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Title: Comparative genomics of Mortierella elongata and its bacterial endosymbiont Mycoavidus cysteinexigens

Abstract

Endosymbiosis of bacteria by eukaryotes is a defining feature of cellular evolution. In addition to well-known bacterial origins for mitochondria and chloroplasts, multiple origins of bacterial endosymbiosis are known within the cells of diverse animals, plants and fungi. Early-diverging lineages of terrestrial fungi harbor endosymbiotic bacteria belonging to the Burkholderiaceae. Furthermore, we sequenced the metagenome of the soil-inhabiting fungus Mortierella elongata and assembled the complete circular chromosome of its endosymbiont, Mycoavidus cysteinexigens, which we place within a lineage of endofungal symbionts that are sister clade to Burkholderia. The genome of M. elongata strain AG77 features a core set of primary metabolic pathways for degradation of simple carbohydrates and lipid biosynthesis, while the M. cysteinexigens (AG77) genome is reduced in size and function. Experiments using antibiotics to cure the endobacterium from the host demonstrate that the fungal host metabolism is highly modulated by presence/ absence of M. cysteinexigens. In independent comparative phylogenomic analyses of fungal and bacterial genomes we find that they are consistent with an ancient origin for M. elongata M. cysteinexigens symbiosis, most likely over 350 million years ago and concomitant with the terrestrialization of Earth and diversification of land fungi and plants.

Authors:
 [1];  [2];  [1];  [3];  [4];  [5];  [6];  [6];  [6];  [6];  [6];  [7];  [7];  [8];  [9];  [9];  [10];  [11];  [11];  [11] more »;  [11];  [11];  [11];  [4];  [3];  [3];  [3];  [11];  [7];  [1];  [6] « less
  1. Duke Univ., Durham, NC (United States). Dept. of Biology
  2. LF Lambert Spawn Company, Coatesville, PA (United States)
  3. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Biosciences Division
  4. Univ. of California, Berkeley, CA (United States)
  5. Arizona State Univ., Tempe, AZ (United States)
  6. Michigan State Univ., East Lansing, MI (United States). MSU-DOE Plant Research Lab.
  7. Univ. of Lorraine, Nancy (France). National Inst. for Agricultural Research
  8. Goethe Univ., Frankfurt (Germany). Inst. for Molecular Biosciences
  9. Aix-Marseille Univ., and CNRS/IN2P3, Marseille (France). Architecture and Function of Biological Molecules
  10. Utrecht Univ., (The Netherlands). Dept. of Biology
  11. Joint Genome Inst., Oakland CA (United States)
Publication Date:
Research Org.:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Biological and Environmental Research (BER) (SC-23)
OSTI Identifier:
1342658
Alternate Identifier(s):
OSTI ID: 1342680; OSTI ID: 1375465
Grant/Contract Number:  
AC05-00OR22725; AC02-05CH11231
Resource Type:
Accepted Manuscript
Journal Name:
Environmental Microbiology
Additional Journal Information:
Journal Volume: 19; Journal Issue: 8; Journal ID: ISSN 1462-2912
Publisher:
Wiley
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; Mortierella elongata; Bacterial Endosymbiosis; Mycoavidus cysteinexigens

