Geant4 Monte Carlo simulation of absorbed dose and radiolysis yields enhancement from a gold nanoparticle under MeV proton irradiation

Tran, H. N.; Karamitros, M.; Ivanchenko, V. N.; Guatelli, S.; McKinnon, S.; Murakami, K.; Sasaki, T.; Okada, S.; Bordage, M. C.; Francis, Z.; El Bitar, Z.; Bernal, M. A.; Shin, J. I.; Lee, S. B.; Barberet, Ph.; Tran, T. T.; Brown, J. M. C.; Nhan Hao, T. V.; Incerti, S.

doi:10.1016/j.nimb.2016.01.017

Title: Geant4 Monte Carlo simulation of absorbed dose and radiolysis yields enhancement from a gold nanoparticle under MeV proton irradiation

Full Record
Other Related Research

Authors:: Tran, H. N.; Karamitros, M.; Ivanchenko, V. N.; Guatelli, S.; McKinnon, S.; Murakami, K.; Sasaki, T.; Okada, S.; Bordage, M. C.; Francis, Z.; El Bitar, Z.; Bernal, M. A.; Shin, J. I.; Lee, S. B.; Barberet, Ph.; Tran, T. T.; Brown, J. M. C.; Nhan Hao, T. V.; Incerti, S.

Publication Date:: Fri Apr 01 00:00:00 EDT 2016

Sponsoring Org.:: USDOE

OSTI Identifier:: 1349130

Grant/Contract Number:: FG02- 08ER41533

Resource Type:: Publisher's Accepted Manuscript

Journal Name:: Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms

Additional Journal Information:: Journal Name: Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms Journal Volume: 373 Journal Issue: C; Journal ID: ISSN 0168-583X

Publisher:: Elsevier

Country of Publication:: Netherlands

Language:: English

Citation Formats


                    Tran, H. N., Karamitros, M., Ivanchenko, V. N., Guatelli, S., McKinnon, S., Murakami, K., Sasaki, T., Okada, S., Bordage, M. C., Francis, Z., El Bitar, Z., Bernal, M. A., Shin, J. I., Lee, S. B., Barberet, Ph., Tran, T. T., Brown, J. M. C., Nhan Hao, T. V., and Incerti, S. Geant4 Monte Carlo simulation of absorbed dose and radiolysis yields enhancement from a gold nanoparticle under MeV proton irradiation.  Netherlands: N. p., 2016. 
Web.  doi:10.1016/j.nimb.2016.01.017.

Copy to clipboard


                    Tran, H. N., Karamitros, M., Ivanchenko, V. N., Guatelli, S., McKinnon, S., Murakami, K., Sasaki, T., Okada, S., Bordage, M. C., Francis, Z., El Bitar, Z., Bernal, M. A., Shin, J. I., Lee, S. B., Barberet, Ph., Tran, T. T., Brown, J. M. C., Nhan Hao, T. V., & Incerti, S. Geant4 Monte Carlo simulation of absorbed dose and radiolysis yields enhancement from a gold nanoparticle under MeV proton irradiation.  Netherlands.  https://doi.org/10.1016/j.nimb.2016.01.017

Copy to clipboard


                    Tran, H. N., Karamitros, M., Ivanchenko, V. N., Guatelli, S., McKinnon, S., Murakami, K., Sasaki, T., Okada, S., Bordage, M. C., Francis, Z., El Bitar, Z., Bernal, M. A., Shin, J. I., Lee, S. B., Barberet, Ph., Tran, T. T., Brown, J. M. C., Nhan Hao, T. V., and Incerti, S. Fri .  
"Geant4 Monte Carlo simulation of absorbed dose and radiolysis yields enhancement from a gold nanoparticle under MeV proton irradiation".  Netherlands.  https://doi.org/10.1016/j.nimb.2016.01.017.

Copy to clipboard


                    
@article{osti_1349130,

  title        = {Geant4 Monte Carlo simulation of absorbed dose and radiolysis yields enhancement from a gold nanoparticle under MeV proton irradiation},

  author       = {Tran, H. N. and Karamitros, M. and Ivanchenko, V. N. and Guatelli, S. and McKinnon, S. and Murakami, K. and Sasaki, T. and Okada, S. and Bordage, M. C. and Francis, Z. and El Bitar, Z. and Bernal, M. A. and Shin, J. I. and Lee, S. B. and Barberet, Ph. and Tran, T. T. and Brown, J. M. C. and Nhan Hao, T. V. and Incerti, S.},

  abstractNote = {},

  doi          = {10.1016/j.nimb.2016.01.017},

  journal      = {Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms},

  number       = C,

  volume       = 373,

  place        = {Netherlands},

  year         = {Fri Apr 01 00:00:00 EDT 2016},

  month        = {Fri Apr 01 00:00:00 EDT 2016}

}

Copy to clipboard

Journal Article:

Free Publicly Available Full Text

Accepted Manuscript (Publisher)

