Comparative genomics of Mortierella elongata and its bacterial endosymbiont Mycoavidus cysteinexigens

Uehling, J.; Gryganskyi, A.; Hameed, K.; Tschaplinski, T.; Misztal, P. K.; Wu, S.; Desirò, A.; Vande Pol, N.; Du, Z.; Zienkiewicz, A.; Zienkiewicz, K.; Morin, E.; Tisserant, E.; Splivallo, R.; Hainaut, M.; Henrissat, B.; Ohm, R.; Kuo, A.; Yan, J.; Lipzen, A.; Nolan, M.; LaButti, K.; Barry, K.; Goldstein, A. H.; Labbé, J.; Schadt, C.; Tuskan, G.; Grigoriev, I.; Martin, F.; Vilgalys, R.; Bonito, G.

doi:10.1111/1462-2920.13669

Title: Comparative genomics of Mortierella elongata and its bacterial endosymbiont Mycoavidus cysteinexigens

Journal Article · 10 January 2017 · Environmental Microbiology

DOI: https://doi.org/10.1111/1462-2920.13669 · OSTI ID:1342658

Uehling, J. ^[1]; Gryganskyi, A. ^[2]; Hameed, K. ^[1]; Tschaplinski, T. ^[3]; Misztal, P. K. ^[4]; Wu, S. ^[5]; Desirò, A. ^[6]; Vande Pol, N. ^[6]; Du, Z. ^[6]; Zienkiewicz, A. ^[6]; Zienkiewicz, K. ^[6]; Morin, E. ^[7]; Tisserant, E. ^[7]; Splivallo, R. ^[8]; Hainaut, M. ^[9]; Henrissat, B. ^[9]; Ohm, R. ^[10]; Kuo, A. ^[11]; Yan, J. ^[11]; Lipzen, A. ^[11] more »

Duke Univ., Durham, NC (United States). Dept. of Biology
LF Lambert Spawn Company, Coatesville, PA (United States)
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Biosciences Division
Univ. of California, Berkeley, CA (United States)
Arizona State Univ., Tempe, AZ (United States)
Michigan State Univ., East Lansing, MI (United States). MSU-DOE Plant Research Lab.
Univ. of Lorraine, Nancy (France). National Inst. for Agricultural Research
Goethe Univ., Frankfurt (Germany). Inst. for Molecular Biosciences
Aix-Marseille Univ., and CNRS/IN2P3, Marseille (France). Architecture and Function of Biological Molecules
Utrecht Univ., (The Netherlands). Dept. of Biology
Joint Genome Inst., Oakland CA (United States)

Endosymbiosis of bacteria by eukaryotes is a defining feature of cellular evolution. In addition to well-known bacterial origins for mitochondria and chloroplasts, multiple origins of bacterial endosymbiosis are known within the cells of diverse animals, plants and fungi. Early-diverging lineages of terrestrial fungi harbor endosymbiotic bacteria belonging to the Burkholderiaceae. Furthermore, we sequenced the metagenome of the soil-inhabiting fungus Mortierella elongata and assembled the complete circular chromosome of its endosymbiont, Mycoavidus cysteinexigens, which we place within a lineage of endofungal symbionts that are sister clade to Burkholderia. The genome of M. elongata strain AG77 features a core set of primary metabolic pathways for degradation of simple carbohydrates and lipid biosynthesis, while the M. cysteinexigens (AG77) genome is reduced in size and function. Experiments using antibiotics to cure the endobacterium from the host demonstrate that the fungal host metabolism is highly modulated by presence/ absence of M. cysteinexigens. In independent comparative phylogenomic analyses of fungal and bacterial genomes we find that they are consistent with an ancient origin for M. elongata M. cysteinexigens symbiosis, most likely over 350 million years ago and concomitant with the terrestrialization of Earth and diversification of land fungi and plants.

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Research Organization:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER) (SC-23)

Grant/Contract Number:: AC05-00OR22725; AC02-05CH11231

OSTI ID:: 1342658

Journal Information:: Environmental Microbiology, Journal Name: Environmental Microbiology Journal Issue: 8 Vol. 19; ISSN 1462-2912

Publisher:: WileyCopyright Statement

Country of Publication:: United States

Language:: English

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Detection of a novel intracellular microbiome hosted in arbuscular mycorrhizal fungi Desirò, Alessandro; Salvioli, Alessandra; Ngonkeu, Eddy L. Nature Publishing Group https://doi.org/10.5167/uzh-91822	text	January 2014
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