Receptor signaling clusters in the immune synapse

doi:10.1146/annurev-biophys-042910-155238

Title: Receptor signaling clusters in the immune synapse (in eng)

Abstract

Signaling processes between various immune cells involve large-scale spatial reorganization of receptors and signaling molecules within the cell-cell junction. These structures, now collectively referred to as immune synapses, interleave physical and mechanical processes with the cascades of chemical reactions that constitute signal transduction systems. Molecular level clustering, spatial exclusion, and long-range directed transport are all emerging as key regulatory mechanisms. The study of these processes is drawing researchers from physical sciences to join the effort and represents a rapidly growing branch of biophysical chemistry. Furthermore, recent advances in physical and quantitative analyses of signaling within the immune synapses are reviewed here.

Authors:

Dustin, Michael L. ^[1]; Groves, Jay T. ^[2]

New York Univ. School of Medicine, New York, NY (United States)
Univ. of California, Berkeley, CA (United States); Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

Publication Date:: 2012-02-23

Research Org.:: Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

Sponsoring Org.:: Physical Biosciences Division; USDOE

OSTI Identifier:: 1363640

Report Number(s):: LBNL-1004332
Journal ID: ISSN 1936-122X; ir:1004332

Resource Type:: Accepted Manuscript

Journal Name:: Annual Review of Biophysics

Additional Journal Information:: Journal Volume: 41; Journal Issue: 1; Journal ID: ISSN 1936-122X

Publisher:: Annual Reviews

Country of Publication:: United States

Language:: eng

Subject:: 59 BASIC BIOLOGICAL SCIENCES; cytoskeleton; signal transduction; spatial mutation

Citation Formats


                    Dustin, Michael L., and Groves, Jay T. Receptor signaling clusters in the immune synapse.  United States: N. p., 2012. 
        Web.  doi:10.1146/annurev-biophys-042910-155238.

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                    Dustin, Michael L., & Groves, Jay T. Receptor signaling clusters in the immune synapse.  United States.  doi:10.1146/annurev-biophys-042910-155238.

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                    Dustin, Michael L., and Groves, Jay T. Thu .  
        "Receptor signaling clusters in the immune synapse".  United States.  doi:10.1146/annurev-biophys-042910-155238.  https://www.osti.gov/servlets/purl/1363640.

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@article{osti_1363640,

  title        = {Receptor signaling clusters in the immune synapse},

  author       = {Dustin, Michael L. and Groves, Jay T.},

  abstractNote = {Signaling processes between various immune cells involve large-scale spatial reorganization of receptors and signaling molecules within the cell-cell junction. These structures, now collectively referred to as immune synapses, interleave physical and mechanical processes with the cascades of chemical reactions that constitute signal transduction systems. Molecular level clustering, spatial exclusion, and long-range directed transport are all emerging as key regulatory mechanisms. The study of these processes is drawing researchers from physical sciences to join the effort and represents a rapidly growing branch of biophysical chemistry. Furthermore, recent advances in physical and quantitative analyses of signaling within the immune synapses are reviewed here.},

  doi          = {10.1146/annurev-biophys-042910-155238},

  journal      = {Annual Review of Biophysics},

  number       = 1,

  volume       = 41,

  place        = {United States},

  year         = {2012},

  month        = {2}

}

Copy to clipboard

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DOI: 10.1146/annurev-biophys-042910-155238

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Title: Receptor signaling clusters in the immune synapse (in eng)

Abstract

Citation Formats

Functional single-cell analysis of T-cell activation by supported lipid bilayer-tethered ligands on arrays of nanowells journal, January 2013

Membrane Organization and Physical Regulation of Lymphocyte Antigen Receptors: A Biophysicist’s Perspective journal, July 2019

The structural basis of αβ T-lineage immune recognition: TCR docking topologies, mechanotransduction, and co-receptor function journal, October 2012

Biomolecular condensates in neurodegeneration and cancer journal, November 2019

Arp2/3 complex-driven spatial patterning of the BCR enhances immune synapse formation, BCR signaling and B cell activation journal, June 2019

Membrane Organization and Physical Regulation of Lymphocyte Antigen Receptors: A Biophysicist’s Perspective journal, July 2019

Functional single-cell analysis of T-cell activation by supported lipid bilayer-tethered ligands on arrays of nanowells journal, January 2013

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Arp2/3 complex-driven spatial patterning of the BCR enhances immune synapse formation, BCR signaling and B cell activation journal, June 2019

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journal, January 2013

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journal, November 2019

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journal, June 2019

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journal, July 2019

Functional single-cell analysis of T-cell activation by supported lipid bilayer-tethered ligands on arrays of nanowells
journal, January 2013

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journal, October 2012

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journal, November 2019

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journal, June 2019

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journal, November 2016

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journal, November 2017

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journal, February 2019

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journal, June 2019

Neuronal adhesion and growth on nanopatterned EA5-POPC synthetic membranes
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journal, January 2017

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journal, July 2016

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journal, September 2015

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journal, June 2017

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journal, April 2018

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journal, October 2013

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journal, August 2019

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journal, August 2019

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journal, April 2016

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journal, January 2019

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journal, January 2019

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journal, November 2016

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journal, September 2018

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journal, February 2019

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journal, February 2014

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journal, February 2020

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journal, December 2017

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journal, September 2018

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journal, December 2018

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journal, October 2013

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journal, October 2017

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