Citation Formats

Uehling, J., Gryganskyi, A., Hameed, K., Tschaplinski, T., Misztal, P. K., Wu, S., Desirò, A., Vande Pol, N., Du, Z., Zienkiewicz, A., Zienkiewicz, K., Morin, E., Tisserant, E., Splivallo, R., Hainaut, M., Henrissat, B., Ohm, R., Kuo, A., Yan, J., Lipzen, A., Nolan, M., LaButti, K., Barry, K., Goldstein, A. H., Labbé, J., Schadt, C., Tuskan, G., Grigoriev, I., Martin, F., Vilgalys, R., and Bonito, G. Comparative genomics of Mortierella elongata and its bacterial endosymbiont Mycoavidus cysteinexigens. United States: N. p., 2017. Web. doi:10.1111/1462-2920.13669.
Uehling, J., Gryganskyi, A., Hameed, K., Tschaplinski, T., Misztal, P. K., Wu, S., Desirò, A., Vande Pol, N., Du, Z., Zienkiewicz, A., Zienkiewicz, K., Morin, E., Tisserant, E., Splivallo, R., Hainaut, M., Henrissat, B., Ohm, R., Kuo, A., Yan, J., Lipzen, A., Nolan, M., LaButti, K., Barry, K., Goldstein, A. H., Labbé, J., Schadt, C., Tuskan, G., Grigoriev, I., Martin, F., Vilgalys, R., & Bonito, G. Comparative genomics of Mortierella elongata and its bacterial endosymbiont Mycoavidus cysteinexigens. United States. doi:10.1111/1462-2920.13669.
Uehling, J., Gryganskyi, A., Hameed, K., Tschaplinski, T., Misztal, P. K., Wu, S., Desirò, A., Vande Pol, N., Du, Z., Zienkiewicz, A., Zienkiewicz, K., Morin, E., Tisserant, E., Splivallo, R., Hainaut, M., Henrissat, B., Ohm, R., Kuo, A., Yan, J., Lipzen, A., Nolan, M., LaButti, K., Barry, K., Goldstein, A. H., Labbé, J., Schadt, C., Tuskan, G., Grigoriev, I., Martin, F., Vilgalys, R., and Bonito, G. Wed . "Comparative genomics of Mortierella elongata and its bacterial endosymbiont Mycoavidus cysteinexigens". United States. doi:10.1111/1462-2920.13669. https://www.osti.gov/servlets/purl/1342658.
@article{osti_1342658,
title = {Comparative genomics of Mortierella elongata and its bacterial endosymbiont Mycoavidus cysteinexigens},
author = {Uehling, J. and Gryganskyi, A. and Hameed, K. and Tschaplinski, T. and Misztal, P. K. and Wu, S. and Desirò, A. and Vande Pol, N. and Du, Z. and Zienkiewicz, A. and Zienkiewicz, K. and Morin, E. and Tisserant, E. and Splivallo, R. and Hainaut, M. and Henrissat, B. and Ohm, R. and Kuo, A. and Yan, J. and Lipzen, A. and Nolan, M. and LaButti, K. and Barry, K. and Goldstein, A. H. and Labbé, J. and Schadt, C. and Tuskan, G. and Grigoriev, I. and Martin, F. and Vilgalys, R. and Bonito, G.},
abstractNote = {Endosymbiosis of bacteria by eukaryotes is a defining feature of cellular evolution. In addition to well-known bacterial origins for mitochondria and chloroplasts, multiple origins of bacterial endosymbiosis are known within the cells of diverse animals, plants and fungi. Early-diverging lineages of terrestrial fungi harbor endosymbiotic bacteria belonging to the Burkholderiaceae. Furthermore, we sequenced the metagenome of the soil-inhabiting fungus Mortierella elongata and assembled the complete circular chromosome of its endosymbiont, Mycoavidus cysteinexigens, which we place within a lineage of endofungal symbionts that are sister clade to Burkholderia. The genome of M. elongata strain AG77 features a core set of primary metabolic pathways for degradation of simple carbohydrates and lipid biosynthesis, while the M. cysteinexigens (AG77) genome is reduced in size and function. Experiments using antibiotics to cure the endobacterium from the host demonstrate that the fungal host metabolism is highly modulated by presence/ absence of M. cysteinexigens. In independent comparative phylogenomic analyses of fungal and bacterial genomes we find that they are consistent with an ancient origin for M. elongata M. cysteinexigens symbiosis, most likely over 350 million years ago and concomitant with the terrestrialization of Earth and diversification of land fungi and plants.},
doi = {10.1111/1462-2920.13669},
journal = {Environmental Microbiology},
number = 8,
volume = 19,
place = {United States},
year = {2017},
month = {1}
}

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Works referenced in this record:

Fatty Acid-Derived Biofuels and Chemicals Production in Saccharomyces cerevisiae
journal, September 2014

  • Zhou, Yongjin J.; Buijs, Nicolaas A.; Siewers, Verena
  • Frontiers in Bioengineering and Biotechnology, Vol. 2
  • DOI: 10.3389/fbioe.2014.00032

Phylogenomic Analyses Indicate that Early Fungi Evolved Digesting Cell Walls of Algal Ancestors of Land Plants
journal, May 2015

  • Chang, Ying; Wang, Sishuo; Sekimoto, Satoshi
  • Genome Biology and Evolution, Vol. 7, Issue 6
  • DOI: 10.1093/gbe/evv090

Bacterial Membrane Lipids: Where Do We Stand?
journal, October 2003


Endofungal bacterium controls its host by an hrp type III secretion system
journal, August 2010

  • Lackner, Gerald; Moebius, Nadine; Hertweck, Christian
  • The ISME Journal, Vol. 5, Issue 2
  • DOI: 10.1038/ismej.2010.126

Diverse Bacteria Inhabit Living Hyphae of Phylogenetically Diverse Fungal Endophytes
journal, April 2010

  • Hoffman, M. T.; Arnold, A. E.
  • Applied and Environmental Microbiology, Vol. 76, Issue 12
  • DOI: 10.1128/AEM.02928-09

Evolution of an endofungal Lifestyle: Deductions from the Burkholderia rhizoxinica Genome
journal, May 2011

  • Lackner, Gerald; Moebius, Nadine; Partida-Martinez, Laila P.
  • BMC Genomics, Vol. 12, Issue 1
  • DOI: 10.1186/1471-2164-12-210

Diversity Patterns, Ecology and Biological Activities of Fungal Communities Associated with the Endemic Macroalgae Across the Antarctic Peninsula
journal, February 2014

  • Furbino, Laura E.; Godinho, Valéria M.; Santiago, Iara F.
  • Microbial Ecology, Vol. 67, Issue 4
  • DOI: 10.1007/s00248-014-0374-9

The standard operating procedure of the DOE-JGI Microbial Genome Annotation Pipeline (MGAP v.4)
journal, October 2015

  • Huntemann, Marcel; Ivanova, Natalia N.; Mavromatis, Konstantinos
  • Standards in Genomic Sciences, Vol. 10, Issue 1
  • DOI: 10.1186/s40793-015-0077-y

A novel intracellular nitrogen-fixing symbiosis made by Ustilago maydis and Bacillus spp.
journal, March 2015

  • Ruiz-Herrera, José; León-Ramírez, Claudia; Vera-Nuñez, Antonio
  • New Phytologist, Vol. 207, Issue 3
  • DOI: 10.1111/nph.13359

Genome Characterization of the Oleaginous Fungus Mortierella alpina
journal, December 2011


Origin and diversification of endomycorrhizal fungi and coincidence with vascular land plants
journal, May 1993

  • Simon, Luc; Bousquet, Jean; Lévesque, Roger C.
  • Nature, Vol. 363, Issue 6424
  • DOI: 10.1038/363067a0

Review and re-analysis of domain-specific 16S primers
journal, December 2003


TagFinder for the quantitative analysis of gas chromatography—mass spectrometry (GC-MS)-based metabolite profiling experiments
journal, January 2008


Symbiosis with an endobacterium increases the fitness of a mycorrhizal fungus, raising its bioenergetic potential
journal, June 2015

  • Salvioli, Alessandra; Ghignone, Stefano; Novero, Mara
  • The ISME Journal, Vol. 10, Issue 1
  • DOI: 10.1038/ismej.2015.91

Mycoavidus cysteinexigens gen. nov., sp. nov., an endohyphal bacterium isolated from a soil isolate of the fungus Mortierella elongata
journal, May 2016

  • Nishizawa, Tomoyasu; Ohshima, Shoko; Hamada, Moriyuki
  • International Journal of Systematic and Evolutionary Microbiology, Vol. 66, Issue 5
  • DOI: 10.1099/ijsem.0.000990

Bayesian Phylogenetics with BEAUti and the BEAST 1.7
journal, February 2012

  • Drummond, Alexei J.; Suchard, Marc A.; Xie, Dong
  • Molecular Biology and Evolution, Vol. 29, Issue 8
  • DOI: 10.1093/molbev/mss075

A Gene Cluster Encoding Rhizoxin Biosynthesis in “Burkholderia rhizoxina”, the Bacterial Endosymbiont of the FungusRhizopus microsporus
journal, January 2007


Reconstructing the early evolution of Fungi using a six-gene phylogeny
journal, October 2006

  • James, Timothy Y.; Kauff, Frank; Schoch, Conrad L.
  • Nature, Vol. 443, Issue 7113
  • DOI: 10.1038/nature05110

High-quality draft assemblies of mammalian genomes from massively parallel sequence data
journal, December 2010

  • Gnerre, S.; MacCallum, I.; Przybylski, D.
  • Proceedings of the National Academy of Sciences, Vol. 108, Issue 4
  • DOI: 10.1073/pnas.1017351108

'Candidatus Glomeribacter gigasporarum' gen. nov., sp. nov., an endosymbiont of arbuscular mycorrhizal fungi
journal, January 2003

  • Bianciotto, V.
  • INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY, Vol. 53, Issue 1
  • DOI: 10.1099/ijs.0.02382-0

The Fungi
journal, September 2009


Presymbiotic growth and sporal morphology are affected in the arbuscular mycorrhizal fungus Gigaspora margarita cured of its endobacteria
journal, July 2007


A Mammalian Type I Fatty Acid Synthase Acyl Carrier Protein Domain Does Not Sequester Acyl Chains
journal, October 2007

  • Ploskoń, Eliza; Arthur, Christopher J.; Evans, Simon E.
  • Journal of Biological Chemistry, Vol. 283, Issue 1
  • DOI: 10.1074/jbc.M703454200

Improvement of Phylogenies after Removing Divergent and Ambiguously Aligned Blocks from Protein Sequence Alignments
journal, August 2007


antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences
journal, June 2011

  • Medema, Marnix H.; Blin, Kai; Cimermancic, Peter
  • Nucleic Acids Research, Vol. 39, Issue suppl_2
  • DOI: 10.1093/nar/gkr466

Detection of a novel intracellular microbiome hosted in arbuscular mycorrhizal fungi
journal, September 2013

  • Desirò, Alessandro; Salvioli, Alessandra; Ngonkeu, Eddy L.
  • The ISME Journal, Vol. 8, Issue 2
  • DOI: 10.1038/ismej.2013.151

Draft Genome Sequence of the Betaproteobacterial Endosymbiont Associated with the Fungus Mortierella elongata FMR23-6
journal, November 2014


Isolation of Endohyphal Bacteria from Foliar Ascomycota and In Vitro Establishment of Their Symbiotic Associations
journal, March 2016

  • Arendt, Kayla R.; Hockett, Kevin L.; Araldi-Brondolo, Sarah J.
  • Applied and Environmental Microbiology, Vol. 82, Issue 10
  • DOI: 10.1128/AEM.00452-16

Roles of the FabA and FabZ β-Hydroxyacyl-Acyl Carrier Protein Dehydratases in Escherichia coli Fatty Acid Biosynthesis
journal, November 1996


CAFE: a computational tool for the study of gene family evolution
journal, March 2006


OrthoMCL: Identification of Ortholog Groups for Eukaryotic Genomes
journal, September 2003


A core gut microbiome in obese and lean twins
journal, November 2008

  • Turnbaugh, Peter J.; Hamady, Micah; Yatsunenko, Tanya
  • Nature, Vol. 457, Issue 7228
  • DOI: 10.1038/nature07540

Isolating a functionally relevant guild of fungi from the root microbiome of Populus
journal, August 2016


Evolutionary Stability in a 400-Million-Year-Old Heritable Facultative Mutualism: Evolution in Glomeromycota-Glomeribacter Symbiosis
journal, March 2012


Mitochondrial Fatty Acid Synthesis Type II: More than Just Fatty Acids
journal, November 2008

  • Hiltunen, J. Kalervo; Schonauer, Melissa S.; Autio, Kaija J.
  • Journal of Biological Chemistry, Vol. 284, Issue 14
  • DOI: 10.1074/jbc.R800068200

RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies
journal, January 2014


Minimal genomes of mycoplasma-related endobacteria are plastic and contain host-derived genes for sustained life within Glomeromycota
journal, May 2015

  • Naito, Mizue; Morton, Joseph B.; Pawlowska, Teresa E.
  • Proceedings of the National Academy of Sciences, Vol. 112, Issue 25
  • DOI: 10.1073/pnas.1501676112

Phosphatidic acid synthesis in bacteria
journal, March 2013

  • Yao, Jiangwei; Rock, Charles O.
  • Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, Vol. 1831, Issue 3
  • DOI: 10.1016/j.bbalip.2012.08.018

The multienzyme architecture of eukaryotic fatty acid synthases
journal, December 2008

  • Leibundgut, Marc; Maier, Timm; Jenni, Simon
  • Current Opinion in Structural Biology, Vol. 18, Issue 6
  • DOI: 10.1016/j.sbi.2008.09.008

Succession of microbial consortia in the developing infant gut microbiome
journal, July 2010

  • Koenig, J. E.; Spor, A.; Scalfone, N.
  • Proceedings of the National Academy of Sciences, Vol. 108, Issue Supplement_1
  • DOI: 10.1073/pnas.1000081107

Genome of an arbuscular mycorrhizal fungus provides insight into the oldest plant symbiosis
journal, November 2013

  • Tisserant, E.; Malbreil, M.; Kuo, A.
  • Proceedings of the National Academy of Sciences, Vol. 110, Issue 50
  • DOI: 10.1073/pnas.1313452110

