skip to main content
DOE PAGES title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Receptor signaling clusters in the immune synapse (in eng)

Abstract

Signaling processes between various immune cells involve large-scale spatial reorganization of receptors and signaling molecules within the cell-cell junction. These structures, now collectively referred to as immune synapses, interleave physical and mechanical processes with the cascades of chemical reactions that constitute signal transduction systems. Molecular level clustering, spatial exclusion, and long-range directed transport are all emerging as key regulatory mechanisms. The study of these processes is drawing researchers from physical sciences to join the effort and represents a rapidly growing branch of biophysical chemistry. Furthermore, recent advances in physical and quantitative analyses of signaling within the immune synapses are reviewed here.

Authors:
 [1];  [2]
  1. New York Univ. School of Medicine, New York, NY (United States)
  2. Univ. of California, Berkeley, CA (United States); Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Publication Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
Physical Biosciences Division; USDOE
OSTI Identifier:
1363640
Report Number(s):
LBNL-1004332
Journal ID: ISSN 1936-122X; ir:1004332
Resource Type:
Accepted Manuscript
Journal Name:
Annual Review of Biophysics
Additional Journal Information:
Journal Volume: 41; Journal Issue: 1; Journal ID: ISSN 1936-122X
Publisher:
Annual Reviews
Country of Publication:
United States
Language:
eng
Subject:
59 BASIC BIOLOGICAL SCIENCES; cytoskeleton; signal transduction; spatial mutation

Citation Formats

Dustin, Michael L., and Groves, Jay T. Receptor signaling clusters in the immune synapse. United States: N. p., 2012. Web. doi:10.1146/annurev-biophys-042910-155238.
Dustin, Michael L., & Groves, Jay T. Receptor signaling clusters in the immune synapse. United States. doi:10.1146/annurev-biophys-042910-155238.
Dustin, Michael L., and Groves, Jay T. Thu . "Receptor signaling clusters in the immune synapse". United States. doi:10.1146/annurev-biophys-042910-155238. https://www.osti.gov/servlets/purl/1363640.
@article{osti_1363640,
title = {Receptor signaling clusters in the immune synapse},
author = {Dustin, Michael L. and Groves, Jay T.},
abstractNote = {Signaling processes between various immune cells involve large-scale spatial reorganization of receptors and signaling molecules within the cell-cell junction. These structures, now collectively referred to as immune synapses, interleave physical and mechanical processes with the cascades of chemical reactions that constitute signal transduction systems. Molecular level clustering, spatial exclusion, and long-range directed transport are all emerging as key regulatory mechanisms. The study of these processes is drawing researchers from physical sciences to join the effort and represents a rapidly growing branch of biophysical chemistry. Furthermore, recent advances in physical and quantitative analyses of signaling within the immune synapses are reviewed here.},
doi = {10.1146/annurev-biophys-042910-155238},
journal = {Annual Review of Biophysics},
number = 1,
volume = 41,
place = {United States},
year = {2012},
month = {2}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record

Citation Metrics:
Cited by: 86 works
Citation information provided by
Web of Science

Save / Share:

Works referencing / citing this record:

Functional single-cell analysis of T-cell activation by supported lipid bilayer-tethered ligands on arrays of nanowells
journal, January 2013

  • Torres, Alexis J.; Contento, Rita Lucia; Gordo, Susana
  • Lab Chip, Vol. 13, Issue 1
  • DOI: 10.1039/c2lc40869d

Membrane Organization and Physical Regulation of Lymphocyte Antigen Receptors: A Biophysicist’s Perspective
journal, July 2019


The structural basis of αβ T-lineage immune recognition: TCR docking topologies, mechanotransduction, and co-receptor function
journal, October 2012


Biomolecular condensates in neurodegeneration and cancer
journal, November 2019

  • Spannl, Stephanie; Tereshchenko, Maria; Mastromarco, Giovanni J.
  • Traffic, Vol. 20, Issue 12
  • DOI: 10.1111/tra.12704

Arp2/3 complex-driven spatial patterning of the BCR enhances immune synapse formation, BCR signaling and B cell activation
journal, June 2019


