Polyvalent vaccine approaches to combat HIV-1 diversity
Abstract
In this study, a key unresolved challenge for developing an effective HIV-1 vaccine is the discovery of strategies to elicit immune responses that are able to cross-protect against a significant fraction of the diverse viruses that are circulating worldwide. Here, we summarize some of the immunological implications of HIV-1 diversity, and outline the rationale behind several polyvalent vaccine design strategies that are currently under evaluation. Vaccine-elicited T-cell responses, which contribute to the control of HIV-1 in natural infections, are currently being considered in both prevention and treatment settings. Approaches now in preclinical and human trials include full proteins in novel vectors, concatenated conserved protein regions, and polyvalent strategies that improve coverage of epitope diversity and enhance the cross-reactivity of responses. While many barriers to vaccine induction of broadly neutralizing antibody (bNAb) responses remain, epitope diversification has emerged as both a challenge and an opportunity. Recent longitudinal studies have traced the emergence of bNAbs in HIV-1 infection, inspiring novel approaches to recapitulate and accelerate the events that give rise to potent bNAb in vivo. In this review, we have selected two such lineage-based design strategies to illustrate how such in-depth analysis can offer conceptual improvements that may bring us closer tomore »
- Authors:
-
[2];
[2];
- Los Alamos National Lab. (LANL), Los Alamos, NM (United States); New Mexico Consortium, Los Alamos, NM (United States)
- Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
- Univ. of Pennsylvania, Philadelphia, PA (United States)
- Publication Date:
- Research Org.:
- Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
- Sponsoring Org.:
- National Institutes of Health (NIH); USDOE
- OSTI Identifier:
- 1346839
- Report Number(s):
- LA-UR-16-26755
Journal ID: ISSN 0105-2896
- Grant/Contract Number:
- AC52-06NA25396
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Immunological Reviews
- Additional Journal Information:
- Journal Volume: 275; Journal Issue: 1; Journal ID: ISSN 0105-2896
- Publisher:
- Wiley
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 60 APPLIED LIFE SCIENCES; Biological Science; AIDS; antibodies; antigens/peptides/epitopes; B cells; vaccination; viral
Citation Formats
Korber, Bette, Hraber, Peter Thomas, Wagh, Kshitij, and Hahn, Beatrice H. Polyvalent vaccine approaches to combat HIV-1 diversity. United States: N. p., 2017.
Web. doi:10.1111/imr.12516.
Korber, Bette, Hraber, Peter Thomas, Wagh, Kshitij, & Hahn, Beatrice H. Polyvalent vaccine approaches to combat HIV-1 diversity. United States. https://doi.org/10.1111/imr.12516
Korber, Bette, Hraber, Peter Thomas, Wagh, Kshitij, and Hahn, Beatrice H. Mon .
"Polyvalent vaccine approaches to combat HIV-1 diversity". United States. https://doi.org/10.1111/imr.12516. https://www.osti.gov/servlets/purl/1346839.
@article{osti_1346839,
title = {Polyvalent vaccine approaches to combat HIV-1 diversity},
author = {Korber, Bette and Hraber, Peter Thomas and Wagh, Kshitij and Hahn, Beatrice H.},
abstractNote = {In this study, a key unresolved challenge for developing an effective HIV-1 vaccine is the discovery of strategies to elicit immune responses that are able to cross-protect against a significant fraction of the diverse viruses that are circulating worldwide. Here, we summarize some of the immunological implications of HIV-1 diversity, and outline the rationale behind several polyvalent vaccine design strategies that are currently under evaluation. Vaccine-elicited T-cell responses, which contribute to the control of HIV-1 in natural infections, are currently being considered in both prevention and treatment settings. Approaches now in preclinical and human trials include full proteins in novel vectors, concatenated conserved protein regions, and polyvalent strategies that improve coverage of epitope diversity and enhance the cross-reactivity of responses. While many barriers to vaccine induction of broadly neutralizing antibody (bNAb) responses remain, epitope diversification has emerged as both a challenge and an opportunity. Recent longitudinal studies have traced the emergence of bNAbs in HIV-1 infection, inspiring novel approaches to recapitulate and accelerate the events that give rise to potent bNAb in vivo. In this review, we have selected two such lineage-based design strategies to illustrate how such in-depth analysis can offer conceptual improvements that may bring us closer to an effective vaccine.},
doi = {10.1111/imr.12516},
journal = {Immunological Reviews},
number = 1,
volume = 275,
place = {United States},
year = {2017},
month = {1}
}
Free Publicly Available Full Text
Publisher's Version of Record
Other availability
Search WorldCat to find libraries that may hold this journal
Cited by: 4 works
Citation information provided by
Web of Science
Web of Science
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.
Works referenced in this record:
Safety and immunogenicity of recombinant low-dosage HIV-1 A vaccine candidates vectored by plasmid pTHr DNA or modified vaccinia virus Ankara (MVA) in humans in East Africa
journal, May 2008
- Jaoko, Walter; Nakwagala, Frederick N.; Anzala, Omu
- Vaccine, Vol. 26, Issue 22
Designing and Testing Broadly-Protective Filoviral Vaccines Optimized for Cytotoxic T-Lymphocyte Epitope Coverage
journal, October 2012
- Fenimore, Paul W.; Muhammad, Majidat A.; Fischer, William M.
- PLoS ONE, Vol. 7, Issue 10
A Multi-Component Prime-Boost Vaccination Regimen with a Consensus MOMP Antigen Enhances Chlamydia trachomatis Clearance
journal, April 2016
- Badamchi-Zadeh, Alexander; McKay, Paul F.; Korber, Bette T.
- Frontiers in Immunology, Vol. 7
The Latent Reservoir for HIV-1: How Immunologic Memory and Clonal Expansion Contribute to HIV-1 Persistence
journal, July 2016
- Murray, Alexandra J.; Kwon, Kyungyoon J.; Farber, Donna L.
- The Journal of Immunology, Vol. 197, Issue 2
The first T cell response to transmitted/founder virus contributes to the control of acute viremia in HIV-1 infection
journal, June 2009
- Goonetilleke, Nilu; Liu, Michael K. P.; Salazar-Gonzalez, Jesus F.
- The Journal of Experimental Medicine, Vol. 206, Issue 6
Efficacy Trial of a DNA/rAd5 HIV-1 Preventive Vaccine
journal, November 2013
- Hammer, Scott M.; Sobieszczyk, Magdalena E.; Janes, Holly
- New England Journal of Medicine, Vol. 369, Issue 22
Broad and potent neutralization of HIV-1 by a gp41-specific human antibody
journal, September 2012
- Huang, Jinghe; Ofek, Gilad; Laub, Leo
- Nature, Vol. 491, Issue 7424
Envelope residue 375 substitutions in simian–human immunodeficiency viruses enhance CD4 binding and replication in rhesus macaques
journal, May 2016
- Li, Hui; Wang, Shuyi; Kong, Rui
- Proceedings of the National Academy of Sciences, Vol. 113, Issue 24
Optimal Combinations of Broadly Neutralizing Antibodies for Prevention and Treatment of HIV-1 Clade C Infection
journal, March 2016
- Wagh, Kshitij; Bhattacharya, Tanmoy; Williamson, Carolyn
- PLOS Pathogens, Vol. 12, Issue 3
Affinity maturation in an HIV broadly neutralizing B-cell lineage through reorientation of variable domains
journal, June 2014
- Fera, D.; Schmidt, A. G.; Haynes, B. F.
- Proceedings of the National Academy of Sciences, Vol. 111, Issue 28
Cytomegalovirus Vectors Violate CD8+ T Cell Epitope Recognition Paradigms
journal, May 2013
- Hansen, S. G.; Sacha, J. B.; Hughes, C. M.
- Science, Vol. 340, Issue 6135
Justification for the inclusion of Gag in HIV vaccine candidates
journal, December 2015
- Williamson, Anna-Lise; Rybicki, Edward P.
- Expert Review of Vaccines, Vol. 15, Issue 5
Design and Pre-Clinical Evaluation of a Universal HIV-1 Vaccine
journal, October 2007
- Létourneau, Sven; Im, Eung-Jun; Mashishi, Tumelo
- PLoS ONE, Vol. 2, Issue 10, Article No. e984
T-Cell Vaccine Strategies for Human Immunodeficiency Virus, the Virus with a Thousand Faces
journal, May 2009
- Korber, B. T.; Letvin, N. L.; Haynes, B. F.
- Journal of Virology, Vol. 83, Issue 17, p. 8300-8314
Mosaic vaccines elicit CD8+ T lymphocyte responses that confer enhanced immune coverage of diverse HIV strains in monkeys
journal, February 2010
- Santra, Sampa; Liao, Hua-Xin; Zhang, Ruijin
- Nature Medicine, Vol. 16, Issue 3, p. 324-328
Complete epitopes for vaccine design derived from a crystal structure of the broadly neutralizing antibodies PGT128 and 8ANC195 in complex with an HIV-1 Env trimer
journal, September 2015
- Kong, Leopold; Torrents de la Peña, Alba; Deller, Marc C.
- Acta Crystallographica Section D Biological Crystallography, Vol. 71, Issue 10
Immune-Correlates Analysis of an HIV-1 Vaccine Efficacy Trial
journal, April 2012
- Haynes, Barton F.; Gilbert, Peter B.; McElrath, M. Juliana
- New England Journal of Medicine, Vol. 366, Issue 14
The role of recombination in the emergence of a complex and dynamic HIV epidemic
journal, March 2010
- Zhang, Ming; Foley, Brian; Schultz, Anne-Kathrin
- Retrovirology, Vol. 7, Issue 1
Protective Efficacy of a Global HIV-1 Mosaic Vaccine against Heterologous SHIV Challenges in Rhesus Monkeys
journal, October 2013
- Barouch, Dan H.; Stephenson, Kathryn E.; Borducchi, Erica N.
- Cell, Vol. 155, Issue 3
Persistent HIV-1 replication during antiretroviral therapy
journal, January 2016
- Martinez-Picado, Javier; Deeks, Steven G.
- Current Opinion in HIV and AIDS, Vol. 11, Issue 4
HIV-1 Conserved Elements p24CE DNA Vaccine Induces Humoral Immune Responses with Broad Epitope Recognition in Macaques
journal, October 2014
- Kulkarni, Viraj; Valentin, Antonio; Rosati, Margherita
- PLoS ONE, Vol. 9, Issue 10
A Next-Generation Cleaved, Soluble HIV-1 Env Trimer, BG505 SOSIP.664 gp140, Expresses Multiple Epitopes for Broadly Neutralizing but Not Non-Neutralizing Antibodies
journal, September 2013
- Sanders, Rogier W.; Derking, Ronald; Cupo, Albert
- PLoS Pathogens, Vol. 9, Issue 9, Article No. e1003618
Achieving Potent Autologous Neutralizing Antibody Responses against Tier 2 HIV-1 Viruses by Strategic Selection of Envelope Immunogens
journal, March 2016
- Hessell, Ann J.; Malherbe, Delphine C.; Pissani, Franco
- The Journal of Immunology, Vol. 196, Issue 7
Early Low-Titer Neutralizing Antibodies Impede HIV-1 Replication and Select for Virus Escape
journal, May 2012
- Bar, Katharine J.; Tsao, Chun-yen; Iyer, Shilpa S.
- PLoS Pathogens, Vol. 8, Issue 5
Optimization and delivery of plasmid DNA for vaccination
journal, December 2006
- Jechlinger, Wolfgang
- Expert Review of Vaccines, Vol. 5, Issue 6
HIV-1 Dynamics in Vivo: Virion Clearance Rate, Infected Cell Life-Span, and Viral Generation Time
journal, March 1996
- Perelson, A. S.; Neumann, A. U.; Markowitz, M.
- Science, Vol. 271, Issue 5255
Safety and immunogenicity of cytotoxic T-lymphocyte poly-epitope, DNA plasmid (EP HIV-1090) vaccine in healthy, human immunodeficiency virus type 1 (HIV-1)-uninfected adults
journal, January 2008
- Gorse, Geoffrey J.; Baden, Lindsey R.; Wecker, Margaret
- Vaccine, Vol. 26, Issue 2
New Member of the V1V2-Directed CAP256-VRC26 Lineage That Shows Increased Breadth and Exceptional Potency
journal, October 2015
- Doria-Rose, Nicole A.; Bhiman, Jinal N.; Roark, Ryan S.
- Journal of Virology, Vol. 90, Issue 1
Definition of the viral targets of protective HIV-1-specific T cell responses
journal, January 2011
- Mothe, Beatriz; Llano, Anuska; Ibarrondo, Javier
- Journal of Translational Medicine, Vol. 9, Issue 1
Nanoparticle vaccines
journal, January 2014
- Zhao, Liang; Seth, Arjun; Wibowo, Nani
- Vaccine, Vol. 32, Issue 3
Effect of the cytoplasmic domain on antigenic characteristics of HIV-1 envelope glycoprotein
journal, June 2015
- Chen, J.; Kovacs, J. M.; Peng, H.
