Autophagic Degradation of the 26S Proteasome Is Mediated by the Dual ATG8/Ubiquitin Receptor RPN10 in Arabidopsis
Abstract
Autophagic turnover of intracellular constituents is critical for cellular housekeeping, nutrient recycling, and various aspects of growth and development in eukaryotes. In this paper, we show that autophagy impacts the other major degradative route involving the ubiquitin-proteasome system by eliminating 26S proteasomes, a process we termed proteaphagy. Using Arabidopsis proteasomes tagged with GFP, we observed their deposition into vacuoles via a route requiring components of the autophagy machinery. This transport can be initiated separately by nitrogen starvation and chemical or genetic inhibition of the proteasome, implying distinct induction mechanisms. Proteasome inhibition stimulates comprehensive ubiquitylation of the complex, with the ensuing proteaphagy requiring the proteasome subunit RPN10, which can simultaneously bind both ATG8 and ubiquitin. Finally and collectively, we propose that Arabidopsis RPN10 acts as a selective autophagy receptor that targets inactive 26S proteasomes by concurrent interactions with ubiquitylated proteasome subunits/targets and lipidated ATG8 lining the enveloping autophagic membranes.
- Authors:
- Publication Date:
- Research Org.:
- Univ. of Wisconsin, Madison, WI (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC), Basic Energy Sciences (BES)
- OSTI Identifier:
- 1259320
- Alternate Identifier(s):
- OSTI ID: 1250268; OSTI ID: 1344491
- Grant/Contract Number:
- FG02-88ER13968
- Resource Type:
- Published Article
- Journal Name:
- Molecular Cell
- Additional Journal Information:
- Journal Name: Molecular Cell Journal Volume: 58 Journal Issue: 6; Journal ID: ISSN 1097-2765
- Publisher:
- Elsevier
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Marshall, Richard S., Li, Faqiang, Gemperline, David C., Book, Adam J., and Vierstra, Richard D. Autophagic Degradation of the 26S Proteasome Is Mediated by the Dual ATG8/Ubiquitin Receptor RPN10 in Arabidopsis. United States: N. p., 2015.
Web. doi:10.1016/j.molcel.2015.04.023.
Marshall, Richard S., Li, Faqiang, Gemperline, David C., Book, Adam J., & Vierstra, Richard D. Autophagic Degradation of the 26S Proteasome Is Mediated by the Dual ATG8/Ubiquitin Receptor RPN10 in Arabidopsis. United States. https://doi.org/10.1016/j.molcel.2015.04.023
Marshall, Richard S., Li, Faqiang, Gemperline, David C., Book, Adam J., and Vierstra, Richard D. Mon .
"Autophagic Degradation of the 26S Proteasome Is Mediated by the Dual ATG8/Ubiquitin Receptor RPN10 in Arabidopsis". United States. https://doi.org/10.1016/j.molcel.2015.04.023.
@article{osti_1259320,
title = {Autophagic Degradation of the 26S Proteasome Is Mediated by the Dual ATG8/Ubiquitin Receptor RPN10 in Arabidopsis},
author = {Marshall, Richard S. and Li, Faqiang and Gemperline, David C. and Book, Adam J. and Vierstra, Richard D.},
abstractNote = {Autophagic turnover of intracellular constituents is critical for cellular housekeeping, nutrient recycling, and various aspects of growth and development in eukaryotes. In this paper, we show that autophagy impacts the other major degradative route involving the ubiquitin-proteasome system by eliminating 26S proteasomes, a process we termed proteaphagy. Using Arabidopsis proteasomes tagged with GFP, we observed their deposition into vacuoles via a route requiring components of the autophagy machinery. This transport can be initiated separately by nitrogen starvation and chemical or genetic inhibition of the proteasome, implying distinct induction mechanisms. Proteasome inhibition stimulates comprehensive ubiquitylation of the complex, with the ensuing proteaphagy requiring the proteasome subunit RPN10, which can simultaneously bind both ATG8 and ubiquitin. Finally and collectively, we propose that Arabidopsis RPN10 acts as a selective autophagy receptor that targets inactive 26S proteasomes by concurrent interactions with ubiquitylated proteasome subunits/targets and lipidated ATG8 lining the enveloping autophagic membranes.},