Publisher's Version of Record
https://doi.org/10.1016/j.nimb.2016.01.017

Other availability

Search WorldCat to find libraries that may hold this journal

Citation Metrics:

Cited by: 50 works

Citation information provided by
Web of Science

Save / Share:

Export Metadata

Save to My Library

Similar Records in DOE PAGES and OSTI.GOV collections:

Irradiation of gold nanoparticles by x-rays: Monte Carlo simulation of dose enhancements and the spatial properties of the secondary electrons production

Journal Article Leung, Michael K. K. ; Chow, James C. L. ; Chithrani, B. Devika ; ... - Medical Physics

Purpose: The aim of this study is to understand the characteristics of secondary electrons generated from the interaction of gold nanoparticles (GNPs) with x-rays as a function of nanoparticle size and beam energy and thereby further the understanding of GNP-enhanced radiotherapy. Methods: The effective range, deflection angle, dose deposition, energy, and interaction processes of electrons produced from the interaction of x-rays with a GNP were calculated by Monte Carlo simulations. The GEANT4 code was used to simulate and track electrons generated from a 2, 50, and 100 nm diameter GNP when it is irradiated with a 50 kVp, 250 kVp,more »« less
https://doi.org/10.1118/1.3539623
SU-G-TeP3-03: Dose Enhancement of Gold Nanoparticle in Proton Therapy: A Monte Carlo Study Based On the Transmission Electron Microscopy Imaging

Journal Article Ma, Y ; Beaulieu, L ; Laprise-Pelletier, M ; ... - Medical Physics

Purpose: Gold nanoparticle (GNP) is a promising radiosensitizer that selectively boosts tumor dose in radiotherapy. Transmission electron microscopy (TEM) imaging observations recently revealed for the first time that GNP exists in vivo in the form of highly localized vesicles, instead of hypothetical uniform distribution. This work investigates the corresponding difference of energy deposition in proton therapy. Methods: First, single vesicles of various radii were constructed by packing GNPs (as Φ50 nm gold spheres) in spheres and were simulated, as well as a single GNP. The radial energy depositions (REDs) were scored using 100 concentric spherical shells from 0.1µm to 10µm,more »« less
https://doi.org/10.1118/1.4957083
Investigation of the effects of cell model and subcellular location of gold nanoparticles on nuclear dose enhancement factors using Monte Carlo simulation

Journal Article Cai, Zhongli ; Chattopadhyay, Niladri ; Kwon, Yongkyu Luke ; ... - Medical Physics

Purpose: The authors’ aims were to model how various factors influence radiation dose enhancement by gold nanoparticles (AuNPs) and to propose a new modeling approach to the dose enhancement factor (DEF).Methods: The authors used Monte Carlo N-particle (MCNP 5) computer code to simulate photon and electron transport in cells. The authors modeled human breast cancer cells as a single cell, a monolayer, or a cluster of cells. Different numbers of 5, 30, or 50 nm AuNPs were placed in the extracellular space, on the cell surface, in the cytoplasm, or in the nucleus. Photon sources examined in the simulation includedmore »« less
https://doi.org/10.1118/1.4823787
SU-E-T-519: Emission of Secondary Particles From a PMMA Phantom During Proton Irradiation: A Simulation Study with the Geant4 Monte Carlo Toolkit

Journal Article Lau, A ; Chen, Y ; Ahmad, S - Medical Physics

Purpose: Proton therapy exhibits several advantages over photon therapy due to depth-dose distributions from proton interactions within the target material. However, uncertainties associated with protons beam range in the patient limit the advantage of proton therapy applications. To quantify beam range, positron-emitting nuclei (PEN) and prompt gamma (PG) techniques have been developed. These techniques use de-excitation photons to describe the location of the beam in the patient. To develop a detector system for implementing the PG technique for range verification applications in proton therapy, we studied the yields, energy and angular distributions of the secondary particles emitted from a PMMAmore »« less
https://doi.org/10.1118/1.4888852
SU-E-T-289: Scintillating Fiber Based In-Vivo Dose Monitoring System to the Rectum in Proton Therapy of Prostate Cancer: A Geant4 Monte Carlo Simulation

Journal Article Tesfamicael, B ; Gueye, P ; Lyons, D ; ... - Medical Physics

Purpose: To construct a dose monitoring system based on an endorectal balloon coupled to thin scintillating fibers to study the dose delivered to the rectum during prostate cancer proton therapy Methods: The Geant4 Monte Carlo toolkit version 9.6p02 was used to simulate prostate cancer proton therapy treatments of an endorectal balloon (for immobilization of a 2.9 cm diameter prostate gland) and a set of 34 scintillating fibers symmetrically placed around the balloon and perpendicular to the proton beam direction (for dosimetry measurements) Results: A linear response of the fibers to the dose delivered was observed within <2%, a property thatmore »« less
https://doi.org/10.1118/1.4888621

Similar Records