- Science, Vol. 349, Issue 6244
Burden of tuberculosis at post mortem in inpatients at a tertiary referral centre in sub-Saharan Africa: a prospective descriptive autopsy study
journal, May 2015
- Bates, Matthew; Mudenda, Victor; Shibemba, Aaron
- The Lancet Infectious Diseases, Vol. 15, Issue 5
Novel Conserved-region T-cell Mosaic Vaccine With High Global HIV-1 Coverage Is Recognized by Protective Responses in Untreated Infection
journal, April 2016
- Ondondo, Beatrice; Murakoshi, Hayato; Clutton, Genevieve
- Molecular Therapy, Vol. 24, Issue 4
Immune System Regulation in the Induction of Broadly Neutralizing HIV-1 Antibodies
journal, December 2013
- Kelsoe, Garnett; Verkoczy, Laurent; Haynes, Barton
- Vaccines, Vol. 2, Issue 1
Structures of HIV-1 Env V1V2 with broadly neutralizing antibodies reveal commonalities that enable vaccine design
journal, December 2015
- Gorman, Jason; Soto, Cinque; Yang, Max M.
- Nature Structural & Molecular Biology, Vol. 23, Issue 1
Recent Developments in Preclinical DNA Vaccination
journal, January 2014
- Okuda, Kenji; Wada, Yoshiyuki; Shimada, Masaru
- Vaccines, Vol. 2, Issue 1
Human Non-neutralizing HIV-1 Envelope Monoclonal Antibodies Limit the Number of Founder Viruses during SHIV Mucosal Infection in Rhesus Macaques
journal, August 2015
- Santra, Sampa; Tomaras, Georgia D.; Warrier, Ranjit
- PLOS Pathogens, Vol. 11, Issue 8
Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus
journal, April 2013
- Liao, Hua-Xin; Lynch, Rebecca; Zhou, Tongqing
- Nature, Vol. 496, Issue 7446
Increased Valency of Conserved-mosaic Vaccines Enhances the Breadth and Depth of Epitope Recognition
journal, February 2016
- Abdul-Jawad, Sultan; Ondondo, Beatrice; van Hateren, Andy
- Molecular Therapy, Vol. 24, Issue 2
Viral variants that initiate and drive maturation of V1V2-directed HIV-1 broadly neutralizing antibodies
journal, October 2015
- Bhiman, Jinal N.; Anthony, Colin; Doria-Rose, Nicole A.
- Nature Medicine, Vol. 21, Issue 11
Mosaic H5 Hemagglutinin Provides Broad Humoral and Cellular Immune Responses against Influenza Viruses
journal, May 2016
- Kamlangdee, Attapon; Kingstad-Bakke, Brock; Osorio, Jorge E.
- Journal of Virology, Vol. 90, Issue 15
Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody
journal, April 2016
- Bonsignori, Mattia; Zhou, Tongqing; Sheng, Zizhang
- Cell, Vol. 165, Issue 2
Broadly targeted CD8+ T cell responses restricted by major histocompatibility complex E
journal, January 2016
- Hansen, S. G.; Wu, H. L.; Burwitz, B. J.
- Science, Vol. 351, Issue 6274
Development of Broadly Neutralizing Antibodies and Their Mapping by Monomeric gp120 in Human Immunodeficiency Virus Type 1-Infected Humans and Simian-Human Immunodeficiency Virus SHIV SF162P3N -Infected Macaques
journal, February 2016
- Jia, Manxue; Lu, Hong; Markowitz, Martin
- Journal of Virology, Vol. 90, Issue 8
Translating HIV Sequences into Quantitative Fitness Landscapes Predicts Viral Vulnerabilities for Rational Immunogen Design
journal, March 2013
- Ferguson, Andrew L.; Mann, Jaclyn K.; Omarjee, Saleha
- Immunity, Vol. 38, Issue 3
Antibody responses to envelope glycoproteins in HIV-1 infection
journal, May 2015
- Burton, Dennis R.; Mascola, John R.
- Nature Immunology, Vol. 16, Issue 6
Polyvalent vaccines for optimal coverage of potential T-cell epitopes in global HIV-1 variants
journal, December 2006
- Fischer, Will; Perkins, Simon; Theiler, James
- Nature Medicine, Vol. 13, Issue 1, p. 100-106
Immune control of an SIV challenge by a T-cell-based vaccine in rhesus monkeys
journal, November 2008
- Liu, Jinyan; O’Brien, Kara L.; Lynch, Diana M.
- Nature, Vol. 457, Issue 7225
Vaccination with ALVAC and AIDSVAX to Prevent HIV-1 Infection in Thailand
journal, December 2009
- Rerks-Ngarm, Supachai; Pitisuttithum, Punnee; Nitayaphan, Sorachai
- New England Journal of Medicine, Vol. 361, Issue 23
Holes in the Glycan Shield of the Native HIV Envelope Are a Target of Trimer-Elicited Neutralizing Antibodies
journal, August 2016
- McCoy, Laura E.; van Gils, Marit J.; Ozorowski, Gabriel
- Cell Reports, Vol. 16, Issue 9
Structural Basis for Broad and Potent Neutralization of HIV-1 by Antibody VRC01
journal, July 2010
- Zhou, T.; Georgiev, I.; Wu, X.
- Science, Vol. 329, Issue 5993
Vaccine-Elicited Tier 2 HIV-1 Neutralizing Antibodies Bind to Quaternary Epitopes Involving Glycan-Deficient Patches Proximal to the CD4 Binding Site
journal, May 2015
- Crooks, Ema T.; Tong, Tommy; Chakrabarti, Bimal
- PLOS Pathogens, Vol. 11, Issue 5
Recombinant adenovirus type 5 HIV gag/pol/nef vaccine in South Africa: unblinded, long-term follow-up of the phase 2b HVTN 503/Phambili study
journal, May 2014
- Gray, Glenda E.; Moodie, Zoe; Metch, Barbara
- The Lancet Infectious Diseases, Vol. 14, Issue 5
Distinct Evolutionary Pressures Underlie Diversity in Simian Immunodeficiency Virus and Human Immunodeficiency Virus Lineages
journal, October 2012
- Fischer, W.; Apetrei, C.; Santiago, M. L.
- Journal of Virology, Vol. 86, Issue 24
Hepatitis C Genotype 1 Mosaic Vaccines Are Immunogenic in Mice and Induce Stronger T-Cell Responses than Natural Strains
journal, December 2012
- Yusim, Karina; Dilan, Rebecca; Borducchi, Erica
- Clinical and Vaccine Immunology, Vol. 20, Issue 2
Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B, and G
journal, May 2016
- Stewart-Jones, Guillaume B. E.; Soto, Cinque; Lemmin, Thomas
- Cell, Vol. 165, Issue 4
Cooperation of B Cell Lineages in Induction of HIV-1-Broadly Neutralizing Antibodies
journal, July 2014
- Gao, Feng; Bonsignori, Mattia; Liao, Hua-Xin
- Cell, Vol. 158, Issue 3
Immunological and virological mechanisms of vaccine-mediated protection against SIV and HIV
journal, December 2013
- Roederer, Mario; Keele, Brandon F.; Schmidt, Stephen D.
- Nature, Vol. 505, Issue 7484
Early Selection in Gag by Protective HLA Alleles Contributes to Reduced HIV-1 Replication Capacity That May Be Largely Compensated for in Chronic Infection
journal, September 2010
- Brockman, Mark A.; Brumme, Zabrina L.; Brumme, Chanson J.
- Journal of Virology, Vol. 84, Issue 22
Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial
journal, November 2008
- Buchbinder, Susan P.; Mehrotra, Devan V.; Duerr, Ann
- The Lancet, Vol. 372, Issue 9653
Longitudinal Antigenic Sequences and Sites from Intra-Host Evolution (LASSIE) Identifies Immune-Selected HIV Variants
journal, October 2015
- Hraber, Peter; Korber, Bette; Wagh, Kshitij
- Viruses, Vol. 7, Issue 10
Mosaic HIV-1 vaccines expand the breadth and depth of cellular immune responses in rhesus monkeys
journal, February 2010
- Barouch, Dan H.; O'Brien, Kara L.; Simmons, Nathaniel L.
- Nature Medicine, Vol. 16, Issue 3, p. 319-323
Polyvalent HIV-1 Env vaccine formulations delivered by the DNA priming plus protein boosting approach are effective in generating neutralizing antibodies against primary human immunodeficiency virus type 1 isolates from subtypes A, B, C, D and E
journal, June 2006
- Wang, Shixia; Pal, Ranajit; Mascola, John R.