Membrane Organization and Physical Regulation of Lymphocyte Antigen Receptors: A Biophysicist’s Perspective
journal, July 2019


Functional single-cell analysis of T-cell activation by supported lipid bilayer-tethered ligands on arrays of nanowells
journal, January 2013

  • Torres, Alexis J.; Contento, Rita Lucia; Gordo, Susana
  • Lab Chip, Vol. 13, Issue 1
  • DOI: 10.1039/c2lc40869d

The structural basis of αβ T-lineage immune recognition: TCR docking topologies, mechanotransduction, and co-receptor function
journal, October 2012


Biomolecular condensates in neurodegeneration and cancer
journal, November 2019

  • Spannl, Stephanie; Tereshchenko, Maria; Mastromarco, Giovanni J.
  • Traffic, Vol. 20, Issue 12
  • DOI: 10.1111/tra.12704

Arp2/3 complex-driven spatial patterning of the BCR enhances immune synapse formation, BCR signaling and B cell activation
journal, June 2019


DNA Surface Technology: From Gene Sensors to Integrated Systems for Life and Materials Sciences
journal, December 2018

  • Schneider, Ann-Kathrin; Niemeyer, Christof M.
  • Angewandte Chemie International Edition, Vol. 57, Issue 52
  • DOI: 10.1002/anie.201811713

Do Cell Membranes Flow Like Honey or Jiggle Like Jello?
journal, November 2019


The electrical synapse: Molecular complexities at the gap and beyond: Structural Complexity of Electrical Synapses
journal, March 2017

  • Miller, Adam C.; Pereda, Alberto E.
  • Developmental Neurobiology, Vol. 77, Issue 5
  • DOI: 10.1002/dneu.22484

From proteomes to complexomes in the era of systems biology
journal, January 2014


An intermolecular FRET sensor detects the dynamics of T cell receptor clustering
journal, April 2017

  • Ma, Yuanqing; Pandzic, Elvis; Nicovich, Philip R.
  • Nature Communications, Vol. 8, Issue 1
  • DOI: 10.1038/ncomms15100

A cycle of Zap70 kinase activation and release from the TCR amplifies and disperses antigenic stimuli
journal, November 2016

  • Katz, Zachary B.; Novotná, Lucie; Blount, Amy
  • Nature Immunology, Vol. 18, Issue 1
  • DOI: 10.1038/ni.3631

Conventional CD4+ T cells present bacterial antigens to induce cytotoxic and memory CD8+ T cell responses
journal, November 2017

  • Cruz-Adalia, Aránzazu; Ramirez-Santiago, Guillermo; Osuna-Pérez, Jesús
  • Nature Communications, Vol. 8, Issue 1
  • DOI: 10.1038/s41467-017-01661-7

The activity of TRAF RING homo- and heterodimers is regulated by zinc finger 1
journal, November 2017


Quantifying in situ adaptive immune cell cognate interactions in humans
journal, February 2019

  • Liarski, Vladimir M.; Sibley, Adam; van Panhuys, Nicholas
  • Nature Immunology, Vol. 20, Issue 4
  • DOI: 10.1038/s41590-019-0315-3

Neuronal adhesion and growth on nanopatterned EA5-POPC synthetic membranes
journal, January 2018

  • Ghosh Moulick, Ranjita; Panaitov, Gregor; Du, Liping
  • Nanoscale, Vol. 10, Issue 11
  • DOI: 10.1039/c7nr08520f

Janus nanoparticles for T cell activation: clustering ligands to enhance stimulation
journal, January 2017

  • Lee, Kwahun; Yu, Yan
  • Journal of Materials Chemistry B, Vol. 5, Issue 23
  • DOI: 10.1039/c7tb00150a

Phosphotyrosine-mediated LAT assembly on membranes drives kinetic bifurcation in recruitment dynamics of the Ras activator SOS
journal, July 2016

  • Huang, William Y. C.; Yan, Qingrong; Lin, Wan-Chen
  • Proceedings of the National Academy of Sciences, Vol. 113, Issue 29
  • DOI: 10.1073/pnas.1602602113

The Linker for Activation of T Cells (LAT) Signaling Hub: From Signaling Complexes to Microclusters
journal, September 2015

