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Title: A rapid method for quantification of 242Pu in urine using extraction chromatography and ICP-MS

Occupational exposure to plutonium is generally monitored through analysis of urine samples. Typically, plutonium is separated from the sample and other actinides, and the concentration is determined using alpha spectroscopy. Current methods for separations and analysis are lengthy and require long count times. A new method for monitoring occupational exposure levels of plutonium has been developed, which requires fewer steps and overall less time than the alpha spectroscopy method. In this method, the urine is acidified, and a 239Pu internal standard is added. The urine is digested in a microwave oven, and plutonium is separated using an Eichrom TRU Resin column. The plutonium is eluted, and the eluant is injected directly into the Inductively Coupled Plasma–Mass Spectrometer (ICP-MS). Compared to a direct “dilute and shoot” method, a 30-fold improvement in sensitivity is achieved. This method was validated by analyzing several batches of spiked samples. Based on these analyses, a combined standard uncertainty plot, which relates uncertainty to concentration, was produced. As a result, the MDA 95 was calculated to be 7.0 × 10 –7 μg L –1, and the Lc95 was calculated to be 3.5 × 10 –7 μg L –1 for this method.
 [1] ;  [2] ;  [2] ;  [3]
  1. Univ. of Nevada, Las Vegas, NV (United States)
  2. Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
  3. Colorado State Univ., Fort Collins, CO (United States)
Publication Date:
Grant/Contract Number:
Accepted Manuscript
Journal Name:
Health Physics
Additional Journal Information:
Journal Volume: 112; Journal Issue: 3; Journal ID: ISSN 0017-9078
Health Physics Society
Research Org:
Nuclear Science and Security Consortium, Berkeley, CA (United States)
Sponsoring Org:
USDOE National Nuclear Security Administration (NNSA), Office of Defense Programs (DP) (NA-10)
Country of Publication:
United States
60 APPLIED LIFE SCIENCES; 62 RADIOLOGY AND NUCLEAR MEDICINE; bioassay; plasma; plutonium; radiation protection
OSTI Identifier: