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Title: Parts per billion detection of uranium with a porphyrinoid-containing nanoparticle and in vivo photoacoustic imaging

Chemical tools that can report radioactive isotopes would be of interest to the defense community. Here in this paper we report –250 nm polymeric nanoparticles containing porphyrinoid macrocycles with and without pre-complexed depleted uranium and demonstrate that the latter species may be detected easily and with high sensitivity via photoacoustic imaging. The porphyrinoid macrocycles used in the present study are non-aromatic in the absence of the uranyl cation, but aromatic after cation complexation. We solubilized both the freebase and metalated forms of the macrocycles in poly(lactic-co-glycolic acid) and found a peak in the photoacoustic spectrum at 910 nm excitation in the case of the uranyl complex. The signal was stable for at least 15 minutes and allowed detection of uranium concentrations down to 6.2 ppb (5.7 nM) in vitro and 0.57 ppm (19 fCi; 0.52 μM) in vivo. Furthermore, to the best of our knowledge, this is the first report of a nanoparticle that detects an actinide cation via photoacoustic imaging.
Authors:
 [1] ;  [1] ;  [2] ;  [3]
  1. Univ. of Texas, Austin, TX (United States). Dept. of Chemistry
  2. Stanford Univ., Stanford, CA (United States)
  3. Stanford Univ., Stanford, CA (United States) (United States). School of Medicine, Dept. of Radiology
Publication Date:
Grant/Contract Number:
FG02-01ER15186
Type:
Accepted Manuscript
Journal Name:
Analyst
Additional Journal Information:
Journal Volume: 140; Journal Issue: 11; Journal ID: ISSN 0003-2654
Publisher:
Royal Society of Chemistry
Research Org:
Univ. of Texas, Austin, TX (United States)
Sponsoring Org:
USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22)
Country of Publication:
United States
Language:
English
Subject:
46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY; 36 MATERIALS SCIENCE; photoacoustic imaging; porphyrinoid macrocycles; activable nanoparticle; dosimetery
OSTI Identifier:
1346160

Ho, I-Ting, Sessler, Jonathan L., Gambhir, Sanjiv Sam, and Jokerst, Jesse V.. Parts per billion detection of uranium with a porphyrinoid-containing nanoparticle and in vivo photoacoustic imaging. United States: N. p., Web. doi:10.1039/c5an00207a.
Ho, I-Ting, Sessler, Jonathan L., Gambhir, Sanjiv Sam, & Jokerst, Jesse V.. Parts per billion detection of uranium with a porphyrinoid-containing nanoparticle and in vivo photoacoustic imaging. United States. doi:10.1039/c5an00207a.
Ho, I-Ting, Sessler, Jonathan L., Gambhir, Sanjiv Sam, and Jokerst, Jesse V.. 2015. "Parts per billion detection of uranium with a porphyrinoid-containing nanoparticle and in vivo photoacoustic imaging". United States. doi:10.1039/c5an00207a. https://www.osti.gov/servlets/purl/1346160.
@article{osti_1346160,
title = {Parts per billion detection of uranium with a porphyrinoid-containing nanoparticle and in vivo photoacoustic imaging},
author = {Ho, I-Ting and Sessler, Jonathan L. and Gambhir, Sanjiv Sam and Jokerst, Jesse V.},
abstractNote = {Chemical tools that can report radioactive isotopes would be of interest to the defense community. Here in this paper we report –250 nm polymeric nanoparticles containing porphyrinoid macrocycles with and without pre-complexed depleted uranium and demonstrate that the latter species may be detected easily and with high sensitivity via photoacoustic imaging. The porphyrinoid macrocycles used in the present study are non-aromatic in the absence of the uranyl cation, but aromatic after cation complexation. We solubilized both the freebase and metalated forms of the macrocycles in poly(lactic-co-glycolic acid) and found a peak in the photoacoustic spectrum at 910 nm excitation in the case of the uranyl complex. The signal was stable for at least 15 minutes and allowed detection of uranium concentrations down to 6.2 ppb (5.7 nM) in vitro and 0.57 ppm (19 fCi; 0.52 μM) in vivo. Furthermore, to the best of our knowledge, this is the first report of a nanoparticle that detects an actinide cation via photoacoustic imaging.},
doi = {10.1039/c5an00207a},
journal = {Analyst},
number = 11,
volume = 140,
place = {United States},
year = {2015},
month = {4}
}