  • Balagopalan, Lakshmi; Kortum, Robert L.; Coussens, Nathan P.
  • Journal of Biological Chemistry, Vol. 290, Issue 44
  • DOI: 10.1074/jbc.r115.665869

Diffusion of lipids and GPI-anchored proteins in actin-free plasma membrane vesicles measured by STED-FCS
journal, June 2017

  • Schneider, Falk; Waithe, Dominic; Clausen, Mathias P.
  • Molecular Biology of the Cell, Vol. 28, Issue 11
  • DOI: 10.1091/mbc.e16-07-0536

Natural killer cell cytotoxicity and its regulation by inhibitory receptors
journal, April 2018


Mechanical regulation of T-cell functions
journal, October 2013

  • Chen, Wei; Zhu, Cheng
  • Immunological Reviews, Vol. 256, Issue 1
  • DOI: 10.1111/imr.12122

Understanding T cell signaling using membrane reconstitution
journal, August 2019


A PI(4,5)P2‐derived “gasoline engine model” for the sustained B cell receptor activation
journal, August 2019

  • Xu, Chenguang; Wan, Zhengpeng; Shaheen, Samina
  • Immunological Reviews, Vol. 291, Issue 1
  • DOI: 10.1111/imr.12775

Phase separation of signaling molecules promotes T cell receptor signal transduction
journal, April 2016


Mapping the stochastic sequence of individual ligand-receptor binding events to cellular activation: T cells act on the rare events
journal, January 2019

  • Lin, Jenny J. Y.; Low-Nam, Shalini T.; Alfieri, Katherine N.
  • Science Signaling, Vol. 12, Issue 564
  • DOI: 10.1126/scisignal.aat8715

KCa1.1 and Kv1.3 channels regulate the interactions between fibroblast-like synoviocytes and T lymphocytes during rheumatoid arthritis
journal, January 2019

  • Tanner, Mark R.; Pennington, Michael W.; Chauhan, Satendra S.
  • Arthritis Research & Therapy, Vol. 21, Issue 1
  • DOI: 10.1186/s13075-018-1783-9

How cells respond to environmental cues – insights from bio-functionalized substrates
journal, November 2016

  • Ruprecht, Verena; Monzo, Pascale; Ravasio, Andrea
  • Journal of Cell Science, Vol. 130, Issue 1
  • DOI: 10.1242/jcs.196162

Reconstitution of immune cell interactions in free-standing membranes
journal, September 2018

  • Jenkins, Edward; Santos, Ana Mafalda; O'Brien-Ball, Caitlin
  • Journal of Cell Science, Vol. 132, Issue 4
  • DOI: 10.1242/jcs.219709

More from less – bottom-up reconstitution of cell biology
journal, February 2019

  • Ganzinger, Kristina A.; Schwille, Petra
  • Journal of Cell Science, Vol. 132, Issue 4
  • DOI: 10.1242/jcs.227488

T Cell Receptor Signaling Can Directly Enhance the Avidity of CD28 Ligand Binding
journal, February 2014


An agent-based model of molecular aggregation at the cell membrane
journal, February 2020


The “Phagocytic Synapse” and Clearance of Apoptotic Cells
journal, December 2017


Membrane Ultrastructure and T Cell Activation
journal, September 2018


Integrating Experiment and Theory to Understand TCR-pMHC Dynamics
journal, December 2018


Selective Activation of Antigen-Experienced T Cells by Anti-CD3 Constrained on Nanoparticles
journal, October 2013

  • Lo, Ying-Chun; Edidin, Michael A.; Powell, Jonathan D.
  • The Journal of Immunology, Vol. 191, Issue 10
  • DOI: 10.4049/jimmunol.1301433

SHIP-1 Deficiency in AID + B Cells Leads to the Impaired Function of B10 Cells with Spontaneous Autoimmunity
journal, October 2017


Direct single molecule measurement of TCR triggering by agonist pMHC in living primary T cells
journal, July 2013

  • O'Donoghue, Geoff P.; Pielak, Rafal M.; Smoligovets, Alexander A.
  • eLife, Vol. 2
  • DOI: 10.7554/elife.00778