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Title: Hybridization and adaptive evolution of diverse Saccharomyces species for cellulosic biofuel production

Here, lignocellulosic biomass is a common resource across the globe, and its fermentation offers a promising option for generating renewable liquid transportation fuels. The deconstruction of lignocellulosic biomass releases sugars that can be fermented by microbes, but these processes also produce fermentation inhibitors, such as aromatic acids and aldehydes. Several research projects have investigated lignocellulosic biomass fermentation by the baker’s yeast Saccharomyces cerevisiae. Most projects have taken synthetic biological approaches or have explored naturally occurring diversity in S. cerevisiae to enhance stress tolerance, xylose consumption, or ethanol production. Despite these efforts, improved strains with new properties are needed. In other industrial processes, such as wine and beer fermentation, interspecies hybrids have combined important traits from multiple species, suggesting that interspecies hybridization may also offer potential for biofuel research.
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  1. Univ. of Wisconsin, Madison, WI (United States)
  2. Centro Regional Univ. Bariloche, Rio Negro (Argentina)
  3. Univ. of Wisconsin, Madison, WI (United States); Chinese Academy of Sciences, Beijing (China)
  4. Chinese Academy of Sciences, Beijing (China)
  5. Univ. de Montreal, Montreal, QC (Canada); Univ. Laval, Quebec City, QC (Canada)
  6. Univ. Laval, Quebec City, QC (Canada)
  7. Univ. Nova de Lisboa, Caparica (Portugal)
  8. Washington Univ., St. Louis, MO (United States)
Publication Date:
Grant/Contract Number:
Accepted Manuscript
Journal Name:
Biotechnology for Biofuels
Additional Journal Information:
Journal Volume: 10; Journal Issue: 1; Journal ID: ISSN 1754-6834
BioMed Central
Research Org:
Univ. of Wisconsin, Madison, WI (United States)
Sponsoring Org:
USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22)
Country of Publication:
United States
09 BIOMASS FUELS; 60 APPLIED LIFE SCIENCES; Saccharomyces; biodiversity; ammonia fiber expansion (AFEX); AFEX-pretreated corn stover hydrolysate (ACSH); hybridization; bioethanol; xylose; hydrolysate toxins
OSTI Identifier: