3D Motions of Iron in Six-Coordinate {FeNO}7 Hemes by Nuclear Resonance Vibration Spectroscopy [3-D Motions of Iron in Six-coordinate {FeNO}7 Hemes by NRVS

Peng, Qian; Pavlik, Jeffrey W.; Silvernail, Nathan J.; Alp, E. Ercan; Hu, Michael Y.; Zhao, Jiyong; Sage, J. Timothy; Scheidt, W. Robert

doi:10.1002/chem.201505155

Title: 3D Motions of Iron in Six-Coordinate {FeNO}⁷ Hemes by Nuclear Resonance Vibration Spectroscopy [3-D Motions of Iron in Six-coordinate {FeNO}⁷ Hemes by NRVS

Abstract

Abstract The vibrational spectrum of a six‐coordinate nitrosyl iron porphyrinate, monoclinic [Fe(T p FPP)(1‐MeIm)(NO)] (T p FPP=tetra‐ para ‐fluorophenylporphyrin; 1‐MeIm=1‐methylimidazole), has been studied by oriented single‐crystal nuclear resonance vibrational spectroscopy (NRVS). The crystal was oriented to give spectra perpendicular to the porphyrin plane and two in‐plane spectra perpendicular or parallel to the projection of the FeNO plane. These enable assignment of the FeNO bending and stretching modes. The measurements reveal that the two in‐plane spectra have substantial differences that result from the strongly bonded axial NO ligand. The direction of the in‐plane iron motion is found to be largely parallel and perpendicular to the projection of the bent FeNO on the porphyrin plane. The out‐of‐plane Fe‐N‐O stretching and bending modes are strongly mixed with each other, as well as with porphyrin ligand modes. The stretch is mixed with v ₅₀ as was also observed for dioxygen complexes. The frequency of the assigned stretching mode of eight Fe‐X‐O (X=N, C, and O) complexes is correlated with the Fe−XO bond lengths. The nature of highest frequency band at ≈560 cm ⁻¹ has also been examined in two additional new derivatives. Previously assigned as the Fe−NO stretch (by resonance Raman), it is better describedmore »« less

Authors:

Peng, Qian ^[1]; Pavlik, Jeffrey W. ^[1]; Silvernail, Nathan J. ^[1]; Alp, E. Ercan ^[2]; Hu, Michael Y. ^[2]; Zhao, Jiyong ^[2]; Sage, J. Timothy ^[3];

^[1]

Univ. of Notre Dame, Notre Dame, IN (United States)
Argonne National Lab. (ANL), Argonne, IL (United States)
Northeastern Univ., Boston, MA (United States)

Publication Date:: Mon Mar 21 00:00:00 EDT 2016

Research Org.:: Argonne National Laboratory (ANL), Argonne, IL (United States)

Sponsoring Org.:: National Institutes of Health (NIH); National Science Foundation (NSF); USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22), Scientific User Facilities Division; USDOE

OSTI Identifier:: 1373306

Alternate Identifier(s):: OSTI ID: 1400744

Grant/Contract Number:: AC02-06CH11357

Resource Type:: Accepted Manuscript

Journal Name:: Chemistry - A European Journal

Additional Journal Information:: Journal Volume: 22; Journal Issue: 18; Journal ID: ISSN 0947-6539

Publisher:: ChemPubSoc Europe

Country of Publication:: United States

Language:: English

Subject:: 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats


                    Peng, Qian, Pavlik, Jeffrey W., Silvernail, Nathan J., Alp, E. Ercan, Hu, Michael Y., Zhao, Jiyong, Sage, J. Timothy, and Scheidt, W. Robert. 3D Motions of Iron in Six-Coordinate {FeNO}7 Hemes by Nuclear Resonance Vibration Spectroscopy [3-D Motions of Iron in Six-coordinate {FeNO}7 Hemes by NRVS.  United States: N. p., 2016. 
Web.  doi:10.1002/chem.201505155.

