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Title: High-resolution short-exposure small-animal laboratory x-ray phase-contrast tomography

X-ray computed tomography of small animals and their organs is an essential tool in basic and preclinical biomedical research. In both phase-contrast and absorption tomography high spatial resolution and short exposure times are of key importance. However, the observable spatial resolutions and achievable exposure times are presently limited by system parameters rather than more fundamental constraints like, e.g., dose. Here we demonstrate laboratory tomography with few-ten μm spatial resolution and few-minute exposure time at an acceptable dose for small-animal imaging, both with absorption contrast and phase contrast. The method relies on a magnifying imaging scheme in combination with a high-power small-spot liquid-metal-jet electron-impact source. Lastly, the tomographic imaging is demonstrated on intact mouse, phantoms and excised lungs, both healthy and with pulmonary emphysema.
Authors:
 [1] ;  [2] ;  [3] ;  [4] ;  [2]
  1. KTH Royal Institute of Technology/Albanova, Stockholm (Sweden); Stanford Univ., Stanford, CA (United States)
  2. KTH Royal Institute of Technology/Albanova, Stockholm (Sweden)
  3. Technische Univ. Munchen, Garching (Germany)
  4. Helmholtz Zentrum Munchen, Neuherberg (Germany)
Publication Date:
Grant/Contract Number:
AC02-76SF00515
Type:
Accepted Manuscript
Journal Name:
Scientific Reports
Additional Journal Information:
Journal Volume: 6; Journal Issue: 1; Journal ID: ISSN 2045-2322
Publisher:
Nature Publishing Group
Research Org:
SLAC National Accelerator Lab., Menlo Park, CA (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; biomedical engineering; X-ray tomography
OSTI Identifier:
1352154