Engineering lipid overproduction in the oleaginous yeast Yarrowia lipolytica

Qiao, Kangjian; Imam Abidi, Syed Hussain; Liu, Hongjuan; Zhang, Haoran; Chakraborty, Sagar; Watson, Nicki; Kumaran Ajikumar, Parayil; Stephanopoulos, Gregory

doi:10.1016/j.ymben.2015.02.005

Title: Engineering lipid overproduction in the oleaginous yeast Yarrowia lipolytica

Authors:

; Imam Abidi, Syed Hussain; Liu, Hongjuan; Zhang, Haoran; Chakraborty, Sagar; Watson, Nicki; Kumaran Ajikumar, Parayil; Stephanopoulos, Gregory

Publication Date:: Fri May 01 00:00:00 EDT 2015

Sponsoring Org.:: USDOE

OSTI Identifier:: 1357838

Grant/Contract Number:: 6926611; 6922111

Resource Type:: Publisher's Accepted Manuscript

Journal Name:: Metabolic Engineering

Additional Journal Information:: Journal Name: Metabolic Engineering Journal Volume: 29 Journal Issue: C; Journal ID: ISSN 1096-7176

Publisher:: Elsevier

Country of Publication:: Belgium

Language:: English

Citation Formats


                    Qiao, Kangjian, Imam Abidi, Syed Hussain, Liu, Hongjuan, Zhang, Haoran, Chakraborty, Sagar, Watson, Nicki, Kumaran Ajikumar, Parayil, and Stephanopoulos, Gregory. Engineering lipid overproduction in the oleaginous yeast Yarrowia lipolytica.  Belgium: N. p., 2015. 
Web.  doi:10.1016/j.ymben.2015.02.005.

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                    Qiao, Kangjian, Imam Abidi, Syed Hussain, Liu, Hongjuan, Zhang, Haoran, Chakraborty, Sagar, Watson, Nicki, Kumaran Ajikumar, Parayil, & Stephanopoulos, Gregory. Engineering lipid overproduction in the oleaginous yeast Yarrowia lipolytica.  Belgium.  https://doi.org/10.1016/j.ymben.2015.02.005

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                    Qiao, Kangjian, Imam Abidi, Syed Hussain, Liu, Hongjuan, Zhang, Haoran, Chakraborty, Sagar, Watson, Nicki, Kumaran Ajikumar, Parayil, and Stephanopoulos, Gregory. Fri .  
"Engineering lipid overproduction in the oleaginous yeast Yarrowia lipolytica".  Belgium.  https://doi.org/10.1016/j.ymben.2015.02.005.

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@article{osti_1357838,

  title        = {Engineering lipid overproduction in the oleaginous yeast Yarrowia lipolytica},

  author       = {Qiao, Kangjian and Imam Abidi, Syed Hussain and Liu, Hongjuan and Zhang, Haoran and Chakraborty, Sagar and Watson, Nicki and Kumaran Ajikumar, Parayil and Stephanopoulos, Gregory},

  abstractNote = {},

  doi          = {10.1016/j.ymben.2015.02.005},

  journal      = {Metabolic Engineering},

  number       = C,

  volume       = 29,

  place        = {Belgium},

  year         = {Fri May 01 00:00:00 EDT 2015},

  month        = {Fri May 01 00:00:00 EDT 2015}

}

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https://doi.org/10.1016/j.ymben.2015.02.005

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Title: Engineering lipid overproduction in the oleaginous yeast Yarrowia lipolytica

Citation Formats

Environmental, economic, and energetic costs and benefits of biodiesel and ethanol biofuels journal, July 2006

Lipids from heterotrophic microbes: advances in metabolism research journal, February 2011

Ethanol Tolerance in the Yeast Saccharomyces cerevisiae Is Dependent on Cellular Oleic Acid Content journal, March 2003

Placing microalgae on the biofuels priority list: a review of the technological challenges journal, November 2009

Loss of stearoyl–CoA desaturase-1 function protects mice against adiposity journal, August 2002

Selection and optimization of microbial hosts for biofuels production journal, November 2008

Acyl-CoA synthesis, lipid metabolism and lipotoxicity journal, March 2010

Importance of systems biology in engineering microbes for biofuel production journal, June 2008

Yarrowia lipolytica as a model for bio-oil production journal, November 2009

Eyeing Oil, Synthetic Biologists Mine Microbes for Black Gold journal, October 2008

3-Methyladenine: Specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes journal, March 1982

Involvement of the G3P shuttle and β-oxidation pathway in the control of TAG synthesis and lipid accumulation in Yarrowia lipolytica journal, September 2011

Distinct regulation of stearoyl-CoA desaturase 1 gene expression by cis and trans C18:1 fatty acids in human aortic smooth muscle cells journal, November 2011

Polymer-protomer transition of acetyl-CoA carboxylase occurs in vivo and varies with nutritional conditions. journal, November 1980

The role of malic enzyme as the provider of NADPH in oleaginous microorganisms: a reappraisal and unsolved problems journal, April 2014

Biodiesel from microalgae journal, May 2007

Engineering microbes for tolerance to next-generation biofuels journal, January 2011

Role of stearoyl-coenzyme A desaturase in regulating lipid metabolism journal, January 2008

Microbial production of fatty-acid-derived fuels and chemicals from plant biomass journal, January 2010

Overproduction of free fatty acids in E. coli: Implications for biodiesel production journal, November 2008

Metabolic engineering of Escherichia coli for 1-butanol production journal, November 2008

Mechanisms Related to the Homeostatic Regulation of Lipogenesis journal, October 1965

Single cell oil production by Yarrowia lipolytica growing on an industrial derivative of animal fat in batch cultures journal, March 2002

Expression of inulinase gene in the oleaginous yeast Yarrowia lipolytica and single cell oil production from inulin-containingmaterials journal, November 2010

Metabolic engineering of microbial pathways for advanced biofuels production journal, December 2011

Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies journal, July 2008

Microalgal triacylglycerols as feedstocks for biofuel production: perspectives and advances journal, May 2008

Selective activation of the fatty acid synthesis pathway in human prostate cancer journal, January 2000

Engineering the push and pull of lipid biosynthesis in oleaginous yeast Yarrowia lipolytica for biofuel production journal, January 2013

Stress tolerance in a yeast lipid mutant: membrane lipids influence tolerance to heat and ethanol independently of heat shock proteins and trehalose journal, July 1999

Autophagy: process and function journal, November 2007

Dynamics and diversity in autophagy mechanisms: lessons from yeast journal, June 2009

Sugarcane bagasse hemicellulose hydrolysate for ethanol production by acid recovery process journal, January 2008

Inhibition of StearoylCoA Desaturase-1 Inactivates Acetyl-CoA Carboxylase and Impairs Proliferation in Cancer Cells: Role of AMPK journal, August 2009

Advanced biofuel production in microbes journal, January 2010

Renewable fuels from algae: An answer to debatable land based fuels journal, January 2011

Lipid production by Yarrowia lipolytica growing on industrial glycerol in a single-stage continuous culture journal, March 2002

Enzymes of triacylglycerol synthesis and their regulation journal, March 2004

Role of stearoyl-coenzyme A desaturase in lipid metabolism journal, February 2003

Harnessing Yarrowia lipolytica lipogenesis to create a platform for lipid and biofuel production journal, January 2014

Fatty Acid Synthesis and its Regulation journal, June 1983

Microbial Conversion of Olive Oil Mill Wastewaters into Lipids Suitable for Biodiesel Production journal, July 2010

Regulation of the Activity of Acetyl Coenzyme A Carboxylase by Palmitoyl Coenzyme A and Citrate journal, November 1972

Lipid Accumulation, Lipid Body Formation, and Acyl Coenzyme A Oxidases of the Yeast Yarrowia lipolytica journal, July 2004

Autophagy in yeast demonstrated with proteinase-deficient mutants and conditions for its induction journal, October 1992

Environmental, economic, and energetic costs and benefits of biodiesel and ethanol biofuels
journal, July 2006

Lipids from heterotrophic microbes: advances in metabolism research
journal, February 2011

Ethanol Tolerance in the Yeast Saccharomyces cerevisiae Is Dependent on Cellular Oleic Acid Content
journal, March 2003

Placing microalgae on the biofuels priority list: a review of the technological challenges
journal, November 2009

