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Title: Separation of 44Ti from proton irradiated scandium by using solid-phase extraction chromatography and design of 44Ti/ 44Sc generator system

Scandium-44 g (half-life 3.97 h) shows promise for positron emission tomography (PET) imaging of longer biological processes than that of the current gold standard, 18F, due to its favorable decay parameters. One source of 44gSc is the long-lived parent nuclide 44Ti (half-life 60.0 a). A 44Ti/ 44gSc generator would have the ability to provide radionuclidically pure 44gSc on a daily basis. The production of 44Ti via the 45Sc(p,2n) reaction requires high proton beam currents and long irradiation times. Recovery and purification of no-carrier added (nca) 44Ti from scandium metal targets involves complex separation chemistry. In this study, separation systems based on solid phase extraction chromatography were investigated, including branched diglycolamide (BDGA) resin and hydroxamate based ZR resin. Lastly, results indicate that ZR resin in HCl media represents an effective 44Ti/ 44gSc separation system.
Authors:
 [1] ;  [1] ;  [1] ;  [1] ;  [1] ; ORCiD logo [1] ;  [1] ; ORCiD logo [1] ; ORCiD logo [1] ; ORCiD logo [1] ; ORCiD logo [1]
  1. Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Publication Date:
Report Number(s):
LA-UR-16-25223
Journal ID: ISSN 0021-9673
Grant/Contract Number:
AC52-06NA25396
Type:
Accepted Manuscript
Journal Name:
Journal of Chromatography
Additional Journal Information:
Journal Volume: 1477; Journal Issue: A; Journal ID: ISSN 0021-9673
Publisher:
Elsevier
Research Org:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; 44Ti; 44gSc; scandium metal target; solid phase extraction chromatography; BDGA; ZR resin
OSTI Identifier:
1364573
Alternate Identifier(s):
OSTI ID: 1413378

Radchenko, Valery, Meyer, Catherine Anne Louise, Engle, Jonathan Ward, Naranjo, Cleo Micah, Unc, George A., Mastren, Tara, Brugh, Mark, Birnbaum, Eva R., John, Kevin Dale, Nortier, Francois Meiring, and Fassbender, Michael Ernst. Separation of 44Ti from proton irradiated scandium by using solid-phase extraction chromatography and design of 44Ti/44Sc generator system. United States: N. p., Web. doi:10.1016/j.chroma.2016.11.047.
Radchenko, Valery, Meyer, Catherine Anne Louise, Engle, Jonathan Ward, Naranjo, Cleo Micah, Unc, George A., Mastren, Tara, Brugh, Mark, Birnbaum, Eva R., John, Kevin Dale, Nortier, Francois Meiring, & Fassbender, Michael Ernst. Separation of 44Ti from proton irradiated scandium by using solid-phase extraction chromatography and design of 44Ti/44Sc generator system. United States. doi:10.1016/j.chroma.2016.11.047.
Radchenko, Valery, Meyer, Catherine Anne Louise, Engle, Jonathan Ward, Naranjo, Cleo Micah, Unc, George A., Mastren, Tara, Brugh, Mark, Birnbaum, Eva R., John, Kevin Dale, Nortier, Francois Meiring, and Fassbender, Michael Ernst. 2016. "Separation of 44Ti from proton irradiated scandium by using solid-phase extraction chromatography and design of 44Ti/44Sc generator system". United States. doi:10.1016/j.chroma.2016.11.047. https://www.osti.gov/servlets/purl/1364573.
@article{osti_1364573,
title = {Separation of 44Ti from proton irradiated scandium by using solid-phase extraction chromatography and design of 44Ti/44Sc generator system},
author = {Radchenko, Valery and Meyer, Catherine Anne Louise and Engle, Jonathan Ward and Naranjo, Cleo Micah and Unc, George A. and Mastren, Tara and Brugh, Mark and Birnbaum, Eva R. and John, Kevin Dale and Nortier, Francois Meiring and Fassbender, Michael Ernst},
abstractNote = {Scandium-44 g (half-life 3.97 h) shows promise for positron emission tomography (PET) imaging of longer biological processes than that of the current gold standard, 18F, due to its favorable decay parameters. One source of 44gSc is the long-lived parent nuclide 44Ti (half-life 60.0 a). A 44Ti/44gSc generator would have the ability to provide radionuclidically pure 44gSc on a daily basis. The production of 44Ti via the 45Sc(p,2n) reaction requires high proton beam currents and long irradiation times. Recovery and purification of no-carrier added (nca) 44Ti from scandium metal targets involves complex separation chemistry. In this study, separation systems based on solid phase extraction chromatography were investigated, including branched diglycolamide (BDGA) resin and hydroxamate based ZR resin. Lastly, results indicate that ZR resin in HCl media represents an effective 44Ti/44gSc separation system.},
doi = {10.1016/j.chroma.2016.11.047},
journal = {Journal of Chromatography},
number = A,
volume = 1477,
place = {United States},
year = {2016},
month = {11}
}