Complex ancestries of lager-brewing hybrids were shaped by standing variation in the wild yeast Saccharomyces eubayanus
Abstract
Lager-style beers constitute the vast majority of the beer market, and yet, the genetic origin of the yeast strains that brew them has been shrouded in mystery and controversy. Unlike alestyle beers, which are generally brewed with Saccharomyces cerevisiae, lagers are brewed at colder temperatures with allopolyploid hybrids of Saccharomyces eubayanus x S. cerevisiae. Since the discovery of S. eubayanus in 2011, additional strains have been isolated from South America, North America, Australasia, and Asia, but only interspecies hybrids have been isolated in Europe. Here, using genome sequence data, we examine the relationships of these wild S. eubayanus strains to each other and to domesticated lager strains. Our results support the existence of a relatively low-diversity (π = 0.00197) lineage of S. eubayanus whose distribution stretches across the Holarctic ecozone and includes wild isolates from Tibet, new wild isolates from North America, and the S. eubayanus parents of lager yeasts. This Holarctic lineage is closely related to a population with higher diversity (π = 0.00275) that has been found primarily in South America but includes some widely distributed isolates. A second diverse South American population (π = 0.00354) and two early-diverging Asian subspecies are more distantly related. We further showmore »
- Authors:
-
[1];
[1];
[1];
- Univ. of Wisconsin, Madison, WI (United States)
- Univ. Laval, Quebec City, QC (Canada)
- Centro Regional Univ. Bariloche, Rio Negro (Argentina)
- Washington Univ. School of Medicine, St. Louis, MO (United States)
- Publication Date:
- Research Org.:
- Univ. of Wisconsin, Madison, WI (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1363953
- Grant/Contract Number:
- FC02-07ER64494
- Resource Type:
- Accepted Manuscript
- Journal Name:
- PLoS Genetics
- Additional Journal Information:
- Journal Volume: 12; Journal Issue: 7; Journal ID: ISSN 1553-7404
- Publisher:
- Public Library of Science
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Peris, David, Langdon, Quinn K., Moriarty, Ryan V., Sylvester, Kayla, Bontrager, Martin, Charron, Guillaume, Leducq, Jean -Baptiste, Landry, Christian R., Libkind, Diego, Hittinger, Chris Todd, and Fay, Justin C. Complex ancestries of lager-brewing hybrids were shaped by standing variation in the wild yeast Saccharomyces eubayanus. United States: N. p., 2016.
Web. doi:10.1371/journal.pgen.1006155.
Peris, David, Langdon, Quinn K., Moriarty, Ryan V., Sylvester, Kayla, Bontrager, Martin, Charron, Guillaume, Leducq, Jean -Baptiste, Landry, Christian R., Libkind, Diego, Hittinger, Chris Todd, & Fay, Justin C. Complex ancestries of lager-brewing hybrids were shaped by standing variation in the wild yeast Saccharomyces eubayanus. United States. https://doi.org/10.1371/journal.pgen.1006155
Peris, David, Langdon, Quinn K., Moriarty, Ryan V., Sylvester, Kayla, Bontrager, Martin, Charron, Guillaume, Leducq, Jean -Baptiste, Landry, Christian R., Libkind, Diego, Hittinger, Chris Todd, and Fay, Justin C. Wed .
"Complex ancestries of lager-brewing hybrids were shaped by standing variation in the wild yeast Saccharomyces eubayanus". United States. https://doi.org/10.1371/journal.pgen.1006155. https://www.osti.gov/servlets/purl/1363953.