- Virology, Vol. 350, Issue 1
Comparison of Immunogenicity in Rhesus Macaques of Transmitted-Founder, HIV-1 Group M Consensus, and Trivalent Mosaic Envelope Vaccines Formulated as a DNA Prime, NYVAC, and Envelope Protein Boost
journal, April 2015
- Hulot, Sandrine L.; Korber, Bette; Giorgi, Elena E.
- Journal of Virology, Vol. 89, Issue 12
Antiretroviral Treatment of Adult HIV Infection: 2014 Recommendations of the International Antiviral Society–USA Panel
journal, July 2014
- Günthard, Huldrych F.; Aberg, Judith A.; Eron, Joseph J.
- JAMA, Vol. 312, Issue 4
Nanotechnology in vaccine delivery
journal, May 2008
- Peek, Laura J.; Middaugh, C. Russell; Berkland, Cory
- Advanced Drug Delivery Reviews, Vol. 60, Issue 8
Transmission of Single HIV-1 Genomes and Dynamics of Early Immune Escape Revealed by Ultra-Deep Sequencing
journal, August 2010
- Fischer, Will; Ganusov, Vitaly V.; Giorgi, Elena E.
- PLoS ONE, Vol. 5, Issue 8
HIV-1 Vaccine Development After STEP
journal, February 2010
- Barouch, Dan H.; Korber, Bette
- Annual Review of Medicine, Vol. 61, Issue 1
Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine
journal, May 2011
- Hansen, Scott G.; Ford, Julia C.; Lewis, Matthew S.
- Nature, Vol. 473, Issue 7348
Impact of HIV infection on the haemostatic response during sepsis and malaria
journal, March 2016
- Huson, Michaëla A. M.; Kalkman, Rachel; Hoogendijk, Arie J.
- British Journal of Haematology, Vol. 173, Issue 6
Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors
journal, June 2015
- Zhou, Tongqing; Lynch, Rebecca M.; Chen, Lei
- Cell, Vol. 161, Issue 6
Progress in HIV-1 vaccine development
journal, July 2014
- Haynes, Barton F.; Moody, M. Anthony; Alam, Munir
- Journal of Allergy and Clinical Immunology, Vol. 134, Issue 1
Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120
journal, May 2013
- Kong, Leopold; Lee, Jeong Hyun; Doores, Katie J.
- Nature Structural & Molecular Biology, Vol. 20, Issue 7
Safety and Tolerability of Conserved Region Vaccines Vectored by Plasmid DNA, Simian Adenovirus and Modified Vaccinia Virus Ankara Administered to Human Immunodeficiency Virus Type 1-Uninfected Adults in a Randomized, Single-Blind Phase I Trial
journal, July 2014
- Hayton, Emma-Jo; Rose, Annie; Ibrahimsa, Umar
- PLoS ONE, Vol. 9, Issue 7
Pathogen-like particles: biomimetic vaccine carriers engineered at the nanoscale
journal, August 2014
- Rosenthal, Joseph A.; Chen, Linxiao; Baker, Jenny L.
- Current Opinion in Biotechnology, Vol. 28
Focused Evolution of HIV-1 Neutralizing Antibodies Revealed by Structures and Deep Sequencing
journal, August 2011
- Wu, X.; Zhou, T.; Zhu, J.
- Science, Vol. 333, Issue 6049
Vaccine delivery using nanoparticles
journal, January 2013
- Gregory, Anthony E.; Titball, Richard; Williamson, Diane
- Frontiers in Cellular and Infection Microbiology, Vol. 3
Antiretroviral Therapy for the Prevention of HIV-1 Transmission
journal, September 2016
- Cohen, Myron S.; Chen, Ying Q.; McCauley, Marybeth
- New England Journal of Medicine, Vol. 375, Issue 9
Breadth of cellular and humoral immune responses elicited in rhesus monkeys by multi-valent mosaic and consensus immunogens
journal, July 2012
- Santra, Sampa; Muldoon, Mark; Watson, Sydeaka
- Virology, Vol. 428, Issue 2
Web-based design and evaluation of T-cell vaccine candidates
journal, May 2008
- Thurmond, James; Yoon, Hyejin; Kuiken, Carla
- Bioinformatics, Vol. 24, Issue 14
Epigraph: A Vaccine Design Tool Applied to an HIV Therapeutic Vaccine and a Pan-Filovirus Vaccine
journal, October 2016
- Theiler, James; Yoon, Hyejin; Yusim, Karina
- Scientific Reports, Vol. 6, Issue 1
Diversity Considerations in HIV-1 Vaccine Selection
journal, June 2002
- Gaschen, Brian; Taylor, Jesse; Yusim, Karina
- Science, Vol. 296, Issue 5577, p. 2354-2360
Full-Length HIV-1 Immunogens Induce Greater Magnitude and Comparable Breadth of T Lymphocyte Responses to Conserved HIV-1 Regions Compared with Conserved-Region-Only HIV-1 Immunogens in Rhesus Monkeys
journal, August 2012
- Stephenson, K. E.; SanMiguel, A.; Simmons, N. L.