doi = {10.1016/j.molcel.2015.04.023},
journal = {Molecular Cell},
number = 6,
volume = 58,
place = {United States},
year = {Mon Jun 01 00:00:00 EDT 2015},
month = {Mon Jun 01 00:00:00 EDT 2015}
}
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journal, February 2018
- Zhou, Jie; Wang, Zhe; Wang, Xiaoting
- Autophagy, Vol. 14, Issue 3
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journal, October 2018
- Yang, Zhen; Sun, Qi; Guo, Junfei
- Autophagy, Vol. 15, Issue 4
A facile forward-genetic screen for Arabidopsis autophagy mutants reveals twenty-one loss-of-function mutations disrupting six ATG genes
journal, February 2019
- Young, Pierce G.; Passalacqua, Michael J.; Chappell, Kevin
- Autophagy, Vol. 15, Issue 6
Proteasome dysfunction induces excessive proteome instability and loss of mitostasis that can be mitigated by enhancing mitochondrial fusion or autophagy
journal, April 2019
- Tsakiri, Eleni N.; Gumeni, Sentiljana; Vougas, Konstantinos
- Autophagy, Vol. 15, Issue 10
Actin filaments are dispensable for bulk autophagy in plants
journal, March 2019
- Zheng, Xiyin; Wu, Ming; Li, Xinyi
- Autophagy, Vol. 15, Issue 12
An atypical LIR motif within UBA5 (ubiquitin like modifier activating enzyme 5) interacts with GABARAP proteins and mediates membrane localization of UBA5
journal, April 2019
- Huber, Jessica; Obata, Miki; Gruber, Jens
- Autophagy
Understanding and exploiting autophagy signaling in plants
journal, December 2017
- Batoko, Henri; Dagdas, Yasin; Baluska, Frantisek
- Essays in Biochemistry, Vol. 61, Issue 6
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
journal, January 2016
- Klionsky, Daniel J.; Abdelmohsen, Kotb; Abe, Akihisa
- Autophagy, Vol. 12, Issue 1
IRE1B degrades RNAs encoding proteins that interfere with the induction of autophagy by ER stress in Arabidopsis thaliana
journal, August 2018
- Bao, Yan; Pu, Yunting; Yu, Xiang
- Autophagy, Vol. 14, Issue 9
Dehydrin MtCAS31 promotes autophagic degradation under drought stress
journal, July 2019
- Li, Xin; Liu, Qianwen; Feng, Hao
- Autophagy
Autophagy in Plant: A New Orchestrator in the Regulation of the Phytohormones Homeostasis
journal, June 2019
- Gou, Wentao; Li, Xi; Guo, Shaoying
- International Journal of Molecular Sciences, Vol. 20, Issue 12
Cellular Responses to Proteasome Inhibition: Molecular Mechanisms and Beyond
journal, July 2019
- Albornoz, Nicolas; Bustamante, Hianara; Soza, Andrea
- International Journal of Molecular Sciences, Vol. 20, Issue 14
Understanding and exploiting autophagy signaling in plants
journal, December 2017
- Batoko, Henri; Dagdas, Yasin; Baluska, Frantisek
- Essays in Biochemistry, Vol. 61, Issue 6
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
journal, January 2016
- Klionsky, Daniel J.; Abdelmohsen, Kotb; Abe, Akihisa
- Autophagy, Vol. 12, Issue 1
Dicot-specific ATG8-interacting ATI3 proteins interact with conserved UBAC2 proteins and play critical roles in plant stress responses
journal, February 2018
- Zhou, Jie; Wang, Zhe; Wang, Xiaoting
- Autophagy, Vol. 14, Issue 3
GRSF1 -mediated MIR-G-1 promotes malignant behavior and nuclear autophagy by directly upregulating TMED5 and LMNB1 in cervical cancer cells
journal, October 2018
- Yang, Zhen; Sun, Qi; Guo, Junfei
- Autophagy, Vol. 15, Issue 4
A facile forward-genetic screen for Arabidopsis autophagy mutants reveals twenty-one loss-of-function mutations disrupting six ATG genes
journal, February 2019
- Young, Pierce G.; Passalacqua, Michael J.; Chappell, Kevin
- Autophagy, Vol. 15, Issue 6
Proteasome dysfunction induces excessive proteome instability and loss of mitostasis that can be mitigated by enhancing mitochondrial fusion or autophagy
journal, April 2019
- Tsakiri, Eleni N.; Gumeni, Sentiljana; Vougas, Konstantinos
- Autophagy, Vol. 15, Issue 10
Actin filaments are dispensable for bulk autophagy in plants
journal, March 2019
- Zheng, Xiyin; Wu, Ming; Li, Xinyi
- Autophagy, Vol. 15, Issue 12
An atypical LIR motif within UBA5 (ubiquitin like modifier activating enzyme 5) interacts with GABARAP proteins and mediates membrane localization of UBA5
journal, April 2019
- Huber, Jessica; Obata, Miki; Gruber, Jens
- Autophagy
Dehydrin MtCAS31 promotes autophagic degradation under drought stress
journal, July 2019
- Li, Xin; Liu, Qianwen; Feng, Hao
- Autophagy
All roads lead to the vacuole—autophagic transport as part of the endomembrane trafficking network in plants
journal, November 2017
- Kalinowska, Kamila; Isono, Erika
- Journal of Experimental Botany, Vol. 69, Issue 6
Tuning the proteasome to brighten the end of the journey
journal, November 2016
- Mayor, Thibault; Sharon, Michal; Glickman, Michael H.
- American Journal of Physiology-Cell Physiology, Vol. 311, Issue 5
The Role and Regulation of Autophagy and the Proteasome During Aging and Senescence in Plants
journal, April 2019
- Wang, Haojie; Schippers, Jos H. M.
- Genes, Vol. 10, Issue 4
Autophagy in Plant: A New Orchestrator in the Regulation of the Phytohormones Homeostasis
journal, June 2019
- Gou, Wentao; Li, Xi; Guo, Shaoying
- International Journal of Molecular Sciences, Vol. 20, Issue 12
Cellular Responses to Proteasome Inhibition: Molecular Mechanisms and Beyond
journal, July 2019
- Albornoz, Nicolas; Bustamante, Hianara; Soza, Andrea
- International Journal of Molecular Sciences, Vol. 20, Issue 14
IRE1B degrades RNAs encoding proteins that interfere with the induction of autophagy by ER stress in Arabidopsis thaliana
text, January 2019
- Bao, Yan; Pu, Yunting; Yu, Xiang
- Taylor & Francis
Functional characterization of EI24-induced autophagy in the degradation of RING-domain E3 ligases
journal, August 2016
- Devkota, Sushil; Jeong, Hyobin; Kim, Yunmi
- Autophagy, Vol. 12, Issue 11
IRE1B degrades RNAs encoding proteins that interfere with the induction of autophagy by ER stress in Arabidopsis thaliana
journal, August 2018
- Bao, Yan; Pu, Yunting; Yu, Xiang
- Autophagy, Vol. 14, Issue 9
An atypical LIR motif within UBA5 (ubiquitin like modifier activating enzyme 5) interacts with GABARAP proteins and mediates membrane localization of UBA5
text, January 2019
- Huber, Jessica; Obata, Miki; Gruber, Jens
- Taylor & Francis
The paradox of proteasome granules
journal, August 2017
- Enenkel, Cordula
- Current Genetics, Vol. 64, Issue 1
Trehalose Inhibits Protein Aggregation Caused by Transient Ischemic Insults Through Preservation of Proteasome Activity, Not via Induction of Autophagy
journal, October 2016
- Li, Ye; Luo, Yinan; Luo, Tianfei
- Molecular Neurobiology, Vol. 54, Issue 9
The life cycle of the 26S proteasome: from birth, through regulation and function, and onto its death
journal, July 2016
- Livneh, Ido; Cohen-Kaplan, Victoria; Cohen-Rosenzweig, Chen
- Cell Research, Vol. 26, Issue 8
The Arabidopsis MIEL1 E3 ligase negatively regulates ABA signalling by promoting protein turnover of MYB96
journal, September 2016
- Lee, Hong Gil; Seo, Pil Joon
- Nature Communications, Vol. 7, Issue 1
Autophagy and autophagy-related proteins in the immune system
journal, September 2015
- Shibutani, Shusaku T.; Saitoh, Tatsuya; Nowag, Heike
- Nature Immunology, Vol. 16, Issue 10
Mechanistic insights into selective autophagy pathways: lessons from yeast
journal, July 2016
- Farré, Jean-Claude; Subramani, Suresh
- Nature Reviews Molecular Cell Biology, Vol. 17, Issue 9
UIM-UDS: a new interface between ATG8 and its interactors
journal, May 2019
- Lei, Yuchen; Klionsky, Daniel J.
