Pharmacokinetics of isoflavones from soy infant formula in neonatal and adult rhesus monkeys

Doerge, Daniel R.; Woodling, Kellie A.; Churchwell, Mona I.; Fleck, Stefanie C.; Helferich, William G.

doi:10.1016/j.fct.2016.04.005

Title: Pharmacokinetics of isoflavones from soy infant formula in neonatal and adult rhesus monkeys

Full Record
Other Related Research

Authors:: Doerge, Daniel R.; Woodling, Kellie A.; Churchwell, Mona I.; Fleck, Stefanie C.; Helferich, William G.

Publication Date:: 2016-06-01

Sponsoring Org.:: USDOE

OSTI Identifier:: 1359108

Resource Type:: Publisher's Accepted Manuscript

Journal Name:: Food and Chemical Toxicology

Additional Journal Information:: Journal Name: Food and Chemical Toxicology Journal Volume: 92 Journal Issue: C; Journal ID: ISSN 0278-6915

Publisher:: Elsevier

Country of Publication:: United Kingdom

Language:: English

Citation Formats


                    Doerge, Daniel R., Woodling, Kellie A., Churchwell, Mona I., Fleck, Stefanie C., and Helferich, William G. Pharmacokinetics of isoflavones from soy infant formula in neonatal and adult rhesus monkeys.  United Kingdom: N. p., 2016. 
Web.  doi:10.1016/j.fct.2016.04.005.

Copy to clipboard


                    Doerge, Daniel R., Woodling, Kellie A., Churchwell, Mona I., Fleck, Stefanie C., & Helferich, William G. Pharmacokinetics of isoflavones from soy infant formula in neonatal and adult rhesus monkeys.  United Kingdom.  https://doi.org/10.1016/j.fct.2016.04.005

Copy to clipboard


                    Doerge, Daniel R., Woodling, Kellie A., Churchwell, Mona I., Fleck, Stefanie C., and Helferich, William G. Wed .  
"Pharmacokinetics of isoflavones from soy infant formula in neonatal and adult rhesus monkeys".  United Kingdom.  https://doi.org/10.1016/j.fct.2016.04.005.

Copy to clipboard


                    
@article{osti_1359108,

  title        = {Pharmacokinetics of isoflavones from soy infant formula in neonatal and adult rhesus monkeys},

  author       = {Doerge, Daniel R. and Woodling, Kellie A. and Churchwell, Mona I. and Fleck, Stefanie C. and Helferich, William G.},

  abstractNote = {},

  doi          = {10.1016/j.fct.2016.04.005},

  journal      = {Food and Chemical Toxicology},

  number       = C,

  volume       = 92,

  place        = {United Kingdom},

  year         = {2016},

  month        = {6}

}

Copy to clipboard

Journal Article:

Free Publicly Available Full Text

Accepted Manuscript (Publisher)

Publisher's Version of Record
https://doi.org/10.1016/j.fct.2016.04.005

Other availability

Search WorldCat to find libraries that may hold this journal

Citation Metrics:

Cited by: 14 works

Citation information provided by
Web of Science

Save / Share:

Export Metadata

Save to My Library

Similar Records in DOE PAGES and OSTI.GOV collections:

Pharmacokinetics of bisphenol A in neonatal and adult rhesus monkeys

Journal Article Doerge, Daniel R., E-mail: daniel.doerge@fda.hhs.go ; Twaddle, Nathan C ; Woodling, Kellie A ; ... - Toxicology and Applied Pharmacology

Bisphenol A (BPA) is a high-production volume industrial chemical used in the manufacture of polycarbonate plastic products and epoxy resin-based food can liners. The presence of BPA in urine of > 90% of Americans aged 6-60 is controversial because of the potential for endocrine disruption, particularly during perinatal development, as suggested by in vitro, experimental animal, and epidemiological studies. The current study used LC/MS/MS to measure serum pharmacokinetics of aglycone (active) and conjugated (inactive) BPA in adult and neonatal rhesus monkeys by oral (PND 5, 35, 70) and intravenous injection (PND 77) routes using d6-BPA to avoid sample contamination. Themore »« less
https://doi.org/10.1016/j.taap.2010.07.009
Effect of marginal maternal zinc intake on zinc absorption and growth of 3-month-old infant rhesus monkeys

Journal Article Loennerdal, B K ; Keen, C L ; Bell, J G ; ... - American Journal of Diseases of Children; (USA)

One compensatory mechanism for marginal zinc intake may be through an enhanced absorption of zinc. Such a compensatory mechanism could be of value to the neonate, as poor zinc nutriture during early life has severe consequences on growth and development. We studied the uptake of zinc by 3-month-old infant rhesus monkeys born to dams fed control diets 100 micrograms of zinc per gram of diet or zinc-restricted diets (4 micrograms of zinc per gram of diet). Zinc uptake/retention was studied by feeding 3-month-old infant monkeys that had fasted an infant formula containing zinc 65 by gavage. Whole body radioactivity wasmore »« less
Transfer of hexachlorobenzene and polychlorinated biphenyls to nursing infant rhesus monkeys: enhanced toxicity

Journal Article Bailey, J ; Knauf, V ; Mueller, W ; ... - Environ. Res.; (United States)

Clophen A-30 (CA-30 or PCB) or hexachlorobenzene (HCB) were given daily by gavage to lactating rhesus monkeys for either 30 days (CA-30, 16 mg/kg/day) or 60 days (HCB, 64 mg/kg/day) to three infant-mother pairs per compound. The extent to which the CA-30 or HCB were concentreated in the milk of the mothers and consequently transferred to the nursing infants was determined by measuring concentrations of both substances in milk and serum samples collected at frequent intervals. One mother and all the infants from each group were sacrificed and the tissue content of HCB or PCBs measured. Milk concentrations averaged 20more »« less
https://doi.org/10.1016/0013-9351(80)90021-3
Effect of restricted maternal zinc intake on zinc absorption in infant rhesus monkeys

Conference Loennerdal, B ; Keen, C L ; Bell, J G ; ... - Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)

One compensatory mechanism for marginal Zn intake may be enhanced absorption of Zn. While there is some experimental evidence to support this hypothesis from rodent models, there are few data from higher mammalian species. Such a compensatory mechanism of enhanced Zn absorption could be of value to the neonate, as poor Zn nutriture during early life has severe consequences on growth and development. The authors have investigated the absorption of Zn by infant Rhesus monkeys born to control and Zn-restricted mothers. Fasted infant monkeys (100 d) from mothers fed a 100 or 4 ppm Zn diet were intubated with anmore »« less
Ozone and allergen exposure during postnatal development alters the frequency and airway distribution of CD25+ cells in infant rhesus monkeys

Journal Article Miller, Lisa A ; California National Primate Research Center, University of California, Davis, CA 95616 ; Gerriets, Joan E ; ... - Toxicology and Applied Pharmacology

The epidemiologic link between air pollutant exposure and asthma has been supported by experimental findings, but the mechanisms are not understood. In this study, we evaluated the impact of combined ozone and house dust mite (HDM) exposure on the immunophenotype of peripheral blood and airway lymphocytes from rhesus macaque monkeys during the postnatal period of development. Starting at 30 days of age, monkeys were exposed to 11 cycles of filtered air, ozone, HDM aerosol, or ozone + HDM aerosol. Each cycle consisted of ozone delivered at 0.5 ppm for 5 days (8 h/day), followed by 9 days of filtered air;more »« less
https://doi.org/10.1016/j.taap.2008.12.031

Similar Records