Disposition of the Dietary Mutagen 2-Amino-3,8-dimethylimidazo[4,5- f ]quinoxaline in Healthy and Pancreatic Cancer Compromised Humans

Malfatti, Michael A.; Kuhn, Edward A.; Turteltaub, Kenneth W.; Vickers, Selwyn M.; Jensen, Eric H.; Strayer, Lori; Anderson, Kristin E.

doi:10.1021/acs.chemrestox.5b00495

Title: Disposition of the Dietary Mutagen 2-Amino-3,8-dimethylimidazo[4,5- f ]quinoxaline in Healthy and Pancreatic Cancer Compromised Humans

Authors:

Malfatti, Michael A. ^[1]; Kuhn, Edward A. ^[1]; Turteltaub, Kenneth W. ^[1]; Vickers, Selwyn M. ^[2]; Jensen, Eric H. ^[3]; Strayer, Lori ^[3]; Anderson, Kristin E. ^[3]

Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States). Biosciences and Biotechnology Division
Univ. of Alabama, Birmngham, AL (United States)
Univ. of Minnesota, Minneapolis, MN (United States)

Publication Date:: Fri Feb 26 00:00:00 EST 2016

Research Org.:: Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)

Sponsoring Org.:: USDOE; National Inst. of General Medical Sciences

OSTI Identifier:: 1282119

Alternate Identifier(s):: OSTI ID: 1367983

Report Number(s):: LLNL-JRNL-679828
Journal ID: ISSN 0893-228X

Grant/Contract Number:: AC52-07NA27344; P50 CA101955-07; 2P41GM103483-16

Resource Type:: Accepted Manuscript

Journal Name:: Chemical Research in Toxicology

Additional Journal Information:: Journal Volume: 29; Journal Issue: 3; Journal ID: ISSN 0893-228X

Publisher:: American Chemical Society (ACS)

Country of Publication:: United States

Language:: English

Subject:: 60 APPLIED LIFE SCIENCES; 59 BASIC BIOLOGICAL SCIENCES

Citation Formats


                    Malfatti, Michael A., Kuhn, Edward A., Turteltaub, Kenneth W., Vickers, Selwyn M., Jensen, Eric H., Strayer, Lori, and Anderson, Kristin E. Disposition of the Dietary Mutagen 2-Amino-3,8-dimethylimidazo[4,5- f ]quinoxaline in Healthy and Pancreatic Cancer Compromised Humans.  United States: N. p., 2016. 
Web.  doi:10.1021/acs.chemrestox.5b00495.

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                    Malfatti, Michael A., Kuhn, Edward A., Turteltaub, Kenneth W., Vickers, Selwyn M., Jensen, Eric H., Strayer, Lori, & Anderson, Kristin E. Disposition of the Dietary Mutagen 2-Amino-3,8-dimethylimidazo[4,5- f ]quinoxaline in Healthy and Pancreatic Cancer Compromised Humans.  United States.  https://doi.org/10.1021/acs.chemrestox.5b00495

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                    Malfatti, Michael A., Kuhn, Edward A., Turteltaub, Kenneth W., Vickers, Selwyn M., Jensen, Eric H., Strayer, Lori, and Anderson, Kristin E. Fri .  
"Disposition of the Dietary Mutagen 2-Amino-3,8-dimethylimidazo[4,5- f ]quinoxaline in Healthy and Pancreatic Cancer Compromised Humans".  United States.  https://doi.org/10.1021/acs.chemrestox.5b00495.  https://www.osti.gov/servlets/purl/1282119.

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@article{osti_1282119,

  title        = {Disposition of the Dietary Mutagen 2-Amino-3,8-dimethylimidazo[4,5- f ]quinoxaline in Healthy and Pancreatic Cancer Compromised Humans},

  author       = {Malfatti, Michael A. and Kuhn, Edward A. and Turteltaub, Kenneth W. and Vickers, Selwyn M. and Jensen, Eric H. and Strayer, Lori and Anderson, Kristin E.},

  abstractNote = {},

  doi          = {10.1021/acs.chemrestox.5b00495},

  journal      = {Chemical Research in Toxicology},

  number       = 3,

  volume       = 29,

  place        = {United States},

  year         = {Fri Feb 26 00:00:00 EST 2016},

  month        = {Fri Feb 26 00:00:00 EST 2016}

}

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https://doi.org/10.1021/acs.chemrestox.5b00495

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Works referencing / citing this record:

Environmental risk factors for pancreatic cancer: an update
journal, August 2016

Barone, Elisa; Corrado, Alda; Gemignani, Federica
Archives of Toxicology, Vol. 90, Issue 11
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Title: Disposition of the Dietary Mutagen 2-Amino-3,8-dimethylimidazo[4,5- f ]quinoxaline in Healthy and Pancreatic Cancer Compromised Humans

Citation Formats

Cancer statistics, 2014: Cancer Statistics, 2014 journal, January 2014

Meat and Fat Intake as Risk Factors for Pancreatic Cancer: The Multiethnic Cohort Study journal, October 2005

Meat and fish consumption and risk of pancreatic cancer: Results from the European Prospective Investigation into Cancer and Nutrition journal, June 2012

