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Title: When evolution is the solution to pollution: Key principles, and lessons from rapid repeated adaptation of killifish ( Fundulus heteroclitus ) populations

Abstract

Abstract For most species, evolutionary adaptation is not expected to be sufficiently rapid to buffer the effects of human‐mediated environmental changes, including environmental pollution. Here we review how key features of populations, the characteristics of environmental pollution, and the genetic architecture underlying adaptive traits, may interact to shape the likelihood of evolutionary rescue from pollution. Large populations of Atlantic killifish (Fundulus heteroclitus) persist in some of the most contaminated estuaries of the United States, and killifish studies have provided some of the first insights into the types of genomic changes that enable rapid evolutionary rescue from complexly degraded environments. We describe how selection by industrial pollutants and other stressors has acted on multiple populations of killifish and posit that extreme nucleotide diversity uniquely positions this species for successful evolutionary adaptation. Mechanistic studies have identified some of the genetic underpinnings of adaptation to a well‐studied class of toxic pollutants; however, multiple genetic regions under selection in wild populations seem to reflect more complex responses to diverse native stressors and/or compensatory responses to primary adaptation. The discovery of these pollution‐adapted killifish populations suggests that the evolutionary influence of anthropogenic stressors as selective agents occurs widely. Yet adaptation to chemical pollution in terrestrialmore » and aquatic vertebrate wildlife may rarely be a successful “solution to pollution” because potentially adaptive phenotypes may be complex and incur fitness costs, and therefore be unlikely to evolve quickly enough, especially in species with small population sizes.« less

Authors:
ORCiD logo [1];  [2];  [3]; ORCiD logo [4];  [5]
+ Show Author Affiliations
  1. Department of Environmental Toxicology University of California Davis Davis CA USA
  2. Atlantic Ecology Division National Health and Environmental Effects Research Laboratory Office of Research and Development Oak Ridge Institute for Science and Education US Environmental Protection Agency Narragansett RI USA
  3. Department of Molecular and Cell Biology University of Connecticut Storrs CT USA
  4. Department of Biology Woods Hole Oceanographic Institution Woods Hole MA USA, Superfund Research Program Boston University Boston MA USA
  5. Atlantic Ecology Division National Health and Environmental Effects Research Laboratory Office of Research and Development US Environmental Protection Agency Narragansett RI USA
Publication Date:
Research Org.:
Oak Ridge Institute for Science and Education (ORISE), Oak Ridge, TN (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1353288
Alternate Identifier(s):
OSTI ID: 1353289; OSTI ID: 1625870
Grant/Contract Number:  
SC0014664
Resource Type:
Published Article
Journal Name:
Evolutionary Applications
Additional Journal Information:
Journal Name: Evolutionary Applications Journal Volume: 10 Journal Issue: 8; Journal ID: ISSN 1752-4571
Publisher:
Wiley-Blackwell
Country of Publication:
United Kingdom
Language:
English
Subject:
Evolutionary Biology; adaptation; contemporary evolution; ecological genetics; ecotoxicology; genomics/proteomics; molecular evolution; natural selection and contemporary evolution; population genetics—empirical

Citation Formats

Whitehead, Andrew, Clark, Bryan W., Reid, Noah M., Hahn, Mark E., and Nacci, Diane. When evolution is the solution to pollution: Key principles, and lessons from rapid repeated adaptation of killifish ( Fundulus heteroclitus ) populations. United Kingdom: N. p., 2017. Web. doi:10.1111/eva.12470.
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Whitehead, Andrew, Clark, Bryan W., Reid, Noah M., Hahn, Mark E., & Nacci, Diane. When evolution is the solution to pollution: Key principles, and lessons from rapid repeated adaptation of killifish ( Fundulus heteroclitus ) populations. United Kingdom. https://doi.org/10.1111/eva.12470
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Whitehead, Andrew, Clark, Bryan W., Reid, Noah M., Hahn, Mark E., and Nacci, Diane. Wed . "When evolution is the solution to pollution: Key principles, and lessons from rapid repeated adaptation of killifish ( Fundulus heteroclitus ) populations". United Kingdom. https://doi.org/10.1111/eva.12470.
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@article{osti_1353288,
title = {When evolution is the solution to pollution: Key principles, and lessons from rapid repeated adaptation of killifish ( Fundulus heteroclitus ) populations},
author = {Whitehead, Andrew and Clark, Bryan W. and Reid, Noah M. and Hahn, Mark E. and Nacci, Diane},
abstractNote = {Abstract For most species, evolutionary adaptation is not expected to be sufficiently rapid to buffer the effects of human‐mediated environmental changes, including environmental pollution. Here we review how key features of populations, the characteristics of environmental pollution, and the genetic architecture underlying adaptive traits, may interact to shape the likelihood of evolutionary rescue from pollution. Large populations of Atlantic killifish (Fundulus heteroclitus) persist in some of the most contaminated estuaries of the United States, and killifish studies have provided some of the first insights into the types of genomic changes that enable rapid evolutionary rescue from complexly degraded environments. We describe how selection by industrial pollutants and other stressors has acted on multiple populations of killifish and posit that extreme nucleotide diversity uniquely positions this species for successful evolutionary adaptation. Mechanistic studies have identified some of the genetic underpinnings of adaptation to a well‐studied class of toxic pollutants; however, multiple genetic regions under selection in wild populations seem to reflect more complex responses to diverse native stressors and/or compensatory responses to primary adaptation. The discovery of these pollution‐adapted killifish populations suggests that the evolutionary influence of anthropogenic stressors as selective agents occurs widely. Yet adaptation to chemical pollution in terrestrial and aquatic vertebrate wildlife may rarely be a successful “solution to pollution” because potentially adaptive phenotypes may be complex and incur fitness costs, and therefore be unlikely to evolve quickly enough, especially in species with small population sizes.},
doi = {10.1111/eva.12470},
journal = {Evolutionary Applications},
number = 8,
volume = 10,
place = {United Kingdom},
year = {Wed Apr 26 00:00:00 EDT 2017},
month = {Wed Apr 26 00:00:00 EDT 2017}
}
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https://doi.org/10.1111/eva.12470
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Figures / Tables:

