skip to main content
DOE PAGES title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: A highly sensitive x-ray imaging modality for hepatocellular carcinoma detection in vitro

Abstract

Innovations that improve sensitivity and reduce cost are of paramount importance in diagnostic imaging. The novel x-ray imaging modality called Spatial Frequency Heterodyne Imaging (SFHI) is based on a linear arrangement of x-ray source, tissue, and x-ray detector, much like that of a conventional x-ray imaging apparatus. However, SFHI rests on a complete paradigm reversal compared to conventional x-ray absorption-based radiology: while scattered x-rays are carefully rejected in absorption-based x-ray radiology to enhance the image contrast, SFHI forms images exclusively from x-rays scattered by the tissue. Here in this study we use numerical processing to produce x-ray scatter images of Hepatocellular Carcinoma (HCC) labeled with a nanoparticle contrast agent. We subsequently compare the sensitivity of SFHI in this application to that of both conventional x-ray imaging and Magnetic Resonance Imaging (MRI). Although SFHI is still in the early stages of its development, our results show that the sensitivity of SFHI is an order of magnitude greater than that of absorption-based x-ray imaging and approximately equal to that of MRI. Lastly, as x-ray imaging modalities typically have lower installation and service costs compared to MRI, SFHI could become a cost effective alternative to MRI, particularly in areas of the world withmore » inadequate availability of MRI facilities.« less

Authors:
 [1];  [2];  [3];  [3];  [1]
  1. Brown Univ., Providence, RI (United States). Dept. of Chemistry
  2. Brown Univ., Providence, RI (United States). Dept. of Neuroscience
  3. Brown Univ., Providence, RI (United States). Rhode Island Hospital and Warren Alpert Medical School, Liver Research Center
Publication Date:
Research Org.:
Brown Univ., Providence, RI (United States)
Sponsoring Org.:
USDOE; National Institutes of Health (NIH)
OSTI Identifier:
1357200
Grant/Contract Number:  
FG02-08ER15937; CA123544
Resource Type:
Accepted Manuscript
Journal Name:
Physics in Medicine and Biology
Additional Journal Information:
Journal Volume: 60; Journal Issue: 2; Journal ID: ISSN 0031-9155
Publisher:
IOP Publishing
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; X-ray scatter imaging; magnetic resonance imaging; cancer detection; image processing; nanoparticle contrast agents

Citation Formats

Rand, Danielle, Walsh, Edward G., Derdak, Zoltan, Wands, Jack R., and Rose-Petruck, Christoph. A highly sensitive x-ray imaging modality for hepatocellular carcinoma detection in vitro. United States: N. p., 2015. Web. doi:10.1088/0031-9155/60/2/769.
Rand, Danielle, Walsh, Edward G., Derdak, Zoltan, Wands, Jack R., & Rose-Petruck, Christoph. A highly sensitive x-ray imaging modality for hepatocellular carcinoma detection in vitro. United States. doi:10.1088/0031-9155/60/2/769.
Rand, Danielle, Walsh, Edward G., Derdak, Zoltan, Wands, Jack R., and Rose-Petruck, Christoph. Mon . "A highly sensitive x-ray imaging modality for hepatocellular carcinoma detection in vitro". United States. doi:10.1088/0031-9155/60/2/769. https://www.osti.gov/servlets/purl/1357200.
@article{osti_1357200,
title = {A highly sensitive x-ray imaging modality for hepatocellular carcinoma detection in vitro},
author = {Rand, Danielle and Walsh, Edward G. and Derdak, Zoltan and Wands, Jack R. and Rose-Petruck, Christoph},
abstractNote = {Innovations that improve sensitivity and reduce cost are of paramount importance in diagnostic imaging. The novel x-ray imaging modality called Spatial Frequency Heterodyne Imaging (SFHI) is based on a linear arrangement of x-ray source, tissue, and x-ray detector, much like that of a conventional x-ray imaging apparatus. However, SFHI rests on a complete paradigm reversal compared to conventional x-ray absorption-based radiology: while scattered x-rays are carefully rejected in absorption-based x-ray radiology to enhance the image contrast, SFHI forms images exclusively from x-rays scattered by the tissue. Here in this study we use numerical processing to produce x-ray scatter images of Hepatocellular Carcinoma (HCC) labeled with a nanoparticle contrast agent. We subsequently compare the sensitivity of SFHI in this application to that of both conventional x-ray imaging and Magnetic Resonance Imaging (MRI). Although SFHI is still in the early stages of its development, our results show that the sensitivity of SFHI is an order of magnitude greater than that of absorption-based x-ray imaging and approximately equal to that of MRI. Lastly, as x-ray imaging modalities typically have lower installation and service costs compared to MRI, SFHI could become a cost effective alternative to MRI, particularly in areas of the world with inadequate availability of MRI facilities.},
doi = {10.1088/0031-9155/60/2/769},
journal = {Physics in Medicine and Biology},
number = 2,
volume = 60,
place = {United States},
year = {2015},
month = {1}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record

Citation Metrics:
Cited by: 4 works
Citation information provided by
Web of Science

Save / Share: