Integrating ion mobility spectrometry into mass spectrometry-based exposome measurements: what can it add and how far can it go?
Abstract
Here, measuring the exposome remains a challenge due to the range and number of anthropogenic molecules that are encountered in our daily lives, as well as the complex systemic responses to these exposures. One option for improving the coverage, dynamic range and throughput of measurements is to incorporate ion mobility spectrometry (IMS) into current mass spectrometry (MS)-based analytical methods. In this perspective, we briefly review the state-of-the-art in measuring the exposome, and discuss the potential use for IMS-MS and the physico-chemical property of collisional cross section in both exposure assessment and molecular identification.
- Authors:
-
- Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
- Swiss Federal Institute of Aquatic Science & Technology, Dubendorf (Switzerland)
- Univ. of Natural Resources & Life Sciences (BOKU Vienna), Vienna (Austria)
- Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Oregon State Univ., Corvallis, OR (United States)
- Publication Date:
- Research Org.:
- Pacific Northwest National Laboratory (PNNL), Richland, WA (United States). Environmental Molecular Sciences Laboratory (EMSL)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1342290
- Report Number(s):
- PNNL-SA-121158
Journal ID: ISSN 1757-6180; 48246
- Grant/Contract Number:
- AC05-76RL01830
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Bioanalysis
- Additional Journal Information:
- Journal Volume: 9; Journal Issue: 1; Journal ID: ISSN 1757-6180
- Publisher:
- Future Science Group
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; Environmental Molecular Sciences Laboratory; collision cross section; exposome; ion mobility spectrometry; mass spectrometry; metabolome
Citation Formats
Metz, Thomas O., Baker, Erin S., Schymanski, Emma L., Renslow, Ryan S., Thomas, Dennis G., Causon, Tim J., Webb, Ian K., Hann, Stephan, Smith, Richard D., and Teeguarden, Justin G. Integrating ion mobility spectrometry into mass spectrometry-based exposome measurements: what can it add and how far can it go?. United States: N. p., 2016.
Web. doi:10.4155/bio-2016-0244.
Metz, Thomas O., Baker, Erin S., Schymanski, Emma L., Renslow, Ryan S., Thomas, Dennis G., Causon, Tim J., Webb, Ian K., Hann, Stephan, Smith, Richard D., & Teeguarden, Justin G. Integrating ion mobility spectrometry into mass spectrometry-based exposome measurements: what can it add and how far can it go?. United States. https://doi.org/10.4155/bio-2016-0244
Metz, Thomas O., Baker, Erin S., Schymanski, Emma L., Renslow, Ryan S., Thomas, Dennis G., Causon, Tim J., Webb, Ian K., Hann, Stephan, Smith, Richard D., and Teeguarden, Justin G. Tue .
"Integrating ion mobility spectrometry into mass spectrometry-based exposome measurements: what can it add and how far can it go?". United States. https://doi.org/10.4155/bio-2016-0244. https://www.osti.gov/servlets/purl/1342290.
@article{osti_1342290,
title = {Integrating ion mobility spectrometry into mass spectrometry-based exposome measurements: what can it add and how far can it go?},
author = {Metz, Thomas O. and Baker, Erin S. and Schymanski, Emma L. and Renslow, Ryan S. and Thomas, Dennis G. and Causon, Tim J. and Webb, Ian K. and Hann, Stephan and Smith, Richard D. and Teeguarden, Justin G.},
abstractNote = {Here, measuring the exposome remains a challenge due to the range and number of anthropogenic molecules that are encountered in our daily lives, as well as the complex systemic responses to these exposures. One option for improving the coverage, dynamic range and throughput of measurements is to incorporate ion mobility spectrometry (IMS) into current mass spectrometry (MS)-based analytical methods. In this perspective, we briefly review the state-of-the-art in measuring the exposome, and discuss the potential use for IMS-MS and the physico-chemical property of collisional cross section in both exposure assessment and molecular identification.},
doi = {10.4155/bio-2016-0244},
journal = {Bioanalysis},
number = 1,
volume = 9,
place = {United States},
year = {Tue Dec 06 00:00:00 EST 2016},
month = {Tue Dec 06 00:00:00 EST 2016}
}
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