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Title: Enabling the democratization of the genomics revolution with a fully integrated web-based bioinformatics platform

Continued advancements in sequencing technologies have fueled the development of new sequencing applications and promise to flood current databases with raw data. A number of factors prevent the seamless and easy use of these data, including the breadth of project goals, the wide array of tools that individually perform fractions of any given analysis, the large number of associated software/hardware dependencies, and the detailed expertise required to perform these analyses. To address these issues, we have developed an intuitive web-based environment with a wide assortment of integrated and cutting-edge bioinformatics tools in pre-configured workflows. These workflows, coupled with the ease of use of the environment, provide even novice next-generation sequencing users with the ability to perform many complex analyses with only a few mouse clicks and, within the context of the same environment, to visualize and further interrogate their results. As a result, this bioinformatics platform is an initial attempt at Empowering the Development of Genomics Expertise (EDGE) in a wide range of applications for microbial research.
Authors:
 [1] ;  [1] ;  [2] ;  [1] ;  [3] ;  [1] ;  [1] ;  [1] ;  [4] ; ORCiD logo [1]
  1. Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
  2. Defense Threat Reduction Agency, Fort Belvoir, VA (United States); Naval Medical Research Center-Frederick, Fort Detrick, MD (United States)
  3. Naval Medical Research Center-Frederick, Fort Detrick, MD (United States); Henry M. Jackson Foundation, Bethesda, MD (United States)
  4. Naval Medical Research Center-Frederick, Fort Detrick, MD (United States)
Publication Date:
Report Number(s):
LA-UR-15-27035; LA-UR-15-22467
Journal ID: ISSN 0305-1048; TRN: US1701210
Grant/Contract Number:
AC52-06NA25396
Type:
Accepted Manuscript
Journal Name:
Nucleic Acids Research
Additional Journal Information:
Journal Volume: 45; Journal Issue: 1; Conference: DHS Biodetection strategy meeting, Los Alamos, NM (United States), 15-16 Apr 2015; Journal ID: ISSN 0305-1048
Publisher:
Oxford University Press
Research Org:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Sponsoring Org:
USDOD; USDOE
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 97 MATHEMATICS AND COMPUTING; Biological Science; Computer Science; cloud compatible bioinformatics pipelines and workflows; integrated web-based genome analysis; isolate and metagenome NGS data analysis and visualization; next generation sequencing genomics and metagenome
OSTI Identifier:
1342855