- Cell Research, Vol. 29, Issue 7
Maize multi-omics reveal roles for autophagic recycling in proteome remodelling and lipid turnover
journal, November 2018
- McLoughlin, Fionn; Augustine, Robert C.; Marshall, Richard S.
- Nature Plants, Vol. 4, Issue 12
Regulation of proteasome assembly and activity in health and disease
journal, July 2018
- Rousseau, Adrien; Bertolotti, Anne
- Nature Reviews Molecular Cell Biology, Vol. 19, Issue 11
The ubiquitin–proteasome system in kidney physiology and disease
journal, April 2019
- Meyer-Schwesinger, Catherine
- Nature Reviews Nephrology, Vol. 15, Issue 7
The role of the immunoproteasome in interferon-γ-mediated microglial activation
journal, August 2017
- Moritz, Kasey E.; McCormack, Nikki M.; Abera, Mahlet B.
- Scientific Reports, Vol. 7, Issue 1
Accumulation of protein aggregates induces autolytic programmed cell death in hybrid tobacco cells expressing hybrid lethality
journal, July 2019
- Ueno, Naoya; Kashiwagi, Megumi; Kanekatsu, Motoki
- Scientific Reports, Vol. 9, Issue 1
The transmembrane autophagy cargo receptors ATI1 and ATI2 interact with ATG8 through intrinsically disordered regions with distinct biophysical properties
journal, February 2019
- Sjøgaard, Ida Marie Zobbe; Bressendorff, Simon; Prestel, Andreas
- Biochemical Journal, Vol. 476, Issue 3
p62- and ubiquitin-dependent stress-induced autophagy of the mammalian 26S proteasome
journal, October 2016
- Cohen-Kaplan, Victoria; Livneh, Ido; Avni, Noa
- Proceedings of the National Academy of Sciences, Vol. 113, Issue 47
The viral F-box protein P0 induces an ER-derived autophagy degradation pathway for the clearance of membrane-bound AGO1
journal, October 2019
- Michaeli, Simon; Clavel, Marion; Lechner, Esther
- Proceedings of the National Academy of Sciences, Vol. 116, Issue 45
Autophagic clearance of proteasomes in yeast requires the conserved sorting nexin Snx4
journal, November 2017
- Nemec, Antonia A.; Howell, Lauren A.; Peterson, Anna K.
- Journal of Biological Chemistry, Vol. 292, Issue 52
Proteomic analysis of affinity-purified 26S proteasomes identifies a suite of assembly chaperones in Arabidopsis
journal, September 2019
- Gemperline, David C.; Marshall, Richard S.; Lee, Kwang-Hee
- Journal of Biological Chemistry, Vol. 294, Issue 46
Ubiquitin signaling and autophagy
journal, November 2017
- Grumati, Paolo; Dikic, Ivan
- Journal of Biological Chemistry, Vol. 293, Issue 15
Comparative analyses of ubiquitin-like ATG8 and cysteine protease ATG4 autophagy genes in the plant lineage and cross-kingdom processing of ATG8 by ATG4
journal, September 2016
- Seo, Eunyoung; Woo, Jongchan; Park, Eunsook
- Autophagy, Vol. 12, Issue 11
An additional role for chloroplast proteins—an amino acid reservoir for energy production during sugar starvation
journal, December 2018
- Izumi, Masanori; Ishida, Hiroyuki
- Plant Signaling & Behavior, Vol. 14, Issue 1
Protein quality control in the secretory pathway
journal, September 2019
- Sun, Zhihao; Brodsky, Jeffrey L.
