Transgenerational inheritance of neurobehavioral and physiological deficits from developmental exposure to benzo[a]pyrene in zebrafish
Abstract
Benzo[a]pyrene (B[a]P) is a well-known genotoxic polycylic aromatic compound whose toxicity is dependent on signaling via the aryl hydrocarbon receptor (AHR). It is unclear to what extent detrimental effects of B[a]P exposures might impact future generations and whether transgenerational effects might be AHR-dependent. This study examined the effects of developmental B[a]P exposure on 3 generations of zebrafish. Zebrafish embryos were exposed from 6 to 120 h post fertilization (hpf) to 5 and 10 μM B[a]P and raised in chemical-free water until adulthood (F0). Two generations were raised from F0 fish to evaluate transgenerational inheritance. Morphological, physiological and neurobehavioral parameters were measured at two life stages. Juveniles of the F0 and F2 exhibited hyper locomotor activity, decreased heartbeat and mitochondrial function. B[a]P exposure during development resulted in decreased global DNA methylation levels and generally reduced expression of DNA methyltransferases in wild type zebrafish, with the latter effect largely reversed in an AHR2-null background. Adults from the F0 B[a]P exposed lineage displayed social anxiety-like behavior. Adults in the F2 transgeneration manifested gender-specific increased body mass index (BMI), increased oxygen consumption and hyper-avoidance behavior. Exposure to benzo[a]pyrene during development resulted in transgenerational inheritance of neurobehavioral and physiological deficiencies. Indirect evidence suggested the potentialmore »
- Publication Date:
- Research Org.:
- Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1770626
- Alternate Identifier(s):
- OSTI ID: 1365446
- Report Number(s):
- PNNL-SA-125262
Journal ID: ISSN 0041-008X; S0041008X17302399; PII: S0041008X17302399
- Grant/Contract Number:
- P30 ES000210; P42 ES016465; AC05-76RL01830
- Resource Type:
- Published Article
- Journal Name:
- Toxicology and Applied Pharmacology
- Additional Journal Information:
- Journal Name: Toxicology and Applied Pharmacology Journal Volume: 329 Journal Issue: C; Journal ID: ISSN 0041-008X
- Publisher:
- Elsevier
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 54 ENVIRONMENTAL SCIENCES; Zebrafish; Benzo[a]pyrene; Transgenerational; Neurobehavioral; Developmental toxicity; Physiological deficits; Aryl hydrocarbon receptor
Citation Formats
Knecht, Andrea L., Truong, Lisa, Marvel, Skylar W., Reif, David M., Garcia, Abraham, Lu, Catherine, Simonich, Michael T., Teeguarden, Justin G., and Tanguay, Robert L. Transgenerational inheritance of neurobehavioral and physiological deficits from developmental exposure to benzo[a]pyrene in zebrafish. United States: N. p., 2017.
Web. doi:10.1016/j.taap.2017.05.033.
Knecht, Andrea L., Truong, Lisa, Marvel, Skylar W., Reif, David M., Garcia, Abraham, Lu, Catherine, Simonich, Michael T., Teeguarden, Justin G., & Tanguay, Robert L. Transgenerational inheritance of neurobehavioral and physiological deficits from developmental exposure to benzo[a]pyrene in zebrafish. United States. https://doi.org/10.1016/j.taap.2017.05.033
Knecht, Andrea L., Truong, Lisa, Marvel, Skylar W., Reif, David M., Garcia, Abraham, Lu, Catherine, Simonich, Michael T., Teeguarden, Justin G., and Tanguay, Robert L. Tue .
"Transgenerational inheritance of neurobehavioral and physiological deficits from developmental exposure to benzo[a]pyrene in zebrafish". United States. https://doi.org/10.1016/j.taap.2017.05.033.
@article{osti_1770626,
title = {Transgenerational inheritance of neurobehavioral and physiological deficits from developmental exposure to benzo[a]pyrene in zebrafish},
author = {Knecht, Andrea L. and Truong, Lisa and Marvel, Skylar W. and Reif, David M. and Garcia, Abraham and Lu, Catherine and Simonich, Michael T. and Teeguarden, Justin G. and Tanguay, Robert L.},
abstractNote = {Benzo[a]pyrene (B[a]P) is a well-known genotoxic polycylic aromatic compound whose toxicity is dependent on signaling via the aryl hydrocarbon receptor (AHR). It is unclear to what extent detrimental effects of B[a]P exposures might impact future generations and whether transgenerational effects might be AHR-dependent. This study examined the effects of developmental B[a]P exposure on 3 generations of zebrafish. Zebrafish embryos were exposed from 6 to 120 h post fertilization (hpf) to 5 and 10 μM B[a]P and raised in chemical-free water until adulthood (F0). Two generations were raised from F0 fish to evaluate transgenerational inheritance. Morphological, physiological and neurobehavioral parameters were measured at two life stages. Juveniles of the F0 and F2 exhibited hyper locomotor activity, decreased heartbeat and mitochondrial function. B[a]P exposure during development resulted in decreased global DNA methylation levels and generally reduced expression of DNA methyltransferases in wild type zebrafish, with the latter effect largely reversed in an AHR2-null background. Adults from the F0 B[a]P exposed lineage displayed social anxiety-like behavior. Adults in the F2 transgeneration manifested gender-specific increased body mass index (BMI), increased oxygen consumption and hyper-avoidance behavior. Exposure to benzo[a]pyrene during development resulted in transgenerational inheritance of neurobehavioral and physiological deficiencies. Indirect evidence suggested the potential for an AHR2-dependent epigenetic route.},
doi = {10.1016/j.taap.2017.05.033},
journal = {Toxicology and Applied Pharmacology},
number = C,
volume = 329,
place = {United States},
year = {Tue Aug 01 00:00:00 EDT 2017},
month = {Tue Aug 01 00:00:00 EDT 2017}
}
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https://doi.org/10.1016/j.taap.2017.05.033
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