@article{osti_1363953,
title = {Complex ancestries of lager-brewing hybrids were shaped by standing variation in the wild yeast Saccharomyces eubayanus},
author = {Peris, David and Langdon, Quinn K. and Moriarty, Ryan V. and Sylvester, Kayla and Bontrager, Martin and Charron, Guillaume and Leducq, Jean -Baptiste and Landry, Christian R. and Libkind, Diego and Hittinger, Chris Todd and Fay, Justin C.},
abstractNote = {Lager-style beers constitute the vast majority of the beer market, and yet, the genetic origin of the yeast strains that brew them has been shrouded in mystery and controversy. Unlike alestyle beers, which are generally brewed with Saccharomyces cerevisiae, lagers are brewed at colder temperatures with allopolyploid hybrids of Saccharomyces eubayanus x S. cerevisiae. Since the discovery of S. eubayanus in 2011, additional strains have been isolated from South America, North America, Australasia, and Asia, but only interspecies hybrids have been isolated in Europe. Here, using genome sequence data, we examine the relationships of these wild S. eubayanus strains to each other and to domesticated lager strains. Our results support the existence of a relatively low-diversity (π = 0.00197) lineage of S. eubayanus whose distribution stretches across the Holarctic ecozone and includes wild isolates from Tibet, new wild isolates from North America, and the S. eubayanus parents of lager yeasts. This Holarctic lineage is closely related to a population with higher diversity (π = 0.00275) that has been found primarily in South America but includes some widely distributed isolates. A second diverse South American population (π = 0.00354) and two early-diverging Asian subspecies are more distantly related. We further show that no single wild strain from the Holarctic lineage is the sole closest relative of lager yeasts. Instead, different parts of the genome portray different phylogenetic signals and ancestry, likely due to outcrossing and incomplete lineage sorting. Indeed, standing genetic variation within this wild Holarctic lineage of S. eubayanus is responsible for genetic variation still segregating among modern lager-brewing hybrids. Furthermore, we conclude that the relationships among wild strains of S. eubayanus and their domesticated hybrids reflect complex biogeographical and genetic processes.},
doi = {10.1371/journal.pgen.1006155},
journal = {PLoS Genetics},
number = 7,
volume = 12,
place = {United States},
year = {Wed Jul 06 00:00:00 EDT 2016},
month = {Wed Jul 06 00:00:00 EDT 2016}
}
Free Publicly Available Full Text
Publisher's Version of Record
Other availability
Search WorldCat to find libraries that may hold this journal
Cited by: 67 works
Citation information provided by
Web of Science
Web of Science
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.
Works referenced in this record:
A distinct population of Saccharomyces cerevisiae in New Zealand: evidence for local dispersal by insects and human-aided global dispersal in oak barrels
journal, January 2010
- Goddard, Matthew R.; Anfang, Nicole; Tang, Rongying
- Environmental Microbiology, Vol. 12, Issue 1
Hypervariable Noncoding Sequences in Saccharomyces cerevisiae
journal, June 2005
- Fay, Justin C.; Benavides, Joseph A.
- Genetics, Vol. 170, Issue 4
Sequencing and Characterisation of Rearrangements in Three S. pastorianus Strains Reveals the Presence of Chimeric Genes and Gives Evidence of Breakpoint Reuse
journal, March 2014
- Hewitt, Sarah K.; Donaldson, Ian J.; Lovell, Simon C.
- PLoS ONE, Vol. 9, Issue 3
Recombination-filtered genomic datasets by information maximization
journal, May 2007
- Woerner, A. E.; Cox, M. P.; Hammer, M. F.
- Bioinformatics, Vol. 23, Issue 14
Saccharomyces diversity and evolution: a budding model genus
journal, May 2013
- Hittinger, Chris Todd
- Trends in Genetics, Vol. 29, Issue 5
Saccharomyces eubayanus and Saccharomyces uvarum associated with the fermentation of Araucaria araucana seeds in Patagonia
journal, August 2014
- Rodríguez, M. Eugenia; Pérez-Través, Laura; Sangorrín, Marcela P.
- FEMS Yeast Research, Vol. 14, Issue 6
Exploring the northern limit of the distribution of Saccharomyces cerevisiae and Saccharomyces paradoxus in North America
journal, October 2013
- Charron, Guillaume; Leducq, Jean-Baptiste; Bertin, Chloé
- FEMS Yeast Research, Vol. 14, Issue 2
FASconCAT: Convenient handling of data matrices
journal, September 2010
- Kück, Patrick; Meusemann, Karen
- Molecular Phylogenetics and Evolution, Vol. 56, Issue 3
Genome Sequence of Saccharomyces carlsbergensis , the World’s First Pure Culture Lager Yeast
journal, February 2014
- Walther, Andrea; Hesselbart, Ana; Wendland, Jürgen
- G3: Genes|Genomes|Genetics, Vol. 4, Issue 5
Genome Sequence of the Lager Brewing Yeast, an Interspecies Hybrid
journal, January 2009
- Nakao, Y.; Kanamori, T.; Itoh, T.