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                    Peng, Qian, Pavlik, Jeffrey W., Silvernail, Nathan J., Alp, E. Ercan, Hu, Michael Y., Zhao, Jiyong, Sage, J. Timothy, & Scheidt, W. Robert. 3D Motions of Iron in Six-Coordinate {FeNO}7 Hemes by Nuclear Resonance Vibration Spectroscopy [3-D Motions of Iron in Six-coordinate {FeNO}7 Hemes by NRVS.  United States.  https://doi.org/10.1002/chem.201505155

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                    Peng, Qian, Pavlik, Jeffrey W., Silvernail, Nathan J., Alp, E. Ercan, Hu, Michael Y., Zhao, Jiyong, Sage, J. Timothy, and Scheidt, W. Robert. Mon .  
"3D Motions of Iron in Six-Coordinate {FeNO}7 Hemes by Nuclear Resonance Vibration Spectroscopy [3-D Motions of Iron in Six-coordinate {FeNO}7 Hemes by NRVS".  United States.  https://doi.org/10.1002/chem.201505155.  https://www.osti.gov/servlets/purl/1373306.

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@article{osti_1373306,

  title        = {3D Motions of Iron in Six-Coordinate {FeNO}7 Hemes by Nuclear Resonance Vibration Spectroscopy [3-D Motions of Iron in Six-coordinate {FeNO}7 Hemes by NRVS},

  author       = {Peng, Qian and Pavlik, Jeffrey W. and Silvernail, Nathan J. and Alp, E. Ercan and Hu, Michael Y. and Zhao, Jiyong and Sage, J. Timothy and Scheidt, W. Robert},

  abstractNote = {Abstract The vibrational spectrum of a six‐coordinate nitrosyl iron porphyrinate, monoclinic [Fe(T p FPP)(1‐MeIm)(NO)] (T p FPP=tetra‐ para ‐fluorophenylporphyrin; 1‐MeIm=1‐methylimidazole), has been studied by oriented single‐crystal nuclear resonance vibrational spectroscopy (NRVS). The crystal was oriented to give spectra perpendicular to the porphyrin plane and two in‐plane spectra perpendicular or parallel to the projection of the FeNO plane. These enable assignment of the FeNO bending and stretching modes. The measurements reveal that the two in‐plane spectra have substantial differences that result from the strongly bonded axial NO ligand. The direction of the in‐plane iron motion is found to be largely parallel and perpendicular to the projection of the bent FeNO on the porphyrin plane. The out‐of‐plane Fe‐N‐O stretching and bending modes are strongly mixed with each other, as well as with porphyrin ligand modes. The stretch is mixed with v 50 as was also observed for dioxygen complexes. The frequency of the assigned stretching mode of eight Fe‐X‐O (X=N, C, and O) complexes is correlated with the Fe−XO bond lengths. The nature of highest frequency band at ≈560 cm −1 has also been examined in two additional new derivatives. Previously assigned as the Fe−NO stretch (by resonance Raman), it is better described as the bend, as the motion of the central nitrogen atom of the FeNO group is very large. There is significant mixing of this mode. The results emphasize the importance of mode mixing; the extent of mixing must be related to the peripheral phenyl substituents.},

  doi          = {10.1002/chem.201505155},

  journal      = {Chemistry - A European Journal},

  number       = 18,

  volume       = 22,

  place        = {United States},

  year         = {Mon Mar 21 00:00:00 EDT 2016},

  month        = {Mon Mar 21 00:00:00 EDT 2016}

}

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Works referencing / citing this record:

What Can Be Learned from Nuclear Resonance Vibrational Spectroscopy: Vibrational Dynamics and Hemes
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Scheidt, W. Robert; Li, Jianfeng; Sage, J. Timothy
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Comprehensive Fe-ligand vibration identification in {FeNO}⁶ Hemes

Journal Article Li, Jianfeng ; Peng, Qian ; Oliver, Allen G. ; ... - Journal of the American Chemical Society

Oriented single-crystal nuclear resonance vibrational spectroscopy (NRVS) has been used to obtain all iron vibrations in two {FeNO}⁶ porphyrinate complexes, five-coordinate [Fe(OEP)(NO)]ClO₄ and six-coordinate [Fe(OEP)(2-MeHIm)(NO)]ClO₄. A new crystal structure was required for measurements of [Fe(OEP)(2-MeHIm)(NO)]ClO₄, and the new structure is reported herein. Single crystals of both complexes were oriented to be either parallel or perpendicular to the porphyrin plane and/or axial imidazole ligand plane. Thus, the FeNO bending and stretching modes can now be unambiguously assigned; the pattern of shifts in frequency as a function of coordination number can also be determined. The pattern is quite distinct from those foundmore »« less
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Nuclear resonance vibrational spectroscopy applied to [Fe(OEP)(NO)] : the vibrational assignments of five-coordinate ferrous heme-nitrosyls and implications for electronic structure.

