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Title: Gold–silica quantum rattles for multimodal imaging and therapy

Abstract

Gold quantum dots exhibit distinctive optical and magnetic behaviors compared with larger gold nanoparticles. However, their unfavorable interaction with living systems and lack of stability in aqueous solvents has so far prevented their adoption in biology and medicine. In this paper, a simple synthetic pathway integrates gold quantum dots within a mesoporous silica shell, alongside larger gold nanoparticles within the shell’s central cavity. This “quantum rattle” structure is stable in aqueous solutions, does not elicit cell toxicity, preserves the attractive near-infrared photonics and paramagnetism of gold quantum dots, and enhances the drug-carrier performance of the silica shell. In vivo, the quantum rattles reduced tumor burden in a single course of photothermal therapy while coupling three complementary imaging modalities: near-infrared fluorescence, photoacoustic, and magnetic resonance imaging. The incorporation of gold within the quantum rattles significantly enhanced the drug-carrier performance of the silica shell. Finally, this innovative material design based on the mutually beneficial interaction of gold and silica introduces the use of gold quantum dots for imaging and therapeutic applications.

Authors:
 [1]; ORCiD logo [1];  [1];  [2];  [3];  [2];  [2];  [4];  [1];  [2];  [4];  [1];  [2];  [3];  [3];  [1]
  1. Imperial College, London (United Kingdom)
  2. Univ. College London, London (United Kingdom)
  3. Sorbonne Univ., Univ. Pierre et Marie Curie Paris, Paris (France); CNRS, Paris (France); College de France, Paris (France)
  4. Louisiana State Univ., Baton Rouge, LA (United States)
Publication Date:
Research Org.:
Energy Frontier Research Centers (EFRC) (United States). Center for Atomic-Level Catalyst Design (CALCD); Louisiana State Univ., Baton Rouge, LA (United States); Imperial College London (United Kingdom)
Sponsoring Org.:
USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22)
OSTI Identifier:
1347971
Grant/Contract Number:  
SC0001058
Resource Type:
Accepted Manuscript
Journal Name:
Proceedings of the National Academy of Sciences of the United States of America
Additional Journal Information:
Journal Volume: 112; Journal Issue: 7; Journal ID: ISSN 0027-8424
Publisher:
National Academy of Sciences, Washington, DC (United States)
Country of Publication:
United States
Language:
English
Subject:
77 NANOSCIENCE AND NANOTECHNOLOGY; nanomedicine; hybrid nanoparticle; cancer nanotechnology; gold quantum dots; mesoporous silica

Citation Formats

Hembury, Mathew, Chiappini, Ciro, Bertazzo, Sergio, Kalber, Tammy L., Drisko, Glenna L., Ogunlade, Olumide, Walker-Samuel, Simon, Krishna, Katla Sai, Jumeaux, Coline, Beard, Paul, Kumar, Challa S. S. R., Porter, Alexandra E., Lythgoe, Mark F., Boissière, Cédric, Sanchez, Clément, and Stevens, Molly M. Gold–silica quantum rattles for multimodal imaging and therapy. United States: N. p., 2015. Web. doi:10.1073/pnas.1419622112.
Hembury, Mathew, Chiappini, Ciro, Bertazzo, Sergio, Kalber, Tammy L., Drisko, Glenna L., Ogunlade, Olumide, Walker-Samuel, Simon, Krishna, Katla Sai, Jumeaux, Coline, Beard, Paul, Kumar, Challa S. S. R., Porter, Alexandra E., Lythgoe, Mark F., Boissière, Cédric, Sanchez, Clément, & Stevens, Molly M. Gold–silica quantum rattles for multimodal imaging and therapy. United States. doi:10.1073/pnas.1419622112.
Hembury, Mathew, Chiappini, Ciro, Bertazzo, Sergio, Kalber, Tammy L., Drisko, Glenna L., Ogunlade, Olumide, Walker-Samuel, Simon, Krishna, Katla Sai, Jumeaux, Coline, Beard, Paul, Kumar, Challa S. S. R., Porter, Alexandra E., Lythgoe, Mark F., Boissière, Cédric, Sanchez, Clément, and Stevens, Molly M. Wed . "Gold–silica quantum rattles for multimodal imaging and therapy". United States. doi:10.1073/pnas.1419622112. https://www.osti.gov/servlets/purl/1347971.
@article{osti_1347971,
title = {Gold–silica quantum rattles for multimodal imaging and therapy},
author = {Hembury, Mathew and Chiappini, Ciro and Bertazzo, Sergio and Kalber, Tammy L. and Drisko, Glenna L. and Ogunlade, Olumide and Walker-Samuel, Simon and Krishna, Katla Sai and Jumeaux, Coline and Beard, Paul and Kumar, Challa S. S. R. and Porter, Alexandra E. and Lythgoe, Mark F. and Boissière, Cédric and Sanchez, Clément and Stevens, Molly M.},
abstractNote = {Gold quantum dots exhibit distinctive optical and magnetic behaviors compared with larger gold nanoparticles. However, their unfavorable interaction with living systems and lack of stability in aqueous solvents has so far prevented their adoption in biology and medicine. In this paper, a simple synthetic pathway integrates gold quantum dots within a mesoporous silica shell, alongside larger gold nanoparticles within the shell’s central cavity. This “quantum rattle” structure is stable in aqueous solutions, does not elicit cell toxicity, preserves the attractive near-infrared photonics and paramagnetism of gold quantum dots, and enhances the drug-carrier performance of the silica shell. In vivo, the quantum rattles reduced tumor burden in a single course of photothermal therapy while coupling three complementary imaging modalities: near-infrared fluorescence, photoacoustic, and magnetic resonance imaging. The incorporation of gold within the quantum rattles significantly enhanced the drug-carrier performance of the silica shell. Finally, this innovative material design based on the mutually beneficial interaction of gold and silica introduces the use of gold quantum dots for imaging and therapeutic applications.},
doi = {10.1073/pnas.1419622112},
journal = {Proceedings of the National Academy of Sciences of the United States of America},
number = 7,
volume = 112,
place = {United States},
year = {2015},
month = {2}
}

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