Bulk production and evaluation of high specific activity 186g Re for cancer therapy using enriched 186 WO 3 targets in a proton beam

Mastren, Tara; Radchenko, Valery; Bach, Hong T.; Balkin, Ethan R.; Birnbaum, Eva R.; Brugh, Mark; Engle, Jonathan W.; Gott, Matthew D.; Guthrie, James; Hennkens, Heather M.; John, Kevin D.; Ketring, Alan R.; Kuchuk, Marina; Maassen, Joel R.; Naranjo, Cleo M.; Nortier, F. Meiring; Phelps, Tim E.; Jurisson, Silvia S.; Wilbur, D. Scott; Fassbender, Michael E.

doi:10.1016/j.nucmedbio.2017.02.006

Title: Bulk production and evaluation of high specific activity 186g Re for cancer therapy using enriched 186 WO 3 targets in a proton beam

Abstract

Rhenium-186 g (t_1/2 = 3.72 d) is a β– emitting isotope suitable for theranostic applications. Current production methods rely on reactor production by way of the reaction ¹⁸⁵Re(n,γ)^186gRe, which results in low specific activities limiting its use for cancer therapy. Production via charged particle activation of enriched ¹⁸⁶W results in a ^186gRe product with a much specific activity, allowing it to be used more broadly for targeted radiotherapy applications. Furthermore, this targets the unmet clinical need for more efficient radiotherapeutics.

Publication Date:: 2017-06-01

Research Org.:: Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

Sponsoring Org.:: USDOE Office of Science (SC), Nuclear Physics (NP)

OSTI Identifier:: 1345946

Alternate Identifier(s):: OSTI ID: 1415249

Report Number(s):: LA-UR-16-29352
Journal ID: ISSN 0969-8051; TRN: US1700520

Grant/Contract Number:: AC52-06NA25396

Resource Type:: Accepted Manuscript

Journal Name:: Nuclear Medicine and Biology

Additional Journal Information:: Journal Volume: 49; Journal Issue: C; Journal ID: ISSN 0969-8051

Publisher:: Elsevier

Country of Publication:: United States

Language:: English

Subject:: 62 RADIOLOGY AND NUCLEAR MEDICINE; Inorganic and Physical Chemistry

Citation Formats


                    Mastren, Tara, Radchenko, Valery, Bach, Hong T., Balkin, Ethan R., Birnbaum, Eva R., Brugh, Mark, Engle, Jonathan W., Gott, Matthew D., Guthrie, James, Hennkens, Heather M., John, Kevin D., Ketring, Alan R., Kuchuk, Marina, Maassen, Joel R., Naranjo, Cleo M., Nortier, F. Meiring, Phelps, Tim E., Jurisson, Silvia S., Wilbur, D. Scott, and Fassbender, Michael E. Bulk production and evaluation of high specific activity 186g Re for cancer therapy using enriched 186 WO 3 targets in a proton beam.  United States: N. p., 2017. 
Web.  doi:10.1016/j.nucmedbio.2017.02.006.

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                    Mastren, Tara, Radchenko, Valery, Bach, Hong T., Balkin, Ethan R., Birnbaum, Eva R., Brugh, Mark, Engle, Jonathan W., Gott, Matthew D., Guthrie, James, Hennkens, Heather M., John, Kevin D., Ketring, Alan R., Kuchuk, Marina, Maassen, Joel R., Naranjo, Cleo M., Nortier, F. Meiring, Phelps, Tim E., Jurisson, Silvia S., Wilbur, D. Scott, & Fassbender, Michael E. Bulk production and evaluation of high specific activity 186g Re for cancer therapy using enriched 186 WO 3 targets in a proton beam.  United States.  https://doi.org/10.1016/j.nucmedbio.2017.02.006

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                    Mastren, Tara, Radchenko, Valery, Bach, Hong T., Balkin, Ethan R., Birnbaum, Eva R., Brugh, Mark, Engle, Jonathan W., Gott, Matthew D., Guthrie, James, Hennkens, Heather M., John, Kevin D., Ketring, Alan R., Kuchuk, Marina, Maassen, Joel R., Naranjo, Cleo M., Nortier, F. Meiring, Phelps, Tim E., Jurisson, Silvia S., Wilbur, D. Scott, and Fassbender, Michael E. Thu .  
"Bulk production and evaluation of high specific activity 186g Re for cancer therapy using enriched 186 WO 3 targets in a proton beam".  United States.  https://doi.org/10.1016/j.nucmedbio.2017.02.006.  https://www.osti.gov/servlets/purl/1345946.

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@article{osti_1345946,

  title        = {Bulk production and evaluation of high specific activity 186g Re for cancer therapy using enriched 186 WO 3 targets in a proton beam},

  author       = {Mastren, Tara and Radchenko, Valery and Bach, Hong T. and Balkin, Ethan R. and Birnbaum, Eva R. and Brugh, Mark and Engle, Jonathan W. and Gott, Matthew D. and Guthrie, James and Hennkens, Heather M. and John, Kevin D. and Ketring, Alan R. and Kuchuk, Marina and Maassen, Joel R. and Naranjo, Cleo M. and Nortier, F. Meiring and Phelps, Tim E. and Jurisson, Silvia S. and Wilbur, D. Scott and Fassbender, Michael E.},

  abstractNote = {Rhenium-186 g (t1/2 = 3.72 d) is a β– emitting isotope suitable for theranostic applications. Current production methods rely on reactor production by way of the reaction 185Re(n,γ)186gRe, which results in low specific activities limiting its use for cancer therapy. Production via charged particle activation of enriched 186W results in a 186gRe product with a much specific activity, allowing it to be used more broadly for targeted radiotherapy applications. Furthermore, this targets the unmet clinical need for more efficient radiotherapeutics.},

  doi          = {10.1016/j.nucmedbio.2017.02.006},

  journal      = {Nuclear Medicine and Biology},

  number       = C,

  volume       = 49,

  place        = {United States},

  year         = {2017},

  month        = {6}

}

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https://doi.org/10.1016/j.nucmedbio.2017.02.006

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Radionuclide Therapy of Painful Bone Metastases—A Comparative Study Between Consecutive Radionuclide Infusions, Combination With Chemotherapy, and Radionuclide Infusions Alone: An In Vivo Comparison of Their Effectiveness
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Works referencing / citing this record:

Steric influence of salicylaldehyde-based Schiff base ligands on the formation of trans -[Re(PR ₃ ) ₂ (Schiff base)] ⁺ complexes
journal, January 2019

Baumeister, Jakob E.; Mitchell, Andrew W.; Kelley, Steven P.
Dalton Transactions, Vol. 48, Issue 34
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Chemistry and radiochemistry of As, Re and Rh isotopes relevant to radiopharmaceutical applications: high specific activity radionuclides for imaging and treatment
journal, January 2017

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Title: Bulk production and evaluation of high specific activity 186g Re for cancer therapy using enriched 186 WO 3 targets in a proton beam

Abstract

Citation Formats

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Proton irradiation parameters and chemical separation procedure for the bulk production of high-specific-activity 186g Re using WO 3 targets journal, May 2013

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Evaluation of charged particle induced reaction cross section data for production of the important therapeutic radionuclide ¹⁸⁶ Re
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Excitation Functions for natW(p,xn)181-186Re Reactions and Production of No-Carrier-Added 186Re via 186W(p,n) 186Re Reaction
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Deuteron irradiation of W and WO3 for production of high specific activity 186Re: Challenges associated with thick target preparation
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Monooxorhenium(V) complexes with 222-N2S2 MAMA ligands for bifunctional chelator agents: Syntheses and preliminary in vivo evaluation
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