Journal Article Lehnert, N ; Galinato, M I ; Paulat, F ; ... - Inorg. Chem.

This study presents Nuclear Resonance Vibrational Spectroscopy (NRVS) data on the five-coordinate (5C) ferrous heme-nitrosyl complex [Fe(OEP)(NO)] (1, OEP{sup 2-} = octaethylporphyrinato dianion) and the corresponding {sup 15}N{sup 18}O labeled complex. The obtained spectra identify two isotope sensitive features at 522 and 388 cm{sup -1}, which shift to 508 and 381 cm{sup -1}, respectively, upon isotope labeling. These features are assigned to the Fe-NO stretch v(Fe-NO) and the in-plane Fe-N-O bending mode {delta}{sub ip}(Fe-N-O), the latter has been unambiguously assigned for the first time for 1. The obtained NRVS data were simulated using our quantum chemistry centered normal coordinate analysismore »« less
https://doi.org/10.1021/ic902181e
Axial ligand and out-of-plane vibrations for bis(imidazolyl)heme: Raman and infrared /sup 54/Fe, /sup 15/N, and /sup 2/H isotope shifts and normal coordinate calculations

Journal Article Mitchell, M L ; Li, X Y ; Kincaid, J R ; ... - J. Phys. Chem.; (United States)

Resonance Raman spectra of bis(imidazole) (ImH) complexes of Fe/sup II/ and Fe/sup III/ porphyrins reveal a band at approx.200 cm/sup -1/, assignable to the symmetric Fe-(ImH)/sub 2/ stretch via its 5-cm/sup -1/ downshift upon ImH-d/sub 4/ substitution. This band is enhanced in resonance with the Soret band for Fe/sup II/ porphyrins, suggesting direct coupling with the ..pi..-..pi.. state. For Fe/sup III/, this is observed only for protoporphyrin IX in aqueous solution, associated with aggregate formation. The low-frequency infrared spectrum of ((ImH)/sub 2/Fe/sup III/OEP)ClO/sub 4/ has been analyzed with the aid of /sup 54/Fe, /sup 15/N(pyrrole), meso-d/sub 4/, and ImH-d/sub 4/more »« less
https://doi.org/10.1021/j100302a013
Interplay of structure and vibrational dynamics in six-coordinate heme nitrosyls.

Journal Article Silvernail, N J ; Barabanschikov, A ; Pavlik, J W ; ... - J. Am. Chem. Soc. Commun.

The isolation of two polymorphic forms of nitrosyl(1-methylimidazole)(tetra-p-fluorophenylporphinato)iron(II) provides a unique opportunity to explore the interplay of structure and vibrational dynamics in six-coordinate {l_brace}FeNO{r_brace}{sup 7} nitrosyliron porphyrinates. The two species display differing vibrational spectroscopic properties both in {nu}{sub NO} (IR) and the iron vibrational modes obtained through the use of nuclear resonance vibrational spectroscopy. Structural characterization of the two complexes has yielded extremely high-quality structures that further confirm that coordination of NO leads to ligand tilting and asymmetry in the equatorial Fe-Np bond distances. The two polymorphic structures (monoclinic and triclinic crystal systems) differ in the relative orientations of themore »« less
https://doi.org/10.1021/ja066869k
Vibrational Assignments of Six-Coordinate Ferrous Heme Nitrosyls: New Insight From Nuclear Resonance Vibrational Spectroscopy

Journal Article Paulat, F ; Berto, T C ; George, S DeBeer ; ... - Inorg. Chem.47:11449,2008

This Communication addresses a long-standing problem: the exact vibrational assignments of the low-energy modes of the Fe-N-O subunit in six-coordinate ferrous heme nitrosyl model complexes. This problem is addressed using nuclear resonance vibrational spectroscopy (NRVS) coupled to {sup 15}N{sup 18}O isotope labeling and detailed simulations of the obtained data. Two isotope-sensitive features are identified at 437 and 563 cm{sup -1}. Normal coordinate analysis shows that the 437 cm{sup -1} mode corresponds to the Fe-NO stretch, whereas the 563 cm{sup -1} band is identified with the Fe-N-O bend. The relative NRVS intensities of these features determine the degree of vibrational mixingmore »« less

