc , A Highly Prevalent Operon of Enterotoxin Gene, Forms a Putative Nursery of Superantigens in Staphylococcus aureus
journal, January 2001

Successful correction of the human β-thalassemia major phenotype using a lentiviral vector
journal, December 2004

Position-independent, high-level expression of the human β-globin gene in transgenic mice
journal, December 1987

Potentially therapeutic levels of anti-sickling globin gene expression following lentivirus-mediated gene transfer in sickle cell disease bone marrow CD34 + cells
journal, May 2015

Targeted Cancer Therapeutics
journal, February 2009

Profound deletion of mature T cells in vivo by chronic exposure to exogenous superantigen.
journal, May 1993

Drug delivery by red blood cells
journal, July 2011

Correction of Sickle Cell Disease in Transgenic Mouse Models by Gene Therapy
journal, December 2001

Extracellular granzyme A, complexed to proteoglycans, is protected against inactivation by protease inhibitors
journal, February 2000

Targeting hypoxia in cancer therapy
journal, May 2011

Locus control region elements HS1 and HS4 enhance the therapeutic efficacy of globin gene transfer in β-thalassemic mice
journal, December 2007

Molecular analysis of the human beta-globin locus activation region.
journal, July 1989

Pathogenesis of the toxic shock syndrome: T cell mediated lethal shock caused by the superantigen TSST-1
journal, July 1993

Exploiting tumour hypoxia in cancer treatment
journal, June 2004

Intrapleural Staphylococcal Superantigen Induces Resolution of Malignant Pleural Effusions and a Survival Benefit in Non-Small Cell Lung Cancer
journal, November 2004

Sickle Erythrocytes Target Cytotoxics to Hypoxic Tumor Microvessels and Potentiate a Tumoricidal Response
journal, January 2013

Drug-loaded sickle cells programmed ex vivo for delayed hemolysis target hypoxic tumor microvessels and augment tumor drug delivery
journal, October 2013

Stem cell–derived erythroid cells mediate long-term systemic protein delivery
journal, July 2006

Synthesis of functional human hemoglobin in transgenic mice
journal, September 1989

Staphylococcal entertotoxins of the enterotoxin Gene cluster (egcSEs) induce nitrous oxide- and cytokine dependent tumor cell apoptosis in a broad panel of human tumor cells
journal, January 2013

Correction of a mouse model of sickle cell disease: lentiviral/antisickling β-globin gene transduction of unmobilized, purified hematopoietic stem cells
journal, December 2003

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journal, June 2006

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Sickle Cells Abolish Melanoma Tumorigenesis in Hemoglobin SS Knockin Mice and Augment the Tumoricidal Effect of Oncolytic Virus In Vivo
journal, July 2016

International seminar on the red blood cells as vehicles for drugs
journal, October 2011

Two 3' sequences direct adult erythroid-specific expression of human beta-globin genes in transgenic mice.
journal, October 1987

Therapeutic haemoglobin synthesis in β-thalassaemic mice expressing lentivirus-encoded human β-globin
journal, July 2000

The toxicity of staphylococcal enterotoxin B in mice is mediated by T cells
journal, February 1990

Staphylococcal Superantigens of the Enterotoxin Gene Cluster (egc) for Treatment of Stage IIIb Non–Small Cell Lung Cancer with Pleural Effusion
journal, June 2006