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Title: Systems pharmacology modeling of drug-induced hyperbilirubinemia: Differentiating hepatotoxicity and inhibition of enzymes/transporters

Authors:
 [1] ;  [2] ;  [1] ;  [3] ;  [4] ;  [5] ;  [1] ;  [1]
  1. DILIsym Services Inc, Research Triangle Park North Carolina USA
  2. DILIsym Services Inc, Research Triangle Park North Carolina USA, University of North Carolina Institute for Drug Safety Sciences, The Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill North Carolina USA
  3. ADME Transporters, Drug Safety and Metabolism, Innovative Medicines and Early Development, AstraZeneca, Cambridge United Kingdom
  4. Drug Safety and Metabolism, AstraZeneca R&D, Waltham Massachusetts USA
  5. University of North Carolina Institute for Drug Safety Sciences, The Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill North Carolina USA
Publication Date:
Type:
Published Article
Journal Name:
Clinical Pharmacology and Therapeutics
Additional Journal Information:
Journal Volume: 101; Journal Issue: 4; Related Information: CHORUS Timestamp: 2017-10-20 16:30:25; Journal ID: ISSN 0009-9236
Publisher:
Wiley Blackwell (John Wiley & Sons)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
OSTI Identifier:
1344128
Alternate Identifier(s):
OSTI ID: 1344129