skip to main content
DOE PAGES title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: The impacts of pharmaceutical drugs under ocean acidification: New data on single and combined long-term effects of carbamazepine on Scrobicularia plana

; ; ; ; ; ; ; ; ;
Publication Date:
Sponsoring Org.:
USDOE Office of Nuclear Energy (NE), Nuclear Fuel Cycle and Supply Chain
OSTI Identifier:
Grant/Contract Number:  
PEst-C/MAR/LA0017/2013; SFRH/BPD/92258/2013; SFRH/BPD/78645/2011; SFRH/BD/86356/2012; SFRH/BD/93107/2013
Resource Type:
Publisher's Accepted Manuscript
Journal Name:
Science of the Total Environment
Additional Journal Information:
Journal Name: Science of the Total Environment Journal Volume: 541 Journal Issue: C; Journal ID: ISSN 0048-9697
Country of Publication:

Citation Formats

Freitas, Rosa, Almeida, Ângela, Calisto, Vânia, Velez, Cátia, Moreira, Anthony, Schneider, Rudolf J., Esteves, Valdemar I., Wrona, Frederick J., Figueira, Etelvina, and Soares, Amadeu M. V. M. The impacts of pharmaceutical drugs under ocean acidification: New data on single and combined long-term effects of carbamazepine on Scrobicularia plana. Netherlands: N. p., 2016. Web.
Freitas, Rosa, Almeida, Ângela, Calisto, Vânia, Velez, Cátia, Moreira, Anthony, Schneider, Rudolf J., Esteves, Valdemar I., Wrona, Frederick J., Figueira, Etelvina, & Soares, Amadeu M. V. M. The impacts of pharmaceutical drugs under ocean acidification: New data on single and combined long-term effects of carbamazepine on Scrobicularia plana. Netherlands.
Freitas, Rosa, Almeida, Ângela, Calisto, Vânia, Velez, Cátia, Moreira, Anthony, Schneider, Rudolf J., Esteves, Valdemar I., Wrona, Frederick J., Figueira, Etelvina, and Soares, Amadeu M. V. M. Fri . "The impacts of pharmaceutical drugs under ocean acidification: New data on single and combined long-term effects of carbamazepine on Scrobicularia plana". Netherlands.
title = {The impacts of pharmaceutical drugs under ocean acidification: New data on single and combined long-term effects of carbamazepine on Scrobicularia plana},
author = {Freitas, Rosa and Almeida, Ângela and Calisto, Vânia and Velez, Cátia and Moreira, Anthony and Schneider, Rudolf J. and Esteves, Valdemar I. and Wrona, Frederick J. and Figueira, Etelvina and Soares, Amadeu M. V. M.},
abstractNote = {},
doi = {10.1016/j.scitotenv.2015.09.138},
journal = {Science of the Total Environment},
number = C,
volume = 541,
place = {Netherlands},
year = {2016},
month = {1}

Journal Article:
Free Publicly Available Full Text

Citation Metrics:
Cited by: 20 works
Citation information provided by
Web of Science

Save / Share:

Works referenced in this record:

Ocean Acidification: Present Conditions and Future Changes in a High-CO2 World
journal, December 2009

Metabolic depression in animals: physiological perspectives and biochemical generalizations
journal, February 1999

  • Guppy, Michael; Withers, Philip
  • Biological Reviews of the Cambridge Philosophical Society, Vol. 74, Issue 1
  • DOI: 10.1017/S0006323198005258

Climate Change Impacts on Marine Ecosystems
journal, January 2012

Impacts of ocean acidification on marine fauna and ecosystem processes
journal, April 2008

  • Fabry, Victoria J.; Seibel, Brad A.; Feely, Richard A.
  • ICES Journal of Marine Science, Vol. 65, Issue 3
  • DOI: 10.1093/icesjms/fsn048

Acidified seawater impacts sea urchin larvae pH regulatory systems relevant for calcification
journal, October 2012

  • Stumpp, M.; Hu, M. Y.; Melzner, F.
  • Proceedings of the National Academy of Sciences, Vol. 109, Issue 44
  • DOI: 10.1073/pnas.1209174109

The Biuret Reaction in the Determination of Serum Proteins
journal, September 1940

Interactions between climate change and contaminants
journal, December 2007

Pollution biomarkers in two estuarine invertebrates, Nereis diversicolor and Scrobicularia plana, from a Marsh ecosystem in SW Spain
journal, April 2009

  • Solé, Montserrat; Kopecka-Pilarczyk, Justyna; Blasco, Julián
  • Environment International, Vol. 35, Issue 3
  • DOI: 10.1016/j.envint.2008.09.013

Does non-steroidal anti-inflammatory (NSAID) ibuprofen induce antioxidant stress and endocrine disruption in mussel Mytilus galloprovincialis?
journal, March 2012

  • Gonzalez-Rey, Maria; Bebianno, Maria João
  • Environmental Toxicology and Pharmacology, Vol. 33, Issue 2
  • DOI: 10.1016/j.etap.2011.12.017

A comparison of the equilibrium constants for the dissociation of carbonic acid in seawater media
journal, October 1987

  • Dickson, A. G.; Millero, F. J.
  • Deep Sea Research Part A. Oceanographic Research Papers, Vol. 34, Issue 10
  • DOI: 10.1016/0198-0149(87)90021-5

Presence of the pharmaceutical drug carbamazepine in coastal systems: Effects on bivalves
journal, November 2014

Ruditapes decussatus and Ruditapes philippinarum exposed to cadmium: Toxicological effects and bioaccumulation patterns
journal, August 2012

  • Figueira, Etelvina; Cardoso, Paulo; Freitas, Rosa
  • Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, Vol. 156, Issue 2
  • DOI: 10.1016/j.cbpc.2012.04.004

Does zinc produce reactive oxygen species in Ruditapes decussatus?
journal, March 2004

Immunoassays as high-throughput tools: Monitoring spatial and temporal variations of carbamazepine, caffeine and cetirizine in surface and wastewaters
journal, November 2012

Assay for quantitative determination of glutathione and glutathione disulfide levels using enzymatic recycling method
journal, December 2006

Glutathione S-Transferases
journal, November 1974

  • Habig, William H.; Pabst, Michael J.; Jakoby, William B.
  • Journal of Biological Chemistry, Vol. 249, Issue 22
  • DOI: 10.1016/S0021-9258(19)42083-8

Hepatic antioxidant status and hematological parameters in rainbow trout, Oncorhynchus mykiss, after chronic exposure to carbamazepine
journal, January 2010

  • Li, Zhi-Hua; Velisek, Josef; Zlabek, Vladimir
  • Chemico-Biological Interactions, Vol. 183, Issue 1
  • DOI: 10.1016/j.cbi.2009.09.009

Photodegradation of psychiatric pharmaceuticals in aquatic environments – Kinetics and photodegradation products
journal, November 2011

Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
journal, June 1979

A rapid method to measure the solid–water distribution coefficient (Kd) for pharmaceuticals and musk fragrances in sewage sludge
journal, November 2004

189 Metabolic Acidosis, Hyperglycemia, and Ketonuria in Carbamazepine Overdose
journal, April 1985

Effects of long-term moderate hypercapnia on acid-base balance and growth rate in marine mussels Mytilus galloprovincialis
journal, January 2005

  • Michaelidis, B.; Ouzounis, C.; Paleras, A.
  • Marine Ecology Progress Series, Vol. 293
  • DOI: 10.3354/meps293109

Ecotoxicological aspects related to the presence of pharmaceuticals in the aquatic environment
journal, March 2010

  • Santos, Lúcia H. M. L. M.; Araújo, A. N.; Fachini, Adriano
  • Journal of Hazardous Materials, Vol. 175, Issue 1-3
  • DOI: 10.1016/j.jhazmat.2009.10.100

Superoxide dismutase: Improved assays and an assay applicable to acrylamide gels
journal, November 1971

Predicting the impact of ocean acidification on benthic biodiversity: What can animal physiology tell us?
journal, November 2008

  • Widdicombe, Stephen; Spicer, John I.
  • Journal of Experimental Marine Biology and Ecology, Vol. 366, Issue 1-2
  • DOI: 10.1016/j.jembe.2008.07.024

Seawater acidification by CO2 in a coastal lagoon environment: Effects on life history traits of juvenile mussels Mytilus galloprovincialis
journal, August 2012

  • Range, P.; Piló, D.; Ben-Hamadou, R.
  • Journal of Experimental Marine Biology and Ecology, Vol. 424-425
  • DOI: 10.1016/j.jembe.2012.05.010

Physiological and biochemical responses of three Veneridae clams exposed to salinity changes
journal, November 2014