The Subsystems Approach to Genome Annotation and its Use in the Project to Annotate 1000 Genomes
journal, September 2005


Bacterial Long Chain Fatty Acid Transport: Gateway to a Fatty Acid-responsive Signaling System
journal, August 2004

  • DiRusso, Concetta C.; Black, Paul N.
  • Journal of Biological Chemistry, Vol. 279, Issue 48
  • DOI: 10.1074/jbc.R400026200

Global diversity and geography of soil fungi
journal, November 2014


A high resolution and high sensitivity proton-transfer-reaction time-of-flight mass spectrometer (PTR-TOF-MS)
journal, September 2009

  • Jordan, A.; Haidacher, S.; Hanel, G.
  • International Journal of Mass Spectrometry, Vol. 286, Issue 2-3
  • DOI: 10.1016/j.ijms.2009.07.005

Glomalean Fungi from the Ordovician
journal, September 2000


PATRIC, the bacterial bioinformatics database and analysis resource
journal, November 2013

  • Wattam, Alice R.; Abraham, David; Dalay, Oral
  • Nucleic Acids Research, Vol. 42, Issue D1
  • DOI: 10.1093/nar/gkt1099

Detection of Betaproteobacteria inside the Mycelium of the Fungus Mortierella elongata
journal, January 2010

  • Sato, Yoshinori; Narisawa, Kazuhiko; Tsuruta, Kazuto
  • Microbes and Environments, Vol. 25, Issue 4
  • DOI: 10.1264/jsme2.ME10134

Mechanistic diversity and regulation of Type II fatty acid synthesis
journal, November 2002

  • Marrakchi, H.; Zhang, Y.-M.; Rock, C. O.
  • Biochemical Society Transactions, Vol. 30, Issue 6, p. 1050-1055
  • DOI: 10.1042/bst0301050

Phylogenetic mixture models for proteins
journal, October 2008

  • Le, Si Quang; Lartillot, Nicolas; Gascuel, Olivier
  • Philosophical Transactions of the Royal Society B: Biological Sciences, Vol. 363, Issue 1512
  • DOI: 10.1098/rstb.2008.0180

The rhizosphere microbiome and plant health
journal, August 2012

  • Berendsen, Roeland L.; Pieterse, Corné M. J.; Bakker, Peter A. H. M.
  • Trends in Plant Science, Vol. 17, Issue 8
  • DOI: 10.1016/j.tplants.2012.04.001

Mosaic genome of endobacteria in arbuscular mycorrhizal fungi: Transkingdom gene transfer in an ancient mycoplasma-fungus association
journal, May 2015

  • Torres-Cortés, Gloria; Ghignone, Stefano; Bonfante, Paola
  • Proceedings of the National Academy of Sciences, Vol. 112, Issue 25
  • DOI: 10.1073/pnas.1501540112

RASTtk: A modular and extensible implementation of the RAST algorithm for building custom annotation pipelines and annotating batches of genomes
journal, February 2015

  • Brettin, Thomas; Davis, James J.; Disz, Terry
  • Scientific Reports, Vol. 5, Issue 1
  • DOI: 10.1038/srep08365

Diet Drives Convergence in Gut Microbiome Functions Across Mammalian Phylogeny and Within Humans
journal, May 2011


The genome of the obligate endobacterium of an AM fungus reveals an interphylum network of nutritional interactions
journal, August 2011

  • Ghignone, Stefano; Salvioli, Alessandra; Anca, Iulia
  • The ISME Journal, Vol. 6, Issue 1
  • DOI: 10.1038/ismej.2011.110

Regulation of cell size in response to nutrient availability by fatty acid biosynthesis in Escherichia coli
journal, August 2012

  • Yao, Z.; Davis, R. M.; Kishony, R.
  • Proceedings of the National Academy of Sciences, Vol. 109, Issue 38
  • DOI: 10.1073/pnas.1209742109

In Situ Identification of Intracellular Bacteria Related to Paenibacillus spp. in the Mycelium of the Ectomycorrhizal Fungus Laccaria bicolor S238N
journal, July 2003


Pathogenic fungus harbours endosymbiotic bacteria for toxin production
journal, October 2005

  • Partida-Martinez, Laila P.; Hertweck, Christian
  • Nature, Vol. 437, Issue 7060
  • DOI: 10.1038/nature03997

Endofungal bacteria as producers of mycotoxins
journal, December 2009

  • Lackner, Gerald; Partida-Martinez, Laila P.; Hertweck, Christian
  • Trends in Microbiology, Vol. 17, Issue 12
  • DOI: 10.1016/j.tim.2009.09.003