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Title: 3D Motions of Iron in Six-Coordinate {FeNO}7 Hemes by Nuclear Resonance Vibration Spectroscopy [3-D Motions of Iron in Six-coordinate {FeNO}7 Hemes by NRVS

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Citation Formats

Relationships between nitric oxide, nitroxyl ion, nitrosonium cation and peroxynitrite journal, May 1999

Five- to Six-Coordination in (Nitrosyl)iron(II) Porphyrinates: Effects of Binding the Sixth Ligand journal, September 2003

The Diagnostic Vibrational Signature of Pentacoordination in Heme Carbonyls journal, July 2014

Nitric Oxide Synthases: Properties and Catalytic Mechanism journal, October 1995

Structure?function studies on nitric oxide synthases journal, January 2005

Structure of Nitric Oxide Synthase Oxygenase Dimer with Pterin and Substrate journal, March 1998

First-principles calculation of nuclear resonance vibrational spectra journal, February 2007

Nuclear resonant inelastic absorption of synchrotron radiation in an anisotropic single crystal journal, October 1998

Electronic Configuration of High-Spin Imidazole-Ligated Iron(II) Octaethylporphyrinates journal, May 2006

Nitric oxide signaling: no longer simply on or off journal, April 2006

A structural basis for H-NOX signaling in Shewanella oneidensis by trapping a histidine kinase inhibitory conformation journal, November 2009

New Perspectives on Iron-Ligand Vibrations of Oxyheme Complexes journal, August 2011

Heme-based sensors in biological systems journal, April 1999

Tetragonal to TriclinicA Phase Change for [Fe(TPP)(NO)] journal, February 2009

Nitrite as regulator of hypoxic signaling in mammalian physiology journal, September 2009

Phonon Density of States Measured by Inelastic Nuclear Resonant Scattering journal, May 1995

Probing Heme Vibrational Anisotropy: An Imidazole Orientation Effect? journal, September 2013

Nitric oxide interaction with insect nitrophorins and thoughts on the electron configuration of the FeNO complex journal, January 2005

Nitric Oxide: A Physiologic Messenger Molecule journal, June 1994

Nitrosyl adducts of FixL as probes of heme environment journal, October 2000

Nitrosylmetalloporphyrins. II. Synthesis and molecular stereochemistry of nitrosyl-.alpha.,.beta.,.gamma.,.delta.-tetraphenylporphinatoiron(II) journal, January 1975

Role of the anion nitrite in ischemia-reperfusion cytoprotection and therapeutics journal, July 2007

Fully optimized contracted Gaussian basis sets for atoms Li to Kr journal, August 1992

Nuclear resonance vibrational spectroscopy ? NRVS journal, January 2005

NO Orientation and Tilting in (Nitrosyl)iron(II) Deuteroporphyrin IX journal, July 2003

NO activation of guanylyl cyclase journal, October 2004

Ligand?protein interactions in nitric oxide synthase journal, January 2005

Structural Origin of Two Paramagnetic Species in Six-Coordinated Nitrosoiron(II) Porphyrins Revealed by Density Functional Theory Analysis of the g Tensors journal, November 2000

Reversible NO Motion in Crystalline [Fe(Porph)(1-MeIm)(NO)] Derivatives journal, February 2008

Resonance Raman characterization of nitric oxide adducts of cytochrome P450cam: the effect of substrate structure on the iron-ligand vibrations journal, April 1991

Correlated Ligand Dynamics in Oxyiron Picket Fence Porphyrins: Structural and Mössbauer Investigations journal, October 2013

Nonheme Iron-Nitrosyl Complex Formation in Rat Hepatocytes: Detection by Electron Paramagnetic Resonance Spectroscopy journal, April 1993

Principles of structure, bonding, and reactivity for metal nitrosyl complexes journal, September 1974

Convenient small-scale method for the insertion of iron into porphyrins journal, February 1990

The New Chemical Biology of Nitrite Reactions with Hemoglobin: R-State Catalysis, Oxidative Denitrosylation, and Nitrite Reductase/Anhydrase journal, January 2009

Biochemistry of nitric oxide and its redox-activated forms journal, December 1992

Oriented Single-Crystal Nuclear Resonance Vibrational Spectroscopy of [Fe(TPP)(MI)(NO)]: Quantitative Assessment of the trans Effect of NO journal, August 2010