- Journal of Cell Biology, Vol. 218, Issue 10
Ubiquitin recognition by the proteasome
journal, January 2017
- Saeki, Yasushi
- Journal of Biochemistry
Increases in activity of proteasome and papain-like cysteine protease in Arabidopsis autophagy mutants: back-up compensatory effect or cell-death promoting effect?
journal, January 2018
- Havé, Marien; Balliau, Thierry; Cottyn-Boitte, Betty
- Journal of Experimental Botany, Vol. 69, Issue 6
Autophagy-related approaches for improving nutrient use efficiency and crop yield protection
journal, March 2018
- Avin-Wittenberg, Tamar; Baluška, Frantisek; Bozhkov, Peter V.
- Journal of Experimental Botany, Vol. 69, Issue 6
Plant autophagy: mechanisms and functions
journal, March 2018
- Bozhkov, Peter V.
- Journal of Experimental Botany, Vol. 69, Issue 6
Proteolysis and nitrogen: emerging insights
journal, January 2019
- Tornkvist, Anna; Liu, Chen; Moschou, Panagiotis N.
- Journal of Experimental Botany, Vol. 70, Issue 7
TOR inhibitors: from mammalian outcomes to pharmacogenetics in plants and algae
journal, March 2019
- Montané, Marie-Hélène; Menand, Benoît
- Journal of Experimental Botany, Vol. 70, Issue 8
Arabidopsis cargo receptor NBR1 mediates selective autophagy of defective proteins
journal, September 2019
- Jung, Hyera; Lee, Han Nim; Marshall, Richard S.
- Journal of Experimental Botany, Vol. 71, Issue 1
The Proteasome and Its Network: Engineering for Adaptability
journal, March 2019
- Finley, Daniel; Prado, Miguel A.
- Cold Spring Harbor Perspectives in Biology, Vol. 12, Issue 1
Hydrogen sulfide regulates muscle RING finger‐1 protein S‐sulfhydration at Cys 44 to prevent cardiac structural damage in diabetic cardiomyopathy
journal, April 2019
- Sun, Xiaojiao; Zhao, Dechao; Lu, Fangping
- British Journal of Pharmacology, Vol. 177, Issue 4
To deliver or to degrade - an interplay of the ubiquitin-proteasome system, autophagy and vesicular transport in plants
journal, October 2016
- Zientara-Rytter, Katarzyna; Sirko, Agnieszka
- The FEBS Journal, Vol. 283, Issue 19
Autophagy proteins in antigen processing for presentation on MHC molecules
journal, June 2016
- Münz, Christian
- Immunological Reviews, Vol. 272, Issue 1
Nuclear autophagy degrades a geminivirus nuclear protein to restrict viral infection in solanaceous plants
journal, November 2019
- Li, Fangfang; Zhang, Mingzhen; Zhang, Changwei
- New Phytologist, Vol. 225, Issue 4
The ubiquitin‐proteasome system in plant responses to environments
journal, August 2019
- Xu, Fa‐Qing; Xue, Hong‐Wei
- Plant, Cell & Environment, Vol. 42, Issue 10
Proteasome 19S RP and translation preinitiation complexes are secreted within exosomes upon serum starvation
journal, May 2019
- Bec, Nicole; Bonhoure, Anne; Henry, Laurent
- Traffic, Vol. 20, Issue 7
Precision autophagy directed by receptor regulators – emerging examples within the TRIM family
journal, February 2016
- Kimura, Tomonori; Mandell, Michael; Deretic, Vojo
- Journal of Cell Science, Vol. 129, Issue 5
p62-mediated phase separation at the intersection of the ubiquitin-proteasome system and autophagy
journal, October 2018
- Danieli, Alberto; Martens, Sascha
- Journal of Cell Science, Vol. 131, Issue 19
Graded Proteasome Dysfunction in Caenorhabditis elegans Activates an Adaptive Response Involving the Conserved SKN-1 and ELT-2 Transcription Factors and the Autophagy-Lysosome Pathway