SseBCD Proteins Are Secreted by the Type III Secretion System of Salmonella Pathogenicity Island 2 and Function as a Translocon
journal, October 2001


Ecological and evolutionary significance of mycorrhizal symbioses in vascular plants (A Review)
journal, April 1980

  • Malloch, D. W.; Pirozynski, K. A.; Raven, P. H.
  • Proceedings of the National Academy of Sciences, Vol. 77, Issue 4
  • DOI: 10.1073/pnas.77.4.2113

Lipid production by oleaginous Mucorales cultivated on renewable carbon sources
journal, November 2007

  • Papanikolaou, Seraphim; Galiotou-Panayotou, Maria; Fakas, Stylianos
  • European Journal of Lipid Science and Technology, Vol. 109, Issue 11
  • DOI: 10.1002/ejlt.200700169

NORINE: a database of nonribosomal peptides
journal, December 2007

  • Caboche, S.; Pupin, M.; Leclere, V.
  • Nucleic Acids Research, Vol. 36, Issue Database
  • DOI: 10.1093/nar/gkm792

An interdomain network: the endobacterium of a mycorrhizal fungus promotes antioxidative responses in both fungal and plant hosts
journal, February 2016

  • Vannini, Candida; Carpentieri, Andrea; Salvioli, Alessandra
  • New Phytologist, Vol. 211, Issue 1
  • DOI: 10.1111/nph.13895

A phylum-level phylogenetic classification of zygomycete fungi based on genome-scale data
journal, September 2016

  • Spatafora, Joseph W.; Chang, Ying; Benny, Gerald L.
  • Mycologia, Vol. 108, Issue 5
  • DOI: 10.3852/16-042

Rnnotator: an automated de novo transcriptome assembly pipeline from stranded RNA-Seq reads
journal, January 2010


Non-pathogenic Rhizobium radiobacter F4 deploys plant beneficial activity independent of its host Piriformospora indica
journal, October 2015

  • Glaeser, Stefanie P.; Imani, Jafargholi; Alabid, Ibrahim
  • The ISME Journal, Vol. 10, Issue 4
  • DOI: 10.1038/ismej.2015.163

Plant host and soil origin influence fungal and bacterial assemblages in the roots of woody plants
journal, June 2014

  • Bonito, Gregory; Reynolds, Hannah; Robeson, Michael S.
  • Molecular Ecology, Vol. 23, Issue 13
  • DOI: 10.1111/mec.12821

PartitionFinder: Combined Selection of Partitioning Schemes and Substitution Models for Phylogenetic Analyses
journal, January 2012

  • Lanfear, R.; Calcott, B.; Ho, S. Y. W.
  • Molecular Biology and Evolution, Vol. 29, Issue 6
  • DOI: 10.1093/molbev/mss020

Phylogenomics and evolution of secondary metabolism in plant-associated fungi
journal, August 2015


Horizontal Gene Transfer in Eukaryotic Plant Pathogens
journal, August 2014


High resolution PTR-TOF: Quantification and formula confirmation of VOC in real time
journal, June 2010

  • Graus, Martin; Müller, Markus; Hansel, Armin
  • Journal of the American Society for Mass Spectrometry, Vol. 21, Issue 6
  • DOI: 10.1016/j.jasms.2010.02.006

Microbial Type I Fatty Acid Synthases (FAS): Major Players in a Network of Cellular FAS Systems
journal, September 2004


Down-regulation of the caffeic acid O-methyltransferase gene in switchgrass reveals a novel monolignol analog
journal, January 2012

  • Tschaplinski, Timothy J.; Standaert, Robert F.; Engle, Nancy L.
  • Biotechnology for Biofuels, Vol. 5, Issue 1
  • DOI: 10.1186/1754-6834-5-71

MycoCosm portal: gearing up for 1000 fungal genomes
journal, December 2013

  • Grigoriev, Igor V.; Nikitin, Roman; Haridas, Sajeet
  • Nucleic Acids Research, Vol. 42, Issue D1
  • DOI: 10.1093/nar/gkt1183

Creating the CIPRES Science Gateway for inference of large phylogenetic trees
conference, November 2010

  • Miller, Mark A.; Pfeiffer, Wayne; Schwartz, Terri
  • 2010 Gateway Computing Environments Workshop (GCE)
  • DOI: 10.1109/GCE.2010.5676129

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