Loss of stearoyl–CoA desaturase-1 function protects mice against adiposity
journal, August 2002

Selection and optimization of microbial hosts for biofuels production
journal, November 2008

Acyl-CoA synthesis, lipid metabolism and lipotoxicity
journal, March 2010

Importance of systems biology in engineering microbes for biofuel production
journal, June 2008

Yarrowia lipolytica as a model for bio-oil production
journal, November 2009

Eyeing Oil, Synthetic Biologists Mine Microbes for Black Gold
journal, October 2008

3-Methyladenine: Specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes
journal, March 1982

Involvement of the G3P shuttle and β-oxidation pathway in the control of TAG synthesis and lipid accumulation in Yarrowia lipolytica
journal, September 2011

Distinct regulation of stearoyl-CoA desaturase 1 gene expression by cis and trans C18:1 fatty acids in human aortic smooth muscle cells
journal, November 2011

Polymer-protomer transition of acetyl-CoA carboxylase occurs in vivo and varies with nutritional conditions.
journal, November 1980

The role of malic enzyme as the provider of NADPH in oleaginous microorganisms: a reappraisal and unsolved problems
journal, April 2014

Biodiesel from microalgae
journal, May 2007

Engineering microbes for tolerance to next-generation biofuels
journal, January 2011

Role of stearoyl-coenzyme A desaturase in regulating lipid metabolism
journal, January 2008

Microbial production of fatty-acid-derived fuels and chemicals from plant biomass
journal, January 2010

Overproduction of free fatty acids in E. coli: Implications for biodiesel production
journal, November 2008

Metabolic engineering of Escherichia coli for 1-butanol production
journal, November 2008

Mechanisms Related to the Homeostatic Regulation of Lipogenesis
journal, October 1965

Single cell oil production by Yarrowia lipolytica growing on an industrial derivative of animal fat in batch cultures
journal, March 2002

Expression of inulinase gene in the oleaginous yeast Yarrowia lipolytica and single cell oil production from inulin-containingmaterials
journal, November 2010

Metabolic engineering of microbial pathways for advanced biofuels production
journal, December 2011

Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies
journal, July 2008

Microalgal triacylglycerols as feedstocks for biofuel production: perspectives and advances
journal, May 2008

Selective activation of the fatty acid synthesis pathway in human prostate cancer
journal, January 2000

Engineering the push and pull of lipid biosynthesis in oleaginous yeast Yarrowia lipolytica for biofuel production
journal, January 2013

Stress tolerance in a yeast lipid mutant: membrane lipids influence tolerance to heat and ethanol independently of heat shock proteins and trehalose
journal, July 1999

Autophagy: process and function
journal, November 2007

Dynamics and diversity in autophagy mechanisms: lessons from yeast
journal, June 2009

Sugarcane bagasse hemicellulose hydrolysate for ethanol production by acid recovery process
journal, January 2008

Inhibition of StearoylCoA Desaturase-1 Inactivates Acetyl-CoA Carboxylase and Impairs Proliferation in Cancer Cells: Role of AMPK
journal, August 2009

Advanced biofuel production in microbes
journal, January 2010

Renewable fuels from algae: An answer to debatable land based fuels
journal, January 2011

Lipid production by Yarrowia lipolytica growing on industrial glycerol in a single-stage continuous culture
journal, March 2002

Enzymes of triacylglycerol synthesis and their regulation
journal, March 2004

Role of stearoyl-coenzyme A desaturase in lipid metabolism
journal, February 2003

Harnessing Yarrowia lipolytica lipogenesis to create a platform for lipid and biofuel production
journal, January 2014

Fatty Acid Synthesis and its Regulation
journal, June 1983

Microbial Conversion of Olive Oil Mill Wastewaters into Lipids Suitable for Biodiesel Production
journal, July 2010

Regulation of the Activity of Acetyl Coenzyme A Carboxylase by Palmitoyl Coenzyme A and Citrate
journal, November 1972

Lipid Accumulation, Lipid Body Formation, and Acyl Coenzyme A Oxidases of the Yeast Yarrowia lipolytica
journal, July 2004

Autophagy in yeast demonstrated with proteinase-deficient mutants and conditions for its induction
journal, October 1992