Probing Vibrational Anisotropy with Nuclear Resonance Vibrational Spectroscopy journal, June 2010

Six- to Five-Coordinate Heme−Nitrosyl Conversion in Cytochrome c‘ and Its Relevance to Guanylate Cyclase † journal, February 2002

Femtomolar Sensitivity of a NO Sensor from Clostridium botulinum journal, November 2004

NO news is good news journal, December 1992

NO and CO differentially activate soluble guanylyl cyclase via a heme pivot-bend mechanism journal, January 2007

How Biology Handles Nitrite journal, April 2014

Interplay of Structure and Vibrational Dynamics in Six-Coordinate Heme Nitrosyls journal, February 2007

Monochromatization of synchrotron radiation for nuclear resonant scattering experiments journal, January 2000

Solid-State Structures of Metalloporphyrin NO x Compounds journal, April 2002

A new local density functional for main-group thermochemistry, transition metal bonding, thermochemical kinetics, and noncovalent interactions journal, November 2006

Nitric oxide: first in a new class of neurotransmitters journal, July 1992

Consistent porphyrin force field. 2. Nickel octaethylporphyrin skeletal and substituent mode assignments from nitrogen-15, meso-d4, and methylene-d16 Raman and infrared isotope shifts journal, January 1990

Influence of magnetic interaction on lattice dynamics of FeBO 3 journal, October 2001

Heme Carbonyls: Environmental Effects on ν C - O and Fe−C/C−O Bond Length Correlations journal, October 2005

Anisotropic Iron Motion in Nitrosyl Iron Porphyrinates: Natural and Synthetic Hemes journal, February 2014

Nuclear resonance vibrational spectroscopy of a protein active-site mimic journal, August 2001

Embracing sulfide and CO to understand nitric oxide biology journal, November 2013

Mapping NO Movements in Crystalline [Fe(Porph)(NO)(1-MeIm)] journal, February 2009

Bacterial Lipopeptides Induce Nitric Oxide Synthase and Promote Apoptosis through Nitric Oxide-independent Pathways in Rat Macrophages journal, March 1995

Observation of coherent reaction dynamics in heme proteins journal, October 1994

Electronic Structure of Six-Coordinate Iron(III)−Porphyrin NO Adducts: The Elusive Iron(III)−NO(radical) State and Its Influence on the Properties of These Complexes journal, November 2008

Predicting Nuclear Resonance Vibrational Spectra of [Fe(OEP)(NO)] journal, December 2011

FTIR and Resonance Raman Studies of Nitric Oxide Binding to H93G Cavity Mutants of Myoglobin † journal, December 2001

Probing Vibrational Anisotropy with Nuclear Resonance Vibrational Spectroscopy journal, June 2010

Quantitative Vibrational Dynamics of Iron in Carbonyl Porphyrins journal, June 2007

The Chemical Biology of Nitric Oxide book, January 2000

The physiological role of nitric oxide journal, January 1993

Microwave-Assisted Piloty−Robinson Synthesis of 3,4-Disubstituted Pyrroles journal, April 2007

Nuclear resonant spectroscopy journal, January 2004

Resonance Raman Investigation of Fe−N−O Structure of Nitrosylheme in Myoglobin and Its Mutants journal, August 1999

Vibrational Probes and Determinants of the S = 0 ⇌ S = 2 Spin Crossover in Five-Coordinate [Fe(TPP)(CN)] − journal, October 2012

Comprehensive Fe–Ligand Vibration Identification in {FeNO} 6 Hemes journal, December 2014

Nitric oxide and iron proteins journal, May 1999

Direct Probe of Iron Vibrations Elucidates NO Activation of Heme Proteins journal, August 2005

Generation of EPR-detectable nitrosyl-iron complexes in tumor target cells cocultured with activated macrophages journal, June 1991

Heme coordination and structure of the catalytic site in nitric oxide synthase. journal, October 1993

Nitric oxide synthase structure and mechanism journal, June 1993

Microwave-Assisted Piloty−Robinson Synthesis of 3,4-Disubstituted Pyrroles journal, April 2007

What Can Be Learned from Nuclear Resonance Vibrational Spectroscopy: Vibrational Dynamics and Hemes journal, September 2017

