Integrative genomic and proteomic profiling of human neuroblastoma SH-SY5Y cells reveals signatures of endosulfan exposure

Gandhi, Deepa; Tarale, Prashant; Naoghare, Pravin K.; Bafana, Amit; Kannan, Krishnamurthi; Sivanesan, Saravanadevi

doi:10.1016/j.etap.2015.11.021

Title: Integrative genomic and proteomic profiling of human neuroblastoma SH-SY5Y cells reveals signatures of endosulfan exposure

Full Record
Other Related Research

Authors:: Gandhi, Deepa; Tarale, Prashant; Naoghare, Pravin K.; Bafana, Amit; Kannan, Krishnamurthi; Sivanesan, Saravanadevi

Publication Date:: Fri Jan 01 00:00:00 EST 2016

Sponsoring Org.:: USDOE

OSTI Identifier:: 1359100

Grant/Contract Number:: G-1-1872

Resource Type:: Publisher's Accepted Manuscript

Journal Name:: Environmental Toxicology and Pharmacology

Additional Journal Information:: Journal Name: Environmental Toxicology and Pharmacology Journal Volume: 41 Journal Issue: C; Journal ID: ISSN 1382-6689

Publisher:: Elsevier

Country of Publication:: Country unknown/Code not available

Language:: English

Citation Formats


                    Gandhi, Deepa, Tarale, Prashant, Naoghare, Pravin K., Bafana, Amit, Kannan, Krishnamurthi, and Sivanesan, Saravanadevi. Integrative genomic and proteomic profiling of human neuroblastoma SH-SY5Y cells reveals signatures of endosulfan exposure.  Country unknown/Code not available: N. p., 2016. 
Web.  doi:10.1016/j.etap.2015.11.021.

Copy to clipboard


                    Gandhi, Deepa, Tarale, Prashant, Naoghare, Pravin K., Bafana, Amit, Kannan, Krishnamurthi, & Sivanesan, Saravanadevi. Integrative genomic and proteomic profiling of human neuroblastoma SH-SY5Y cells reveals signatures of endosulfan exposure.  Country unknown/Code not available.  https://doi.org/10.1016/j.etap.2015.11.021

Copy to clipboard


                    Gandhi, Deepa, Tarale, Prashant, Naoghare, Pravin K., Bafana, Amit, Kannan, Krishnamurthi, and Sivanesan, Saravanadevi. Fri .  
"Integrative genomic and proteomic profiling of human neuroblastoma SH-SY5Y cells reveals signatures of endosulfan exposure".  Country unknown/Code not available.  https://doi.org/10.1016/j.etap.2015.11.021.

Copy to clipboard


                    
@article{osti_1359100,

  title        = {Integrative genomic and proteomic profiling of human neuroblastoma SH-SY5Y cells reveals signatures of endosulfan exposure},

  author       = {Gandhi, Deepa and Tarale, Prashant and Naoghare, Pravin K. and Bafana, Amit and Kannan, Krishnamurthi and Sivanesan, Saravanadevi},

  abstractNote = {},

  doi          = {10.1016/j.etap.2015.11.021},

  journal      = {Environmental Toxicology and Pharmacology},

  number       = C,

  volume       = 41,

  place        = {Country unknown/Code not available},

  year         = {Fri Jan 01 00:00:00 EST 2016},

  month        = {Fri Jan 01 00:00:00 EST 2016}

}

Copy to clipboard

Journal Article:

Free Publicly Available Full Text

Accepted Manuscript (Publisher)

Publisher's Version of Record
https://doi.org/10.1016/j.etap.2015.11.021

Other availability

Search WorldCat to find libraries that may hold this journal

Citation Metrics:

Cited by: 8 works

Citation information provided by
Web of Science

Save / Share:

Export Metadata

Save to My Library

Similar Records in DOE PAGES and OSTI.GOV collections:

Rosiglitazone protects human neuroblastoma SH-SY5Y cells against acetaldehyde-induced cytotoxicity

Journal Article Jung, Tae Woo ; Lee, Ji Young ; Shim, Wan Sub ; ... - Biochemical and Biophysical Research Communications

Acetaldehyde, an inhibitor of mitochondrial function, has been widely used as a neurotoxin because it elicits a severe Parkinson's disease-like syndrome with elevation of the intracellular reactive oxygen species level and apoptosis. Rosiglitazone, a peroxisome proliferator-activated receptor-{gamma} agonist, has been known to show various non-hypoglycemic effects, including anti-inflammatory, anti-atherogenic, and anti-apoptotic. In this study, we investigated the protective effects of rosiglitazone on acetaldehyde-induced apoptosis in human neuroblastoma SH-SY5Y cells and attempted to examine its mechanism. Acetaldehyde-induced apoptosis was moderately reversed by rosiglitazone treatment. Our results suggest that the protective effects of rosiglitazone on acetaldehyde-induced apoptosis may be ascribed to abilitymore »« less
https://doi.org/10.1016/j.bbrc.2005.11.177
Effect of toluene diisocyanate on homeostasis of intracellular-free calcium in human neuroblastoma SH-SY5Y Cells

Journal Article Liu, P -S ; Chiung, Y -M ; Department of Microbiology and Immunology, National Defense Medical Center, Taipei, Taiwan ; ... - Toxicology and Applied Pharmacology

The mechanisms of TDI (2,4-toluene diisocyanate)-induced occupational asthma are not fully established. Previous studies have indicated that TDI induces non-specific bronchial hyperreactivity to methacholine and induces contraction of smooth muscle tissue by activating 'capsaicin-sensitive' nerves resulting asthma. Cytosolic-free calcium ion concentrations ([Ca{sup 2+}]{sub c}) are elevated when either capsaicin acts at vanilloid receptors, or methacholine at muscarinic receptors. This study therefore investigated the effects of TDI on Ca{sup 2+} mobilization in human neuroblastoma SH-SY5Y cells. TDI was found to elevate [Ca{sup 2+}]{sub c} by releasing Ca{sup 2+} from the intracellular stores and extracellular Ca{sup 2+} influx. 500 {mu}M TDI inducedmore »« less
https://doi.org/10.1016/j.taap.2005.06.019
Cyclophilin B protects SH-SY5Y human neuroblastoma cells against MPP{sup +}-induced neurotoxicity via JNK pathway

Journal Article Oh, Yoojung ; Jeong, Kwon ; Kim, Kiyoon ; ... - Biochemical and Biophysical Research Communications

Parkinson's disease (PD) is the second most common neurodegenerative disorder of aging. PD involves a progressive loss of dopaminergic neurons in the substantia nigra pars compacta. 1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyidine (MPTP) and its toxic metabolite 1-methyl-4-phenylpyridinium ion (MPP+) inhibit the complex I of the mitochondrial electron transport chain, and have been widely used to construct PD models. Cyclophilin B (CypB) is an endoplasmic reticulum protein that binds to cyclosporine A as a cyclophilin family member. CypB has peptidyl-prolyl cis-trans isomerase (PPIase) activity. We investigated the protective effects of overexpressed CypB on MPP+-induced neurocytotoxicity in SH-SY5Y human neuroblastoma cells. Overexpressed CypBmore »« less
https://doi.org/10.1016/J.BBRC.2016.08.135
Enhanced oxidative stress and aberrant mitochondrial biogenesis in human neuroblastoma SH-SY5Y cells during methamphetamine induced apoptosis

Journal Article Wu, C -W ; Ping, Y -H ; Department of Education and Research, Taipei City Hospital, Taipei, Taiwan ; ... - Toxicology and Applied Pharmacology

Methamphetamine (METH) is an abused drug that may cause psychiatric and neurotoxic damage, including degeneration of monoaminergic terminals and apoptosis of non-monoaminergic cells in Brain. The cellular and molecular mechanisms underlying these METH-induced neurotoxic effects remain to be clarified. In this study, we performed a time course assessment to investigate the effects of METH on intracellular oxidative stress and mitochondrial alterations in a human dopaminergic neuroblastoma SH-SY5Y cell line. We characterized that METH induces a temporal sequence of several cellular events including, firstly, a decrease in mitochondrial membrane potential within 1 h of the METH treatment, secondly, an extensive declinemore »« less
https://doi.org/10.1016/j.taap.2007.01.011
Neurofunctional endpoints assessed in human neuroblastoma SH-SY5Y cells for estimation of acute systemic toxicity

Journal Article Gustafsson, Helena ; Runesson, Johan ; Lundqvist, Jessica ; ... - Toxicology and Applied Pharmacology

The objective of the EU-funded integrated project ACuteTox is to develop a strategy in which general cytotoxicity, together with organ-specific toxicity and biokinetic features, are used for the estimation of human acute systemic toxicity. Our role in the project is to characterise the effect of reference chemicals with regard to neurotoxicity. We studied cell membrane potential (CMP), noradrenalin (NA) uptake, acetylcholine esterase (AChE) activity, acetylcholine receptor (AChR) signalling and voltage-operated calcium channel (VOCC) function in human neuroblastoma SH-SY5Y cells after exposure to 23 pharmaceuticals, pesticides or industrial chemicals. Neurotoxic alert chemicals were identified by comparing the obtained data with cytotoxicitymore »« less
https://doi.org/10.1016/j.taap.2010.02.018

Similar Records