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Title: Molecular Design of Antifouling Polymer Brushes Using Sequence-Specific Peptoids

Material systems that can be used to flexibly and precisely define the chemical nature and molecular arrangement of a surface would be invaluable for the control of complex biointerfacial interactions. For example, progress in antifouling polymer biointerfaces that prevents nonspecific protein adsorption and cell attachment, which can significantly improve the performance of an array of biomedical and industrial applications, is hampered by a lack of chemical models to identify the molecular features conferring their properties. Poly(N-substituted glycine) “peptoids” are peptidomimetic polymers that can be conveniently synthesized with specific monomer sequences and chain lengths, and are presented as a versatile platform for investigating the molecular design of antifouling polymer brushes. Zwitterionic antifouling polymer brushes have captured significant recent attention, and a targeted library of zwitterionic peptoid brushes with different charge densities, hydration, separations between charged groups, chain lengths, and grafted chain densities, is quantitatively evaluated for their antifouling properties through a range of protein adsorption and cell attachment assays. Specific zwitterionic brush designs are found to give rise to distinct but subtle differences in properties. In conclusion, the results also point to the dominant roles of the grafted chain density and chain length in determining the performance of antifouling polymer brushes.
Authors:
 [1] ;  [1] ;  [1] ;  [2] ;  [1] ;  [3] ;  [1]
  1. Northwestern Univ., Evanston, IL (United States). Biomedical Engineering Dept., Chemistry of Life Processes Inst.
  2. Univ. of Strathclyde, Glasgow (United Kingdom). Depy. of Pure and Applied Chemistry
  3. Northwestern Univ., Evanston, IL (United States). Biomedical Engineering Dept., Chemistry of Life Processes Inst.; Northwestern Univ., Evanston, IL (United States). Dept. of Chemistry, Dept. of Chemical and Biological Engineering, and the Robert H. Lurie Comprehensive Cancer Center
Publication Date:
Grant/Contract Number:
AC02-05CH11231; EB005772; 2011124091
Type:
Accepted Manuscript
Journal Name:
Advanced Materials Interfaces
Additional Journal Information:
Journal Volume: 2; Journal Issue: 1; Journal ID: ISSN 2196-7350
Publisher:
Wiley-VCH
Research Org:
Northwestern Univ., Evanston, IL (United States)
Sponsoring Org:
USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22)
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; 59 BASIC BIOLOGICAL SCIENCES; biointerface; protein and cell surface interactions; zwitterionic polymer brush; surface modification
OSTI Identifier:
1343092

Lau, King Hang Aaron, Sileika, Tadas S., Park, Sung Hyun, Sousa, Ana M. L., Burch, Patrick, Szleifer, Igal, and Messersmith, Phillip B.. Molecular Design of Antifouling Polymer Brushes Using Sequence-Specific Peptoids. United States: N. p., Web. doi:10.1002/admi.201400225.
Lau, King Hang Aaron, Sileika, Tadas S., Park, Sung Hyun, Sousa, Ana M. L., Burch, Patrick, Szleifer, Igal, & Messersmith, Phillip B.. Molecular Design of Antifouling Polymer Brushes Using Sequence-Specific Peptoids. United States. doi:10.1002/admi.201400225.
Lau, King Hang Aaron, Sileika, Tadas S., Park, Sung Hyun, Sousa, Ana M. L., Burch, Patrick, Szleifer, Igal, and Messersmith, Phillip B.. 2014. "Molecular Design of Antifouling Polymer Brushes Using Sequence-Specific Peptoids". United States. doi:10.1002/admi.201400225. https://www.osti.gov/servlets/purl/1343092.
@article{osti_1343092,
title = {Molecular Design of Antifouling Polymer Brushes Using Sequence-Specific Peptoids},
author = {Lau, King Hang Aaron and Sileika, Tadas S. and Park, Sung Hyun and Sousa, Ana M. L. and Burch, Patrick and Szleifer, Igal and Messersmith, Phillip B.},
abstractNote = {Material systems that can be used to flexibly and precisely define the chemical nature and molecular arrangement of a surface would be invaluable for the control of complex biointerfacial interactions. For example, progress in antifouling polymer biointerfaces that prevents nonspecific protein adsorption and cell attachment, which can significantly improve the performance of an array of biomedical and industrial applications, is hampered by a lack of chemical models to identify the molecular features conferring their properties. Poly(N-substituted glycine) “peptoids” are peptidomimetic polymers that can be conveniently synthesized with specific monomer sequences and chain lengths, and are presented as a versatile platform for investigating the molecular design of antifouling polymer brushes. Zwitterionic antifouling polymer brushes have captured significant recent attention, and a targeted library of zwitterionic peptoid brushes with different charge densities, hydration, separations between charged groups, chain lengths, and grafted chain densities, is quantitatively evaluated for their antifouling properties through a range of protein adsorption and cell attachment assays. Specific zwitterionic brush designs are found to give rise to distinct but subtle differences in properties. In conclusion, the results also point to the dominant roles of the grafted chain density and chain length in determining the performance of antifouling polymer brushes.},
doi = {10.1002/admi.201400225},
journal = {Advanced Materials Interfaces},
number = 1,
volume = 2,
place = {United States},
year = {2014},
month = {11}
}