- DNA Research, Vol. 16, Issue 2
Comparative physiology and fermentation performance of Saaz and Frohberg lager yeast strains and the parental species Saccharomyces eubayanus : Fermentaton performance of Saaz and Frohberg yeast
journal, June 2013
- Gibson, Brian R.; Storgårds, Erna; Krogerus, Kristoffer
- Yeast, Vol. 30, Issue 7
Remarkably ancient balanced polymorphisms in a multi-locus gene network
journal, February 2010
- Hittinger, Chris Todd; Gonçalves, Paula; Sampaio, José Paulo
- Nature, Vol. 464, Issue 7285
Genome-scale approaches to resolving incongruence in molecular phylogenies
journal, October 2003
- Rokas, Antonis; Williams, Barry L.; King, Nicole
- Nature, Vol. 425, Issue 6960
Role of social wasps in Saccharomyces cerevisiae ecology and evolution
journal, July 2012
- Stefanini, I.; Dapporto, L.; Legras, J. -L.
- Proceedings of the National Academy of Sciences, Vol. 109, Issue 33
Population genomics of domestic and wild yeasts
journal, February 2009
- Liti, Gianni; Carter, David M.; Moses, Alan M.
- Nature, Vol. 458, Issue 7236
Yeasts vectored by migratory birds collected in the Mediterranean island of Ustica and description of Phaffomyces usticensis f.a. sp. nov., a new species related to the cactus ecoclade
journal, July 2014
- Francesca, Nicola; Carvalho, Cláudia; Sannino, Ciro
- FEMS Yeast Research, Vol. 14, Issue 6
RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies
journal, January 2014
- Stamatakis, Alexandros
- Bioinformatics, Vol. 30, Issue 9
Genome-scale approaches to resolving incongruence in molecular phylogenies
journal, October 2003
- Rokas, Antonis; Williams, Barry L.; King, Nicole
- Nature, Vol. 425, Issue 6960
Population genomics of domestic and wild yeasts
journal, February 2009
- Liti, Gianni; Carter, David M.; Moses, Alan M.
- Nature, Vol. 458, Issue 7236
Evolution of crop species: genetics of domestication and diversification
journal, November 2013
- Meyer, Rachel S.; Purugganan, Michael D.
- Nature Reviews Genetics, Vol. 14, Issue 12
S. cerevisiae × S. eubayanus interspecific hybrid, the best of both worlds and beyond
journal, March 2015
- Hebly, Marit; Brickwedde, Anja; Bolat, Irina
- FEMS Yeast Research, Vol. 15, Issue 3
Temperature and host preferences drive the diversification of Saccharomyces and other yeasts: a survey and the discovery of eight new yeast species
journal, March 2015
- Sylvester, Kayla; Wang, Qi-Ming; James, Brielle
- FEMS Yeast Research, Vol. 15, Issue 3
The Genome Sequence of Saccharomyces eubayanus and the Domestication of Lager-Brewing Yeasts
journal, August 2015
- Baker, EmilyClare; Wang, Bing; Bellora, Nicolas
- Molecular Biology and Evolution, Vol. 32, Issue 11
Saccharomyces eubayanus and Saccharomyces arboricola reside in North Island native New Zealand forests
journal, December 2015
- Gayevskiy, Velimir; Goddard, Matthew R.
- Environmental Microbiology, Vol. 18, Issue 4
Saccharomyces cerevisiae: a nomadic yeast with no niche?
journal, February 2015
- Goddard, Matthew R.; Greig, Duncan
- FEMS Yeast Research, Vol. 15, Issue 3
Mixing of vineyard and oak-tree ecotypes of Saccharomyces cerevisiae in North American vineyards
journal, January 2013
- Hyma, Katie E.; Fay, Justin C.