  • Carregosa, Vanessa; Velez, Cátia; Soares, Amadeu M. V. M.
  • Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, Vol. 177-178
  • DOI: 10.1016/j.cbpb.2014.08.001

The effects of acidic seawater on three species of lamellibranch mollusc
journal, November 1990

Carbamazepine and diclofenac: Removal in wastewater treatment plants and occurrence in water bodies
journal, November 2008

Biochemical, physiological and behavioural markers in the endobenthic bivalve Scrobicularia plana as tools for the assessment of estuarine sediment quality
journal, October 2010

  • Boldina-Cosqueric, Inna; Amiard, Jean-Claude; Amiard-Triquet, Claude
  • Ecotoxicology and Environmental Safety, Vol. 73, Issue 7
  • DOI: 10.1016/j.ecoenv.2010.08.008

Anthropogenic carbon and ocean pH
journal, September 2003

  • Caldeira, Ken; Wickett, Michael E.
  • Nature, Vol. 425, Issue 6956
  • DOI: 10.1038/425365a

Effects of past, present, and future ocean carbon dioxide concentrations on the growth and survival of larval shellfish
journal, September 2010

  • Talmage, S. C.; Gobler, C. J.
  • Proceedings of the National Academy of Sciences, Vol. 107, Issue 40
  • DOI: 10.1073/pnas.0913804107

Ecotoxicology of human pharmaceuticals
journal, February 2006

Food availability outweighs ocean acidification effects in juvenile Mytilus edulis : laboratory and field experiments
journal, January 2013

  • Thomsen, Jörn; Casties, Isabel; Pansch, Christian
  • Global Change Biology, Vol. 19, Issue 4
  • DOI: 10.1111/gcb.12109

Direct photodegradation of carbamazepine followed by micellar electrokinetic chromatography and mass spectrometry
journal, January 2011

Ocean Acidification Increases Copper Toxicity to the Early Life History Stages of the Polychaete Arenicola marina in Artificial Seawater
journal, July 2014

  • Campbell, Anna L.; Mangan, Stephanie; Ellis, Robert P.
  • Environmental Science & Technology, Vol. 48, Issue 16
  • DOI: 10.1021/es502739m

Occurrence of Neutral and Acidic Drugs in the Effluents of Canadian Sewage Treatment Plants
journal, January 2003

  • Metcalfe, Chris D.; Koenig, Brenda G.; Bennie, Don T.
  • Environmental Toxicology and Chemistry, Vol. 22, Issue 12
  • DOI: 10.1897/02-469

Climate change and ocean acidification—Interactions with aquatic toxicology
journal, January 2013

The SLC4 family of HCO3 ? transporters
journal, February 2004

  • Romero, Michael F.; Fulton, Christiaan M.; Boron, Walter F.
  • Pfl�gers Archiv European Journal of Physiology, Vol. 447, Issue 5
  • DOI: 10.1007/s00424-003-1180-2

Biological Impact of Elevated Ocean CO2 Concentrations: Lessons from Animal Physiology and Earth History
journal, August 2004

  • Pörtner, Hans O.; Langenbuch, Martina; Reipschläger, Anke
  • Journal of Oceanography, Vol. 60, Issue 4
  • DOI: 10.1007/s10872-004-5763-0

Respiration and the activity of the respiratory electron transport system in marine zooplankton1
journal, September 1975

Measurement of the Apparent Dissociation Constants of Carbonic acid in Seawater at Atmospheric Pressure1
journal, November 1973

Effects of Ultraviolet Radiation and Contaminant-related Stressors on Arctic Freshwater Ecosystems
journal, November 2006

Occurrence of pharmaceutical products in a municipal effluent and toxicity to rainbow trout (Oncorhynchus mykiss) hepatocytes
journal, July 2006

Recent climate change in the Arctic and its impact on contaminant pathways and interpretation of temporal trend data
journal, April 2005

Ecosystem effects of ocean acidification in times of ocean warming: a physiologist’s view
journal, December 2008

Early responses measured in the brachyuran crab Carcinus maenas exposed to carbamazepine and novobiocin: Application of a 2-tier approach
journal, November 2013

  • Aguirre-Martínez, G. V.; Del Valls, T. A.; Martín-Díaz, M. L.
  • Ecotoxicology and Environmental Safety, Vol. 97
  • DOI: 10.1016/j.ecoenv.2013.07.002

Determination of the equivalence point in potentiometric titrations. Part II
journal, January 1952

Biochemical effects of acetaminophen in aquatic species: edible clams Venerupis decussata and Venerupis philippinarum
journal, June 2013