- Journal of Virology, Vol. 86, Issue 21
Polyreactivity and Autoreactivity among HIV-1 Antibodies
journal, October 2014
- Liu, Mengfei; Yang, Guang; Wiehe, Kevin
- Journal of Virology, Vol. 89, Issue 1
T cells induced by recombinant chimpanzee adenovirus alone and in prime-boost regimens decrease chimeric EcoHIV/NDK challenge virus load: Immunity to infection
journal, October 2012
- Roshorm, Yaowaluck; Cottingham, Mathew G.; Potash, Mary-Jane
- European Journal of Immunology, Vol. 42, Issue 12
Lower in vivo mutation rate of human immunodeficiency virus type 1 than that predicted from the fidelity of purified reverse transcriptase.
journal, January 1995
- Mansky, L. M.; Temin, H. M.
- Journal of virology, Vol. 69, Issue 8
Works referencing / citing this record:
Nanoparticle vaccines against viral infections
journal, May 2018
- Sulczewski, Fernando B.; Liszbinski, Raquel B.; Romão, Pedro R. T.
- Archives of Virology, Vol. 163, Issue 9
Structure and immunogenicity of a stabilized HIV-1 envelope trimer based on a group-M consensus sequence
journal, May 2019
- Sliepen, Kwinten; Han, Byung Woo; Bontjer, Ilja
- Nature Communications, Vol. 10, Issue 1
Phylogenetic patterns recover known HIV epidemiological relationships and reveal common transmission of multiple variants
journal, July 2018
- Leitner, Thomas; Romero-Severson, Ethan
- Nature Microbiology, Vol. 3, Issue 9
Models of immune selection for multi-locus antigenic diversity of pathogens
journal, November 2018
- Georgieva, Maria; Buckee, Caroline O.; Lipsitch, Marc
- Nature Reviews Immunology, Vol. 19, Issue 1
The quest for an antibody-based HIV vaccine
journal, January 2017
- Haynes, Barton F.; Mascola, John R.
- Immunological Reviews, Vol. 275, Issue 1
Simplified steps to heterologous prime-boost HIV vaccine development?
journal, September 2019
- Michael, Nelson L.
- Journal of Clinical Investigation, Vol. 129, Issue 11
A novel polyepitope vaccine elicited HIV peptide specific CD4+ T cell responses in HLA-A2/DRB1 transgenic mice
journal, September 2017
- Liu, Haitao; Shen, Wei; Shu, Jiayi
- PLOS ONE, Vol. 12, Issue 9
Chronic schistosomiasis suppresses HIV-specific responses to DNA-MVA and MVA-gp140 Env vaccine regimens despite antihelminthic treatment and increases helminth-associated pathology in a mouse model
journal, July 2018
- Dzhivhuho, Godfrey A.; Rehrl, Samantha A.; Ndlovu, Hlumani
- PLOS Pathogens, Vol. 14, Issue 7
T = 4 Icosahedral HIV-1 Capsid As an Immunogenic Vector for HIV-1 V3 Loop Epitope Display
journal, November 2018
- Zhang, Zhiqing; He, Maozhou; Bai, Shimeng
- Viruses, Vol. 10, Issue 12
Artificial Anti-HIV-1 Immunogen Comprising Epitopes of Broadly Neutralizing Antibodies 2F5, 10E8, and a Peptide Mimic of VRC01 Discontinuous Epitope
journal, August 2019
- Rudometov, Andrey P.; Chikaev, Anton N.; Rudometova, Nadezhda B.
- Vaccines, Vol. 7, Issue 3