- Molecular Ecology, Vol. 22, Issue 11
RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies
text, January 2014
- Stamatakis, A.
- Karlsruhe
Evidence for a Far East Asian origin of lager beer yeast
journal, May 2014
- Bing, Jian; Han, Pei-Jie; Liu, Wan-Qiu
- Current Biology, Vol. 24, Issue 10
Population structure and reticulate evolution of Saccharomyces eubayanus and its lager-brewing hybrids
journal, April 2014
- Peris, David; Sylvester, Kayla; Libkind, Diego
- Molecular Ecology, Vol. 23, Issue 8
Long-distance dispersal: a framework for hypothesis testing
journal, January 2012
- Gillespie, Rosemary G.; Baldwin, Bruce G.; Waters, Jonathan M.
- Trends in Ecology & Evolution, Vol. 27, Issue 1
New lager yeast strains generated by interspecific hybridization
journal, February 2015
- Krogerus, Kristoffer; Magalhães, Frederico; Vidgren, Virve
- Journal of Industrial Microbiology & Biotechnology, Vol. 42, Issue 5
A distinct population of Saccharomyces cerevisiae in New Zealand: evidence for local dispersal by insects and human-aided global dispersal in oak barrels
journal, January 2010
- Goddard, Matthew R.; Anfang, Nicole; Tang, Rongying
- Environmental Microbiology, Vol. 12, Issue 1
Origin and domestication of the wine yeast Saccharomyces cerevisiae
journal, January 1993
- Martini, Alessandro
- Journal of Wine Research, Vol. 4, Issue 3
An ancient balancing act
journal, March 2010
- Skipper, Magdalena
- Nature Reviews Genetics, Vol. 11, Issue 4
Recombination-filtered genomic datasets by information maximization
journal, May 2007
- Woerner, A. E.; Cox, M. P.; Hammer, M. F.
- Bioinformatics, Vol. 23, Issue 14
PopGenome: An Efficient Swiss Army Knife for Population Genomic Analyses in R
journal, April 2014
- Pfeifer, Bastian; Wittelsbürger, Ulrich; Ramos-Onsins, Sebastian E.
- Molecular Biology and Evolution, Vol. 31, Issue 7
High-resolution mapping of meiotic crossovers and non-crossovers in yeast
journal, July 2008
- Mancera, Eugenio; Bourgon, Richard; Brozzi, Alessandro
- Nature, Vol. 454, Issue 7203
A population genomics insight into the Mediterranean origins of wine yeast domestication
journal, September 2015
- Almeida, Pedro; Barbosa, Raquel; Zalar, Polona
- Molecular Ecology, Vol. 24, Issue 21
Reconstruction of the genome origins and evolution of the hybrid lager yeast Saccharomyces pastorianus
journal, August 2008
- Dunn, B.; Sherlock, G.
- Genome Research, Vol. 18, Issue 10
Genome Sequence of the Lager Brewing Yeast, an Interspecies Hybrid
journal, January 2009
- Nakao, Y.; Kanamori, T.; Itoh, T.
- DNA Research, Vol. 16, Issue 2
A Large Set of Newly Created Interspecific Saccharomyces Hybrids Increases Aromatic Diversity in Lager Beers
journal, September 2015
- Mertens, Stijn; Steensels, Jan; Saels, Veerle
- Applied and Environmental Microbiology, Vol. 81, Issue 23
Inconsistency of Phylogenetic Estimates from Concatenated Data under Coalescence
journal, February 2007
- Kubatko, Laura Salter; Degnan, James H.
- Systematic Biology, Vol. 56, Issue 1
Genome-Wide SNP discovery and genomic characterization in avocado (Persea americana Mill.)
journal, December 2019
- Talavera, Alicia; Soorni, Aboozar; Bombarely, Aureliano
- Scientific Reports, Vol. 9, Issue 1
Sequencing and characterisation of rearrangements in three S. pastorianus strains reveals the presence of chimeric genes and gives evidence of breakpoint reuse
text, January 2013
- Hewitt, Sarah K.; Donaldson, Ian; Lovell, Simon C.
- arXiv
Saccharomyces diversity and evolution: a budding model genus
journal, May 2013
- Hittinger, Chris Todd
- Trends in Genetics, Vol. 29, Issue 5
Loss of lager specific genes and subtelomeric regions define two different Saccharomyces cerevisiae lineages for Saccharomyces pastorianus Group I and II strains
journal, February 2015
- Monerawela, Chandre; James, Tharappel C.; Wolfe, Kenneth H.
- FEMS Yeast Research, Vol. 15, Issue 2
Application of Phylogenetic Networks in Evolutionary Studies
journal, October 2005
- Huson, Daniel H.; Bryant, David
- Molecular Biology and Evolution, Vol. 23, Issue 2
A Gondwanan imprint on global diversity and domestication of wine and cider yeast Saccharomyces uvarum
journal, June 2014
- Almeida, Pedro; Gonçalves, Carla; Teixeira, Sara
- Nature Communications, Vol. 5, Issue 1
Genomic Ancestry of North Africans Supports Back-to-Africa Migrations
journal, January 2012
- Henn, Brenna M.; Botigué, Laura R.; Gravel, Simon
- PLoS Genetics, Vol. 8, Issue 1
Saccharomyces eubayanus and Saccharomyces arboricola reside in North Island native New Zealand forests
journal, December 2015
- Gayevskiy, Velimir; Goddard, Matthew R.
- Environmental Microbiology, Vol. 18, Issue 4
The Genome Sequence of Saccharomyces eubayanus and the Domestication of Lager-Brewing Yeasts
journal, August 2015
- Baker, EmilyClare; Wang, Bing; Bellora, Nicolas
- Molecular Biology and Evolution, Vol. 32, Issue 11
Next-generation sequencing analysis of lager brewing yeast strains reveals the evolutionary history of interspecies hybridization
journal, January 2016
- Okuno, Miki; Kajitani, Rei; Ryusui, Rie
- DNA Research
Saccharomyces paradoxus and Saccharomyces cerevisiae reside on oak trees in New Zealand: evidence for migration from Europe and interspecies hybrids: New Zealand Saccharomyces ecology
journal, September 2010
- Zhang, Hanyao; Skelton, Aaron; Gardner, Richard C.
- FEMS Yeast Research, Vol. 10, Issue 7
Inferences of evolutionary relationships from a population survey of LTR-retrotransposons and telomeric-associated sequences in theSaccharomyces sensu stricto complex
journal, January 2005
- Liti, Gianni; Peruffo, Antonella; James, Steve A.
- Yeast, Vol. 22, Issue 3
Ancient Admixture in Human History
journal, September 2012
- Patterson, Nick; Moorjani, Priya; Luo, Yontao
- Genetics, Vol. 192, Issue 3
Domestication Genomics: Evidence from Animals
journal, February 2014
- Wang, Guo-Dong; Xie, Hai-Bing; Peng, Min-Sheng
- Annual Review of Animal Biosciences, Vol. 2, Issue 1
Microbe domestication and the identification of the wild genetic stock of lager-brewing yeast
journal, August 2011
- Libkind, D.; Hittinger, C. T.; Valerio, E.
- Proceedings of the National Academy of Sciences, Vol. 108, Issue 35
in silico Whole Genome Sequencer & Analyzer (iWGS): a computational pipeline to guide the design and analysis of de novo genome sequencing studies
posted_content, August 2016
- Zhou, Xiaofan; Peris, David; Kominek, Jacek
- bioRxiv
Genomic polymorphism in North-western Indian population based on autosomal STR’s: a population data study
journal, June 2020
- Kumar, Rajesh; Kumar, Anand; Kumawat, R. K.
- International Journal of Legal Medicine, Vol. 135, Issue 3
Dissemination of wine-related yeasts by migratory birds: Yeasts carried by birds
journal, November 2011
- Francesca, Nicola; Canale, Domenica E.; Settanni, Luca
- Environmental Microbiology Reports, Vol. 4, Issue 1
Speciation driven by hybridization and chromosomal plasticity in a wild yeast
journal, January 2016
- Leducq, Jean-Baptiste; Nielly-Thibault, Lou; Charron, Guillaume
- Nature Microbiology, Vol. 1, Issue 1
RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies
text, January 2014
- Stamatakis, A.
