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Title: Cross-sections for (p,x) reactions on natural chromium for the production of 52,52m,54Mn radioisotopes

The production of positron-emitting isotopes of manganese is potentially important for developing contrast agents for dual-modality positron emission tomography and magnetic resonance (PET/MR) imaging, as well as for in vivo imaging of the biodistribution and toxicity of manganese. Furthermore, the decay properties of 52Mn make it an excellent candidate for these applications, and it can easily be produced by bombardment of a chromium target with protons or deuterons from a low-energy biomedical cyclotron. There are several parameters essential to this mode of production—target thickness, beam energy, beam current, and bombardment time—depend heavily on the availability of reliable, reproducible cross-section data. Our paper contributes to the routine production of 52gMn for biomedical research by contributing experimental cross-sections for natural chromium ( natCr) targets for the natCr(p,x) 52gMn reaction, as well as for the production of the radiocontaminants 52m, 54Mn.
 [1] ;  [2] ;  [1]
  1. Washington Univ., St. Louis, MO (United States). Dept. of Biomedical Engineering; Washington Univ. School of Medicine, St. Louis, MO (United States). Mallinckrodt Inst. of Radiology
  2. Washington Univ. School of Medicine, St. Louis, MO (United States). Mallinckrodt Inst. of Radiology
Publication Date:
Grant/Contract Number:
Accepted Manuscript
Journal Name:
Applied Radiation and Isotopes
Additional Journal Information:
Journal Volume: 96; Journal Issue: C; Journal ID: ISSN 0969-8043
Research Org:
Washington Univ., St. Louis, MO (United States)
Sponsoring Org:
USDOE National Nuclear Security Administration (NNSA); National Institutes of Health (NIH)
Country of Publication:
United States
07 ISOTOPE AND RADIATION SOURCES; 52Mn; 52mMn; 54Mn; Cross-section; Solid target; Radiometal; PET isotopes; Isotope production
OSTI Identifier:
Alternate Identifier(s):
OSTI ID: 1250574