Designing allostery-inspired response in mechanical networks
Abstract
Recent advances in designing metamaterials have demonstrated that global mechanical properties of disordered spring networks can be tuned by selectively modifying only a small subset of bonds. Here, using a computationally efficient approach, we extend this idea to tune more general properties of networks. With nearly complete success, we are then able to produce a strain between any two target nodes in a network in response to an applied source strain on any other pair of nodes by removing only ~1% of the bonds. We are also able to control multiple pairs of target nodes, each with a different individual response, from a single source, and to tune multiple independent source/target responses simultaneously into a network. We have fabricated physical networks in macroscopic 2D and 3D systems that exhibit these responses. This work is inspired by the long-range coupled conformational changes that constitute allosteric function in proteins. The fact that allostery is a common means for regulation in biological molecules suggests that it is a relatively easy property to develop through evolution. In analogy, our results show that long-range coupled mechanical responses are similarly easy to achieve in disordered networks.
- Authors:
-
- Univ. of Pennsylvania, Philadelphia, PA (United States). Dept. of Physics and Astronomy
- Univ. of Chicago, IL (United States). Dept. of Physics
- Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States). Dept. of Mechanical Engineering
- Harvard Univ., Cambridge, MA (United States). School of Engineering and Applied Sciences
- Publication Date:
- Research Org.:
- Univ. of Pennsylvania, Philadelphia, PA (United States); Univ. of Chicago, IL (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22). Materials Sciences & Engineering Division; Inst. for Advanced Study (IAS) The Simons Center for Systems Biology, Princeton, NJ (United States); Simons Foundation; National Science Foundation (NSF); National Inst. of Standards and Technology (NIST)
- OSTI Identifier:
- 1344433
- Alternate Identifier(s):
- OSTI ID: 1430120
- Grant/Contract Number:
- FG02-05ER46199; FG02-03ER46088; 305547; 327939; 60NANB15D055
- Resource Type:
- Published Article
- Journal Name:
- Proceedings of the National Academy of Sciences of the United States of America
- Additional Journal Information:
- Journal Name: Proceedings of the National Academy of Sciences of the United States of America Journal Volume: 114 Journal Issue: 10; Journal ID: ISSN 0027-8424
- Publisher:
- National Academy of Sciences
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 36 MATERIALS SCIENCE; 97 MATHEMATICS AND COMPUTING; 74 ATOMIC AND MOLECULAR PHYSICS; 75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND SUPERFLUIDITY; mechanical metamaterials; allostery; tunable response; proteins; disordered networks
Citation Formats
Rocks, Jason W., Pashine, Nidhi, Bischofberger, Irmgard, Goodrich, Carl P., Liu, Andrea J., and Nagel, Sidney R. Designing allostery-inspired response in mechanical networks. United States: N. p., 2017.
Web. doi:10.1073/pnas.1612139114.
Rocks, Jason W., Pashine, Nidhi, Bischofberger, Irmgard, Goodrich, Carl P., Liu, Andrea J., & Nagel, Sidney R. Designing allostery-inspired response in mechanical networks. United States. https://doi.org/10.1073/pnas.1612139114
Rocks, Jason W., Pashine, Nidhi, Bischofberger, Irmgard, Goodrich, Carl P., Liu, Andrea J., and Nagel, Sidney R. Tue .
"Designing allostery-inspired response in mechanical networks". United States. https://doi.org/10.1073/pnas.1612139114.
@article{osti_1344433,
title = {Designing allostery-inspired response in mechanical networks},
author = {Rocks, Jason W. and Pashine, Nidhi and Bischofberger, Irmgard and Goodrich, Carl P. and Liu, Andrea J. and Nagel, Sidney R.},
abstractNote = {Recent advances in designing metamaterials have demonstrated that global mechanical properties of disordered spring networks can be tuned by selectively modifying only a small subset of bonds. Here, using a computationally efficient approach, we extend this idea to tune more general properties of networks. With nearly complete success, we are then able to produce a strain between any two target nodes in a network in response to an applied source strain on any other pair of nodes by removing only ~1% of the bonds. We are also able to control multiple pairs of target nodes, each with a different individual response, from a single source, and to tune multiple independent source/target responses simultaneously into a network. We have fabricated physical networks in macroscopic 2D and 3D systems that exhibit these responses. This work is inspired by the long-range coupled conformational changes that constitute allosteric function in proteins. The fact that allostery is a common means for regulation in biological molecules suggests that it is a relatively easy property to develop through evolution. In analogy, our results show that long-range coupled mechanical responses are similarly easy to achieve in disordered networks.},
doi = {10.1073/pnas.1612139114},
journal = {Proceedings of the National Academy of Sciences of the United States of America},
number = 10,
volume = 114,
place = {United States},
year = {Tue Feb 21 00:00:00 EST 2017},
month = {Tue Feb 21 00:00:00 EST 2017}
}
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https://doi.org/10.1073/pnas.1612139114
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