- Karlsruhe
Reconstruction of the Evolutionary History of Saccharomyces cerevisiae x S. kudriavzevii Hybrids Based on Multilocus Sequence Analysis
journal, September 2012
- Peris, David; Lopes, Christian A.; Arias, Armando
- PLoS ONE, Vol. 7, Issue 9
Allopatric Divergence, Secondary Contact, and Genetic Isolation in Wild Yeast Populations
journal, March 2007
- Kuehne, Heidi A.; Murphy, Helen A.; Francis, Chantal A.
- Current Biology, Vol. 17, Issue 5
Inference of Population Structure using Dense Haplotype Data
journal, January 2012
- Lawson, Daniel John; Hellenthal, Garrett; Myers, Simon
- PLoS Genetics, Vol. 8, Issue 1
Inference of Population Structure Using Multilocus Genotype Data
journal, June 2000
- Pritchard, Jonathan K.; Stephens, Matthew; Donnelly, Peter
- Genetics, Vol. 155, Issue 2
Works referencing / citing this record:
Characterization of Saccharomyces uvarum (Beijerinck, 1898) and related hybrids: assessment of molecular markers that predict the parent and hybrid genomes and a proposal to name yeast hybrids
journal, March 2017
- Nguyen, Huu-Vang; Boekhout, Teun
- FEMS Yeast Research, Vol. 17, Issue 2
Loss of Heterozygosity Drives Adaptation in Hybrid Yeast
journal, March 2017
- Smukowski Heil, Caiti S.; DeSevo, Christopher G.; Pai, Dave A.
- Molecular Biology and Evolution, Vol. 34, Issue 7
Designing New Yeasts for Craft Brewing: When Natural Biodiversity Meets Biotechnology
journal, January 2020
- Iattici, Fabrizio; Catallo, Martina; Solieri, Lisa
- Beverages, Vol. 6, Issue 1
Saccharomyces interspecies hybrids as model organisms for studying yeast adaptation to stressful environments: Adaptation of Saccharomyces hybrids to stressful environments
journal, January 2018
- Lopandic, Ksenija
- Yeast, Vol. 35, Issue 1
Temperature preference can bias parental genome retention during hybrid evolution
journal, September 2019
- Smukowski Heil, Caiti S.; Large, Christopher R. L.; Patterson, Kira
- PLOS Genetics, Vol. 15, Issue 9
Structural, Physiological and Regulatory Analysis of Maltose Transporter Genes in Saccharomyces eubayanus CBS 12357T
journal, August 2018
- Brickwedde, Anja; Brouwers, Nick; van den Broek, Marcel
- Frontiers in Microbiology, Vol. 9
Genome Diversity and Evolution in the Budding Yeasts (Saccharomycotina)
journal, June 2017
- Dujon, Bernard A.; Louis, Edward J.
- Genetics, Vol. 206, Issue 2
sppIDer: A Species Identification Tool to Investigate Hybrid Genomes with High-Throughput Sequencing
journal, September 2018
- Langdon, Quinn K.; Peris, David; Kyle, Brian
- Molecular Biology and Evolution
sppIDer: a species identification tool to investigate hybrid genomes with high-throughput sequencing
journal, May 2018
- Langdon, Quinn K.; Peris, David; Kyle, Brian
- bioRxiv
Mitochondrial DNA and temperature tolerance in lager yeasts
journal, January 2019
- Baker, EmilyClare P.; Peris, David; Moriarty, Ryan V.
- Science Advances, Vol. 5, Issue 1
Horizontal transfer and proliferation of Tsu4 in Saccharomyces paradoxus
journal, June 2018
- Bergman, Casey M.
- Mobile DNA, Vol. 9, Issue 1
Natural Variation in the Multidrug Efflux Pump SGE1 Underlies Ionic Liquid Tolerance in Yeast
journal, July 2018
- Higgins, Douglas A.; Young, Megan K. M.; Tremaine, Mary
- Genetics, Vol. 210, Issue 1
Discordant evolution of mitochondrial and nuclear yeast genomes at population level
posted_content, November 2019
- De Chiara, Matteo; Friedrich, Anne; Barré, Benjamin
- bioRxiv
New yeasts—new brews: modern approaches to brewing yeast design and development
journal, June 2017
- Gibson, B.; Geertman, J. -M. A.; Hittinger, C. T.
