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Title: Applications of “Tender” Energy (1-5 keV) X-ray Absorption Spectroscopy in Life Sciences

The “tender” energy range of 1 to 5 keV, between the energy ranges of most “hard” (>5 keV) and “soft” (<1 keV) synchrotron X-ray facilities, offers some unique opportunities for synchrotron-based X-ray absorption fine structure spectroscopy in life sciences. In particular the K absorption edges of Na through Ca offer opportunities to study local structure, speciation, and chemistry of many important biological compounds, structures and processes. This is an area of largely untapped science, in part due to a scarcity of optimized facilities. Such measurements also entail unique experimental challenges. Lastly, this brief review describes the technique, its experimental challenges, recent progress in development of microbeam measurement capabilities, and several highlights illustrating applications in life sciences.
Authors:
 [1] ;  [2] ;  [3]
  1. Brookhaven National Lab. (BNL), Upton, NY (United States). National Synchrotron Light Source II (NSLS-II); Stony Brook Univ., NY (United States). Dept. of Geosciences
  2. Marymount Manhattan College, New York, NY (United States). Dept. of Natural Sciences
  3. Brookhaven National Lab. (BNL), Upton, NY (United States). National Synchrotron Light Source II (NSLS-II)
Publication Date:
Report Number(s):
BNL-112578-2016-JA; BNL-108478-2015-JA
Journal ID: ISSN 0929-8665
Grant/Contract Number:
SC0012704; SC00112704
Type:
Accepted Manuscript
Journal Name:
Protein and Peptide Letters
Additional Journal Information:
Journal Volume: 23; Journal Issue: 3; Journal ID: ISSN 0929-8665
Publisher:
Bentham Science Publishers
Research Org:
Brookhaven National Laboratory (BNL), Upton, NY (United States)
Sponsoring Org:
USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22)
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; Calcium; EXAFS; microbeam; natural organochlorine; sulfur; tender-energy; XANES; X-ray absorption spectroscopy; X-ray spectromicroscopy; 36 MATERIALS SCIENCE; calcium
OSTI Identifier:
1340387
Alternate Identifier(s):
OSTI ID: 1341507