skip to main content

DOE PAGESDOE PAGES

Title: High-pressure high-temperature phase diagram of organic crystal paracetamol

High-pressure high-temperature (HPHT) Raman spectroscopy studies have been performed on the organic crystal paracetamol in a diamond anvil cell utilizing boron-doped heating diamond anvil. Isobaric measurements were conducted at pressures up to 8.5 GPa and temperature up to 520 K in five different experiments. Solid state phase transitions from monoclinic Form I → orthorhombic Form II were observed at various pressures and temperatures as well as transitions from Form II → unknown Form IV. The melting temperature for paracetamol was observed to increase with increasing pressures to 8.5 GPa. As a result, this new data is combined with previous ambient temperature high-pressure Raman and X- ray diffraction data to create the first HPHT phase diagram of paracetamol.
Authors:
 [1] ;  [1] ;  [1]
  1. Univ. of Alabama, Birmingham, AL (United States)
Publication Date:
Grant/Contract Number:
NA0002006
Type:
Accepted Manuscript
Journal Name:
Journal of Physics. Condensed Matter
Additional Journal Information:
Journal Volume: 28; Journal Issue: 3; Journal ID: ISSN 0953-8984
Publisher:
IOP Publishing
Research Org:
Carnegie Institution of Washington, Washington, D.C. (United States)
Sponsoring Org:
USDOE National Nuclear Security Administration (NNSA)
Country of Publication:
United States
Language:
English
Subject:
75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND SUPERFLUIDITY; high-pressure; high-temperature; organic crystals; pharmaceuticals; Raman spectroscopy
OSTI Identifier:
1364615

Smith, Spencer J., Montgomery, Jeffrey M., and Vohra, Yogesh K.. High-pressure high-temperature phase diagram of organic crystal paracetamol. United States: N. p., Web. doi:10.1088/0953-8984/28/3/035101.
Smith, Spencer J., Montgomery, Jeffrey M., & Vohra, Yogesh K.. High-pressure high-temperature phase diagram of organic crystal paracetamol. United States. doi:10.1088/0953-8984/28/3/035101.
Smith, Spencer J., Montgomery, Jeffrey M., and Vohra, Yogesh K.. 2016. "High-pressure high-temperature phase diagram of organic crystal paracetamol". United States. doi:10.1088/0953-8984/28/3/035101. https://www.osti.gov/servlets/purl/1364615.
@article{osti_1364615,
title = {High-pressure high-temperature phase diagram of organic crystal paracetamol},
author = {Smith, Spencer J. and Montgomery, Jeffrey M. and Vohra, Yogesh K.},
abstractNote = {High-pressure high-temperature (HPHT) Raman spectroscopy studies have been performed on the organic crystal paracetamol in a diamond anvil cell utilizing boron-doped heating diamond anvil. Isobaric measurements were conducted at pressures up to 8.5 GPa and temperature up to 520 K in five different experiments. Solid state phase transitions from monoclinic Form I → orthorhombic Form II were observed at various pressures and temperatures as well as transitions from Form II → unknown Form IV. The melting temperature for paracetamol was observed to increase with increasing pressures to 8.5 GPa. As a result, this new data is combined with previous ambient temperature high-pressure Raman and X- ray diffraction data to create the first HPHT phase diagram of paracetamol.},
doi = {10.1088/0953-8984/28/3/035101},
journal = {Journal of Physics. Condensed Matter},
number = 3,
volume = 28,
place = {United States},
year = {2016},
month = {1}
}