- FEMS Yeast Research, Vol. 17, Issue 4
Comparative genomics provides new insights into the diversity, physiology, and sexuality of the only industrially exploited tremellomycete: Phaffia rhodozyma
journal, November 2016
- Bellora, Nicolás; Moliné, Martín; David-Palma, Márcia
- BMC Genomics, Vol. 17, Issue 1
Discordant evolution of mitochondrial and nuclear yeast genomes at population level
journal, May 2020
- De Chiara, Matteo; Friedrich, Anne; Barré, Benjamin
- BMC Biology, Vol. 18, Issue 1
Fermentation innovation through complex hybridization of wild and domesticated yeasts
journal, October 2019
- Langdon, Quinn K.; Peris, David; Baker, EmilyClare P.
- Nature Ecology & Evolution, Vol. 3, Issue 11
Horizontal transfer and proliferation of Tsu4 in Saccharomyces paradoxus
journal, June 2018
- Bergman, Casey M.
- Mobile DNA, Vol. 9, Issue 1
Himalayan Saccharomyces eubayanus Genome Sequences Reveal Genetic Markers Explaining Heterotic Maltotriose Consumption by Saccharomyces pastorianus Hybrids
journal, September 2019
- Brouwers, Nick; Brickwedde, Anja; Gorter de Vries, Arthur R.
- Applied and Environmental Microbiology, Vol. 85, Issue 22
Hybridization and adaptive evolution of diverse Saccharomyces species for cellulosic biofuel production
journal, March 2017
- Peris, David; Moriarty, Ryan V.; Alexander, William G.
- Biotechnology for Biofuels, Vol. 10, Issue 1
Novel brewing yeast hybrids: creation and application
journal, November 2016
- Krogerus, Kristoffer; Magalhães, Frederico; Vidgren, Virve
- Applied Microbiology and Biotechnology, Vol. 101, Issue 1
On the origins and industrial applications of Saccharomyces cerevisiae × Saccharomyces kudriavzevii hybrids : Origins and applications of S. cerevisiae x S. kudriavzevii hybrids
journal, December 2017
- Peris, David; Pérez-Torrado, Roberto; Hittinger, Chris Todd
- Yeast, Vol. 35, Issue 1
Temperature preference can bias parental genome retention during hybrid evolution
journal, September 2019
- Smukowski Heil, Caiti S.; Large, Christopher R. L.; Patterson, Kira
- PLOS Genetics, Vol. 15, Issue 9
Genome Diversity and Evolution in the Budding Yeasts (Saccharomycotina)
journal, June 2017
- Dujon, Bernard A.; Louis, Edward J.
- Genetics, Vol. 206, Issue 2
Himalayan Saccharomyces eubayanus Genome Sequences Reveal Genetic Markers Explaining Heterotic Maltotriose Consumption by Saccharomyces pastorianus Hybrids
journal, September 2019
- Brouwers, Nick; Brickwedde, Anja; Gorter de Vries, Arthur R.
- Applied and Environmental Microbiology, Vol. 85, Issue 22
Structural, Physiological and Regulatory Analysis of Maltose Transporter Genes in Saccharomyces eubayanus CBS 12357T
journal, August 2018
- Brickwedde, Anja; Brouwers, Nick; van den Broek, Marcel
- Frontiers in Microbiology, Vol. 9
Saccharomyces arboricola and Its Hybrids’ Propensity for Sake Production: Interspecific Hybrids Reveal Increased Fermentation Abilities and a Mosaic Metabolic Profile
journal, January 2020
- Winans, Matthew J.; Yamamoto, Yuki; Fujimaru, Yuki
- Fermentation, Vol. 6, Issue 1
A polyploid admixed origin of beer yeasts derived from European and Asian wine populations
journal, March 2019
- Fay, Justin C.; Liu, Ping; Ong, Giang T.
- PLOS Biology, Vol. 17, Issue 3
Chromosome level assembly and comparative genome analysis confirm lager-brewing yeasts originated from a single hybridization
journal, December 2019
- Salazar, Alex N.; Gorter de Vries, Arthur R.; van den Broek, Marcel
- BMC Genomics, Vol. 20, Issue 1
Interspecific hybridization facilitates niche adaptation in beer yeast
journal, October 2019
- Gallone, Brigida; Steensels, Jan; Mertens, Stijn
- Nature Ecology & Evolution, Vol. 3, Issue 11
Horizontal transfer and proliferation of Tsu4 in Saccharomyces paradoxus
posted_content, March 2018
- Bergman, Casey M.
- bioRxiv
Phylogeography of the wild Lager-brewing ancestor ( Saccharomyces eubayanus ) in Patagonia
journal, October 2018
- Eizaguirre, Juan I.; Peris, David; Rodríguez, María E.
- Environmental Microbiology, Vol. 20, Issue 10
Targeted metagenomics approach to capture the biodiversity of Saccharomyces genus in wild environments
journal, January 2019
- Alsammar, Haya F.; Naseeb, Samina; Brancia, Lorenzo B.
- Environmental Microbiology Reports, Vol. 11, Issue 2
Natural Variation in the Multidrug Efflux Pump SGE1 Underlies Ionic Liquid Tolerance in Yeast
journal, July 2018
- Higgins, Douglas A.; Young, Megan K. M.; Tremaine, Mary
- Genetics, Vol. 210, Issue 1
A polyploid admixed origin of beer yeasts derived from European and Asian wine populations
posted_content, November 2018
- Fay, Justin C.; Liu, Ping; Ong, Giang T.
- bioRxiv
Chromosome level assembly and comparative genome analysis confirm lager-brewing yeasts originated from a single hybridization
journal, December 2019
- Salazar, Alex N.; Gorter de Vries, Arthur R.; van den Broek, Marcel
- BMC Genomics, Vol. 20, Issue 1
Evolutionary biology through the lens of budding yeast comparative genomics
journal, July 2017
- Marsit, Souhir; Leducq, Jean-Baptiste; Durand, Éléonore
- Nature Reviews Genetics, Vol. 18, Issue 10
Evolution of a novel chimeric maltotriose transporter in Saccharomyces eubayanus from parent proteins unable to perform this function
journal, April 2019
- Baker, EmilyClare P.; Hittinger, Chris Todd
- PLOS Genetics, Vol. 15, Issue 4
Bioprospecting for brewers: Exploiting natural diversity for naturally diverse beers
journal, February 2019
- Cubillos, Francisco A.; Gibson, Brian; Grijalva‐Vallejos, Nubia
- Yeast, Vol. 36, Issue 6
Aneuploidy in yeast: Segregation error or adaptation mechanism?
journal, August 2019
- Gilchrist, Ciaran; Stelkens, Rike
- Yeast
Tolerance to winemaking stress conditions of Patagonian strains of Saccharomyces eubayanus and Saccharomyces uvarum
journal, July 2017
- Origone, A. C.; del Mónaco, S. M.; Ávila, J. R.
- Journal of Applied Microbiology, Vol. 123, Issue 2
Hybridization and adaptive evolution of diverse Saccharomyces species for cellulosic biofuel production
journal, March 2017
- Peris, David; Moriarty, Ryan V.; Alexander, William G.
- Biotechnology for Biofuels, Vol. 10, Issue 1
Hybridization is a recurrent evolutionary stimulus in wild yeast speciation
journal, February 2019
- Eberlein, Chris; Hénault, Mathieu; Fijarczyk, Anna
- Nature Communications, Vol. 10, Issue 1
Mitochondrial‐encoded endonucleases drive recombination of protein‐coding genes in yeast
journal, September 2019
- Wu, Baojun; Hao, Weilong
- Environmental Microbiology, Vol. 21, Issue 11
Hybridization is a recurrent evolutionary stimulus in wild yeast speciation
journal, February 2019
- Eberlein, Chris; Hénault, Mathieu; Fijarczyk, Anna
- Nature Communications, Vol. 10, Issue 1