Title: 3D Motions of Iron in Six-Coordinate {FeNO}⁷ Hemes by Nuclear Resonance Vibration Spectroscopy [3-D Motions of Iron in Six-coordinate {FeNO}⁷ Hemes by NRVS

Relationships between nitric oxide, nitroxyl ion, nitrosonium cation and peroxynitrite
journal, May 1999

Five- to Six-Coordination in (Nitrosyl)iron(II) Porphyrinates: Effects of Binding the Sixth Ligand
journal, September 2003

The Diagnostic Vibrational Signature of Pentacoordination in Heme Carbonyls
journal, July 2014

Nitric Oxide Synthases: Properties and Catalytic Mechanism
journal, October 1995

Structure?function studies on nitric oxide synthases
journal, January 2005

Structure of Nitric Oxide Synthase Oxygenase Dimer with Pterin and Substrate
journal, March 1998

First-principles calculation of nuclear resonance vibrational spectra
journal, February 2007

Nuclear resonant inelastic absorption of synchrotron radiation in an anisotropic single crystal
journal, October 1998

Electronic Configuration of High-Spin Imidazole-Ligated Iron(II) Octaethylporphyrinates
journal, May 2006

Nitric oxide signaling: no longer simply on or off
journal, April 2006

A structural basis for H-NOX signaling in Shewanella oneidensis by trapping a histidine kinase inhibitory conformation
journal, November 2009

New Perspectives on Iron-Ligand Vibrations of Oxyheme Complexes
journal, August 2011

Heme-based sensors in biological systems
journal, April 1999

Tetragonal to TriclinicA Phase Change for [Fe(TPP)(NO)]
journal, February 2009

Nitrite as regulator of hypoxic signaling in mammalian physiology
journal, September 2009

Phonon Density of States Measured by Inelastic Nuclear Resonant Scattering
journal, May 1995

Probing Heme Vibrational Anisotropy: An Imidazole Orientation Effect?
journal, September 2013

Nitric oxide interaction with insect nitrophorins and thoughts on the electron configuration of the FeNO complex
journal, January 2005

Nitric Oxide: A Physiologic Messenger Molecule
journal, June 1994

Nitrosyl adducts of FixL as probes of heme environment
journal, October 2000

Nitrosylmetalloporphyrins. II. Synthesis and molecular stereochemistry of nitrosyl-.alpha.,.beta.,.gamma.,.delta.-tetraphenylporphinatoiron(II)
journal, January 1975

Role of the anion nitrite in ischemia-reperfusion cytoprotection and therapeutics
journal, July 2007

Fully optimized contracted Gaussian basis sets for atoms Li to Kr
journal, August 1992

Nuclear resonance vibrational spectroscopy ? NRVS
journal, January 2005

NO Orientation and Tilting in (Nitrosyl)iron(II) Deuteroporphyrin IX
journal, July 2003

NO activation of guanylyl cyclase
journal, October 2004

Ligand?protein interactions in nitric oxide synthase
journal, January 2005

Structural Origin of Two Paramagnetic Species in Six-Coordinated Nitrosoiron(II) Porphyrins Revealed by Density Functional Theory Analysis of the g Tensors
journal, November 2000

Reversible NO Motion in Crystalline [Fe(Porph)(1-MeIm)(NO)] Derivatives
journal, February 2008

Resonance Raman characterization of nitric oxide adducts of cytochrome P450cam: the effect of substrate structure on the iron-ligand vibrations
journal, April 1991

Correlated Ligand Dynamics in Oxyiron Picket Fence Porphyrins: Structural and Mössbauer Investigations
journal, October 2013

Nonheme Iron-Nitrosyl Complex Formation in Rat Hepatocytes: Detection by Electron Paramagnetic Resonance Spectroscopy
journal, April 1993

Principles of structure, bonding, and reactivity for metal nitrosyl complexes
journal, September 1974

Convenient small-scale method for the insertion of iron into porphyrins
journal, February 1990

The New Chemical Biology of Nitrite Reactions with Hemoglobin: R-State Catalysis, Oxidative Denitrosylation, and Nitrite Reductase/Anhydrase
journal, January 2009

Biochemistry of nitric oxide and its redox-activated forms
journal, December 1992

Oriented Single-Crystal Nuclear Resonance Vibrational Spectroscopy of [Fe(TPP)(MI)(NO)]: Quantitative Assessment of the trans Effect of NO
journal, August 2010