  • Antunes, S. C.; Freitas, Rosa; Figueira, E.
  • Environmental Science and Pollution Research, Vol. 20, Issue 9
  • DOI: 10.1007/s11356-013-1784-9

Chronic aquatic environmental risks from exposure to human pharmaceuticals
journal, August 2006

Biological mechanisms supporting adaptation to ocean acidification in coastal ecosystems
journal, January 2015

  • Hendriks, Iris E.; Duarte, Carlos M.; Olsen, Ylva S.
  • Estuarine, Coastal and Shelf Science, Vol. 152
  • DOI: 10.1016/j.ecss.2014.07.019

Yes, caffeine, ibuprofen, carbamazepine, novobiocin and tamoxifen have an effect on Corbicula fluminea (Müller, 1774)
journal, October 2015

  • Aguirre-Martínez, Gabriela V.; DelValls, Angel T.; Laura Martín-Díaz, M.
  • Ecotoxicology and Environmental Safety, Vol. 120
  • DOI: 10.1016/j.ecoenv.2015.05.036

Pharmaceuticals in groundwaters
journal, December 2001

Monitoring carbamazepine in surface and wastewaters by an immunoassay based on a monoclonal antibody
journal, July 2009

  • Bahlmann, Arnold; Weller, Michael G.; Panne, Ulrich
  • Analytical and Bioanalytical Chemistry, Vol. 395, Issue 6
  • DOI: 10.1007/s00216-009-2958-7

Regulation of intracellular pH
journal, December 2004

Synergistic effects of temperature extremes, hypoxia, and increases in CO 2 on marine animals: From Earth history to global change
journal, January 2005

Immunomodulation by the interactive effects of cadmium and hypercapnia in marine bivalves Crassostrea virginica and Mercenaria mercenaria
journal, April 2014

  • Ivanina, Anna V.; Hawkins, Chelsea; Sokolova, Inna M.
  • Fish & Shellfish Immunology, Vol. 37, Issue 2
  • DOI: 10.1016/j.fsi.2014.02.016

Ecotoxicological impact of pharmaceuticals found in treated wastewaters: study of carbamazepine, clofibric acid, and diclofenac
journal, July 2003

  • Ferrari, Benoı̂t; Paxéus, Nicklas; Giudice, Roberto Lo
  • Ecotoxicology and Environmental Safety, Vol. 55, Issue 3
  • DOI: 10.1016/S0147-6513(02)00082-9

Occurrence, fate and effects of pharmaceutical substances in the environment- A review
journal, January 1998

First Evidence of Immunomodulation in Bivalves under Seawater Acidification and Increased Temperature
journal, March 2012

Tolerance of Venerupis philippinarum to salinity: Osmotic and metabolic aspects
journal, May 2014

  • Carregosa, Vanessa; Figueira, Etelvina; Gil, Ana M.
  • Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, Vol. 171
  • DOI: 10.1016/j.cbpa.2014.02.009

Consequences of a simulated rapid ocean acidification event for benthic ecosystem processes and functions
journal, August 2013

Pharmaceuticals in the environment: expected and unexpected effects on aquatic fauna: Adverse effects of environmental pharmaceuticals
journal, December 2014

  • Fabbri, Elena
  • Annals of the New York Academy of Sciences, Vol. 1340, Issue 1
  • DOI: 10.1111/nyas.12605

Gene transcription and biomarker responses in the clam Ruditapes philippinarum after exposure to ibuprofen
journal, January 2013

A spectrophotometric method for determination of catalase activity in small tissue samples
journal, October 1988

Hypoxia and Acidification Have Additive and Synergistic Negative Effects on the Growth, Survival, and Metamorphosis of Early Life Stage Bivalves
journal, January 2014

Anthropogenic ocean acidification over the twenty-first century and its impact on calcifying organisms
journal, September 2005

  • Orr, James C.; Fabry, Victoria J.; Aumont, Olivier
  • Nature, Vol. 437, Issue 7059
  • DOI: 10.1038/nature04095

Interactive effects of elevated temperature and CO2 levels on metabolism and oxidative stress in two common marine bivalves (Crassostrea virginica and Mercenaria mercenaria)
journal, April 2013

  • Matoo, Omera B.; Ivanina, Anna V.; Ullstad, Claus
  • Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, Vol. 164, Issue 4
  • DOI: 10.1016/j.cbpa.2012.12.025