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Title: Modeling Zika plasma viral dynamics in non-human primates: insights into viral pathogenesis and antiviral strategies

The recent outbreak of Zika virus (ZIKV) has been associated with fetal abnormalities and neurological complications, prompting global concern. Here we present the first mathematical analysis of the within-host dynamics of plasma ZiKV burden in a non-human primate model, allowing for characterization of the growth and clearance of ZIKV within an individual macaque.
Authors:
 [1] ;  [2] ;  [3] ;  [4] ;  [5] ;  [5] ;  [5] ;  [1]
  1. Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
  2. Univ. of Paris (France). IAME
  3. Univ. of Paris (France)
  4. Aix-Marseille Univ. (France)
  5. Harvard Univ., Cambridge, MA (United States). Center for Virology and Vaccine Research
Publication Date:
Report Number(s):
LA-UR-16-28095
Grant/Contract Number:
AC52-06NA25396
Type:
Published Article
Research Org:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Sponsoring Org:
USDOE; National Institutes of Health (NIH)
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; Biological Science
OSTI Identifier:
1373602
Alternate Identifier(s):
OSTI ID: 1330177