Figure 1 Figure 1: Population variation in killifish larval survival when challenged with increasing exposure concentrations of PCB126. Modeled responses from repeated laboratory tests show that populations from polluted sites (solid curves) exhibit tolerance to pollutants at concentrations hundreds to thousands of times normally lethal levels (sensitive populations, dashed curves). Populations aremore » indicated by colors as shown in the map, which shows locations of tolerant populations (solid circles: New Bedford Harbor [NBH], Bridgeport [BP], Newark [NWK], and Elizabeth River [ER] from north to south) and sensitive reference populations (open circles: Block Island [BI], Flax Pond [FP], Sandy Hook [SH], and Kings Creek [KC], from north to south). PCB, polychlorinated biphenyl« less
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Works referenced in this record:

Aryl hydrocarbon receptor polymorphisms and dioxin resistance in Atlantic killifish (Fundulus heteroclitus)
journal, January 2004

PNAS Plus: From the Cover: Deepwater Horizon crude oil impacts the developing hearts of large predatory pelagic fish
journal, March 2014

  • Incardona, J. P.; Gardner, L. D.; Linbo, T. L.
  • Proceedings of the National Academy of Sciences, Vol. 111, Issue 15
  • DOI: 10.1073/pnas.1320950111

Patent Ductus Venosus and Dioxin Resistance in Mice Harboring a Hypomorphic Arnt Allele
journal, February 2004

  • Walisser, Jacqueline A.; Bunger, Maureen K.; Glover, Edward
  • Journal of Biological Chemistry, Vol. 279, Issue 16
  • DOI: 10.1074/jbc.M400784200

Aryl hydrocarbon receptor control of a disease tolerance defence pathway
journal, July 2014

  • Bessede, Alban; Gargaro, Marco; Pallotta, Maria T.
  • Nature, Vol. 511, Issue 7508
  • DOI: 10.1038/nature13323

Levels and patterns of PCDD and PCDF contamination in fish, crabs, and lobsters from Newark Bay and the New York Bight
journal, January 1991

Altered CYP1A expression in Fundulus heteroclitus adults and larvae: a sign of pollutant resistance?
journal, April 1999

AhR sensing of bacterial pigments regulates antibacterial defence
journal, August 2014

  • Moura-Alves, Pedro; Faé, Kellen; Houthuys, Erica
  • Nature, Vol. 512, Issue 7515
  • DOI: 10.1038/nature13684

Emerging contaminants—pesticides, PPCPs, microbial degradation products and natural substances as inhibitors of multixenobiotic defense in aquatic organisms
journal, August 2004

  • Smital, Tvrtko; Luckenbach, Till; Sauerborn, Roberta
  • Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, Vol. 552, Issue 1-2
  • DOI: 10.1016/j.mrfmmm.2004.06.006

Synergistic Embryotoxicity of Polycyclic Aromatic Hydrocarbon Aryl Hydrocarbon Receptor Agonists with Cytochrome P4501A Inhibitors in Fundulus heteroclitus
journal, December 2004

  • Wassenberg, Deena M.; Di Giulio, Richard T.
  • Environmental Health Perspectives, Vol. 112, Issue 17
  • DOI: 10.1289/ehp.7168

A novel CPx-ATPase from the cadmium hyperaccumulator Thlaspi caerulescens
journal, June 2004

The PAS Superfamily: Sensors of Environmental and Developmental Signals
journal, April 2000

Unexpected diversity of aryl hydrocarbon receptors in non-mammalian vertebrates: insights from comparative genomics
journal, January 2006

  • Hahn, Mark E.; Karchner, Sibel I.; Evans, Brad R.
  • Journal of Experimental Zoology Part A: Comparative Experimental Biology, Vol. 305A, Issue 9
  • DOI: 10.1002/jez.a.323

Adaptations of wild populations of the estuarine fish Fundulus heteroclitus to persistent environmental contaminants
journal, June 1999

Molecular biology and evolution of resistance of toxicants
journal, July 1996

The genetics and genomics of insecticide resistance
journal, March 2004

  • ffrench-Constant, Richard H.; Daborn, Phillip J.; Goff, Gaelle Le
  • Trends in Genetics, Vol. 20, Issue 3
  • DOI: 10.1016/j.tig.2004.01.003

The probability of parallel genetic evolution from standing genetic variation
journal, November 2016

  • MacPherson, A.; Nuismer, S. L.
  • Journal of Evolutionary Biology, Vol. 30, Issue 2
  • DOI: 10.1111/jeb.13006

Caenorhabditis elegans orthologs of the aryl hydrocarbon receptor and its heterodimerization partner the aryl hydrocarbon receptor nuclear translocator
journal, March 1998

  • Powell-Coffman, J. A.; Bradfield, C. A.; Wood, W. B.
  • Proceedings of the National Academy of Sciences, Vol. 95, Issue 6
  • DOI: 10.1073/pnas.95.6.2844

Regulation of pregnane-X-receptor, CYP3A and P-glycoprotein genes in the PCB-resistant killifish (Fundulus heteroclitus) population from New Bedford Harbor
journal, February 2015

Utility of Natural Populations for Microarray Analyses: Isolation of Genes Necessary for Functional Genomic Studies
journal, November 2001

  • Oleksiak, Marjorie F.; Kolell, Kevin J.; Crawford, Douglas L.
  • Marine Biotechnology, Vol. 3, Issue 0
  • DOI: 10.1007/s10126-001-0043-0

Reproductive and developmental toxicity of dioxin in fish
journal, May 2012

  • King-Heiden, Tisha C.; Mehta, Vatsal; Xiong, Kong M.
  • Molecular and Cellular Endocrinology, Vol. 354, Issue 1-2
  • DOI: 10.1016/j.mce.2011.09.027

Genomic Evidence of Rapid and Stable Adaptive Oscillations over Seasonal Time Scales in Drosophila
journal, November 2014

Effects of Aryl Hydrocarbon Receptor-Mediated Early Life Stage Toxicity on Lake Trout Populations in Lake Ontario during the 20th Century
journal, September 2003

  • Cook, Philip M.; Robbins, John A.; Endicott, Douglas D.
  • Environmental Science & Technology, Vol. 37, Issue 17
  • DOI: 10.1021/es034045m

Evaluation of the effects of dioxin and PCBs on Fundulus heteroclitus populations using a modeling approach
journal, May 1997

  • Munns, Wayne R.; Black, Dianne E.; Gleason, Timothy R.
  • Environmental Toxicology and Chemistry, Vol. 16, Issue 5
  • DOI: 10.1002/etc.5620160530

Impact of environment on mosquito response to pyrethroid insecticides: Facts, evidences and prospects
journal, April 2013

  • Nkya, Theresia Estomih; Akhouayri, Idir; Kisinza, William
  • Insect Biochemistry and Molecular Biology, Vol. 43, Issue 4
  • DOI: 10.1016/j.ibmb.2012.10.006

Evolution of Character Displacement in Darwin's Finches
journal, July 2006

Summer Home Range and Movements of Fundulus Heteroclitus (Pisces: Cyprinodontidae) in a Tidal Creek
journal, January 1975

Interaction of structurally diverse pesticides with thehuman MDR1 gene product P-glycoprotein
journal, November 1996

Effects of contaminated sediments and sediment-exposed effluent water on an estuarine fish: Acute toxicity
journal, January 1984

  • Hargis, William J.; Roberts, Morris H.; Zwerner, David E.
  • Marine Environmental Research, Vol. 14, Issue 1-4
  • DOI: 10.1016/0141-1136(84)90087-4

Aryl Hydrocarbon Receptor–Independent Toxicity of Weathered Crude Oil during Fish Development
journal, December 2005

  • Incardona, John P.; Carls, Mark G.; Teraoka, Hiroki
  • Environmental Health Perspectives, Vol. 113, Issue 12
  • DOI: 10.1289/ehp.8230

The hsp90 Co-chaperone XAP2 Alters Importin β Recognition of the Bipartite Nuclear Localization Signal of the Ah Receptor and Represses Transcriptional Activity
journal, November 2002

  • Petrulis, John R.; Kusnadi, Ann; Ramadoss, Preeti
  • Journal of Biological Chemistry, Vol. 278, Issue 4
  • DOI: 10.1074/jbc.M209331200

Nonadditive effects of PAHs on Early Vertebrate Development: mechanisms and implications for risk assessment
journal, December 2007

  • Billiard, Sonya M.; Meyer, Joel N.; Wassenberg, Deena M.
  • Toxicological Sciences, Vol. 105, Issue 1
  • DOI: 10.1093/toxsci/kfm303

The Population Genetics of Evolutionary Rescue
journal, August 2014

Environmental stress and recovery: the geochemical record of human disturbance in New Bedford Harbor and Apponagansett Bay, Massachusetts (USA)
journal, September 2003

  • Latimer, James S.; Boothman, Warren S.; Pesch, Carol E.
  • Science of The Total Environment, Vol. 313, Issue 1-3
  • DOI: 10.1016/S0048-9697(03)00269-9

Genetic diversity and structure of an estuarine fish (Fundulus heteroclitus) indigenous to sites associated with a highly contaminated urban harbor
journal, August 2006

The Genetical Structure of Populations
journal, January 1949

Chronic exposure of killifish to a highly polluted environment desensitizes estrogen-responsive reproductive and biomarker genes
journal, July 2014

Humans as the World's Greatest Evolutionary Force
journal, September 2001

Cross-resistance in Gulf killifish (Fundulus grandis) populations resistant to dioxin-like compounds
journal, June 2016

The Aryl Hydrocarbon Receptor Complex and the Control of Gene Expression
journal, January 2008

Endocrine Disrupting Chemicals Targeting Estrogen Receptor Signaling: Identification and Mechanisms of Action
journal, January 2011

  • Shanle, Erin K.; Xu, Wei
  • Chemical Research in Toxicology, Vol. 24, Issue 1
  • DOI: 10.1021/tx100231n

Sustaining Fisheries Yields Over Evolutionary Time Scales
journal, July 2002

AhR signaling activation disrupts migration and dendritic growth of olfactory interneurons in the developing mouse
journal, May 2016

  • Kimura, Eiki; Ding, Yunjie; Tohyama, Chiharu
  • Scientific Reports, Vol. 6, Issue 1
  • DOI: 10.1038/srep26386

Maturation trends indicative of rapid evolution preceded the collapse of northern cod
journal, April 2004

  • Olsen, Esben M.; Heino, Mikko; Lilly, George R.
  • Nature, Vol. 428, Issue 6986
  • DOI: 10.1038/nature02430

Aryl Hydrocarbon Receptor Control of Adaptive Immunity
journal, August 2013

  • Quintana, Francisco J.; Sherr, David H.
  • Pharmacological Reviews, Vol. 65, Issue 4
  • DOI: 10.1124/pr.113.007823

Cloning of the Ah-receptor cDNA reveals a distinctive ligand-activated transcription factor.
journal, September 1992

  • Burbach, K. M.; Poland, A.; Bradfield, C. A.
  • Proceedings of the National Academy of Sciences, Vol. 89, Issue 17
  • DOI: 10.1073/pnas.89.17.8185

Growth and production of the mummichog (Fundulus heteroclitus) in a restored salt marsh
journal, February 2003

Detecting genetic responses to environmental change
journal, June 2008

  • Hoffmann, Ary A.; Willi, Yvonne
  • Nature Reviews Genetics, Vol. 9, Issue 6
  • DOI: 10.1038/nrg2339

Mechanistic Basis of Resistance to PCBs in Atlantic Tomcod from the Hudson River
journal, February 2011

Resistance to xenobiotics and parasites: can we count the cost?
journal, September 2000

  • Coustau, Christine; Chevillon, Christine; ffrench-Constant, Richard
  • Trends in Ecology & Evolution, Vol. 15, Issue 9
  • DOI: 10.1016/S0169-5347(00)01929-7

Altered gene expression and genetic damage in North American fish populations
journal, March 1998

  • Wirgin, Isaac; Waldman, John R.
  • Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, Vol. 399, Issue 2
  • DOI: 10.1016/S0027-5107(97)00256-X

Characterization of a murine Ahr null allele: involvement of the Ah receptor in hepatic growth and development.
journal, June 1996

  • Schmidt, J. V.; Su, G. H.; Reddy, J. K.
  • Proceedings of the National Academy of Sciences, Vol. 93, Issue 13
  • DOI: 10.1073/pnas.93.13.6731

Genetic Linkage Map and Comparative Genome Analysis for the Atlantic Killifish (<i>Fundulus heteroclitus</i>)
journal, January 2016

  • Waits, Eric R.; Martinson, John; Rinner, Brian
  • Open Journal of Genetics, Vol. 06, Issue 01
  • DOI: 10.4236/ojgen.2016.61004

Polychlorinated biphenyls are not substrates for the multidrug resistance transporter-1
journal, March 2003

  • Tampal, Nilufer M.; Robertson, Larry W.; Srinivasan, Cidambi
  • Toxicology and Applied Pharmacology, Vol. 187, Issue 3
  • DOI: 10.1016/S0041-008X(02)00069-8

Exactly the Same but Different: Promiscuity and Diversity in the Molecular Mechanisms of Action of the Aryl Hydrocarbon (Dioxin) Receptor
journal, September 2011

  • Denison, Michael S.; Soshilov, Anatoly A.; He, Guochun
  • Toxicological Sciences, Vol. 124, Issue 1
  • DOI: 10.1093/toxsci/kfr218

Hepatic Vitamin A Depletion Is a Sensitive Marker of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Exposure in Four Rodent Species
journal, July 2001

The Role of the Aryl Hydrocarbon Receptor Pathway in Mediating Synergistic Developmental Toxicity of Polycyclic Aromatic Hydrocarbons to Zebrafish
journal, May 2006

  • Billiard, Sonya M.; Timme-Laragy, Alicia R.; Wassenberg, Deena M.
  • Toxicological Sciences, Vol. 92, Issue 2
  • DOI: 10.1093/toxsci/kfl011

Bioindicators of Immune Function in Creosote-adapted Estuarine Killifish, Fundulus heteroclitus
journal, July 2007

  • Frederick, Lee A.; Van Veld, Peter A.; Rice, Charles D.
  • Journal of Toxicology and Environmental Health, Part A, Vol. 70, Issue 17
  • DOI: 10.1080/15287390701382910

Tolerance and Stress in a Polluted Environment
journal, February 1989

  • Weis, Judith S.; Weis, Peddrick
  • BioScience, Vol. 39, Issue 2
  • DOI: 10.2307/1310907

Zebrafish cardiotoxicity: the effects of CYP1A inhibition and AHR2 knockdown following exposure to weak aryl hydrocarbon receptor agonists
journal, December 2014

  • Brown, Daniel R.; Clark, Bryan W.; Garner, Lindsey V. T.
  • Environmental Science and Pollution Research, Vol. 22, Issue 11
  • DOI: 10.1007/s11356-014-3969-2

The aryl hydrocarbon receptor cross-talks with multiple signal transduction pathways
journal, February 2009

Multiple Origins of Cyclodiene Insecticide Resistance in Tribolium castaneum (Coleoptera: Tenebrionidae)
journal, May 1999

  • Andreev, Dmitri; Kreitman, Martin; Phillips, Thomas W.
  • Journal of Molecular Evolution, Vol. 48, Issue 5
  • DOI: 10.1007/PL00006504

Carcinogenicity of Black Rock Harbor Sediment to the Eastern Oyster and Trophic Transfer of Black Rock Harbor Carcinogens from the Blue Mussel to the Winter Flounder
journal, January 1991

  • Gardner, George R.; Yevich, Paul P.; Harshbarger, John C.
  • Environmental Health Perspectives, Vol. 90
  • DOI: 10.2307/3430845

The Nature of Limits to Natural Selection
journal, January 1976

  • Antonovics, Janis
  • Annals of the Missouri Botanical Garden, Vol. 63, Issue 2
  • DOI: 10.2307/2395303

Relative Contributions of Affinity and Intrinsic Efficacy to Aryl Hydrocarbon Receptor Ligand Potency
journal, October 2000

  • Hestermann, Eli V.; Stegeman, John J.; Hahn, Mark E.
  • Toxicology and Applied Pharmacology, Vol. 168, Issue 2
  • DOI: 10.1006/taap.2000.9026

A Dominant Negative Zebrafish Ahr2 Partially Protects Developing Zebrafish from Dioxin Toxicity
journal, December 2011

A single-amino acid substitution in a gamma-aminobutyric acid subtype A receptor locus is associated with cyclodiene insecticide resistance in Drosophila populations.
journal, March 1993

  • ffrench-Constant, R. H.; Steichen, J. C.; Rocheleau, T. A.
  • Proceedings of the National Academy of Sciences, Vol. 90, Issue 5
  • DOI: 10.1073/pnas.90.5.1957

The molecular basis for differential dioxin sensitivity in birds: Role of the aryl hydrocarbon receptor
journal, April 2006

  • Karchner, S. I.; Franks, D. G.; Kennedy, S. W.
  • Proceedings of the National Academy of Sciences, Vol. 103, Issue 16
  • DOI: 10.1073/pnas.0509950103

Polycyclic Aromatic Hydrocarbons in a Highly Industrialized Urban Estuary: Inventories and Trends
journal, January 2004

  • Walker, Shelby E.; Dickhut, Rebecca M.; Chisholm-Brause, Catherine
  • Environmental Toxicology and Chemistry, Vol. 23, Issue 11
  • DOI: 10.1897/03-628

Geochemical study of sediment contamination in New Bedford Harbor, Massachusetts
journal, January 1990

  • Pruell, Richard J.; Norwood, Curtis B.; Bowen, Robert D.
  • Marine Environmental Research, Vol. 29, Issue 2
  • DOI: 10.1016/0141-1136(90)90030-R

AHR2 Mutant Reveals Functional Diversity of Aryl Hydrocarbon Receptors in Zebrafish
journal, January 2012

The molecular biology of knockdown resistance to pyrethroid insecticides
journal, June 2003

Identification of acute toxicants in new bedford harbor sediments
journal, March 1997

  • Ho, Kay T.; McKinney, Richard A.; Kuhn, Anne
  • Environmental Toxicology and Chemistry, Vol. 16, Issue 3
  • DOI: 10.1002/etc.5620160322

Genetic Architecture of Susceptibility to PCB126-Induced Developmental Cardiotoxicity in Zebrafish
journal, May 2011

Environmental Monitoring Of Remedial Dredging At The New Bedford Harbor, Ma, Superfund Site
journal, December 2005

  • Bergen, Barbara J.; Nelson, William G.; Mackay, Joseph
  • Environmental Monitoring and Assessment, Vol. 111, Issue 1-3
  • DOI: 10.1007/s10661-005-8223-4

The Aryl Hydrocarbon Receptor-interacting Protein (AIP) Is Required for Dioxin-induced Hepatotoxicity but Not for the Induction of the Cyp1a1 and Cyp1a2 Genes
journal, September 2010

  • Nukaya, Manabu; Lin, Bernice C.; Glover, Edward
  • Journal of Biological Chemistry, Vol. 285, Issue 46
  • DOI: 10.1074/jbc.M110.132043

A single mutation in the GSTe2 gene allows tracking of metabolically based insecticide resistance in a major malaria vector
journal, January 2014

  • Riveron, Jacob M.; Yunta, Cristina; Ibrahim, Sulaiman S.
  • Genome Biology, Vol. 15, Issue 2
  • DOI: 10.1186/gb-2014-15-2-r27

Rapid loss of genetically based resistance to metals after the cleanup of a Superfund site
journal, August 2003

  • Levinton, J. S.; Suatoni, E.; Wallace, W.
  • Proceedings of the National Academy of Sciences, Vol. 100, Issue 17
  • DOI: 10.1073/pnas.1731446100

Effect of highly bioaccumulated polychlorinated biphenyl congeners on estrogen and androgen receptor activity
journal, February 2001

  • Bonefeld-Jørgensen, Eva Cecilie; Andersen, Helle Raun; Rasmussen, Thomas Høj
  • Toxicology, Vol. 158, Issue 3
  • DOI: 10.1016/S0300-483X(00)00368-1

Molecular Mechanisms of Metabolic Resistance to Synthetic and Natural Xenobiotics
journal, January 2007

Developmental toxicity of 4-ring polycyclic aromatic hydrocarbons in zebrafish is differentially dependent on AH receptor isoforms and hepatic cytochrome P4501A metabolism
journal, December 2006

  • Incardona, John P.; Day, Heather L.; Collier, Tracy K.
  • Toxicology and Applied Pharmacology, Vol. 217, Issue 3
  • DOI: 10.1016/j.taap.2006.09.018

PCB contamination in and around New Bedford, Mass.
journal, January 1984

Chemical contaminants and hepatic lesions in winter flounder (Pleuronectes americanus) from the northeast coast of the United States
journal, December 1993

  • Johnson, Lyndal L.; Stehr, Carla M.; Olson, O. Paul
  • Environmental Science & Technology, Vol. 27, Issue 13
  • DOI: 10.1021/es00049a015

Physiological Role of the Aryl Hydrocarbon Receptor in Mouse Ovary Development
journal, August 2000

The Aryl Hydrocarbon Receptor Is Required for Developmental Closure of the Ductus Venosus in the Neonatal Mouse
journal, December 2004

  • Lahvis, Garet P.; Pyzalski, Robert W.; Glover, Edward
  • Molecular Pharmacology, Vol. 67, Issue 3
  • DOI: 10.1124/mol.104.008888

The Molecular Genetics of Insecticide Resistance
journal, August 2013

Xenobiotic compounds in blue crabs from a highly contaminated urban subestuary
journal, October 1991

  • Mothershead, Robert F.; Hale, Robert C.; Greaves, John
  • Environmental Toxicology and Chemistry, Vol. 10, Issue 10
  • DOI: 10.1002/etc.5620101013

The Aryl Hydrocarbon Receptor: Multitasking in the Immune System
journal, March 2014

Targeted approach to identify genetic loci associated with evolved dioxin tolerance in Atlantic Killifish (Fundulus heteroclitus)
journal, January 2014

  • Proestou, Dina A.; Flight, Patrick; Champlin, Denise
  • BMC Evolutionary Biology, Vol. 14, Issue 1
  • DOI: 10.1186/1471-2148-14-7

Relative influences of historical and contemporary forces shaping the distribution of genetic variation in the Atlantic killifish, Fundulus heteroclitus
journal, March 2008

Fitness Costs of Insect Resistance to Bacillus thuringiensis
journal, January 2009

Genetic variation at aryl hydrocarbon receptor (AHR) loci in populations of Atlantic killifish (Fundulus heteroclitus) inhabiting polluted and reference habitats
journal, January 2014

  • Reitzel, Adam M.; Karchner, Sibel I.; Franks, Diana G.
  • BMC Evolutionary Biology, Vol. 14, Issue 1
  • DOI: 10.1186/1471-2148-14-6

Genomic mechanisms of evolved physiological plasticity in killifish distributed along an environmental salinity gradient
journal, March 2011

  • Whitehead, A.; Roach, J. L.; Zhang, S.
  • Proceedings of the National Academy of Sciences, Vol. 108, Issue 15
  • DOI: 10.1073/pnas.1017542108

Can Population Genetics Adapt to Rapid Evolution?
journal, July 2016

  • Messer, Philipp W.; Ellner, Stephen P.; Hairston, Nelson G.
  • Trends in Genetics, Vol. 32, Issue 7
  • DOI: 10.1016/j.tig.2016.04.005

Evolutionary rescue and the limits of adaptation
journal, January 2013

  • Bell, Graham
  • Philosophical Transactions of the Royal Society B: Biological Sciences, Vol. 368, Issue 1610
  • DOI: 10.1098/rstb.2012.0080

Global marine pollutants inhibit P-glycoprotein: Environmental levels, inhibitory effects, and cocrystal structure
journal, April 2016

  • Nicklisch, Sascha C. T.; Rees, Steven D.; McGrath, Aaron P.
  • Science Advances, Vol. 2, Issue 4
  • DOI: 10.1126/sciadv.1600001

Common mechanism underlies repeated evolution of extreme pollution tolerance
journal, July 2011

  • Whitehead, Andrew; Pilcher, Whitney; Champlin, Denise
  • Proceedings of the Royal Society B: Biological Sciences, Vol. 279, Issue 1728
  • DOI: 10.1098/rspb.2011.0847

Antibiotic resistance and its cost: is it possible to reverse resistance?
journal, March 2010

  • Andersson, Dan I.; Hughes, Diarmaid
  • Nature Reviews Microbiology, Vol. 8, Issue 4
  • DOI: 10.1038/nrmicro2319

Gender benders at the beach: Endocrine disruption in marine and estuarine organisms
journal, January 2001

  • Oberdörster, Eva; Cheek, Ann Oliver
  • Environmental Toxicology and Chemistry, Vol. 20, Issue 1
  • DOI: 10.1002/etc.5620200103

Loss of teratogenic response to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice lacking the Ah (dioxin) receptor
journal, October 1997

Quantitative genetics approaches to study evolutionary processes in ecotoxicology; a perspective from research on the evolution of resistance
journal, March 2011

Heritable Adaptation and Fitness Costs in Killifish (Fundulus Heteroclitus) Inhabiting a Polluted Estuary
journal, April 2003

GENETIC BASIS OF A BETWEEN-ENVIRONMENT TRADE-OFF INVOLVING RESISTANCE TO CADMIUM IN DROSOPHILA MELANOGASTER
journal, June 1999

Ecologically and Evolutionarily Important SNPs Identified in Natural Populations
journal, January 2011

  • Williams, L. M.; Oleksiak, M. F.
  • Molecular Biology and Evolution, Vol. 28, Issue 6
  • DOI: 10.1093/molbev/msr004

Integrating Monitoring and Genetic Methods To Infer Historical Risks of PCBs and DDE to Common and Roseate Terns Nesting Near the New Bedford Harbor Superfund Site (Massachusetts, USA)
journal, September 2016

  • Nacci, Diane E.; Hahn, Mark E.; Karchner, Sibel I.
  • Environmental Science & Technology, Vol. 50, Issue 18
  • DOI: 10.1021/acs.est.6b02108

Rapid Evolution of Metal Resistance in a Benthic Oligochaete Inhabiting a Metal-polluted Site
journal, April 1989

  • Klerks, P. L.; Levinton, J. S.
  • The Biological Bulletin, Vol. 176, Issue 2
  • DOI: 10.2307/1541580

Diversity as opportunity: Insights from 600 million years of AHR evolution
journal, February 2017

Multixenobiotic resistance as a cellular defense mechanism in aquatic organisms
journal, April 2000

Fundulus as the premier teleost model in environmental biology: Opportunities for new insights using genomics
journal, December 2007

  • Burnett, Karen G.; Bain, Lisa J.; Baldwin, William S.
  • Comparative Biochemistry and Physiology Part D: Genomics and Proteomics, Vol. 2, Issue 4
  • DOI: 10.1016/j.cbd.2007.09.001

Cloning of three estrogen receptors (ER) from killifish (Fundulus heteroclitus): Differences in populations from polluted and reference environments
journal, January 2007

Differential sensitivity to pro-oxidant exposure in two populations of killifish (Fundulus heteroclitus)
journal, January 2013

  • Harbeitner, Rachel C.; Hahn, Mark E.; Timme-Laragy, Alicia R.
  • Ecotoxicology, Vol. 22, Issue 2
  • DOI: 10.1007/s10646-012-1033-x

Predicting the occurrence of genetic adaptation to dioxinlike compounds in populations of the estuarine fish Fundulus heteroclitus
journal, July 2002

  • Nacci, Diane E.; Champlin, Denise; Coiro, Laura
  • Environmental Toxicology and Chemistry, Vol. 21, Issue 7
  • DOI: 10.1002/etc.5620210726

Embryonic gene expression among pollutant resistant and sensitive Fundulus heteroclitus populations
journal, July 2010

Mutation and duplication of arthropod acetylcholinesterase: Implications for pesticide resistance and tolerance
journal, May 2015

Crude Oil Impairs Cardiac Excitation-Contraction Coupling in Fish
journal, February 2014

Changes in gene expression due to chronic exposure to environmental pollutants
journal, November 2008

Inhibition of cellular efflux pumps involved in multi xenobiotic resistance (MXR) in echinoid larvae as a possible mode of action for increased ecotoxicological risk of mixtures
journal, August 2012

  • Anselmo, Henrique M. R.; van den Berg, Johannes H. J.; Rietjens, Ivonne M. C. M.
  • Ecotoxicology, Vol. 21, Issue 8
  • DOI: 10.1007/s10646-012-0984-2

Amino Acid Sequence of the Ligand-Binding Domain of the Aryl Hydrocarbon Receptor 1 Predicts Sensitivity of Wild Birds to Effects of Dioxin-Like Compounds
journal, August 2012

  • Farmahin, Reza; Manning, Gillian E.; Crump, Doug
  • Toxicological Sciences, Vol. 131, Issue 1
  • DOI: 10.1093/toxsci/kfs259

Cardiac toxicity of 5-ring polycyclic aromatic hydrocarbons is differentially dependent on the aryl hydrocarbon receptor 2 isoform during zebrafish development
journal, December 2011

  • Incardona, John P.; Linbo, Tiffany L.; Scholz, Nathaniel L.
  • Toxicology and Applied Pharmacology, Vol. 257, Issue 2
  • DOI: 10.1016/j.taap.2011.09.010

Impacts of Petroleum-Derived Pollutants on Fish Development
journal, February 2017

Aryl-hydrocarbon Receptor-Deficient Mice Are Resistant to 2,3,7,8-Tetrachlorodibenzo-p-dioxin-Induced Toxicity
journal, September 1996

  • Fernandez-Salguero, Pedro M.; Hilbert, David M.; Rudikoff, Stuart
  • Toxicology and Applied Pharmacology, Vol. 140, Issue 1
  • DOI: 10.1006/taap.1996.0210

Duplication of the Rdl GABA receptor subunit gene in an insecticide-resistant aphid, Myzus persicae
journal, November 1998

  • Anthony, N.; Unruh, T.; Ganser, D.
  • Molecular and General Genetics MGG, Vol. 260, Issue 2-3
  • DOI: 10.1007/s004380050882

The Evolution and Genetics of Herbicide Resistance in Weeds
journal, March 1996

Incidence of adverse biological effects within ranges of chemical concentrations in marine and estuarine sediments
journal, January 1995

  • Long, Edward R.; Macdonald, Donald D.; Smith, Sherri L.
  • Environmental Management, Vol. 19, Issue 1
  • DOI: 10.1007/BF02472006

The Genomic Landscape of Compensatory Evolution
journal, August 2014

Polycyclic Aromatic Hydrocarbon (PAH) Ecotoxicology in Marine Ecosystems
journal, January 2006

Carbonized coal products as a source of aromatic hydrocarbons to sediments from a highly industrialized estuary
journal, July 1985

  • Merrill, Elizabeth G.; Wade, Terry L.
  • Environmental Science & Technology, Vol. 19, Issue 7
  • DOI: 10.1021/es00137a003

Genetic compensation induced by deleterious mutations but not gene knockdowns
journal, July 2015

  • Rossi, Andrea; Kontarakis, Zacharias; Gerri, Claudia
  • Nature, Vol. 524, Issue 7564
  • DOI: 10.1038/nature14580

Tolerance to Environmental Contaminants in the Mummichog, Fundulus heteroclitus
journal, July 2002

  • Weis, Judith S.
  • Human and Ecological Risk Assessment: An International Journal, Vol. 8, Issue 5
  • DOI: 10.1080/1080-700291905756

Evolutionary rescue can prevent extinction following environmental change
journal, September 2009

Convergence and divergence in gene expression among natural populations exposed to pollution
journal, January 2007

Growth, production and energy transformations in the salt-marsh killifish Fundulus heteroclitus
journal, January 1977

  • Valiela, I.; Wright, J. E.; Teal, J. M.
  • Marine Biology, Vol. 40, Issue 2
  • DOI: 10.1007/BF00396259

Blocking Expression of AHR2 and ARNT1 in Zebrafish Larvae Protects Against Cardiac Toxicity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin
journal, June 2006

  • Antkiewicz, D. S.; Peterson, R. E.; Heideman, W.
  • Toxicological Sciences, Vol. 94, Issue 1
  • DOI: 10.1093/toxsci/kfl093

Aryl Hydrocarbon Receptor Splice Variants in the Dioxin-Resistant Rat: Tissue Expression and Transactivational Activity
journal, July 2007

  • Moffat, Ivy D.; Roblin, Steven; Harper, Patricia A.
  • Molecular Pharmacology, Vol. 72, Issue 4
  • DOI: 10.1124/mol.107.037218

Evolutionary rescue from extinction is contingent on a lower rate of environmental change
journal, February 2013

  • Lindsey, Haley A.; Gallie, Jenna; Taylor, Susan
  • Nature, Vol. 494, Issue 7438
  • DOI: 10.1038/nature11879

Stored Retinoids in Populations of the Estuarine Fish Fundulus heteroclitus Indigenous to PCB-Contaminated and Reference Sites
journal, April 2001

  • Nacci, S. Jayaraman, J. Specker, D.
  • Archives of Environmental Contamination and Toxicology, Vol. 40, Issue 4
  • DOI: 10.1007/s002440010204

Expression of P-glycoprotein in killifish (Fundulus heteroclitus) exposed to environmental xenobiotics
journal, September 2002

AIP and its interacting partners
journal, March 2011

  • Trivellin, Giampaolo; Korbonits, Márta
  • Journal of Endocrinology, Vol. 210, Issue 2
  • DOI: 10.1530/JOE-11-0054

Adaptation from standing genetic variation
journal, January 2008

The Aryl Hydrocarbon Receptor in Barrier Organ Physiology, Immunology, and Toxicology
journal, February 2015

Regulation of zebrafish CYP3A65 transcription by AHR2
journal, July 2013

  • Chang, Chin-Teng; Chung, Hsin-Yu; Su, Hsiao-Ting
  • Toxicology and Applied Pharmacology, Vol. 270, Issue 2
  • DOI: 10.1016/j.taap.2013.04.010

The Elizabeth River Story: A Case Study in Evolutionary Toxicology
journal, August 2015

  • Di Giulio, Richard T.; Clark, Bryan W.
  • Journal of Toxicology and Environmental Health, Part B, Vol. 18, Issue 6
  • DOI: 10.1080/15320383.2015.1074841

A Possible Role of Multidrug Resistance–Associated Protein 2 (Mrp2) in Hepatic Excretion of PCB126, an Environmental Contaminant: PBPK/PD Modeling
journal, February 2008

  • Lohitnavy, Manupat; Lu, Yasong; Lohitnavy, Ornrat
  • Toxicological Sciences, Vol. 104, Issue 1
  • DOI: 10.1093/toxsci/kfn026

Fundulus heteroclitus adapted to PAHs are cross-resistant to multiple insecticides
journal, October 2011

Indole and Tryptophan Metabolism: Endogenous and Dietary Routes to Ah Receptor Activation
journal, June 2015

  • Hubbard, Troy D.; Murray, Iain A.; Perdew, Gary H.
  • Drug Metabolism and Disposition, Vol. 43, Issue 10
  • DOI: 10.1124/dmd.115.064246

The E-SCREEN assay as a tool to identify estrogens: an update on estrogenic environmental pollutants.
journal, October 1995

  • Soto, A. M.; Sonnenschein, C.; Chung, K. L.
  • Environmental Health Perspectives, Vol. 103, Issue suppl 7
  • DOI: 10.1289/ehp.95103s7113

Fish ( Fundulus heteroclitus ) populations with different exposure histories differ in tolerance of creosote-contaminated sediments
journal, September 2002

  • Ownby, David R.; Newman, Michael C.; Mulvey, Margaret
  • Environmental Toxicology and Chemistry, Vol. 21, Issue 9
  • DOI: 10.1002/etc.5620210917

The genomic landscape of rapid repeated evolutionary adaptation to toxic pollution in wild fish
journal, December 2016

Mutations of acetylcholinesterase which confer insecticide resistance in insect populations
journal, December 2005

Genetic basis for rapidly evolved tolerance in the wild: adaptation to toxic pollutants by an estuarine fish species
journal, October 2016

  • Nacci, Diane; Proestou, Dina; Champlin, Denise
  • Molecular Ecology, Vol. 25, Issue 21
  • DOI: 10.1111/mec.13848

Effects of ortho- and non-ortho-substituted polychlorinated biphenyl congeners on the hepatic monooxygenase system in scup (Stenotomus chrysops)
journal, May 1989

  • Gooch, Jay W.; Elskus, Adria A.; Kloepper-Sams, Pamela J.
  • Toxicology and Applied Pharmacology, Vol. 98, Issue 3
  • DOI: 10.1016/0041-008X(89)90171-3

Intense Natural Selection in a Population of Darwin's Finches (Geospizinae) in the Galapagos
journal, October 1981

Toxicity Resistance
book, February 2008

Aryl Hydrocarbon Receptor Nuclear Translocator in Hepatocytes Is Required for Aryl Hydrocarbon Receptor–Mediated Adaptive and Toxic Responses in Liver
journal, October 2010

  • Nukaya, Manabu; Walisser, Jacqueline A.; Moran, Susan M.
  • Toxicological Sciences, Vol. 118, Issue 2
  • DOI: 10.1093/toxsci/kfq305

The Ah receptor in stem cell cycling, regulation, and quiescence: Ah receptor in hematopoietic stem cells
journal, February 2014

  • Gasiewicz, Thomas A.; Singh, Kameshwar P.; Bennett, J. Allen
  • Annals of the New York Academy of Sciences, Vol. 1310, Issue 1
  • DOI: 10.1111/nyas.12361

Methylmercury tolerance of killifish (Fundulus heteroclitus) embryos from a polluted vs non-polluted environment
journal, December 1981

  • Weis, J. S.; Weis, P.; Heber, M.
  • Marine Biology, Vol. 65, Issue 3
  • DOI: 10.1007/BF00397123

The Aryl hydrocarbon receptor is activated by modified low-density lipoprotein
journal, January 2007

  • McMillan, B. J.; Bradfield, C. A.
  • Proceedings of the National Academy of Sciences, Vol. 104, Issue 4
  • DOI: 10.1073/pnas.0607296104

Common Tern (Sterna hirundo)
journal, January 2002

Characterization of Chemical Contamination in Shallow-Water Estuarine Habitats of an Industrialized River. Part 1: Organic Compounds
journal, January 2005

  • Iannuzzi, Timothy J.; Armstrong, Tina N.; Thelen, John B.
  • Soil and Sediment Contamination: An International Journal, Vol. 14, Issue 1
  • DOI: 10.1080/15320380590891790

Gene amplification and insecticide resistance
journal, May 2011

  • Bass, Chris; Field, Linda M.
  • Pest Management Science, Vol. 67, Issue 8
  • DOI: 10.1002/ps.2189

Differential resistance of insect sodium channels with kdr mutations to deltamethrin, permethrin and DDT
journal, September 2011

  • Burton, Mark J.; Mellor, Ian R.; Duce, Ian R.
  • Insect Biochemistry and Molecular Biology, Vol. 41, Issue 9
  • DOI: 10.1016/j.ibmb.2011.05.004

Mammalian Per-Arnt-Sim Proteins in Environmental Adaptation
journal, March 2010

Ah receptor pathway intricacies; signaling through diverse protein partners and DNA-motifs
journal, January 2015

  • Jackson, D. P.; Joshi, A. D.; Elferink, C. J.
  • Toxicology Research, Vol. 4, Issue 5
  • DOI: 10.1039/C4TX00236A

Rapid evolution and the convergence of ecological and evolutionary time: Rapid evolution and the convergence of ecological and evolutionary time
journal, August 2005

Neoplasms in Mummichogs from the Elizabeth River, Virginia
journal, September 1989

Fitness cost of Resistance to Cadmium in the Least Killifish (Heterandria Formosa)
journal, January 2004

  • Xie, Lingtian; Klerks, Paul L.
  • Environmental Toxicology and Chemistry, Vol. 23, Issue 6
  • DOI: 10.1897/03-96

Adaptation of the Estuarine Fish Fundulus heteroclitus (Atlantic Killifish) to Polychlorinated Biphenyls (PCBs)
journal, January 2010

Estrogen responses in killifish (Fundulus heteroclitus) from polluted and unpolluted environments are site- and gene-specific
journal, August 2010

AHR2 mediates cardiac teratogenesis of polycyclic aromatic hydrocarbons and PCB-126 in Atlantic killifish (Fundulus heteroclitus)
journal, August 2010

Pest Toxicology: The Primary Mechanisms of Pesticide Action
journal, April 2009

  • Casida, John E.
  • Chemical Research in Toxicology, Vol. 22, Issue 4
  • DOI: 10.1021/tx8004949

Comparisons of patterns of polychlorinated biphenyl congeners in water, sediment, and indigenous organisms from New Bedford Harbor, Massachusetts
journal, August 1995

  • Lake, J. L.; McKinney, R.; Lake, C. A.
  • Archives of Environmental Contamination and Toxicology, Vol. 29, Issue 2
  • DOI: 10.1007/BF00212972
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