Receptor signaling clusters in the immune synapse (in eng)
Abstract
Signaling processes between various immune cells involve large-scale spatial reorganization of receptors and signaling molecules within the cell-cell junction. These structures, now collectively referred to as immune synapses, interleave physical and mechanical processes with the cascades of chemical reactions that constitute signal transduction systems. Molecular level clustering, spatial exclusion, and long-range directed transport are all emerging as key regulatory mechanisms. The study of these processes is drawing researchers from physical sciences to join the effort and represents a rapidly growing branch of biophysical chemistry. Furthermore, recent advances in physical and quantitative analyses of signaling within the immune synapses are reviewed here.
- Authors:
-
- New York Univ. School of Medicine, New York, NY (United States)
- Univ. of California, Berkeley, CA (United States); Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
- Publication Date:
- Research Org.:
- Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
- Sponsoring Org.:
- Physical Biosciences Division; USDOE
- OSTI Identifier:
- 1363640
- Report Number(s):
- LBNL-1004332
Journal ID: ISSN 1936-122X; ir:1004332
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Annual Review of Biophysics
- Additional Journal Information:
- Journal Volume: 41; Journal Issue: 1; Journal ID: ISSN 1936-122X
- Publisher:
- Annual Reviews
- Country of Publication:
- United States
- Language:
- eng
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; cytoskeleton; signal transduction; spatial mutation
Citation Formats
Dustin, Michael L., and Groves, Jay T. Receptor signaling clusters in the immune synapse. United States: N. p., 2012.
Web. doi:10.1146/annurev-biophys-042910-155238.
Dustin, Michael L., & Groves, Jay T. Receptor signaling clusters in the immune synapse. United States. doi:10.1146/annurev-biophys-042910-155238.
Dustin, Michael L., and Groves, Jay T. Thu .
"Receptor signaling clusters in the immune synapse". United States. doi:10.1146/annurev-biophys-042910-155238. https://www.osti.gov/servlets/purl/1363640.
@article{osti_1363640,
title = {Receptor signaling clusters in the immune synapse},
author = {Dustin, Michael L. and Groves, Jay T.},
abstractNote = {Signaling processes between various immune cells involve large-scale spatial reorganization of receptors and signaling molecules within the cell-cell junction. These structures, now collectively referred to as immune synapses, interleave physical and mechanical processes with the cascades of chemical reactions that constitute signal transduction systems. Molecular level clustering, spatial exclusion, and long-range directed transport are all emerging as key regulatory mechanisms. The study of these processes is drawing researchers from physical sciences to join the effort and represents a rapidly growing branch of biophysical chemistry. Furthermore, recent advances in physical and quantitative analyses of signaling within the immune synapses are reviewed here.},
doi = {10.1146/annurev-biophys-042910-155238},
journal = {Annual Review of Biophysics},
number = 1,
volume = 41,
place = {United States},
year = {2012},
month = {2}
}
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