journal, February 2016
- Keith, Scott A.; Maddux, Sarah K.; Zhong, Yayu
- PLOS Genetics, Vol. 12, Issue 2
AMPK regulates ESCRT-dependent microautophagy of proteasomes concomitant with proteasome storage granule assembly during glucose starvation
journal, November 2019
- Li, Jianhui; Breker, Michal; Graham, Morven
- PLOS Genetics, Vol. 15, Issue 11
Molecular definitions of autophagy and related processes
journal, May 2017
- Galluzzi, Lorenzo; Baehrecke, Eric H.; Ballabio, Andrea
- The EMBO Journal, Vol. 36, Issue 13
Proteasomal degradation within endocytic organelles mediates antigen cross‐presentation
journal, July 2019
- Sengupta, Debrup; Graham, Morven; Liu, Xinran
- The EMBO Journal, Vol. 38, Issue 16
Crosstalk Between Mammalian Autophagy and the Ubiquitin-Proteasome System
journal, October 2018
- Kocaturk, Nur Mehpare; Gozuacik, Devrim
- Frontiers in Cell and Developmental Biology, Vol. 6
Modulating T Cell Responses via Autophagy: The Intrinsic Influence Controlling the Function of Both Antigen-Presenting Cells and T Cells
journal, December 2018
- Merkley, Seth D.; Chock, Cameron J.; Yang, Xuexian O.
- Frontiers in Immunology, Vol. 9
Dynamic Regulation of the 26S Proteasome: From Synthesis to Degradation
journal, June 2019
- Marshall, Richard S.; Vierstra, Richard D.
- Frontiers in Molecular Biosciences, Vol. 6
Spatial Organization of Proteasome Aggregates in the Regulation of Proteasome Homeostasis
journal, January 2020
- Karmon, Ofri; Ben Aroya, Shay
- Frontiers in Molecular Biosciences, Vol. 6
Autophagic Turnover of Chloroplasts: Its Roles and Regulatory Mechanisms in Response to Sugar Starvation
journal, March 2019
- Izumi, Masanori; Nakamura, Sakuya; Li, Nan
- Frontiers in Plant Science, Vol. 10
The Proteasome Lid Triggers COP9 Signalosome Activity during the Transition of Saccharomyces cerevisiae Cells into Quiescence
journal, September 2019
- Bramasole, Laylan; Sinha, Abhishek; Harshuk, Dana
- Biomolecules, Vol. 9, Issue 9
Multiscale and Multimodal Approaches to Study Autophagy in Model Plants
journal, January 2018
- Marion, Jessica; Le Bars, Romain; Besse, Laetitia
- Cells, Vol. 7, Issue 1
The Role of ATG16 in Autophagy and The Ubiquitin Proteasome System
journal, December 2018
- Xiong, Qiuhong; Li, Wenjing; Li, Ping
- Cells, Vol. 8, Issue 1
Functional Characterization of Ubiquitin-Like Core Autophagy Protein ATG12 in Dictyostelium discoideum
journal, January 2019
- Fischer, Sarah; Rijal, Ramesh; Frommolt, Peter
- Cells, Vol. 8, Issue 1
The Ins and Outs of Autophagic Ribosome Turnover
journal, December 2019
- Kazibwe, Zakayo; Liu, Ang-Yu; MacIntosh, Gustavo C.
- Cells, Vol. 8, Issue 12
Autophagic Machinery of Plant Peroxisomes
journal, September 2019
- Borek, Sławomir; Stefaniak, Szymon; Śliwiński, Jan
- International Journal of Molecular Sciences, Vol. 20, Issue 19
The Ubiquitin System and Jasmonate Signaling
journal, January 2016
- Nagels Durand, Astrid; Pauwels, Laurens; Goossens, Alain
- Plants, Vol. 5, Issue 1
Dynamics of Short-Term Metabolic Profiling in Radish Sprouts (Raphanus sativus L.) in Response to Nitrogen Deficiency
text, January 2019
- Baek, Seung-A; Im, Kyung-Hoan; Park, Sang Un
- Zenodo
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journal, April 2018
- Marshall, Richard S.; Vierstra, Richard D.
- eLife, Vol. 7