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Title: A mild, rapid synthesis of freebase [ 11C]nicotine from [ 11C]methyl triflate

Here a rapid, mild radiosynthesis of freebase [ 11C]nicotine was developed by the methylation of freebase nornicotine with [ 11C]methyl triflate in acetone (5 min, 45 ºC). A basic (pH 10.5-11.0) HPLC system reproducibly yielded freebase [ 11C]nicotine as a well-defined single peak. The freebase [ 11C]nicotine was concentrated by solid phase extraction and formulated in 50 μL ethanol (370 MBq/50 μL) without evaporative loss suitable for a cigarette spiking study. A radiochemical yield of 60.4 ± 4.7 % (n = 3), radiochemical purity ≥ 99.9 % and specific activity of 648 GBq/μmol at EOB for 5 min beams were achieved.
Authors:
 [1] ;  [1] ;  [1] ;  [1] ;  [1] ;  [1]
  1. Brookhaven National Lab. (BNL), Upton, NY (United States). Biology Dept.
Publication Date:
Report Number(s):
BNL-112719-2016-JA
Journal ID: ISSN 0969-8043; TRN: US1701687
Grant/Contract Number:
SC00112704; AC02-98CH10886
Type:
Accepted Manuscript
Journal Name:
Applied Radiation and Isotopes
Additional Journal Information:
Journal Volume: 118; Journal Issue: C; Journal ID: ISSN 0969-8043
Publisher:
Elsevier
Research Org:
Brookhaven National Laboratory (BNL), Upton, NY (United States)
Sponsoring Org:
USDOE Office of Science (SC), Biological and Environmental Research (BER) (SC-23)
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; Freebase [(11)C]nicotine; [(11)C]methyl triflate
OSTI Identifier:
1340399
Alternate Identifier(s):
OSTI ID: 1397558