Probing Vibrational Anisotropy with Nuclear Resonance Vibrational Spectroscopy
journal, June 2010

Six- to Five-Coordinate Heme−Nitrosyl Conversion in Cytochrome c‘ and Its Relevance to Guanylate Cyclase ^†
journal, February 2002

Femtomolar Sensitivity of a NO Sensor from Clostridium botulinum
journal, November 2004

NO news is good news
journal, December 1992

NO and CO differentially activate soluble guanylyl cyclase via a heme pivot-bend mechanism
journal, January 2007

How Biology Handles Nitrite
journal, April 2014

Interplay of Structure and Vibrational Dynamics in Six-Coordinate Heme Nitrosyls
journal, February 2007

Monochromatization of synchrotron radiation for nuclear resonant scattering experiments
journal, January 2000

Solid-State Structures of Metalloporphyrin NO _x Compounds
journal, April 2002

A new local density functional for main-group thermochemistry, transition metal bonding, thermochemical kinetics, and noncovalent interactions
journal, November 2006

Nitric oxide: first in a new class of neurotransmitters
journal, July 1992

Consistent porphyrin force field. 2. Nickel octaethylporphyrin skeletal and substituent mode assignments from nitrogen-15, meso-d4, and methylene-d16 Raman and infrared isotope shifts
journal, January 1990

Influence of magnetic interaction on lattice dynamics of FeBO ₃
journal, October 2001

Heme Carbonyls: Environmental Effects on ν _C _- _O and Fe−C/C−O Bond Length Correlations
journal, October 2005

Anisotropic Iron Motion in Nitrosyl Iron Porphyrinates: Natural and Synthetic Hemes
journal, February 2014

Nuclear resonance vibrational spectroscopy of a protein active-site mimic
journal, August 2001

Embracing sulfide and CO to understand nitric oxide biology
journal, November 2013

Mapping NO Movements in Crystalline [Fe(Porph)(NO)(1-MeIm)]
journal, February 2009

Bacterial Lipopeptides Induce Nitric Oxide Synthase and Promote Apoptosis through Nitric Oxide-independent Pathways in Rat Macrophages
journal, March 1995

Observation of coherent reaction dynamics in heme proteins
journal, October 1994

Electronic Structure of Six-Coordinate Iron(III)−Porphyrin NO Adducts: The Elusive Iron(III)−NO(radical) State and Its Influence on the Properties of These Complexes
journal, November 2008

Predicting Nuclear Resonance Vibrational Spectra of [Fe(OEP)(NO)]
journal, December 2011

FTIR and Resonance Raman Studies of Nitric Oxide Binding to H93G Cavity Mutants of Myoglobin ^†
journal, December 2001

Probing Vibrational Anisotropy with Nuclear Resonance Vibrational Spectroscopy
journal, June 2010

Quantitative Vibrational Dynamics of Iron in Carbonyl Porphyrins
journal, June 2007

The Chemical Biology of Nitric Oxide
book, January 2000

The physiological role of nitric oxide
journal, January 1993

Microwave-Assisted Piloty−Robinson Synthesis of 3,4-Disubstituted Pyrroles
journal, April 2007

Nuclear resonant spectroscopy
journal, January 2004

Resonance Raman Investigation of Fe−N−O Structure of Nitrosylheme in Myoglobin and Its Mutants
journal, August 1999

Vibrational Probes and Determinants of the S = 0 ⇌ S = 2 Spin Crossover in Five-Coordinate [Fe(TPP)(CN)] ⁻
journal, October 2012

Comprehensive Fe–Ligand Vibration Identification in {FeNO} ⁶ Hemes
journal, December 2014

Nitric oxide and iron proteins
journal, May 1999

Direct Probe of Iron Vibrations Elucidates NO Activation of Heme Proteins
journal, August 2005

Generation of EPR-detectable nitrosyl-iron complexes in tumor target cells cocultured with activated macrophages
journal, June 1991

Heme coordination and structure of the catalytic site in nitric oxide synthase.
journal, October 1993

Nitric oxide synthase structure and mechanism
journal, June 1993

Microwave-Assisted Piloty−Robinson Synthesis of 3,4-Disubstituted Pyrroles
journal, April 2007

What Can Be Learned from Nuclear Resonance Vibrational Spectroscopy: Vibrational Dynamics and Hemes
journal, September 2017