Meat intake and cooking techniques: associations with pancreatic cancer journal, September 2002

Dietary Intake of Heterocyclic Amines and Benzo(a)Pyrene: Associations with Pancreatic Cancer journal, September 2005

Dietary Mutagen Exposure and Risk of Pancreatic Cancer journal, April 2007

Meat and Meat-Mutagen Intake and Pancreatic Cancer Risk in the NIH-AARP Cohort journal, December 2007

A Prospective Study of Meat and Meat Mutagens and Prostate Cancer Risk journal, December 2005

Well-Done Meat Intake, Heterocyclic Amine Exposure, and Cancer Risk journal, July 2009

Pancreatic cancer risk: Associations with meat-derived carcinogen intake in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) cohort journal, December 2011

Carcinogenicity in rats of a mutagenic compound, 2-amino-3,8-dimethylimidazo[4,5- f ]quinoxaline journal, January 1988

Carcinogenicity in mice of a mutagenic compound, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) from cooked foods journal, January 1987

Meat-Related Mutagens and Pancreatic Cancer: Null Results from a Clinic-Based Case–Control Study journal, April 2013

Accelerator mass spectrometry in biomedical dosimetry: relationship between low-level exposure and covalent binding of heterocyclic amine carcinogens to DNA. journal, July 1990

Accelerator Mass Spectrometry journal, June 1995

Metabolism of the Food-Borne Mutagen 2-Amino-3,8-dimethylimidazo[4,5- f ]quinoxaline in Humans journal, March 1998

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Rapid Production of Graphite Without Contamination for Biomedical AMS journal, January 1992

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Red Meat-Derived Heterocyclic Amines Increase Risk of Colon Cancer: A Population-Based Case-Control Study journal, November 2013

Heterocyclic Amines, Meat Intake, and Association with Colon Cancer in a Population-based Study journal, March 2003

Analysis of total meat intake and exposure to individual heterocyclic amines in a case-control study of colorectal cancer: contribution of metabolic variation to risk journal, September 2002

Meat-related mutagen exposure, xenobiotic metabolizing gene polymorphisms and the risk of advanced colorectal adenoma and cancer journal, May 2012

A study of malabsorption in pancreatic cancer journal, January 1996

DNA Adducts Formed by 2-Amino-3,8-dimethylimidazo[4,5- f ]quinoxaline in Rat Liver: Dose-Response on Chronic Administration journal, May 1990

Comparison of DNA‐adduct and tissue‐available dose levels of MeIQx in human and rodent colon following administration of a very low dose journal, February 1999

DNA Modification by 2-Amino-1-methyl-6-phenylimidazo[4,5- b ]pyridine in Rats journal, December 1989

Effect of N -Acetyltransferase 2 Polymorphism on Tumor Target Tissue DNA Adduct Levels in Rapid and Slow Acetylator Congenic Rats Administered 2-Amino-1-methyl-6-phenylimidazo[4,5- b ]pyridine or 2-Amino-3,8-dimethylimidazo-[4,5- f ]quinoxaline journal, August 2009

Cytochrome P450-Mediated Metabolism and DNA Binding of 2-Amino-1,7-dimethylimidazo[4,5- g ]quinoxaline and Its Carcinogenic Isomer 2-Amino-3,8-dimethylimidazo[4,5- f ]quinoxaline in Mice journal, December 2011

Pancreatic DNA adducts formed in vitro and in vivo by the food mutagens 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and 2-amino-3-methyl-9H-pyrido[2,3-b]indole (MeAαC) journal, August 1997

Detection of 2-amino-1-methyl-6-phenylimidazo [4,5-b]-pyridine (PhIP)–DNA adducts in human pancreatic tissues journal, January 2006

Meat and fish consumption and risk of pancreatic cancer: Results from the European Prospective Investigation into Cancer and Nutrition journal, June 2012

MeIQx-DNA adduct formation in rodent and human tissues at low doses journal, May 1997

Accelerator mass spectrometry in biomedical dosimetry: relationship between low-level exposure and covalent binding of heterocyclic amine carcinogens to DNA. journal, July 1990

Detection of 2-amino-1-methyl-6-phenylimidazo [4,5-b]-pyridine (PhIP)–DNA adducts in human pancreatic tissues journal, January 2006

Meat-related mutagen exposure, xenobiotic metabolizing gene polymorphisms and the risk of advanced colorectal adenoma and cancer journal, May 2012

Meat and Fat Intake as Risk Factors for Pancreatic Cancer: The Multiethnic Cohort Study journal, October 2005

Red Meat Intake, Doneness, Polymorphisms in Genes that Encode Carcinogen-Metabolizing Enzymes, and Colorectal Cancer Risk journal, November 2008

Environmental risk factors for pancreatic cancer: an update journal, August 2016

Cancer statistics, 2014: Cancer Statistics, 2014
journal, January 2014

Meat and Fat Intake as Risk Factors for Pancreatic Cancer: The Multiethnic Cohort Study
journal, October 2005

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journal, June 2012

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journal, September 2002

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journal, September 2005

Dietary Mutagen Exposure and Risk of Pancreatic Cancer
journal, April 2007

Meat and Meat-Mutagen Intake and Pancreatic Cancer Risk in the NIH-AARP Cohort
journal, December 2007

A Prospective Study of Meat and Meat Mutagens and Prostate Cancer Risk
journal, December 2005

Well-Done Meat Intake, Heterocyclic Amine Exposure, and Cancer Risk
journal, July 2009

Pancreatic cancer risk: Associations with meat-derived carcinogen intake in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) cohort
journal, December 2011

Carcinogenicity in rats of a mutagenic compound, 2-amino-3,8-dimethylimidazo[4,5- f ]quinoxaline
journal, January 1988

Carcinogenicity in mice of a mutagenic compound, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) from cooked foods
journal, January 1987

Meat-Related Mutagens and Pancreatic Cancer: Null Results from a Clinic-Based Case–Control Study
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Accelerator mass spectrometry in biomedical dosimetry: relationship between low-level exposure and covalent binding of heterocyclic amine carcinogens to DNA.
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Accelerator Mass Spectrometry
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Metabolism of the Food-Borne Mutagen 2-Amino-3,8-dimethylimidazo[4,5- f ]quinoxaline in Humans
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Tissue distribution and macromolecular binding of extremely low doses of [14C]-benzene in B6C3F1 mice
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A High-Throughput Method for the Conversion of CO ₂ Obtained from Biochemical Samples to Graphite in Septa-Sealed Vials for Quantification of ¹⁴ C via Accelerator Mass Spectrometry
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Rapid Production of Graphite Without Contamination for Biomedical AMS
journal, January 1992

Metabolism of 2-Amino-3,8-dimethylimidazo[4,5- f ]- quinoxaline in Human Hepatocytes: 2-Amino-3-methylimidazo[4,5- f ]quinoxaline-8-carboxylic Acid Is a Major Detoxication Pathway Catalyzed by Cytochrome P450 1A2
journal, January 2001

Red Meat-Derived Heterocyclic Amines Increase Risk of Colon Cancer: A Population-Based Case-Control Study
journal, November 2013

Heterocyclic Amines, Meat Intake, and Association with Colon Cancer in a Population-based Study
journal, March 2003

Analysis of total meat intake and exposure to individual heterocyclic amines in a case-control study of colorectal cancer: contribution of metabolic variation to risk
journal, September 2002

Meat-related mutagen exposure, xenobiotic metabolizing gene polymorphisms and the risk of advanced colorectal adenoma and cancer
journal, May 2012

A study of malabsorption in pancreatic cancer
journal, January 1996

DNA Adducts Formed by 2-Amino-3,8-dimethylimidazo[4,5- f ]quinoxaline in Rat Liver: Dose-Response on Chronic Administration
journal, May 1990

Comparison of DNA‐adduct and tissue‐available dose levels of MeIQx in human and rodent colon following administration of a very low dose
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DNA Modification by 2-Amino-1-methyl-6-phenylimidazo[4,5- b ]pyridine in Rats
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Effect of N -Acetyltransferase 2 Polymorphism on Tumor Target Tissue DNA Adduct Levels in Rapid and Slow Acetylator Congenic Rats Administered 2-Amino-1-methyl-6-phenylimidazo[4,5- b ]pyridine or 2-Amino-3,8-dimethylimidazo-[4,5- f ]quinoxaline
journal, August 2009

Cytochrome P450-Mediated Metabolism and DNA Binding of 2-Amino-1,7-dimethylimidazo[4,5- g ]quinoxaline and Its Carcinogenic Isomer 2-Amino-3,8-dimethylimidazo[4,5- f ]quinoxaline in Mice
journal, December 2011

Pancreatic DNA adducts formed in vitro and in vivo by the food mutagens 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and 2-amino-3-methyl-9H-pyrido[2,3-b]indole (MeAαC)
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Detection of 2-amino-1-methyl-6-phenylimidazo [4,5-b]-pyridine (PhIP)–DNA adducts in human pancreatic tissues
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Meat and fish consumption and risk of pancreatic cancer: Results from the European Prospective Investigation into Cancer and Nutrition
journal, June 2012

MeIQx-DNA adduct formation in rodent and human tissues at low doses
journal, May 1997

Accelerator mass spectrometry in biomedical dosimetry: relationship between low-level exposure and covalent binding of heterocyclic amine carcinogens to DNA.
journal, July 1990

Detection of 2-amino-1-methyl-6-phenylimidazo [4,5-b]-pyridine (PhIP)–DNA adducts in human pancreatic tissues
journal, January 2006

Meat-related mutagen exposure, xenobiotic metabolizing gene polymorphisms and the risk of advanced colorectal adenoma and cancer
journal, May 2012

Meat and Fat Intake as Risk Factors for Pancreatic Cancer: The Multiethnic Cohort Study
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Red Meat Intake, Doneness, Polymorphisms in Genes that Encode Carcinogen-Metabolizing Enzymes, and Colorectal Cancer Risk
journal, November 2008

Environmental risk factors for pancreatic cancer: an update
journal, August 2016