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Title: Separation of 44Ti from proton irradiated scandium by using solid-phase extraction chromatography and design of 44Ti/ 44Sc generator system

Scandium-44 g (half-life 3.97 h) shows promise for positron emission tomography (PET) imaging of longer biological processes than that of the current gold standard, 18F, due to its favorable decay parameters. One source of 44gSc is the long-lived parent nuclide 44Ti (half-life 60.0 a). A 44Ti/ 44gSc generator would have the ability to provide radionuclidically pure 44gSc on a daily basis. The production of 44Ti via the 45Sc(p,2n) reaction requires high proton beam currents and long irradiation times. Recovery and purification of no-carrier added (nca) 44Ti from scandium metal targets involves complex separation chemistry. In this study, separation systems based on solid phase extraction chromatography were investigated, including branched diglycolamide (BDGA) resin and hydroxamate based ZR resin. Lastly, results indicate that ZR resin in HCl media represents an effective 44Ti/ 44gSc separation system.
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  1. Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Publication Date:
Report Number(s):
Journal ID: ISSN 0021-9673
Grant/Contract Number:
Accepted Manuscript
Journal Name:
Journal of Chromatography
Additional Journal Information:
Journal Volume: 1477; Journal Issue: A; Journal ID: ISSN 0021-9673
Research Org:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Sponsoring Org:
USDOE Office of Science (SC), Nuclear Physics (NP) (SC-26)
Country of Publication:
United States
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; 44Ti; 44gSc; scandium metal target; solid phase extraction chromatography; BDGA; ZR resin
OSTI Identifier:
Alternate Identifier(s):
OSTI ID: 1413378