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Title: Casting inorganic structures with DNA molds

Here we report a general strategy for designing and synthesizing inorganic nanostructures with arbitrarily prescribed three-dimensional shapes. Computationally designed DNA strands self-assemble into a stiff “nano-mold” that contains a user-specified three-dimensional cavity and encloses a nucleating gold “seed”. Under mild conditions, this seed grows into a larger cast structure that fills and thus replicates the cavity. We synthesized a variety of nanoparticles with three nanometer resolution: three distinct silver cuboids with three independently tunable dimensions, silver and gold nanoparticles with diverse cross sections, and composite structures with homo-/heterogeneous components. The designer equilateral silver triangular and spherical nanoparticles exhibited plasmonic properties consistent with electromagnetism-based simulations. Our framework is generalizable to more complex geometries and diverse inorganic materials, offering a range of applications in biosensing, photonics, and nanoelectronics.
Authors:
 [1] ;  [2] ;  [2] ;  [1] ;  [3] ;  [2] ;  [1]
  1. Harvard Univ., Boston, MA (United States); Harvard Medical School, Boston, MA (United States)
  2. Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States)
  3. Harvard Univ., Boston, MA (United States)
Publication Date:
Grant/Contract Number:
AC02-05CH11231
Type:
Accepted Manuscript
Journal Name:
Science
Additional Journal Information:
Journal Volume: 346; Journal Issue: 6210; Journal ID: ISSN 0036-8075
Publisher:
AAAS
Research Org:
Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States)
Sponsoring Org:
USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22)
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES
OSTI Identifier:
1344929

Sun, Wei, Boulais, Etienne, Hakobyan, Yera, Wang, Wei Li, Guan, Amy, Bathe, Mark, and Yin, Peng. Casting inorganic structures with DNA molds. United States: N. p., Web. doi:10.1126/science.1258361.
Sun, Wei, Boulais, Etienne, Hakobyan, Yera, Wang, Wei Li, Guan, Amy, Bathe, Mark, & Yin, Peng. Casting inorganic structures with DNA molds. United States. doi:10.1126/science.1258361.
Sun, Wei, Boulais, Etienne, Hakobyan, Yera, Wang, Wei Li, Guan, Amy, Bathe, Mark, and Yin, Peng. 2014. "Casting inorganic structures with DNA molds". United States. doi:10.1126/science.1258361. https://www.osti.gov/servlets/purl/1344929.
@article{osti_1344929,
title = {Casting inorganic structures with DNA molds},
author = {Sun, Wei and Boulais, Etienne and Hakobyan, Yera and Wang, Wei Li and Guan, Amy and Bathe, Mark and Yin, Peng},
abstractNote = {Here we report a general strategy for designing and synthesizing inorganic nanostructures with arbitrarily prescribed three-dimensional shapes. Computationally designed DNA strands self-assemble into a stiff “nano-mold” that contains a user-specified three-dimensional cavity and encloses a nucleating gold “seed”. Under mild conditions, this seed grows into a larger cast structure that fills and thus replicates the cavity. We synthesized a variety of nanoparticles with three nanometer resolution: three distinct silver cuboids with three independently tunable dimensions, silver and gold nanoparticles with diverse cross sections, and composite structures with homo-/heterogeneous components. The designer equilateral silver triangular and spherical nanoparticles exhibited plasmonic properties consistent with electromagnetism-based simulations. Our framework is generalizable to more complex geometries and diverse inorganic materials, offering a range of applications in biosensing, photonics, and nanoelectronics.},
doi = {10.1126/science.1258361},
journal = {Science},
number = 6210,
volume = 346,
place = {United States},
year = {2014},
month = {10}
}